iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028077

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Kelch-like protein 40b; Kelch repeat and BTB domain-containing protein 5b

Genbank Nucleotide ID

BX571770

Gene Name

klhl40b; kbtbd5b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000019125.6	ENSDART00000010488.6	ENSDARP00000012991.6

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.80e-21	76.1	34	99
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.50e-09	36.3	132	162

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 2    DvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           D++l+++++ef++h++vLaa+Ss+F+a f+++ eesk + +++++dv+p+v+  +lk+lYt+ ++ +
   Q: 34   DCVLKIKDKEFPCHRLVLAACSSYFRAFFKSGVEESK-QREIVLEDVEPGVMGIILKYLYTSNINVT 99
           9************************************.***********************998765 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           l+Ncl+i+r++ ++dcp+L+ +a++f++  F
   Q: 132  LSNCLAIFRLGLMLDCPRLAISARNFACERF 162
           69**************************988 PP

Organism

Danio rerio

Functional Description
(View)

ubstrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex (By similarity). Required for skeletal muscle development (PubMed:23746549).

Protein Sequence
(Fasta)

MALPIDPMEE PRMYQQTLLQ DGLYDLLESD MMVDCVLKIK DKEFPCHRLV LAACSSYFRA 60
FFKSGVEESK QREIVLEDVE PGVMGIILKY LYTSNINVTE QNVQDIFALS NMLQIPSIFT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATTCATTGA CTTCAGTGGG ACACTAAGGG ATTGAAGACA GTCAGCATGG CTCTACCCAT 60
AGACCCAATG GAGGAGCCGC GAATGTACCA GCAAACCTTG CTGCAGGACG GCCTGTATGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0217--Developmental protein
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030607--KLHL40
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031672--C:A band
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0031674--C:I band
GO:0061061--P:muscle structure development
GO:0032435--P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031397--P:negative regulation of protein ubiquitination
GO:0016567--P:protein ubiquitination
GO:0048741--P:skeletal muscle fiber development
GO:0036268--P:swimming

KEGG

dre:795319

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ame-011294	Astyanax mexicanus	79.94	0.00e+00	983.00
IUUC-Cre-022734	Chlamydomonas reinhardtii	44.44	1.00e-05	46.20
IUUC-Cin-025237	Ciona intestinalis	28.69	3.00e-62	233.00
IUUC-Gmo-039697	Gadus morhua	69.14	0.00e+00	878.00
IUUC-Gac-042421	Gasterosteus aculeatus	71.84	0.00e+00	927.00
IUUC-Mdo-062563	Monodelphis domestica	59.01	5.00e-168	584.00
IUUC-Ont-071273	Oreochromis niloticus	71.84	0.00e+00	926.00
IUUC-Ola-087175	Oryzias latipes	69.47	0.00e+00	882.00
IUUC-Pno-094910	Phaeosphaeria nodorum	30.88	3.00e-05	42.40
IUUC-Pfo-096216	Poecilia formosa	69.09	0.00e+00	898.00
IUUC-Tru-118614	Takifugu rubripes	70.71	0.00e+00	912.00
IUUC-Tni-119776	Tetraodon nigroviridis	70.71	0.00e+00	910.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence