iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074453

Ensembl Protein ID

ENSOCUP00000010223.2

UniProt Accession

G1T269; G1T269_RABIT

Genbank Protein ID

ENSOCUP00000010223

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02048349

Gene Name

TLE4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000011891.3	ENSOCUT00000011895.2	ENSOCUP00000010223.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	2.20e-22	78.2	617	655
UBD/Beta-Prp	3.00e-40	138.3	485	655

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvllk 37
           gHtd+ +c++  +d t l++G+ D+t++ WDlr+g++l+
   Q: 617  GHTDGASCIDIsNDgTKLWTGGLDNTVRSWDLREGRQLQ 655
           8***********999*********************998 PP

UBD/Beta-Prp

   S: 50   gheaevtavkfspdgkilvtgseDrtikvwdls...tgkcvhtlk..ghedsvlslsfspsgdklvsGshdrtirvwdletgqclee.t 132
           +h + v av++s+ +   v ++  + +kvwd+s   + ++v+ l   + +++++s+++ p+g +l++G++ +t+ +wdl   +   +  
   Q: 485  NHGEVVCAVTISNPTR-HVYTGGKGCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKaE 572
           5666688889998884.555555579*******999888999988889*******************************9988766658 PP
   S: 133  lsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvr 216
           l+    +   ++++pd+++++s++ D+ + +Wdl +++l+r+++g htd   +++++ +g+ l +g+ld+tv+ wdl++g+ ++
   Q: 573  LTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQG-HTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQ 655
           88888888999*********************************9.********************************997443 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MIRDLSKMYP QTRHPISHQP SHPEQFTISE SCIRIKEEFQ FFRPQYHSLK LECEKLASEK 60
TEMQRHYVMY YEMSYGLNIE MHKQAEIVKR LNAICAQVIP FLSQEHQQQV VQAVERAKQV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATTCGCG ACCTGAGCAA GATGTACCCG CAGACCAGAC ACCCGGTGAG TGCGGGCGGC 60
CGGGGCGCGC GGGCTCGCCG GGCGCGGGGG GATTCCCCGC GTCGCCCCCC GCGCGCCGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR005617--Groucho/TLE_N
IPR009146--Groucho_enhance
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF03920--TLE_N
PF00400--WD40

PRINTS

PR01850--GROUCHOFAMLY

SMART

SM00320--WD40

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0003714--F:transcription corepressor activity
GO:0003705--F:transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0016055--P:Wnt signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003434	Anas platyrhynchos	88.05	0.00e+00	1127.00
IUUC-Aca-005279	Anolis carolinensis	97.54	0.00e+00	1312.00
IUUC-Bta-012646	Bos taurus	97.55	0.00e+00	1344.00
IUUC-Cel-018361	Caenorhabditis elegans	58.99	2.00e-122	432.00
IUUC-Cja-019079	Callithrix jacchus	98.19	0.00e+00	1386.00
IUUC-Cfa-020987	Canis familiaris	98.53	0.00e+00	1340.00
IUUC-Cpo-021606	Cavia porcellus	95.95	0.00e+00	1299.00
IUUC-Csa-023445	Chlorocebus sabaeus	98.58	0.00e+00	1359.00
IUUC-Cho-024590	Choloepus hoffmanni	85.57	0.00e+00	1209.00
IUUC-Csv-026174	Ciona savignyi	58.33	7.00e-163	567.00
IUUC-Dno-028979	Dasypus novemcinctus	98.11	0.00e+00	1310.00
IUUC-Dor-030533	Dipodomys ordii	92.93	0.00e+00	1157.00
IUUC-Dme-031576	Drosophila melanogaster	86.03	0.00e+00	666.00
IUUC-Ete-032887	Echinops telfairi	87.53	0.00e+00	1200.00
IUUC-Eca-034397	Equus caballus	99.17	0.00e+00	1274.00
IUUC-Fca-036030	Felis catus	98.28	0.00e+00	1347.00
IUUC-Fal-037460	Ficedula albicollis	98.15	0.00e+00	1325.00
IUUC-Gga-040416	Gallus gallus	98.19	0.00e+00	1352.00
IUUC-Ggo-045633	Gorilla gorilla	94.67	0.00e+00	1326.00
IUUC-Hsa-046461	Homo sapiens	94.53	0.00e+00	1358.00
IUUC-Itr-048974	Ictidomys tridecemlineatus	98.45	0.00e+00	1354.00
IUUC-Lch-049943	Latimeria chalumnae	96.29	0.00e+00	1242.00
IUUC-Loc-052835	Lepisosteus oculatus	94.20	0.00e+00	1259.00
IUUC-Laf-053425	Loxodonta africana	98.68	0.00e+00	1355.00
IUUC-Mcc-055766	Macaca mulatta	94.66	0.00e+00	1361.00
IUUC-Mmr-061317	Microcebus murinus	95.13	0.00e+00	1361.00
IUUC-Mdo-062956	Monodelphis domestica	97.55	0.00e+00	1343.00
IUUC-Mmu-063576	Mus musculus	98.32	0.00e+00	1349.00
IUUC-Mpu-066410	Mustela putorius furo	99.58	0.00e+00	1276.00
IUUC-Mlu-067456	Myotis lucifugus	96.78	0.00e+00	1290.00
IUUC-Nle-069495	Nomascus leucogenys	98.81	0.00e+00	1328.00
IUUC-Opr-070645	Ochotona princeps	86.55	0.00e+00	1231.00
IUUC-Ont-071419	Oreochromis niloticus	84.81	0.00e+00	1167.00
IUUC-Oan-072842	Ornithorhynchus anatinus	94.58	0.00e+00	1330.00
IUUC-Ola-087090	Oryzias latipes	84.66	0.00e+00	1179.00
IUUC-Oga-087939	Otolemur garnettii	98.32	0.00e+00	1353.00
IUUC-Oar-090347	Ovis aries	99.02	0.00e+00	1249.00
IUUC-Ptr-091048	Pan troglodytes	98.58	0.00e+00	1359.00
IUUC-Pan-091973	Papio anubis	93.92	0.00e+00	1306.00
IUUC-Pfo-097518	Poecilia formosa	83.95	0.00e+00	1122.00
IUUC-Pab-097539	Pongo abelii	95.56	0.00e+00	1251.00
IUUC-Pca-101137	Procavia capensis	88.33	0.00e+00	1140.00
IUUC-Pva-103037	Pteropus vampyrus	92.04	0.00e+00	1343.00
IUUC-Rno-105314	Rattus norvegicus	98.24	0.00e+00	1281.00
IUUC-Sar-113267	Sorex araneus	88.25	0.00e+00	729.00
IUUC-Ssc-116408	Sus scrofa	97.68	0.00e+00	1372.00
IUUC-Tgu-117068	Taeniopygia guttata	97.73	0.00e+00	1326.00
IUUC-Tru-118782	Takifugu rubripes	81.59	0.00e+00	1121.00
IUUC-Tsy-118884	Tarsius syrichta	85.97	0.00e+00	1083.00
IUUC-Tni-120404	Tetraodon nigroviridis	83.06	0.00e+00	1166.00
IUUC-Tbe-128013	Tupaia belangeri	90.57	0.00e+00	1252.00
IUUC-Vpa-130577	Vicugna pacos	88.52	0.00e+00	693.00
IUUC-Xtr-132974	Xenopus tropicalis	95.50	0.00e+00	1276.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence