iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106169

UUCD1 version

UUC-SaC-00014

Ensembl Protein ID

YDL013W

UniProt Accession

P32828; D6VRX6; SLX5_YEAST

Genbank Protein ID

AAA34671.1; CAA88346.1; CAA98570.1; DAA11836.1

Protein Name

E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5; Hexose metabolism-related protein HEX3; RING-type E3 ubiquitin transferase SLX5; Synthetic lethal of unknown function protein 5

Genbank Nucleotide ID

L07745; Z48432; Z74061; BK006938

Gene Name

SLX5; HEX3; YDL013W; D2875

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YDL013W	YDL013W	YDL013W

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	UniProt
BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20351217

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.00046	19.1	494	600

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiC...............................................ledfkdgplvlpCgHvfhadClqkw...........pglknssskefr... 41
           C++C                                               ++  k+ +++ +CgH+f+  C+ ++           +          +   
   Q: 494  CCLCgaelgvgipddftgisqkdrgvsfeglvskykfhcpyqtlarpsmldRDLSKR-TFIASCGHAFCGRCFARIdnakkkskmpkK----------Klaq 584
           778877777777777777777777777666666666655555544444433333367.99*************888643333332220..........1333 PP
   S: 42   ..............CP 43
                         CP
   Q: 585  lkgsahpdnygpklCP 600
           4444444444444466 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

Mediates ubiquitination and subsequent desumoylation/degradation of sumoylated proteins and proteins containing SUMO-like domains. Promotes UBC4-dependent ubiquitination that mediates the proteolytic down-regulation of sumoylated proteins. Involved in the stimulation of ubiquitin conjugating enzymes, including UBC1, UBC4, UBC5 and UBC13-MMS2. Acts as a critical suppressor of gross chromosomal rearrangements (GCRs) during normal cell cycle progression. Has a role in localizing the DNA damage protein DCD2. Involved in stabilizing, restarting or resolving transiently stalled replication forks. Prevents accumulation of DNA damage during cell cycle progression. Along with SIR2, promotes silencing of genes at telomeric or ribosomal DNA (rDNA) loci.

Protein Sequence
(Fasta)

MHSDTNGRTK SNNSPSDNNP NETVILIDSD KEEDASIREA NLPVRLYPDR RVGRRRDALN 60
RFVRSDSRSR NSQRTHITAS SERPDFQANN DDITIIREVG RFFGDDGPID PSAHYVDLDQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCATAGCG ATACTAACGG TCGAACAAAG AGCAATAATA GCCCATCAGA CAATAATCCA 60
AATGAGACAG TTATATTAAT AGATAGTGAT AAGGAAGAAG ACGCTTCTAT TCGCGAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR013083--Znf_RING/FYVE/PHD

Gene Ontology

GO:0000775--C:chromosome, centromeric region
GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0033768--C:SUMO-targeted ubiquitin ligase complex
GO:0032183--F:SUMO binding
GO:0016740--F:transferase activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006281--P:DNA repair
GO:0016925--P:protein sumoylation
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0006355--P:regulation of transcription, DNA-templated
GO:0000723--P:telomere maintenance
GO:0006351--P:transcription, DNA-templated

KEGG

sce:YDL013W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ago-007925	Ashbya gossypii	42.12	1.00e-122	431.00
IUUC-Afu-008756	Aspergillus fumigatus	44.83	1.90e-01	28.90
IUUC-Bci-013746	Botrytis cinerea	21.48	2.00e-03	35.40
IUUC-Cin-025259	Ciona intestinalis	27.78	5.40e-02	29.60
IUUC-Cgl-026586	Colletotrichum gloeosporioides	43.48	1.70e-02	32.70
IUUC-Dre-027623	Danio rerio	32.43	1.70e-02	32.30
IUUC-Fox-037693	Fusarium oxysporum	33.96	2.00e-02	31.60
IUUC-Ggr-039877	Gaeumannomyces graminis	26.47	3.30e-02	32.00
IUUC-Gma-043366	Glycine max	36.73	6.00e-03	33.10
IUUC-Itr-049016	Ictidomys tridecemlineatus	31.65	2.00e-03	35.40
IUUC-Kpa-049252	Komagataella pastoris	41.33	1.00e-13	69.30
IUUC-Loc-052590	Lepisosteus oculatus	36.36	6.00e-03	33.90
IUUC-Ola-087514	Oryzias latipes	23.81	4.90e-02	31.20
IUUC-Pte-104074	Pyrenophora teres	26.09	5.00e-03	33.90
IUUC-Pyt-104527	Pyrenophora triticirepentis	27.63	6.00e-04	37.00
IUUC-Ssl-108638	Sclerotinia sclerotiorum	21.05	3.00e-03	34.30
IUUC-Tur-126277	Triticum urartu	35.59	4.00e-03	34.70
IUUC-Tme-127182	Tuber melanosporum	25.40	8.00e-03	32.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence