iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090665

UUCD1 version

UUC-PaT-00060

Ensembl Protein ID

ENSPTRP00000033967.4

UniProt Accession

G2HEC7; G2HEC7_PANTR

Genbank Protein ID

BAK62085.1; JAA09509.1; JAA13100.1; JAA29948.1; JAA37339.1

Protein Name

Cullin 1; Cullin-1

Genbank Nucleotide ID

AC188684; GABC01001829; GABF01009045; GABD01003152; GABE01007400

Gene Name

CUL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000019836.6	ENSPTRT00000036732.4	ENSPTRP00000033967.4

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	3.00e-226	752.9	24	660

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 2    lreavkkilrqesv.kkeyeelytavynlclsk...........................vgaklYkklkevleefikqvkkkveesed 62
           lr++++++++++s+ k++y+elyt+vyn+c+s                            vg +lYk+lke+l+++++++ k+ e+ +d
   Q: 24   LRAGIQQVYTRQSMaKSRYMELYTHVYNYCTSVhqsnqargagvppskskkgqtpggaqfVGLELYKRLKEFLKNYLTNLLKDGEDLMD 112
           7899***************************9999****************************************************** PP
   S: 63   eqlLktynreWekfreqlkvlrkifayldrtyvkk.....skkvsevrkLaldlwrkeivedikkrllelllklieaeRkgeavdrrll 146
           e++Lk+y+++We++r ++kvl+ i+ayl+r++v++     +k ++e+++Lal +wr++++++++k++++++lklie+eR+ge++++rl+
   Q: 113  ESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRecdegRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLI 201
           ***********************************999999999********************************************* PP
   S: 147  sgvveslveLslnk.........laiykesFEakfleatqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlev 226
           sgvv+s+veL+ln+         l++ykesFE++fl  t++fy++es+eflq+n v+eY+kk+earl ee++r++ yl+est+++L+++
   Q: 202  SGVVQSYVELGLNEddafakgptLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARK 290
           ***************************************************************************************** PP
   S: 227  vekeliakhlesllaelvallrdkktedlsrmykLlsrvlngleellkeleshikeqgkaalt..aeekekdpkkyVerllelknklqk 313
           +e++li+khle +++e+++ll+ +k+edl+rmy+L+sr+++gl el k le+hi++qg+aa++   e++ +dpk+yV+++l++++k++ 
   Q: 291  CEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEkcGEAALNDPKMYVQTVLDVHKKYNA 379
           ***************************************************************9999999******************* PP
   S: 314  lvseaFnndakFlkaldkafetfvnknsvlka....akspEllAryiDqlLrksskglteeeleaqldkvllvfkyisekdvFekyYkk 398
           lv++aFnnda F+ aldka+ +f+n+n+v+k+    +kspEllAry+D+lL+kssk+++e+ele++l++v++vfkyi++kdvF+k+Y+k
   Q: 380  LVMSAFNNDAGFVAALDKACGRFINNNAVTKMaqssSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAK 468
           ***************************************************************************************** PP
   S: 399  hLakRLlsgksasseaEesviekLkeecgaeftskLerMfqdlkvSedlnrqFkeekenteesesvelsvlvLsagaWptasetekvsL 487
           +LakRL++++sas++aE+s+i+kLk++cg+e+tskL+rMfqd+ vS+dln+qFk++ +n+ e  ++++s++vLs+g+Wp++++   ++L
   Q: 469  MLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNS-EPLDLDFSIQVLSSGSWPFQQSCT-FAL 555
           ******************************************************777776.99******************7755.*** PP
   S: 488  PaelektiekfeefYlekhsgRkLqWqhtlgraelkaelkkgkyelqVstfQmavLLafnnsekvsveelkkatelpeeeLrrtlqsLv 576
           P+ele+++++f++fY ++hsgRkL+W+++l+++el ++++k++y+lq+stfQma+LL++n++++++v++l+++t+++++ L ++lq L+
   Q: 556  PSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILL 644
           ***************************************************************************************** PP
   S: 577  sskkqvlkkepeskeiee 594
           +sk  vl  e+e+++++e
   Q: 645  KSKLLVL--EDENANVDE 660
           **95555..555555443 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSSTRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN 60
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGAGGAGGG CCGGGCGGGC AGGGGAGGAG GAGGAGGCGG GCGCCGTGTC GCACGCAGCT 60
CCAGGCGGGG CAGCCCCGGT AGCTGAGGGA CGCAGCTAGA CCTTGGCGGG ACGGGGCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0019005--C:SCF ubiquitin ligase complex
GO:0031625--F:ubiquitin protein ligase binding
GO:0009887--P:animal organ morphogenesis
GO:0006915--P:apoptotic process
GO:0008283--P:cell proliferation
GO:0006513--P:protein monoubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

KEGG

ptr:107971643; ptr:463821

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002277	Ailuropoda melanoleuca	99.61	0.00e+00	1574.00
IUUC-Apl-003503	Anas platyrhynchos	99.18	0.00e+00	1269.00
IUUC-Aca-005030	Anolis carolinensis	87.36	0.00e+00	1226.00
IUUC-Ago-007977	Ashbya gossypii	32.76	6.00e-119	421.00
IUUC-Acl-008190	Aspergillus clavatus	49.09	0.00e+00	669.00
IUUC-Afl-008542	Aspergillus flavus	49.92	3.00e-157	548.00
IUUC-Afu-009007	Aspergillus fumigatus	48.75	0.00e+00	651.00
IUUC-Ani-009290	Aspergillus nidulans	46.89	0.00e+00	687.00
IUUC-Ang-009600	Aspergillus niger	48.40	0.00e+00	663.00
IUUC-Aor-009978	Aspergillus oryzae	47.61	3.00e-174	605.00
IUUC-Ate-010584	Aspergillus terreus	48.35	0.00e+00	687.00
IUUC-Ame-011861	Astyanax mexicanus	95.32	0.00e+00	1461.00
IUUC-Bgr-012209	Blumeria graminis	48.21	0.00e+00	652.00
IUUC-Bta-012878	Bos taurus	99.74	0.00e+00	1578.00
IUUC-Bci-013941	Botrytis cinerea	48.12	0.00e+00	714.00
IUUC-Cel-018294	Caenorhabditis elegans	46.54	0.00e+00	695.00
IUUC-Cja-018965	Callithrix jacchus	95.11	0.00e+00	1495.00
IUUC-Cfa-020671	Canis familiaris	99.74	0.00e+00	1578.00
IUUC-Cpo-021762	Cavia porcellus	99.74	0.00e+00	1579.00
IUUC-Csa-023873	Chlorocebus sabaeus	100.00	0.00e+00	1582.00
IUUC-Cho-024978	Choloepus hoffmanni	100.00	2.00e-116	412.00
IUUC-Cin-025547	Ciona intestinalis	72.94	0.00e+00	1121.00
IUUC-Csv-026083	Ciona savignyi	71.72	0.00e+00	1163.00
IUUC-Cgl-026452	Colletotrichum gloeosporioides	48.42	0.00e+00	684.00
IUUC-Cne-026919	Cryptococcus neoformans	42.93	0.00e+00	629.00
IUUC-Dre-027875	Danio rerio	95.75	0.00e+00	1478.00
IUUC-Dno-028931	Dasypus novemcinctus	99.61	0.00e+00	1572.00
IUUC-Dor-030846	Dipodomys ordii	99.61	0.00e+00	1016.00
IUUC-Dse-031472	Dothistroma septosporum	45.58	1.00e-178	620.00
IUUC-Dme-031793	Drosophila melanogaster	62.77	0.00e+00	944.00
IUUC-Ete-033112	Echinops telfairi	89.50	5.00e-169	587.00
IUUC-Eca-034309	Equus caballus	99.74	0.00e+00	1578.00
IUUC-Eeu-034450	Erinaceus europaeus	69.36	0.00e+00	716.00
IUUC-Fca-036330	Felis catus	96.29	0.00e+00	1513.00
IUUC-Fal-036899	Ficedula albicollis	99.85	0.00e+00	1377.00
IUUC-Fox-037705	Fusarium oxysporum	48.94	0.00e+00	653.00
IUUC-Fso-038367	Fusarium solani	49.36	0.00e+00	674.00
IUUC-Gmo-038708	Gadus morhua	94.23	0.00e+00	1464.00
IUUC-Ggr-039917	Gaeumannomyces graminis	47.74	0.00e+00	682.00
IUUC-Gga-041038	Gallus gallus	99.87	0.00e+00	1580.00
IUUC-Gac-041820	Gasterosteus aculeatus	94.62	0.00e+00	1514.00
IUUC-Ggo-045154	Gorilla gorilla	83.04	0.00e+00	1113.00
IUUC-Hsa-046034	Homo sapiens	100.00	0.00e+00	1582.00
IUUC-Itr-048285	Ictidomys tridecemlineatus	99.74	0.00e+00	1578.00
IUUC-Kpa-049231	Komagataella pastoris	38.61	8.00e-135	474.00
IUUC-Lch-049673	Latimeria chalumnae	98.45	0.00e+00	1558.00
IUUC-Loc-052490	Lepisosteus oculatus	97.55	0.00e+00	1519.00
IUUC-Lma-053191	Leptosphaeria maculans	48.51	0.00e+00	668.00
IUUC-Laf-054582	Loxodonta africana	99.61	0.00e+00	1577.00
IUUC-Mcc-055162	Macaca mulatta	99.10	0.00e+00	1563.00
IUUC-Meu-055904	Macropus eugenii	87.46	7.00e-160	557.00
IUUC-Mor-057035	Magnaporthe oryzae	47.14	0.00e+00	655.00
IUUC-Mpo-057555	Magnaporthe poae	47.74	0.00e+00	681.00
IUUC-Mla-059021	Melampsora laricipopulina	48.19	0.00e+00	659.00
IUUC-Mga-060078	Meleagris gallopavo	99.87	0.00e+00	1580.00
IUUC-Mvi-060519	Microbotryum violaceum	47.61	0.00e+00	684.00
IUUC-Mmr-061312	Microcebus murinus	100.00	0.00e+00	1582.00
IUUC-Mdo-062867	Monodelphis domestica	99.36	0.00e+00	1572.00
IUUC-Mmu-063336	Mus musculus	99.87	0.00e+00	1580.00
IUUC-Mpu-066400	Mustela putorius furo	99.70	0.00e+00	1376.00
IUUC-Mlu-067800	Myotis lucifugus	99.49	0.00e+00	1571.00
IUUC-Nfi-068384	Neosartorya fischeri	51.01	0.00e+00	652.00
IUUC-Ncr-068965	Neurospora crassa	48.10	0.00e+00	683.00
IUUC-Nle-069729	Nomascus leucogenys	100.00	0.00e+00	1582.00
IUUC-Ont-071729	Oreochromis niloticus	95.49	0.00e+00	1498.00
IUUC-Oan-073309	Ornithorhynchus anatinus	99.74	0.00e+00	1580.00
IUUC-Ocu-074661	Oryctolagus cuniculus	99.48	0.00e+00	1530.00
IUUC-Ola-087422	Oryzias latipes	94.09	0.00e+00	1494.00
IUUC-Oga-088130	Otolemur garnettii	100.00	0.00e+00	1582.00
IUUC-Oar-089510	Ovis aries	98.15	0.00e+00	1507.00
IUUC-Pan-092218	Papio anubis	100.00	0.00e+00	1582.00
IUUC-Psi-093175	Pelodiscus sinensis	99.74	0.00e+00	1579.00
IUUC-Pma-094502	Petromyzon marinus	90.45	0.00e+00	1432.00
IUUC-Pno-095067	Phaeosphaeria nodorum	47.97	0.00e+00	698.00
IUUC-Pfo-096705	Poecilia formosa	95.36	0.00e+00	1533.00
IUUC-Pab-097578	Pongo abelii	100.00	0.00e+00	1582.00
IUUC-Pca-100242	Procavia capensis	85.80	0.00e+00	1144.00
IUUC-Pva-102155	Pteropus vampyrus	87.89	0.00e+00	1350.00
IUUC-Pgr-103297	Puccinia graminis	45.92	0.00e+00	669.00
IUUC-Ptt-103706	Puccinia triticina	45.09	6.00e-94	339.00
IUUC-Pte-104257	Pyrenophora teres	48.29	0.00e+00	695.00
IUUC-Pyt-104795	Pyrenophora triticirepentis	48.84	0.00e+00	695.00
IUUC-Rno-105939	Rattus norvegicus	99.87	0.00e+00	1580.00
IUUC-Sce-106293	Saccharomyces cerevisiae	31.80	9.00e-117	414.00
IUUC-Sha-106949	Sarcophilus harrisii	99.74	0.00e+00	1579.00
IUUC-Sja-107737	Schizosaccharomyces japonicus	42.78	8.00e-158	550.00
IUUC-Spo-108280	Schizosaccharomyces pombe	41.91	3.00e-163	568.00
IUUC-Sre-114984	Sporisorium reilianum	45.96	0.00e+00	632.00
IUUC-Ssc-115829	Sus scrofa	99.10	0.00e+00	1561.00
IUUC-Tgu-116950	Taeniopygia guttata	99.87	0.00e+00	1580.00
IUUC-Tru-118558	Takifugu rubripes	94.97	0.00e+00	1507.00
IUUC-Tsy-118934	Tarsius syrichta	98.06	0.00e+00	738.00
IUUC-Tni-120460	Tetraodon nigroviridis	94.85	0.00e+00	1513.00
IUUC-Tre-122223	Trichoderma reesei	49.65	0.00e+00	638.00
IUUC-Tvi-122539	Trichoderma virens	44.59	5.00e-173	601.00
IUUC-Tme-126926	Tuber melanosporum	47.69	0.00e+00	675.00
IUUC-Tbe-127369	Tupaia belangeri	97.96	0.00e+00	652.00
IUUC-Ttr-129022	Tursiops truncatus	94.15	0.00e+00	1139.00
IUUC-Uma-129341	Ustilago maydis	46.16	2.00e-173	602.00
IUUC-Vda-129857	Verticillium dahliae	47.27	0.00e+00	647.00
IUUC-Vpa-130166	Vicugna pacos	93.36	0.00e+00	1222.00
IUUC-Xtr-131818	Xenopus tropicalis	98.97	0.00e+00	1560.00
IUUC-Xma-134206	Xiphophorus maculatus	95.49	0.00e+00	1494.00
IUUC-Yli-134486	Yarrowia lipolytica	39.92	2.00e-155	542.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence