iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000020905.11	ENSMUST00000021288.9	ENSMUSP00000021288.3
ENSMUSG00000020905.11	ENSMUST00000108677.1	ENSMUSP00000104317.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.80e-92	310.2	101	710

Active Site

Position(s)	Description	Evidence
110	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
668	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           +GlkN+gNtC+mN+v+QcLsn+  l+e+l     ++ +        +e++++l+ l+++lw+++ +     e+++a++k+ ++f+g++q
   Q: 101  QGLKNHGNTCFMNAVVQCLSNTDLLAEFLALGRYRAAPG------RAEVTEQLAALVRALWTREYTPQLSAEFKNAVSKYGSQFQGNSQ 183
           6****************************9955555555......479***************************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +Da Efl +lld+++e+l+ +++  ++e+   + s+ s++   +  +++ ++s+++  Fq q++s+++c++c ++s++++pfl +slp+
   Q: 184  HDALEFLLWLLDRVHEDLEGSAHGLVSEQLPPEVSKISEDlrPSAAPTSLGPSFVQSHFQAQYRSSLTCPHCLKQSNTFDPFLCVSLPI 272
           ******************8866666666555544444444446677888999************************************* PP
   S: 177  pgkeetkke................................................................................ 185
           p ++++ ++                                                                                
   Q: 273  PLRQTRFLSvtlvfpsksqrflrvglavpilstvaalrkmvaeeggvpaeevilvelypngfqrsffdeedlntiaegdnvyafqvpps 361
           ****98888******************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 362  pglgtlsahpsglsvsprlpvrdsqrfsgplhsenrvvflfcnlvgsgqqasrfgppfliredrtiswaqlqqcilskvrclmrsevsa 450
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 451  qdlgtlfsirvvglslacsylspkdnrplchwavdralhlrrpggpphvklavewdssvterlfgslqeervqdadsvwrqqqahqqps 539
           ***************************************************************************************** PP
   S: 186  .slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfctspeekq 272
            +l++c++s+tkee+l ++++++c++c+ +q+ + kl+l++lP++Li+hLkRf   + +++r+k+++ v+fpl+ L+++p+++++++++
   Q: 540  cTLDECFQSYTKEEQLAQDDAWKCPHCQVLQQGVVKLSLWTLPDILIIHLKRF--CQVGERRNKLSTLVKFPLSgLNMAPHVARRSTNS 626
           *****************************************************..88899************************99998 PP
   S: 273  ke....................kkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           k                     +  Y+L+av++H+Gsl++GHY+ay++n  +g+W+ +dDs+V++++e+ev++   + aY+lfY++r
   Q: 627  KAgpgpwsswkqpiclpttyplDFLYDLYAVCNHHGSLQGGHYTAYCRNsLDGQWYSYDDSTVEALREDEVNT---RGAYILFYQKR 710
           889**********************************************55788*******************...********985 PP

Organism

Mus musculus

Functional Description
(View)

May recognize and hydrolyze the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MDPGVGNALG EGPPAPRPRR RRSLRRLLNR FLLALGSRSR SGDSPPRPPA QPSPYDGDGE 60
GGFACAPGPA PASAGSPGPD RPPGSQPQIS SGDGARPPGA QGLKNHGNTC FMNAVVQCLS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTAGCCGG CGCCCGGCGC CTCCGGGAGG CGGTGAGGAC CGGGAAGCTG CCGGCCCGCC 60
TGGGGTCTCG GGGGCTGCGC TCCCGGACCA CCGTGCGTGG CCAGCATGGA TCCGGGCGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:216835

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001922	Ailuropoda melanoleuca	71.37	0.00e+00	1325.00
IUUC-Aca-004436	Anolis carolinensis	51.44	0.00e+00	783.00
IUUC-Ame-011153	Astyanax mexicanus	58.96	0.00e+00	889.00
IUUC-Bta-013560	Bos taurus	74.76	0.00e+00	1482.00
IUUC-Cja-018737	Callithrix jacchus	77.87	0.00e+00	1527.00
IUUC-Cfa-020347	Canis familiaris	72.77	0.00e+00	1367.00
IUUC-Csa-023656	Chlorocebus sabaeus	80.57	0.00e+00	1563.00
IUUC-Cho-024864	Choloepus hoffmanni	69.87	0.00e+00	900.00
IUUC-Dre-028066	Danio rerio	57.59	0.00e+00	867.00
IUUC-Dno-028855	Dasypus novemcinctus	69.42	0.00e+00	1325.00
IUUC-Dor-030475	Dipodomys ordii	89.06	0.00e+00	751.00
IUUC-Dme-032088	Drosophila melanogaster	37.59	6.00e-112	399.00
IUUC-Eca-034147	Equus caballus	81.04	0.00e+00	1363.00
IUUC-Eeu-034703	Erinaceus europaeus	70.21	3.00e-135	476.00
IUUC-Fca-036550	Felis catus	67.56	0.00e+00	1130.00
IUUC-Gac-042087	Gasterosteus aculeatus	49.39	0.00e+00	843.00
IUUC-Ggo-045171	Gorilla gorilla	80.56	0.00e+00	1558.00
IUUC-Hsa-045961	Homo sapiens	80.61	0.00e+00	1566.00
IUUC-Itr-048673	Ictidomys tridecemlineatus	75.38	0.00e+00	699.00
IUUC-Loc-052852	Lepisosteus oculatus	60.57	0.00e+00	904.00
IUUC-Laf-054033	Loxodonta africana	75.21	0.00e+00	1476.00
IUUC-Mcc-055431	Macaca mulatta	79.98	0.00e+00	1560.00
IUUC-Mmr-061035	Microcebus murinus	80.19	0.00e+00	1548.00
IUUC-Mdo-062172	Monodelphis domestica	66.32	0.00e+00	972.00
IUUC-Mpu-066307	Mustela putorius furo	72.14	0.00e+00	1342.00
IUUC-Nle-070172	Nomascus leucogenys	80.65	0.00e+00	1569.00
IUUC-Opr-070499	Ochotona princeps	70.98	0.00e+00	1363.00
IUUC-Ont-071920	Oreochromis niloticus	60.84	0.00e+00	882.00
IUUC-Ocu-074014	Oryctolagus cuniculus	82.53	0.00e+00	1196.00
IUUC-Ola-086360	Oryzias latipes	60.28	0.00e+00	889.00
IUUC-Oga-088202	Otolemur garnettii	76.84	0.00e+00	1533.00
IUUC-Oar-089819	Ovis aries	74.09	0.00e+00	1404.00
IUUC-Ptr-091076	Pan troglodytes	80.32	0.00e+00	1560.00
IUUC-Pan-092248	Papio anubis	80.10	0.00e+00	1548.00
IUUC-Pfo-096534	Poecilia formosa	58.53	0.00e+00	808.00
IUUC-Pab-098453	Pongo abelii	78.24	0.00e+00	1499.00
IUUC-Pca-100290	Procavia capensis	58.36	0.00e+00	657.00
IUUC-Pva-102317	Pteropus vampyrus	67.66	0.00e+00	1274.00
IUUC-Rno-104948	Rattus norvegicus	92.38	0.00e+00	1706.00
IUUC-Sha-106558	Sarcophilus harrisii	57.44	0.00e+00	1121.00
IUUC-Sar-113105	Sorex araneus	59.53	0.00e+00	1002.00
IUUC-Ssc-115312	Sus scrofa	74.93	0.00e+00	1462.00
IUUC-Tru-117995	Takifugu rubripes	59.68	0.00e+00	869.00
IUUC-Tsy-119325	Tarsius syrichta	72.82	0.00e+00	721.00
IUUC-Tni-120517	Tetraodon nigroviridis	59.06	0.00e+00	880.00
IUUC-Tbe-127439	Tupaia belangeri	64.24	4.00e-124	439.00
IUUC-Ttr-128829	Tursiops truncatus	67.30	0.00e+00	1270.00
IUUC-Vpa-130306	Vicugna pacos	77.39	2.00e-171	596.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence