iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Eca-034397

Ensembl Protein ID

ENSECAP00000008613.1

UniProt Accession

F6PVI8; F6PVI8_HORSE

Protein Name

Uncharacterized protein

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000009982.1	ENSECAT00000011068.1	ENSECAP00000008613.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-22	79.3	570	608
UBD/Beta-Prp	8.90e-41	140.1	438	608

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 570  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 608
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 438  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 525
           5666788889998885.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 526  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 608
           88888888999*********************************9.********************************997443 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

SLKLECEKLA SEKTEMQRHY VMYYEMSYGL NIEMHKQAEI VKRLNAICAQ VIPFLSQEHQ 60
QQVVQAVERA KQVTMAELNA IIGQQLQAQH LSHGHGLPVP LTPHPSGLQP PAIPPIGSSA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAGCCTGAA GCTGGAATGT GAGAAACTGG CCAGTGAGAA GACAGAGATG CAGCGGCATT 60
ATGTCATGGT AAGAAAACTG TGTCACAGAT TCAAAGTGCC TGTTAGGTTG GGATACCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003434	Anas platyrhynchos	87.63	0.00e+00	1120.00
IUUC-Aca-005279	Anolis carolinensis	98.35	0.00e+00	1229.00
IUUC-Bta-012646	Bos taurus	99.45	0.00e+00	1271.00
IUUC-Cel-018361	Caenorhabditis elegans	58.71	4.00e-121	428.00
IUUC-Cja-019079	Callithrix jacchus	98.90	0.00e+00	1300.00
IUUC-Cfa-020987	Canis familiaris	99.17	0.00e+00	1297.00
IUUC-Cpo-021606	Cavia porcellus	97.12	0.00e+00	1245.00
IUUC-Csa-023445	Chlorocebus sabaeus	99.31	0.00e+00	1274.00
IUUC-Cho-024590	Choloepus hoffmanni	88.89	0.00e+00	1193.00
IUUC-Cin-025282	Ciona intestinalis	75.14	4.00e-153	535.00
IUUC-Csv-026174	Ciona savignyi	57.82	2.00e-161	562.00
IUUC-Dno-028979	Dasypus novemcinctus	99.28	0.00e+00	1229.00
IUUC-Dor-030533	Dipodomys ordii	92.37	0.00e+00	1149.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	665.00
IUUC-Ete-032887	Echinops telfairi	88.10	0.00e+00	1153.00
IUUC-Fca-036030	Felis catus	99.31	0.00e+00	1298.00
IUUC-Fal-037460	Ficedula albicollis	98.62	0.00e+00	1270.00
IUUC-Gga-040416	Gallus gallus	98.90	0.00e+00	1269.00
IUUC-Ggo-045633	Gorilla gorilla	94.99	0.00e+00	1272.00
IUUC-Hsa-046461	Homo sapiens	94.99	0.00e+00	1273.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	99.17	0.00e+00	1269.00
IUUC-Lch-049943	Latimeria chalumnae	95.87	0.00e+00	1233.00
IUUC-Loc-052835	Lepisosteus oculatus	95.06	0.00e+00	1201.00
IUUC-Laf-053425	Loxodonta africana	99.45	0.00e+00	1303.00
IUUC-Mcc-055766	Macaca mulatta	95.12	0.00e+00	1274.00
IUUC-Mmr-061317	Microcebus murinus	95.62	0.00e+00	1275.00
IUUC-Mdo-062956	Monodelphis domestica	98.49	0.00e+00	1259.00
IUUC-Mmu-063576	Mus musculus	99.04	0.00e+00	1264.00
IUUC-Mpu-066410	Mustela putorius furo	99.58	0.00e+00	1274.00
IUUC-Mlu-067456	Myotis lucifugus	99.31	0.00e+00	1254.00
IUUC-Nle-069495	Nomascus leucogenys	99.31	0.00e+00	1273.00
IUUC-Opr-070645	Ochotona princeps	91.83	0.00e+00	1209.00
IUUC-Oan-072842	Ornithorhynchus anatinus	95.45	0.00e+00	1248.00
IUUC-Ocu-074453	Oryctolagus cuniculus	99.17	0.00e+00	1272.00
IUUC-Ola-087090	Oryzias latipes	85.32	0.00e+00	1095.00
IUUC-Oga-087939	Otolemur garnettii	99.04	0.00e+00	1268.00
IUUC-Oar-090347	Ovis aries	99.30	0.00e+00	1246.00
IUUC-Ptr-091048	Pan troglodytes	99.31	0.00e+00	1274.00
IUUC-Pan-091973	Papio anubis	94.35	0.00e+00	1219.00
IUUC-Psi-093586	Pelodiscus sinensis	98.06	0.00e+00	1170.00
IUUC-Pab-097539	Pongo abelii	95.02	0.00e+00	1244.00
IUUC-Pca-101137	Procavia capensis	88.06	0.00e+00	1134.00
IUUC-Rno-105314	Rattus norvegicus	99.13	0.00e+00	1197.00
IUUC-Sar-113267	Sorex araneus	88.84	0.00e+00	731.00
IUUC-Ssc-116408	Sus scrofa	99.18	0.00e+00	1295.00
IUUC-Tgu-117068	Taeniopygia guttata	98.07	0.00e+00	1282.00
IUUC-Tsy-118884	Tarsius syrichta	85.56	0.00e+00	1077.00
IUUC-Tbe-128013	Tupaia belangeri	91.26	0.00e+00	1206.00
IUUC-Vpa-130577	Vicugna pacos	89.81	2.00e-177	616.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence