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Tag Content
iUUCD ID IUUC-Pab-097543
Ensembl Protein ID ENSPPYP00000001332.2
UniProt Accession Q5R7T9; MTF2_PONAB
Genbank Protein ID CAH92171.1
Protein Name Metal-response element-binding transcription factor 2; Metal regulatory transcription factor 2
Genbank Nucleotide ID CR860020
Gene Name MTF2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPPYG00000001150.2 ENSPPYT00000001377.2 ENSPPYP00000001332.2
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/PHD 4.40e-11 42.9 103 155
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/PHD
   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek.wiCpkCr 52
           +vC +C+e++++   ++v C+kC + +H+ C+ + +++++ +s++ w C++C 
   Q: 103  MVCTICQEEYSEAPnEMVICDKCGQGYHQLCHTPHIDSSVIDSDEkWLCRQCV 155
           79********987569********************9999888777******7 PP
   
Organism Pongo abelii
Functional Description
(View)

Functional Description


     Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
 Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex, leading to enhance PRC2 H3K27me3 methylation activity. Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation. Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells. Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex. In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally. Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity).
Protein Sequence
(Fasta)
MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL 60
FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV 120
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Protein Fasta Sequence


>IUUC-Pab-097543|E3,PHD|Pongo abelii
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Nucleotide Sequence
(Fasta)
CACCGGAGTC GCTCCGCGCT CCCAGAATGC ACCGGCAGTC CGCGGGAAAC CAAAATGGCG 60
AGGGGCTGTA TTGAAGTGGG CTGTGTTTGA GGCCGGTGTA AGAACGCTCA TTCTACCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Pab-097543|E3,PHD|Pongo abelii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
Pfam

PF14061--Mtf2_C
PF00628--PHD
SMART

SM00249--PHD
SM00333--TUDOR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0003677--F:DNA binding
GO:0035064--F:methylated histone binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007379--P:segment specification
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance
KEGG pon:100173244
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001293 Ailuropoda melanoleuca 99.66 0.00e+00 1175.00
IUUC-Apl-004128 Anas platyrhynchos 90.27 0.00e+00 1101.00
IUUC-Aca-004646 Anolis carolinensis 88.99 0.00e+00 985.00
IUUC-Bta-012598 Bos taurus 99.39 0.00e+00 967.00
IUUC-Cja-019930 Callithrix jacchus 99.66 0.00e+00 1206.00
IUUC-Cfa-020413 Canis familiaris 99.49 0.00e+00 1172.00
IUUC-Csa-023605 Chlorocebus sabaeus 99.66 0.00e+00 1181.00
IUUC-Csv-026067 Ciona savignyi 52.30 1.00e-98 352.00
IUUC-Dre-028327 Danio rerio 63.83 0.00e+00 704.00
IUUC-Dno-029487 Dasypus novemcinctus 96.11 0.00e+00 1130.00
IUUC-Dme-031808 Drosophila melanogaster 32.74 5.00e-47 183.00
IUUC-Eca-034332 Equus caballus 98.99 0.00e+00 1195.00
IUUC-Fca-036088 Felis catus 99.49 0.00e+00 1173.00
IUUC-Fal-036851 Ficedula albicollis 90.69 0.00e+00 920.00
IUUC-Gmo-038940 Gadus morhua 64.80 9.00e-144 503.00
IUUC-Gga-041162 Gallus gallus 90.08 0.00e+00 1096.00
IUUC-Gac-041758 Gasterosteus aculeatus 57.69 7.00e-141 494.00
IUUC-Ggo-044658 Gorilla gorilla 100.00 0.00e+00 1182.00
IUUC-Hsa-045895 Homo sapiens 100.00 0.00e+00 1182.00
IUUC-Itr-047940 Ictidomys tridecemlineatus 98.82 0.00e+00 1196.00
IUUC-Lch-050577 Latimeria chalumnae 79.97 0.00e+00 895.00
IUUC-Loc-051747 Lepisosteus oculatus 68.78 0.00e+00 796.00
IUUC-Laf-054500 Loxodonta africana 99.16 0.00e+00 1198.00
IUUC-Mcc-055738 Macaca mulatta 99.66 0.00e+00 1180.00
IUUC-Mga-059203 Meleagris gallopavo 89.93 0.00e+00 1095.00
IUUC-Mmr-061070 Microcebus murinus 98.65 0.00e+00 1165.00
IUUC-Mdo-061878 Monodelphis domestica 95.33 0.00e+00 960.00
IUUC-Mmu-063700 Mus musculus 97.64 0.00e+00 1181.00
IUUC-Mpu-066250 Mustela putorius furo 99.33 0.00e+00 1174.00
IUUC-Mlu-067694 Myotis lucifugus 98.65 0.00e+00 1194.00
IUUC-Nle-069777 Nomascus leucogenys 99.66 0.00e+00 1206.00
IUUC-Ont-072183 Oreochromis niloticus 53.62 7.00e-168 583.00
IUUC-Oan-073204 Ornithorhynchus anatinus 97.52 1.00e-144 504.00
IUUC-Ocu-074279 Oryctolagus cuniculus 98.99 0.00e+00 1197.00
IUUC-Ola-087332 Oryzias latipes 56.00 5.00e-137 481.00
IUUC-Oga-089023 Otolemur garnettii 51.31 3.00e-115 408.00
IUUC-Oar-089543 Ovis aries 99.33 0.00e+00 1174.00
IUUC-Ptr-090676 Pan troglodytes 100.00 0.00e+00 1182.00
IUUC-Pan-092568 Papio anubis 99.83 0.00e+00 1182.00
IUUC-Psi-092976 Pelodiscus sinensis 90.92 0.00e+00 1115.00
IUUC-Pma-094138 Petromyzon marinus 64.16 1.00e-134 472.00
IUUC-Pfo-097187 Poecilia formosa 50.89 4.00e-158 551.00
IUUC-Pca-100289 Procavia capensis 87.76 0.00e+00 854.00
IUUC-Pva-103007 Pteropus vampyrus 54.95 3.00e-103 369.00
IUUC-Rno-105075 Rattus norvegicus 96.96 0.00e+00 1175.00
IUUC-Sha-106522 Sarcophilus harrisii 97.14 2.00e-122 430.00
IUUC-Ssc-116220 Sus scrofa 99.16 0.00e+00 1172.00
IUUC-Tgu-117230 Taeniopygia guttata 88.61 0.00e+00 1060.00
IUUC-Tru-118228 Takifugu rubripes 53.70 7.00e-159 553.00
IUUC-Tsy-119045 Tarsius syrichta 98.65 0.00e+00 1154.00
IUUC-Tni-120342 Tetraodon nigroviridis 56.47 3.00e-176 611.00
IUUC-Ttr-128691 Tursiops truncatus 99.16 0.00e+00 1170.00
IUUC-Vpa-130085 Vicugna pacos 57.04 1.00e-48 186.00
IUUC-Xtr-132767 Xenopus tropicalis 74.58 0.00e+00 884.00
IUUC-Xma-133635 Xiphophorus maculatus 50.57 1.00e-158 552.00
Created Date 25-Jun-2017

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