iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.30e-11	42.9	103	155

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedek.slveCekCrewfHpaClklsveeelpnsek.wiCpkCr 52
           +vC +C+e++++   ++v C+kC + +H+ C+ + +++++ +s++ w C++C 
   Q: 103  MVCTICQEEYSEAPnEMVICDKCGQGYHQLCHTPHIDSSVIDSDEkWLCRQCV 155
           79********987569********************9999888777******7 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MRDSTGAGNS LVHKRSPSRR NQKTSASLNK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL 60
FYLGTIKKIN ILKQSCFITF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAAAATGGCG AAGGGCTGTA GCGAAGTGGT CTGTGTTTGA GGCCGGTGTG AGAACGCATA 60
TTCTCCTCCC CAATCCTCGT CCCCAAGGAA TTCAGTGCGT GTGTGTGCGT GAGCGCAGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR025894--Mtf2_C_dom
IPR002999--Tudor
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF14061--Mtf2_C
PF00628--PHD

SMART

SM00249--PHD
SM00333--TUDOR

Gene Ontology

GO:0005737--C:cytoplasm
GO:0035098--C:ESC/E(Z) complex
GO:0008270--F:zinc ion binding
GO:0061086--P:negative regulation of histone H3-K27 methylation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0061087--P:positive regulation of histone H3-K27 methylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0007379--P:segment specification
GO:0048863--P:stem cell differentiation
GO:0019827--P:stem cell population maintenance

KEGG

rno:360905

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001293	Ailuropoda melanoleuca	96.96	0.00e+00	1150.00
IUUC-Apl-004128	Anas platyrhynchos	89.26	0.00e+00	1089.00
IUUC-Aca-004646	Anolis carolinensis	87.21	0.00e+00	966.00
IUUC-Bta-012598	Bos taurus	97.35	0.00e+00	954.00
IUUC-Cja-019930	Callithrix jacchus	96.96	0.00e+00	1173.00
IUUC-Cfa-020413	Canis familiaris	96.79	0.00e+00	1148.00
IUUC-Csa-023605	Chlorocebus sabaeus	96.96	0.00e+00	1150.00
IUUC-Csv-026067	Ciona savignyi	51.97	4.00e-98	350.00
IUUC-Dre-028327	Danio rerio	61.75	0.00e+00	694.00
IUUC-Dno-029487	Dasypus novemcinctus	93.41	0.00e+00	1105.00
IUUC-Dme-031808	Drosophila melanogaster	32.44	7.00e-47	182.00
IUUC-Eca-034332	Equus caballus	96.46	0.00e+00	1169.00
IUUC-Fca-036088	Felis catus	96.80	0.00e+00	1147.00
IUUC-Fal-036851	Ficedula albicollis	89.47	0.00e+00	910.00
IUUC-Gmo-038940	Gadus morhua	65.08	1.00e-143	503.00
IUUC-Gga-041162	Gallus gallus	89.08	0.00e+00	1085.00
IUUC-Gac-041758	Gasterosteus aculeatus	53.22	5.00e-142	498.00
IUUC-Ggo-044658	Gorilla gorilla	96.96	0.00e+00	1150.00
IUUC-Hsa-045895	Homo sapiens	96.96	0.00e+00	1150.00
IUUC-Itr-047940	Ictidomys tridecemlineatus	96.96	0.00e+00	1174.00
IUUC-Lch-050577	Latimeria chalumnae	78.62	0.00e+00	880.00
IUUC-Loc-051747	Lepisosteus oculatus	68.28	0.00e+00	786.00
IUUC-Laf-054500	Loxodonta africana	96.79	0.00e+00	1172.00
IUUC-Mcc-055738	Macaca mulatta	96.96	0.00e+00	1147.00
IUUC-Mga-059203	Meleagris gallopavo	88.93	0.00e+00	1083.00
IUUC-Mmr-061070	Microcebus murinus	96.29	0.00e+00	1141.00
IUUC-Mdo-061878	Monodelphis domestica	93.90	0.00e+00	947.00
IUUC-Mmu-063700	Mus musculus	97.81	0.00e+00	1182.00
IUUC-Mpu-066250	Mustela putorius furo	96.63	0.00e+00	1148.00
IUUC-Mlu-067694	Myotis lucifugus	96.28	0.00e+00	1166.00
IUUC-Nle-069777	Nomascus leucogenys	96.63	0.00e+00	1172.00
IUUC-Ont-072183	Oreochromis niloticus	55.29	4.00e-167	581.00
IUUC-Oan-073204	Ornithorhynchus anatinus	95.45	3.00e-141	493.00
IUUC-Ocu-074279	Oryctolagus cuniculus	97.13	0.00e+00	1177.00
IUUC-Ola-087332	Oryzias latipes	55.76	5.00e-135	474.00
IUUC-Oga-089023	Otolemur garnettii	51.57	6.00e-116	411.00
IUUC-Oar-089543	Ovis aries	96.80	0.00e+00	1151.00
IUUC-Ptr-090676	Pan troglodytes	96.96	0.00e+00	1150.00
IUUC-Pan-092568	Papio anubis	97.13	0.00e+00	1150.00
IUUC-Psi-092976	Pelodiscus sinensis	89.08	0.00e+00	1091.00
IUUC-Pma-094138	Petromyzon marinus	64.76	9.00e-136	476.00
IUUC-Pfo-097187	Poecilia formosa	51.05	4.00e-158	551.00
IUUC-Pab-097543	Pongo abelii	96.96	0.00e+00	1150.00
IUUC-Pca-100289	Procavia capensis	85.86	0.00e+00	835.00
IUUC-Pva-103007	Pteropus vampyrus	55.27	8.00e-104	370.00
IUUC-Sha-106522	Sarcophilus harrisii	94.76	6.00e-119	419.00
IUUC-Ssc-116220	Sus scrofa	96.80	0.00e+00	1149.00
IUUC-Tgu-117230	Taeniopygia guttata	87.60	0.00e+00	1046.00
IUUC-Tru-118228	Takifugu rubripes	53.29	4.00e-157	548.00
IUUC-Tsy-119045	Tarsius syrichta	96.28	0.00e+00	1129.00
IUUC-Tni-120342	Tetraodon nigroviridis	55.41	1.00e-174	606.00
IUUC-Ttr-128691	Tursiops truncatus	96.46	0.00e+00	1144.00
IUUC-Vpa-130085	Vicugna pacos	57.04	2.00e-48	186.00
IUUC-Xtr-132767	Xenopus tropicalis	74.67	0.00e+00	879.00
IUUC-Xma-133635	Xiphophorus maculatus	50.73	9.00e-159	553.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence