iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000262246.5	ENST00000251166.8	ENSP00000251166.4
ENSG00000262246.5	ENST00000571227.5	ENSP00000458459.1
ENSG00000262246.5	ENST00000537233.6	ENSP00000440460.2
ENSG00000262246.5	ENST00000574025.5	ENSP00000461702.1
ENSG00000262246.5	ENST00000576637.1	ENSP00000460177.1
ENSG00000262246.5	ENST00000570779.1	ENSP00000460956.1
ENSG00000262246.5	ENST00000574311.5	ENSP00000461187.1
ENSG00000262246.5	ENST00000576437.5	ENSP00000459228.1
ENSG00000262246.5	ENST00000571756.5	ENSP00000458828.1
ENSG00000262246.5	ENST00000572549.5	ENSP00000459286.1
ENSG00000262246.5	ENST00000571059.5	ENSP00000460036.1
ENSG00000262246.5	ENST00000570928.5	ENSP00000460199.1
ENSG00000262246.5	ENST00000575850.5	ENSP00000460910.1
ENSG00000262246.5	ENST00000572153.5	ENSP00000461051.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	circRNADb	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
miRNAMap	SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	PHOSIDA	BioGRID
mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	21130766
E3 adaptor/Cullin RING/DCX/DWD	WD_repeat	21130766

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-36	124.1	635	672
UBD/Beta-Prp	2.00e-40	140.5	542	669

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
           gH+d +++la+ +d   l++ + Dg ++v+++r+g+ +
   Q: 635  GHQDQIFSLAWsPDgQQLATVCKDGRVRVYRPRSGPEP 672
           8***********9999*****************99865 PP

UBD/Beta-Prp

   S: 91   kghedsvlslsfsp.sgdklvsGshdrtirvwdletgqclee......tlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkllrt 174
           + + + v++l+++p + ++l+++++d  ir+w ++ +   e       +l+gh++ ++++++hp + n+l+s+s+D tvr+Wdl+ g    +
   Q: 542  Q-NGAAVTDLAWDPfDPHRLAVAGEDARIRLWRVPAEGLEEVlttpetVLTGHTEKICSLRFHPLAaNVLASSSYDLTVRIWDLQAGADRLK 632
           5.66889*******666*****************99877666789*********************************************** PP
   S: 175  ltgghtdsvyslsfdsngkelvsgsldgtvklwdlqtg 212
           l+g h+d++ sl+++++g++l+++ +dg+v+++  ++g
   Q: 633  LQG-HQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSG 669
           **9.*****************************98765 PP

Organism

Homo sapiens

Functional Description
(View)

F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.

Protein Sequence
(Fasta)

MNRFRVSKFR HTEARPPRRE SWISDIRAGT APSCRNHIKS SCSLIAFNSD RPGVLGIVPL 60
QGQGEDKRRV AHLGCHSDLV TDLDFSPFDD FLLATGSADR TVKLWRLPGP GQALPSAPGV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAGGTAGAC TCGCCGTGCA GAACCTCGCT ATTCTGTGCT AGACAACCAA TGGGTGTACG 60
TTATCGGTGT AAGGACGTGG TTGAATGTAG CCGAACTTAA GTGGTCCGAG GGGTCTGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0009--Actin-binding
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0333--Golgi apparatus
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR027331--CORO7
IPR015505--Coronin
IPR003143--Cyt_cd1_C
IPR015048--DUF1899
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0016020--C:membrane
GO:0005802--C:trans-Golgi network
GO:0003779--F:actin binding
GO:0030041--P:actin filament polymerization
GO:0006895--P:Golgi to endosome transport
GO:0015031--P:protein transport

KEGG

hsa:79585

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005201	Anolis carolinensis	67.11	0.00e+00	782.00
IUUC-Cin-025202	Ciona intestinalis	46.05	1.00e-125	444.00
IUUC-Csv-026236	Ciona savignyi	41.11	8.00e-141	494.00
IUUC-Dre-028759	Danio rerio	67.59	0.00e+00	646.00
IUUC-Gac-041680	Gasterosteus aculeatus	65.57	0.00e+00	634.00
IUUC-Loc-052682	Lepisosteus oculatus	62.14	0.00e+00	868.00
IUUC-Mla-058813	Melampsora laricipopulina	28.13	2.00e-68	254.00
IUUC-Ont-071673	Oreochromis niloticus	65.67	0.00e+00	654.00
IUUC-Ola-086479	Oryzias latipes	55.05	0.00e+00	1004.00
IUUC-Psi-093624	Pelodiscus sinensis	54.04	4.00e-109	388.00
IUUC-Pgr-103449	Puccinia graminis	27.55	3.00e-79	290.00
IUUC-Sha-106795	Sarcophilus harrisii	69.97	0.00e+00	1210.00
IUUC-Tni-119997	Tetraodon nigroviridis	64.09	0.00e+00	655.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence