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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105546
Ensembl Protein ID ENSRNOP00000073488.1
UniProt Accession D3ZH40; D3ZH40_RAT
Genbank Protein ID EDL85651.1
Protein Name OTU deubiquitinase 7B; RCG51753
Genbank Nucleotide ID AABR07012580
Gene Name Otud7b; rCG_51753
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000042068.3 ENSRNOT00000078288.1 ENSRNOP00000073488.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/OTU 4.50e-37 127.9 184 365
UBD/ZnF/ZnF_A20 1.20e-16 60.7 794 828
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/OTU
   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseylqkesdffsefieek...........edekefcqklvepe.... 74
           l+l+t+gDGnCLl+A+s +++g++d+d+ l++al+  + + +++++ k+++++++++++k           ++e++++ kl+++e    
   Q: 184  LPLATTGDGNCLLHAASLGMWGFHDRDLvLRKALYALMEKGVEKEALKRRWRWQQTQQNKesglvytedewQKEWNELIKLASSEprmh 272
           6899********************************************************************************98887 PP
   S: 75   ...akg.................eeihifaLaqiLsrpiivvdvdsles.........kvggillpllfpeek.lkkpivLlYrsgHYd 133
                g                 ee+h+f+La++L+rpi+vv++++l++         ++ggi+lpl++p+++ +++p+vL+Y+++H++
   Q: 273  lgtN-GasgggvesseepvyeslEEFHVFVLAHVLKRPIVVVADTMLRDsggeafapiPFGGIYLPLEVPASQcHRSPLVLAYDQAHFS 360
           7640.256689****************************************************************************** PP
   S: 134  aLval 138
           aLv++
   Q: 361  ALVSM 365
           **986 PP
   

   UBD/ZnF/ZnF_A20
   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           +p++++Ck+ +C+fYG+petn++CS+Cyreelrrr
   Q: 794  PPTQTKCKQpNCSFYGHPETNNFCSCCYREELRRR 828
           59********************************9 PP
   
Organism Rattus norvegicus
Protein Sequence
(Fasta)
MTLDMDAVLS DFVRSTGAEP GLARDLLEGK NWDVSAALSD FEQLRQVHAG NLSPPFSGGS 60
TCPKTPEKGG SDREPTRPSR PILQRQDDII QEKRLSRGIS HASSSIVSLA RSHVSSNGGG 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105546|DUB,OTU;UBD,ZnF_A20|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGGGGGCGGC TAGGGTGTCA CCGCCAACCC GCTCCGGCCG GAAACGGGCG CTTGTTTCCG 60
GCCGGACGGC CAAAAGCCAC CGATCCTGAA CCAGCCGCTG GAGTCGGAGT GGCGACCCGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105546|DUB,OTU;UBD,ZnF_A20|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
Interpro

IPR003323--OTU_dom
IPR002653--Znf_A20
PROSITE

PS50802--OTU
PS51036--ZF_A20
Pfam

PF02338--OTU
PF01754--zf-A20
SMART

SM00259--ZnF_A20
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0008234--F:cysteine-type peptidase activity
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006955--P:immune response
GO:0002385--P:mucosal immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0032717--P:negative regulation of interleukin-8 production
GO:1900181--P:negative regulation of protein localization to nucleus
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
KEGG rno:310677
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002119 Ailuropoda melanoleuca 90.90 0.00e+00 1390.00
IUUC-Apl-003567 Anas platyrhynchos 65.34 0.00e+00 934.00
IUUC-Bta-013398 Bos taurus 91.82 0.00e+00 1363.00
IUUC-Cel-018468 Caenorhabditis elegans 50.33 2.00e-84 306.00
IUUC-Cja-019965 Callithrix jacchus 90.66 0.00e+00 1338.00
IUUC-Cfa-020191 Canis familiaris 90.76 0.00e+00 1386.00
IUUC-Cpo-022232 Cavia porcellus 89.50 0.00e+00 1321.00
IUUC-Csa-023593 Chlorocebus sabaeus 92.18 0.00e+00 1430.00
IUUC-Cho-024729 Choloepus hoffmanni 82.51 6.00e-172 597.00
IUUC-Csv-026177 Ciona savignyi 31.94 2.00e-03 36.20
IUUC-Dno-029900 Dasypus novemcinctus 90.40 0.00e+00 1350.00
IUUC-Dor-031121 Dipodomys ordii 85.61 0.00e+00 685.00
IUUC-Ete-032473 Echinops telfairi 85.33 0.00e+00 998.00
IUUC-Eca-033946 Equus caballus 92.12 0.00e+00 1016.00
IUUC-Eeu-034670 Erinaceus europaeus 89.22 0.00e+00 1333.00
IUUC-Fca-035871 Felis catus 90.64 0.00e+00 1294.00
IUUC-Fso-038203 Fusarium solani 30.61 2.60e-02 34.30
IUUC-Gmo-039373 Gadus morhua 77.04 0.00e+00 676.00
IUUC-Gga-041105 Gallus gallus 66.36 0.00e+00 975.00
IUUC-Gac-041806 Gasterosteus aculeatus 57.58 0.00e+00 824.00
IUUC-Ggo-045472 Gorilla gorilla 91.59 0.00e+00 1386.00
IUUC-Hsa-046473 Homo sapiens 91.35 0.00e+00 1386.00
IUUC-Itr-048841 Ictidomys tridecemlineatus 93.13 0.00e+00 1417.00
IUUC-Lch-050432 Latimeria chalumnae 62.61 0.00e+00 946.00
IUUC-Laf-053437 Loxodonta africana 61.72 0.00e+00 744.00
IUUC-Mcc-055261 Macaca mulatta 91.94 0.00e+00 1431.00
IUUC-Meu-056477 Macropus eugenii 78.42 0.00e+00 919.00
IUUC-Mga-059533 Meleagris gallopavo 66.36 0.00e+00 966.00
IUUC-Mdo-062847 Monodelphis domestica 81.65 0.00e+00 1149.00
IUUC-Mmu-064260 Mus musculus 97.03 0.00e+00 1420.00
IUUC-Mpu-066876 Mustela putorius furo 86.52 0.00e+00 1281.00
IUUC-Mlu-068039 Myotis lucifugus 90.06 0.00e+00 1350.00
IUUC-Nle-069260 Nomascus leucogenys 91.23 0.00e+00 1385.00
IUUC-Opr-070564 Ochotona princeps 89.80 0.00e+00 765.00
IUUC-Ont-072431 Oreochromis niloticus 73.54 0.00e+00 715.00
IUUC-Ocu-073824 Oryctolagus cuniculus 92.97 0.00e+00 935.00
IUUC-Ola-087026 Oryzias latipes 53.16 0.00e+00 802.00
IUUC-Oga-088124 Otolemur garnettii 90.65 0.00e+00 1345.00
IUUC-Oar-090086 Ovis aries 92.18 0.00e+00 1367.00
IUUC-Ptr-091622 Pan troglodytes 92.61 0.00e+00 1065.00
IUUC-Pan-092724 Papio anubis 91.94 0.00e+00 1427.00
IUUC-Psi-093333 Pelodiscus sinensis 63.73 0.00e+00 929.00
IUUC-Pfo-096785 Poecilia formosa 73.44 0.00e+00 726.00
IUUC-Pab-098667 Pongo abelii 91.23 0.00e+00 1369.00
IUUC-Pca-100701 Procavia capensis 90.17 0.00e+00 724.00
IUUC-Pva-102136 Pteropus vampyrus 89.45 0.00e+00 1335.00
IUUC-Sha-106732 Sarcophilus harrisii 82.00 0.00e+00 1052.00
IUUC-Sar-113562 Sorex araneus 78.55 0.00e+00 1073.00
IUUC-Ssc-116191 Sus scrofa 91.59 0.00e+00 1379.00
IUUC-Tgu-117218 Taeniopygia guttata 68.30 0.00e+00 781.00
IUUC-Tru-118720 Takifugu rubripes 70.23 0.00e+00 678.00
IUUC-Tsy-119343 Tarsius syrichta 79.75 0.00e+00 1165.00
IUUC-Tni-120795 Tetraodon nigroviridis 72.18 0.00e+00 696.00
IUUC-Tbe-127283 Tupaia belangeri 93.03 0.00e+00 742.00
IUUC-Ttr-128692 Tursiops truncatus 88.15 0.00e+00 1275.00
IUUC-Xtr-132888 Xenopus tropicalis 60.71 0.00e+00 849.00
Created Date 25-Jun-2017

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