iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000170315.13	ENST00000302182.7	ENSP00000304697.3
ENSG00000170315.13	ENST00000535788.1	ENSP00000437475.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circBase	CircNet	miRTarBase
microRNA	TRANSFAC	miRWalk	TargetScan
RepTar	miRNAMap	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Variation
OMIM
Drug and target
DrugBank
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/NEDD8	6.50e-124	406.1	153	228
ULD/UDP/UBQ/UBQ_PIM	1.20e-89	295.9	153	225

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/NEDD8

   S: 1    mlikvktLtgkeieieieesdtierikerveekeGiPPsqqrliyaGkqleddktaadynlekgsvLhLvLaLrGG 76
           m+i+vktLtgk+i++e+e+sdtie++k+++++keGiPP+qqrli+aGkqled++t++dyn++k+s+LhLvL+LrGG
   Q: 153  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG 228
           89*************************************************************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkk 73
           m+++vktl+gk+++lev+++dt+e++K+ki+++ g+pp+qq+LI+aGk+L+D +tLs+++i+++s++hlv++ 
   Q: 153  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRL 225
           99********************************************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling.

Protein Sequence
(Fasta)

MQIFVKTLTG KTITLEVEPS DTIENVKAKI QDKEGIPPDQ QRLIFAGKQL EDGRTLSDYN 60
IQKESTLHLV LRLRGGMQIF VKTLTGKTIT LEVEPSDTIE NVKAKIQDKE GIPPDQQRLI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTTTCCAGA GCTTTCGAGG AAGGTTTCTT CAACTCAAAT TCATCCGCCT GATAATTTTC 60
TTATATTTTC CTAAAGAAGG AAGAGAAGCG CATAGAGGAG AAGGGAAATA ATTTTTTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0903--Direct protein sequencing
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR019956--Ubiquitin
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2

Pfam

PF00240--ubiquitin

PRINTS

PR00348--UBIQUITIN

SMART

SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0030666--C:endocytic vesicle membrane
GO:0044322--C:endoplasmic reticulum quality control compartment
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0005615--C:extracellular space
GO:0005741--C:mitochondrial outer membrane
GO:0005739--C:mitochondrion
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000187--P:activation of MAPK activity
GO:0031145--P:anaphase-promoting complex-dependent catabolic process
GO:0044267--P:cellular protein metabolic process
GO:0042769--P:DNA damage response, detection of DNA damage
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:1904380--P:endoplasmic reticulum mannose trimming
GO:0016197--P:endosomal transport
GO:0035635--P:entry of bacterium into host cell
GO:0038128--P:ERBB2 signaling pathway
GO:0070987--P:error-free translesion synthesis
GO:0042276--P:error-prone translesion synthesis
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0008543--P:fibroblast growth factor receptor signaling pathway
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0070911--P:global genome nucleotide-excision repair
GO:0005978--P:glycogen biosynthetic process
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0045087--P:innate immune response
GO:0036297--P:interstrand cross-link repair
GO:0075733--P:intracellular transport of virus
GO:0034220--P:ion transmembrane transport
GO:0007254--P:JNK cascade
GO:0016236--P:macroautophagy
GO:0000165--P:MAPK cascade
GO:0061024--P:membrane organization
GO:0047497--P:mitochondrion transport along microtubule
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0002756--P:MyD88-independent toll-like receptor signaling pathway
GO:0043066--P:negative regulation of apoptotic process
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0010972--P:negative regulation of G2/M transition of mitotic cell cycle
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032480--P:negative regulation of type I interferon production
GO:0051436--P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0048812--P:neuron projection morphogenesis
GO:0038061--P:NIK/NF-kappaB signaling
GO:0007219--P:Notch signaling pathway
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0000715--P:nucleotide-excision repair, DNA damage recognition
GO:0000717--P:nucleotide-excision repair, DNA duplex unwinding
GO:0006297--P:nucleotide-excision repair, DNA gap filling
GO:0033683--P:nucleotide-excision repair, DNA incision
GO:0006296--P:nucleotide-excision repair, DNA incision, 5'-to lesion
GO:0006294--P:nucleotide-excision repair, preincision complex assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0090263--P:positive regulation of canonical Wnt signaling pathway
GO:0045742--P:positive regulation of epidermal growth factor receptor signaling pathway
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:1902255--P:positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1902527--P:positive regulation of protein monoubiquitination
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0051437--P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0006457--P:protein folding
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0043488--P:regulation of mRNA stability
GO:0060544--P:regulation of necroptotic process
GO:1901214--P:regulation of neuron death
GO:0061136--P:regulation of proteasomal protein catabolic process
GO:1901796--P:regulation of signal transduction by p53 class mediator
GO:0061418--P:regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0032479--P:regulation of type I interferon production
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0051403--P:stress-activated MAPK cascade
GO:0050852--P:T cell receptor signaling pathway
GO:0006283--P:transcription-coupled nucleotide-excision repair
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0019985--P:translesion synthesis
GO:0055085--P:transmembrane transport
GO:0035666--P:TRIF-dependent toll-like receptor signaling pathway
GO:0033209--P:tumor necrosis factor-mediated signaling pathway
GO:0019058--P:viral life cycle
GO:0019068--P:virion assembly
GO:0016055--P:Wnt signaling pathway
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:7314

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000772	Aegilops tauschii	47.35	1.00e-47	185.00
IUUC-Aml-001483	Ailuropoda melanoleuca	100.00	4.00e-130	456.00
IUUC-Bdi-014399	Brachypodium distachyon	96.05	2.00e-124	438.00
IUUC-Bra-017586	Brassica rapa	95.63	1.00e-124	438.00
IUUC-Cja-019680	Callithrix jacchus	100.00	4.00e-130	456.00
IUUC-Cfa-021247	Canis familiaris	99.56	2.00e-129	454.00
IUUC-Cre-022556	Chlamydomonas reinhardtii	97.37	3.00e-82	296.00
IUUC-Csa-024086	Chlorocebus sabaeus	100.00	7.00e-129	452.00
IUUC-Cgl-026543	Colletotrichum gloeosporioides	96.05	3.00e-124	437.00
IUUC-Dor-031044	Dipodomys ordii	100.00	3.00e-76	276.00
IUUC-Dse-031434	Dothistroma septosporum	96.05	3.00e-124	437.00
IUUC-Eca-033850	Equus caballus	100.00	4.00e-130	456.00
IUUC-Fca-036501	Felis catus	100.00	4.00e-130	456.00
IUUC-Fox-037730	Fusarium oxysporum	95.61	5.00e-124	436.00
IUUC-Gga-040636	Gallus gallus	100.00	1.00e-128	452.00
IUUC-Ggo-045286	Gorilla gorilla	100.00	4.00e-130	456.00
IUUC-Mcc-055509	Macaca mulatta	100.00	4.00e-130	456.00
IUUC-Mga-059240	Meleagris gallopavo	98.14	1.00e-87	315.00
IUUC-Mmr-061259	Microcebus murinus	94.76	1.00e-119	421.00
IUUC-Mdo-062396	Monodelphis domestica	100.00	4.00e-130	456.00
IUUC-Mac-065145	Musa acuminata	86.18	2.00e-69	254.00
IUUC-Nle-069822	Nomascus leucogenys	100.00	4.00e-130	456.00
IUUC-Opr-070947	Ochotona princeps	100.00	7.00e-129	452.00
IUUC-Ocu-074508	Oryctolagus cuniculus	100.00	4.00e-130	456.00
IUUC-Oni-082301	Oryza nivara	92.65	1.00e-31	129.00
IUUC-Oru-084544	Oryza rufipogon	78.95	6.00e-60	223.00
IUUC-Ola-086841	Oryzias latipes	100.00	7.00e-129	452.00
IUUC-Oga-089171	Otolemur garnettii	100.00	2.00e-85	307.00
IUUC-Oar-089637	Ovis aries	100.00	4.00e-130	456.00
IUUC-Pno-095087	Phaeosphaeria nodorum	96.05	5.00e-124	436.00
IUUC-Pab-098703	Pongo abelii	100.00	4.00e-130	456.00
IUUC-Pva-102696	Pteropus vampyrus	100.00	4.00e-130	456.00
IUUC-Pte-104277	Pyrenophora teres	96.05	3.00e-124	437.00
IUUC-Pyt-104779	Pyrenophora triticirepentis	96.05	3.00e-124	437.00
IUUC-Sha-107155	Sarcophilus harrisii	99.56	2.00e-129	454.00
IUUC-Ssc-115249	Sus scrofa	100.00	4.00e-130	456.00
IUUC-Tsy-119558	Tarsius syrichta	90.20	6.00e-75	272.00
IUUC-Tni-120338	Tetraodon nigroviridis	100.00	3.00e-84	303.00
IUUC-Tae-124009	Triticum aestivum	96.05	2.00e-124	438.00
IUUC-Ttr-128948	Tursiops truncatus	100.00	4.00e-130	456.00
IUUC-Vda-129663	Verticillium dahliae	96.05	3.00e-124	437.00
IUUC-Xtr-132541	Xenopus tropicalis	100.00	4.00e-130	456.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence