iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-048974

Ensembl Protein ID

ENSSTOP00000011460.2

UniProt Accession

I3MJT0; I3MJT0_ICTTR

Genbank Protein ID

ENSSTOP00000011460

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01081369

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000012776.2	ENSSTOT00000012785.2	ENSSTOP00000011460.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-22	78.2	618	656
UBD/Beta-Prp	2.90e-40	138.3	486	656

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 618  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 656
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 486  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 573
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 574  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 656
           88888888999*********************************9.********************************997443 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MIRDLSKMYP QTRHPAPHQP AQPFKFTISE SCDRIKEEFQ FLQAQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTGTATAT TATTTTGAGG TCGTGTTCGC AGAGTTTGAA AGGAGAGAAT TTTTTTAAAA 60
AGCCGCAAGC GTTTCACTCT TTATTTTTAT AATCCCCTTC AATTTGGGGT TAAAAAAAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001746	Ailuropoda melanoleuca	84.97	0.00e+00	1131.00
IUUC-Aca-005279	Anolis carolinensis	98.84	0.00e+00	1331.00
IUUC-Ame-010724	Astyanax mexicanus	78.46	0.00e+00	1124.00
IUUC-Bta-012646	Bos taurus	99.10	0.00e+00	1374.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	2.00e-122	432.00
IUUC-Cja-019079	Callithrix jacchus	99.48	0.00e+00	1407.00
IUUC-Cfa-020987	Canis familiaris	99.20	0.00e+00	1350.00
IUUC-Cpo-021606	Cavia porcellus	97.39	0.00e+00	1329.00
IUUC-Csa-023445	Chlorocebus sabaeus	99.87	0.00e+00	1379.00
IUUC-Cho-024590	Choloepus hoffmanni	85.59	0.00e+00	1209.00
IUUC-Csv-026174	Ciona savignyi	58.33	4.00e-163	568.00
IUUC-Dre-028595	Danio rerio	79.23	0.00e+00	1117.00
IUUC-Dno-028979	Dasypus novemcinctus	99.46	0.00e+00	1330.00
IUUC-Dor-030533	Dipodomys ordii	92.94	0.00e+00	1154.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	666.00
IUUC-Ete-032887	Echinops telfairi	88.59	0.00e+00	1217.00
IUUC-Eca-034397	Equus caballus	99.17	0.00e+00	1268.00
IUUC-Eeu-035237	Erinaceus europaeus	85.07	0.00e+00	1153.00
IUUC-Fca-036030	Felis catus	99.60	0.00e+00	1378.00
IUUC-Fal-037460	Ficedula albicollis	99.21	0.00e+00	1343.00
IUUC-Gga-040416	Gallus gallus	99.48	0.00e+00	1373.00
IUUC-Gac-041924	Gasterosteus aculeatus	78.91	0.00e+00	1108.00
IUUC-Ggo-045633	Gorilla gorilla	95.70	0.00e+00	1344.00
IUUC-Hsa-046461	Homo sapiens	95.78	0.00e+00	1378.00
IUUC-Lch-049943	Latimeria chalumnae	96.02	0.00e+00	1236.00
IUUC-Loc-052835	Lepisosteus oculatus	95.75	0.00e+00	1281.00
IUUC-Laf-053425	Loxodonta africana	99.74	0.00e+00	1373.00
IUUC-Mcc-055766	Macaca mulatta	95.91	0.00e+00	1380.00
IUUC-Mmr-061317	Microcebus murinus	96.38	0.00e+00	1380.00
IUUC-Mdo-062956	Monodelphis domestica	99.10	0.00e+00	1374.00
IUUC-Mmu-063576	Mus musculus	99.61	0.00e+00	1369.00
IUUC-Mpu-066410	Mustela putorius furo	99.58	0.00e+00	1274.00
IUUC-Mlu-067456	Myotis lucifugus	97.68	0.00e+00	1303.00
IUUC-Nle-069495	Nomascus leucogenys	99.87	0.00e+00	1347.00
IUUC-Opr-071172	Ochotona princeps	85.73	0.00e+00	1129.00
IUUC-Ont-071419	Oreochromis niloticus	86.10	0.00e+00	1194.00
IUUC-Oan-072842	Ornithorhynchus anatinus	95.85	0.00e+00	1350.00
IUUC-Ocu-074453	Oryctolagus cuniculus	98.45	0.00e+00	1354.00
IUUC-Ola-087090	Oryzias latipes	85.46	0.00e+00	1191.00
IUUC-Oga-087939	Otolemur garnettii	99.87	0.00e+00	1384.00
IUUC-Oar-090347	Ovis aries	99.30	0.00e+00	1255.00
IUUC-Ptr-091048	Pan troglodytes	99.87	0.00e+00	1379.00
IUUC-Pan-091973	Papio anubis	95.22	0.00e+00	1323.00
IUUC-Pma-094452	Petromyzon marinus	78.48	0.00e+00	1120.00
IUUC-Pfo-097518	Poecilia formosa	84.98	0.00e+00	1145.00
IUUC-Pab-097539	Pongo abelii	95.56	0.00e+00	1249.00
IUUC-Pca-101137	Procavia capensis	88.35	0.00e+00	1138.00
IUUC-Pva-103037	Pteropus vampyrus	93.29	0.00e+00	1367.00
IUUC-Rno-105314	Rattus norvegicus	99.59	0.00e+00	1299.00
IUUC-Sar-113267	Sorex araneus	88.27	0.00e+00	726.00
IUUC-Ssc-116408	Sus scrofa	99.23	0.00e+00	1402.00
IUUC-Tgu-117068	Taeniopygia guttata	98.67	0.00e+00	1348.00
IUUC-Tru-118782	Takifugu rubripes	82.49	0.00e+00	1133.00
IUUC-Tsy-118884	Tarsius syrichta	84.49	0.00e+00	1082.00
IUUC-Tni-120404	Tetraodon nigroviridis	84.21	0.00e+00	1190.00
IUUC-Tbe-128013	Tupaia belangeri	91.62	0.00e+00	1270.00
IUUC-Vpa-130577	Vicugna pacos	90.62	0.00e+00	712.00
IUUC-Xtr-132974	Xenopus tropicalis	96.66	0.00e+00	1297.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence