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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105114
UUCD1 version UUC-RaN-00775
Ensembl Protein ID ENSRNOP00000023463.3
UniProt Accession P61480; WDR12_RAT
Genbank Protein ID AAH63180.1
Protein Name Ribosome biogenesis protein WDR12; WD repeat-containing protein 12
Genbank Nucleotide ID BC063180
Gene Name Wdr12
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000017340.5 ENSRNOT00000023463.5 ENSRNOP00000023463.3
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
microRNATRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.90e-42 141.2 341 376
UBD/Beta-Prp 9.40e-46 156.7 246 412
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf...sdtllvsGsdDgtikvWDlrtgv 34
           Ht++vt++++   +d  l+sGs D+ +k+WD+r+++
   Q: 341  HTGWVTSVKWsptHDQQLISGSLDNMVKLWDTRSCK 376
           ***********755588**************99876 PP
   

   UBD/Beta-Prp
   S: 83   tgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdl..ktg 169
           t+++++tl+gh++ + s+ +s   d + s+s+d t+rvwd+e+g   + tl+g++ v nc++++p ++ l+sGs+Dr +rlWd   k g
   Q: 246  TRTPLVTLSGHTEAISSVLWSD-ADEVCSASWDHTVRVWDVESGGLKS-TLTGNK-VFNCISYSPLCKRLASGSTDRHIRLWDPrtKDG 331
           67899****************9.9***********************9.***987.99**************************54456 PP
   S: 170  kllrtl.tgghtdsvyslsfdsng.kelvsgsldgtvklwdlq.tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriW 249
           +l+    t+ ht+ v+s++++++  ++l+sgsld+ vklwd +  +  ++ l +h+d v+sv+ + ++ +l+sg++D+ ++ +
   Q: 332  SLVSLSlTS-HTGWVTSVKWSPTHdQQLISGSLDNMVKLWDTRsCKAPLYDLAAHEDKVLSVDWT-DTGLLLSGGADNKLYSY 412
           666644366.************999******************54566****************9.999********998765 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
 Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
Protein Sequence
(Fasta)
MAQLQARFYT ENKKYAVDDV PFSIPATSEV ADLSNIINKL LETKNELHKH VEFDFLIKGQ 60
FLRMPLVKHM ELEDISSEEV VELEYVEKYT APQPEQCMFH DDWISSIKGA EEWILSGSYD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105114|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTAGAAACCC GAGGAAGATA ACTGAAGCCT GTCTTCTACT GCGCTCGAGG TGCAGTCTAC 60
CTTAGAGCTA CTTGATTATC GGCGCATACA TTTTTGTGGA GAAGCCTCGT TGTATACTTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105114|E3,WD_repeat;UBD,Beta-Prp|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0832--Ubl conjugation
KW-0853--WD repeat
Interpro

IPR020472--G-protein_beta_WD-40_rep
IPR012972--NLE
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR028599--WDR12/Ytm1
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF08154--NLE
PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0070545--C:PeBoW complex
GO:0030687--C:preribosome, large subunit precursor
GO:0008283--P:cell proliferation
GO:0000460--P:maturation of 5.8S rRNA
GO:0000466--P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000470--P:maturation of LSU-rRNA
GO:0000463--P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0007219--P:Notch signaling pathway
KEGG rno:363237
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000532 Aegilops tauschii 32.38 5.00e-57 215.00
IUUC-Aml-001997 Ailuropoda melanoleuca 93.17 0.00e+00 750.00
IUUC-Atr-002544 Amborella trichopoda 32.14 3.00e-56 212.00
IUUC-Apl-003981 Anas platyrhynchos 85.11 0.00e+00 658.00
IUUC-Aca-004370 Anolis carolinensis 83.53 0.00e+00 719.00
IUUC-Aly-006455 Arabidopsis lyrata 34.13 8.00e-60 224.00
IUUC-Ath-006669 Arabidopsis thaliana 34.40 2.00e-55 210.00
IUUC-Ago-007864 Ashbya gossypii 29.32 4.00e-38 152.00
IUUC-Acl-008177 Aspergillus clavatus 28.47 1.00e-36 147.00
IUUC-Afl-008617 Aspergillus flavus 29.23 2.00e-36 146.00
IUUC-Afu-008752 Aspergillus fumigatus 28.05 4.00e-34 139.00
IUUC-Ani-009136 Aspergillus nidulans 29.74 5.00e-37 148.00
IUUC-Ang-009701 Aspergillus niger 28.97 9.00e-35 141.00
IUUC-Aor-009884 Aspergillus oryzae 29.23 5.00e-36 145.00
IUUC-Ate-010472 Aspergillus terreus 29.88 7.00e-23 101.00
IUUC-Ame-011432 Astyanax mexicanus 77.07 0.00e+00 672.00
IUUC-Bgr-012218 Blumeria graminis 28.11 1.00e-32 134.00
IUUC-Bta-012829 Bos taurus 92.91 0.00e+00 775.00
IUUC-Bci-013953 Botrytis cinerea 29.54 2.00e-35 143.00
IUUC-Bdi-014351 Brachypodium distachyon 34.83 5.00e-55 208.00
IUUC-Bol-016190 Brassica oleracea 34.81 3.00e-56 212.00
IUUC-Bra-018095 Brassica rapa 33.77 8.00e-56 211.00
IUUC-Cel-018569 Caenorhabditis elegans 31.64 6.00e-49 188.00
IUUC-Cja-019468 Callithrix jacchus 93.14 0.00e+00 762.00
IUUC-Cfa-020471 Canis familiaris 92.20 0.00e+00 745.00
IUUC-Cpo-022260 Cavia porcellus 92.67 0.00e+00 761.00
IUUC-Cre-022614 Chlamydomonas reinhardtii 31.98 9.00e-41 160.00
IUUC-Csa-023989 Chlorocebus sabaeus 93.14 0.00e+00 764.00
IUUC-Cho-024426 Choloepus hoffmanni 89.84 1.00e-162 565.00
IUUC-Cin-025789 Ciona intestinalis 43.44 2.00e-99 355.00
IUUC-Cne-027063 Cryptococcus neoformans 24.27 5.00e-22 99.00
IUUC-Dre-027907 Danio rerio 78.25 0.00e+00 682.00
IUUC-Dno-029225 Dasypus novemcinctus 91.49 0.00e+00 766.00
IUUC-Dor-031082 Dipodomys ordii 77.78 7.00e-173 599.00
IUUC-Dse-031308 Dothistroma septosporum 28.76 2.00e-38 153.00
IUUC-Dme-032189 Drosophila melanogaster 41.02 1.00e-93 336.00
IUUC-Ete-032247 Echinops telfairi 86.52 0.00e+00 714.00
IUUC-Eca-034285 Equus caballus 93.14 0.00e+00 776.00
IUUC-Eeu-035322 Erinaceus europaeus 83.67 0.00e+00 655.00
IUUC-Fca-036114 Felis catus 92.91 0.00e+00 775.00
IUUC-Fal-036891 Ficedula albicollis 83.33 5.00e-176 610.00
IUUC-Fox-037965 Fusarium oxysporum 26.01 3.00e-35 142.00
IUUC-Fso-038244 Fusarium solani 26.64 2.00e-35 143.00
IUUC-Gmo-039040 Gadus morhua 76.36 0.00e+00 686.00
IUUC-Ggr-040093 Gaeumannomyces graminis 24.09 3.00e-11 63.20
IUUC-Gga-040610 Gallus gallus 82.03 0.00e+00 722.00
IUUC-Gac-042117 Gasterosteus aculeatus 75.41 0.00e+00 655.00
IUUC-Gma-043146 Glycine max 36.67 9.00e-67 247.00
IUUC-Ggo-045179 Gorilla gorilla 92.67 0.00e+00 755.00
IUUC-Hsa-046114 Homo sapiens 93.38 0.00e+00 761.00
IUUC-Hvu-047331 Hordeum vulgare 33.16 1.00e-52 200.00
IUUC-Itr-048275 Ictidomys tridecemlineatus 93.85 0.00e+00 781.00
IUUC-Kpa-049304 Komagataella pastoris 30.00 2.00e-43 170.00
IUUC-Lch-050655 Latimeria chalumnae 76.72 3.00e-149 520.00
IUUC-Lpe-051675 Leersia perrieri 34.52 2.00e-58 220.00
IUUC-Loc-052868 Lepisosteus oculatus 79.91 0.00e+00 679.00
IUUC-Lma-053258 Leptosphaeria maculans 26.11 2.00e-31 131.00
IUUC-Laf-053993 Loxodonta africana 92.43 0.00e+00 773.00
IUUC-Mcc-055128 Macaca mulatta 76.60 2.00e-174 604.00
IUUC-Meu-056501 Macropus eugenii 76.14 5.00e-164 570.00
IUUC-Mor-057114 Magnaporthe oryzae 25.56 3.00e-26 112.00
IUUC-Mtr-058367 Medicago truncatula 35.65 6.00e-61 228.00
IUUC-Mla-059107 Melampsora laricipopulina 27.37 2.00e-29 123.00
IUUC-Mga-059745 Meleagris gallopavo 79.76 0.00e+00 694.00
IUUC-Mvi-060362 Microbotryum violaceum 29.78 7.00e-35 141.00
IUUC-Mdo-062257 Monodelphis domestica 83.05 0.00e+00 726.00
IUUC-Mmu-063546 Mus musculus 95.51 0.00e+00 790.00
IUUC-Mac-065540 Musa acuminata 34.04 3.00e-55 209.00
IUUC-Mpu-066284 Mustela putorius furo 93.38 0.00e+00 778.00
IUUC-Mlu-067241 Myotis lucifugus 92.91 0.00e+00 773.00
IUUC-Nfi-068260 Neosartorya fischeri 29.02 1.00e-35 144.00
IUUC-Ncr-068719 Neurospora crassa 26.11 7.00e-28 118.00
IUUC-Nle-068981 Nomascus leucogenys 93.38 0.00e+00 743.00
IUUC-Opr-071218 Ochotona princeps 85.18 0.00e+00 676.00
IUUC-Ont-071646 Oreochromis niloticus 77.83 0.00e+00 686.00
IUUC-Oan-073453 Ornithorhynchus anatinus 87.47 0.00e+00 765.00
IUUC-Ocu-074008 Oryctolagus cuniculus 93.85 0.00e+00 781.00
IUUC-Oba-075712 Oryza barthii 30.12 2.00e-42 166.00
IUUC-Obr-076721 Oryza brachyantha 34.36 8.00e-58 217.00
IUUC-Ogl-077229 Oryza glaberrima 33.73 2.00e-57 216.00
IUUC-Ogu-078977 Oryza glumaepatula 30.12 1.00e-42 167.00
IUUC-Oin-079683 Oryza indica 33.73 1.00e-57 217.00
IUUC-Olo-080291 Oryza longistaminata 29.73 7.00e-29 120.00
IUUC-Ome-081834 Oryza meridionalis 33.97 2.00e-58 220.00
IUUC-Oni-082507 Oryza nivara 32.85 3.00e-54 205.00
IUUC-Opu-083396 Oryza punctata 33.97 3.00e-58 219.00
IUUC-Oru-085220 Oryza rufipogon 33.09 1.00e-53 203.00
IUUC-Osa-085767 Oryza sativa 33.73 1.00e-57 217.00
IUUC-Ola-087420 Oryzias latipes 77.30 0.00e+00 678.00
IUUC-Olu-087740 Ostreococcus lucimarinus 27.87 1.00e-37 150.00
IUUC-Oga-088264 Otolemur garnettii 92.20 0.00e+00 755.00
IUUC-Oar-089335 Ovis aries 92.43 0.00e+00 770.00
IUUC-Ptr-091320 Pan troglodytes 93.38 0.00e+00 761.00
IUUC-Pan-092833 Papio anubis 92.67 0.00e+00 760.00
IUUC-Psi-093504 Pelodiscus sinensis 85.34 0.00e+00 727.00
IUUC-Pma-094189 Petromyzon marinus 68.87 3.00e-176 611.00
IUUC-Pno-094929 Phaeosphaeria nodorum 27.16 9.00e-34 137.00
IUUC-Ppa-095429 Physcomitrella patens 36.07 2.00e-66 246.00
IUUC-Pfo-096337 Poecilia formosa 74.94 0.00e+00 680.00
IUUC-Pab-097571 Pongo abelii 93.14 0.00e+00 760.00
IUUC-Pop-099977 Populus trichocarpa 35.34 1.00e-64 240.00
IUUC-Pca-100394 Procavia capensis 87.29 0.00e+00 677.00
IUUC-Ppe-101848 Prunus persica 34.62 4.00e-61 228.00
IUUC-Pva-102921 Pteropus vampyrus 92.31 6.00e-118 417.00
IUUC-Pgr-103637 Puccinia graminis 28.11 7.00e-35 141.00
IUUC-Ptt-103781 Puccinia triticina 28.82 4.00e-35 142.00
IUUC-Pte-104135 Pyrenophora teres 25.83 5.00e-32 133.00
IUUC-Pyt-104609 Pyrenophora triticirepentis 25.49 3.00e-31 129.00
IUUC-Sce-106401 Saccharomyces cerevisiae 30.26 3.00e-42 166.00
IUUC-Sha-107122 Sarcophilus harrisii 83.70 0.00e+00 697.00
IUUC-Sja-107766 Schizosaccharomyces japonicus 32.48 6.00e-50 191.00
IUUC-Spo-108134 Schizosaccharomyces pombe 29.98 6.00e-41 161.00
IUUC-Ssl-108398 Sclerotinia sclerotiorum 28.37 4.00e-37 149.00
IUUC-Smo-108720 Selaginella moellendorffii 33.57 3.00e-58 219.00
IUUC-Sit-110311 Setaria italica 35.13 4.00e-56 212.00
IUUC-Sly-111023 Solanum lycopersicum 31.19 3.00e-53 202.00
IUUC-Stu-112778 Solanum tuberosum 33.89 1.00e-59 223.00
IUUC-Sar-113596 Sorex araneus 76.60 7.00e-173 599.00
IUUC-Sbi-114193 Sorghum bicolor 35.73 6.00e-59 221.00
IUUC-Sre-115002 Sporisorium reilianum 25.33 3.00e-12 66.60
IUUC-Ssc-116066 Sus scrofa 92.67 0.00e+00 771.00
IUUC-Tgu-117048 Taeniopygia guttata 82.45 0.00e+00 645.00
IUUC-Tsy-119573 Tarsius syrichta 60.77 6.00e-134 470.00
IUUC-Tni-119820 Tetraodon nigroviridis 76.25 0.00e+00 680.00
IUUC-Tca-121605 Theobroma cacao 35.58 1.00e-62 233.00
IUUC-Tre-121947 Trichoderma reesei 27.02 8.00e-35 141.00
IUUC-Tvi-122481 Trichoderma virens 27.45 1.00e-36 147.00
IUUC-Tae-123847 Triticum aestivum 32.38 5.00e-57 215.00
IUUC-Tur-126586 Triticum urartu 33.16 1.00e-54 207.00
IUUC-Tme-126900 Tuber melanosporum 32.39 2.00e-51 196.00
IUUC-Tbe-127736 Tupaia belangeri 71.11 3.00e-150 524.00
IUUC-Ttr-129041 Tursiops truncatus 80.85 0.00e+00 662.00
IUUC-Uma-129628 Ustilago maydis 24.07 8.00e-13 68.60
IUUC-Vpa-130260 Vicugna pacos 93.62 0.00e+00 780.00
IUUC-Vvi-131009 Vitis vinifera 34.76 1.00e-60 227.00
IUUC-Xtr-132083 Xenopus tropicalis 80.38 0.00e+00 694.00
IUUC-Xma-133094 Xiphophorus maculatus 74.70 0.00e+00 679.00
IUUC-Yli-134531 Yarrowia lipolytica 24.59 3.00e-20 93.20
IUUC-Zma-135509 Zea mays 34.29 1.00e-59 223.00
Created Date 25-Jun-2017

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