iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000035293.13	ENSMUST00000054308.12	ENSMUSP00000054474.6
ENSMUSG00000035293.13	ENSMUST00000119211.7	ENSMUSP00000113270.1
ENSMUSG00000035293.13	ENSMUST00000121521.1	ENSMUSP00000113191.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.20e-32	113.0	412	716

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/HECT

   S: 9    levefvg..EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsks 95
           ++v +v+  E g  + G+++efl+ l+++l+n++    +++ +  ++l+ n+++      +++l++ +G++l+++l++g + + ++s++
   Q: 412  IDVVYVNgnEVGSQHLGSKQEFLSHLMHHLENSS----VFEGSLAKNLSLNSQAV-----KENLYYEVGKMLAISLVHGGPSPGFFSET 491
           56777777799***********************....46788888888999885.....689************************** PP
   S: 96   fyklllgkk....lsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvvey 180
           ++++l   +     +l+d++++d      + +i  +  ++ ++  l++  s    ++++ +++  ++g+ +     ++k + vk+++ y
   Q: 492  LFNCLAYGPentlPTLDDVSDID------VAQIIIKI-DSATD--LNILNS----VISQHYNYLEVSGCLRLTTSLSDKFMLVKDILFY 567
           ******99622223444444433......34444331.13333..454444....455666666677********************** PP
   S: 181  rlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevl.eefsseerkafLq.. 266
           ++ +++k  +e+f++G++++  le+++ + e   ++l+++ e++++++l++   ++ +  +d +++ +Fw+ + +++++ + ++ ++  
   Q: 568  HVINRVKAPFESFKQGLKTLGVLEKIQTYPEAFYKILCHKPENLSAKNLSD--LFTIHSVADVQTL-RFWNSYlKAIEDGKSATTMEdi 653
           **************************************************9..6666779999998.8998875888888877776667 PP
   S: 267  ..FvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgF 333
             F+Tg+s++P+ Gf++   ++ +++      ++P + +  n L LP  +++e+++e++ ++i+ t ++
   Q: 654  liFATGCSSVPPTGFKPSL-SVECLHV-----DFPVADKYRNHLVLPATNTYEEFQENMDFTIRDTLRL 716
           77**************877.7899999.....*******************************987665 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MNENKPDNSQ SLACVFCRKN DDCPNKYGEK KTYEKWNFSV HYYCLLMSSG IWQRGKEEEG 60
VYGFLIEDIR KEVQRASKLK CTVCKKNGAS IGCVVPTCKR SYHLPCGLQK ECIFQFTDNF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGGCCTGTT GGGGGGTGAC TGGTGCGCTC CGCACGCCTC CGCGGACGTG CAGGACCGGG 60
AGTTGTTTTC CTGGCCGGGT CCGCGCAGCC ACCCCTGCGC GCACGCCCGA ACTTCATTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR034732--EPHD
IPR000569--HECT_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51805--EPHD
PS50237--HECT
PS01359--ZF_PHD_1

Pfam

PF00632--HECT

SMART

SM00119--HECTc
SM00249--PHD

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001501	Ailuropoda melanoleuca	77.58	0.00e+00	1185.00
IUUC-Apl-003763	Anas platyrhynchos	57.31	0.00e+00	807.00
IUUC-Aca-004328	Anolis carolinensis	55.65	0.00e+00	810.00
IUUC-Ame-011288	Astyanax mexicanus	40.36	1.00e-164	573.00
IUUC-Bta-012496	Bos taurus	74.69	0.00e+00	1137.00
IUUC-Cja-019756	Callithrix jacchus	75.52	0.00e+00	1152.00
IUUC-Cfa-020806	Canis familiaris	76.28	0.00e+00	1170.00
IUUC-Cpo-022519	Cavia porcellus	73.90	0.00e+00	1122.00
IUUC-Csa-023957	Chlorocebus sabaeus	77.72	0.00e+00	1181.00
IUUC-Cho-024375	Choloepus hoffmanni	70.65	0.00e+00	1016.00
IUUC-Cin-025325	Ciona intestinalis	44.15	2.00e-70	259.00
IUUC-Csv-026262	Ciona savignyi	43.34	3.00e-69	255.00
IUUC-Dre-027829	Danio rerio	39.92	6.00e-159	554.00
IUUC-Dno-029362	Dasypus novemcinctus	76.80	0.00e+00	1139.00
IUUC-Dor-030710	Dipodomys ordii	73.83	0.00e+00	1131.00
IUUC-Dme-031692	Drosophila melanogaster	32.84	2.00e-41	164.00
IUUC-Ete-032282	Echinops telfairi	67.58	0.00e+00	1000.00
IUUC-Eca-033963	Equus caballus	76.62	0.00e+00	1175.00
IUUC-Eeu-035029	Erinaceus europaeus	73.87	0.00e+00	1131.00
IUUC-Fca-036229	Felis catus	76.07	0.00e+00	1173.00
IUUC-Fal-037015	Ficedula albicollis	55.59	0.00e+00	835.00
IUUC-Gmo-039715	Gadus morhua	36.14	3.00e-66	245.00
IUUC-Gga-040298	Gallus gallus	56.12	0.00e+00	862.00
IUUC-Gac-041444	Gasterosteus aculeatus	36.93	4.00e-134	471.00
IUUC-Ggo-045456	Gorilla gorilla	76.75	0.00e+00	1165.00
IUUC-Hsa-046297	Homo sapiens	77.17	0.00e+00	1175.00
IUUC-Itr-047897	Ictidomys tridecemlineatus	72.99	0.00e+00	786.00
IUUC-Lch-050287	Latimeria chalumnae	65.87	1.00e-104	374.00
IUUC-Loc-052839	Lepisosteus oculatus	56.88	3.00e-34	136.00
IUUC-Laf-053581	Loxodonta africana	75.72	0.00e+00	1155.00
IUUC-Mcc-055615	Macaca mulatta	77.58	0.00e+00	1179.00
IUUC-Meu-056753	Macropus eugenii	47.71	5.00e-68	252.00
IUUC-Mga-059902	Meleagris gallopavo	55.45	0.00e+00	862.00
IUUC-Mmr-061522	Microcebus murinus	77.99	0.00e+00	1180.00
IUUC-Mdo-063022	Monodelphis domestica	62.67	0.00e+00	857.00
IUUC-Mpu-066656	Mustela putorius furo	75.79	0.00e+00	1167.00
IUUC-Mlu-067011	Myotis lucifugus	76.92	0.00e+00	1151.00
IUUC-Nle-069949	Nomascus leucogenys	76.75	0.00e+00	1168.00
IUUC-Opr-071224	Ochotona princeps	73.66	6.00e-114	404.00
IUUC-Ont-072174	Oreochromis niloticus	36.48	1.00e-133	470.00
IUUC-Oan-072712	Ornithorhynchus anatinus	63.97	0.00e+00	903.00
IUUC-Ocu-073776	Oryctolagus cuniculus	76.45	0.00e+00	1163.00
IUUC-Ola-087247	Oryzias latipes	35.10	9.00e-123	434.00
IUUC-Oga-088094	Otolemur garnettii	73.86	0.00e+00	1054.00
IUUC-Oar-090248	Ovis aries	74.14	0.00e+00	1133.00
IUUC-Ptr-090634	Pan troglodytes	77.03	0.00e+00	1172.00
IUUC-Pan-092876	Papio anubis	77.58	0.00e+00	1179.00
IUUC-Psi-093580	Pelodiscus sinensis	59.54	0.00e+00	837.00
IUUC-Pma-094295	Petromyzon marinus	52.38	5.00e-73	267.00
IUUC-Pfo-096351	Poecilia formosa	35.86	3.00e-139	489.00
IUUC-Pab-097596	Pongo abelii	77.58	0.00e+00	1178.00
IUUC-Pca-100309	Procavia capensis	73.70	9.00e-162	563.00
IUUC-Pva-102526	Pteropus vampyrus	76.57	0.00e+00	736.00
IUUC-Rno-105432	Rattus norvegicus	87.97	0.00e+00	1351.00
IUUC-Sha-107089	Sarcophilus harrisii	61.78	0.00e+00	948.00
IUUC-Sar-113667	Sorex araneus	58.73	0.00e+00	853.00
IUUC-Ssc-116200	Sus scrofa	76.17	0.00e+00	1153.00
IUUC-Tgu-116467	Taeniopygia guttata	55.30	0.00e+00	825.00
IUUC-Tru-117690	Takifugu rubripes	37.03	3.00e-147	515.00
IUUC-Tsy-119481	Tarsius syrichta	74.19	0.00e+00	795.00
IUUC-Tni-119669	Tetraodon nigroviridis	37.00	1.00e-130	460.00
IUUC-Tbe-127241	Tupaia belangeri	69.64	0.00e+00	1008.00
IUUC-Ttr-129057	Tursiops truncatus	67.81	0.00e+00	983.00
IUUC-Vpa-130685	Vicugna pacos	74.79	0.00e+00	1102.00
IUUC-Xtr-132555	Xenopus tropicalis	50.21	0.00e+00	715.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence