iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-047956

Ensembl Protein ID

ENSSTOP00000006944.2

UniProt Accession

I3MAD0; I3MAD0_ICTTR

Genbank Protein ID

ENSSTOP00000006944

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTP01009390

Gene Name

AMFR

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000007758.2	ENSSTOT00000007757.2	ENSSTOP00000006944.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	4.70e-09	36.6	260	298
UBD/Alpha-Helix/CUE	2.00e-11	43.6	375	416

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiC+++++   + lpCgH+fh +Cl  w        +  +CP+Cr
   Q: 260  CAICWDSMQA-ARKLPCGHLFHNSCLRSW------LEQDTSCPTCR 298
           ********99.******************......9*********8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l+ +++q++e+FP+++y ++ ++L ++t s+e +++n+Leg 
   Q: 375  QLNAMAHQIQEMFPQVPYHLVLQDL-QLTRSVEITTDNILEGR 416
           5889*********************.***************95 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

LCVQVLVNTA CCVLMLVAKL IQCIVFGPLR VSERQHLKDK FWNFIFYKFI FIFGVLNVQT 60
VEEVVMWCLW FAGLVFLHLM VQLCKDRFEY LSFSPTTPMS SHGRVLSLLI AMLLSCCGLA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTTTGTGTA CAGGTTCTGG TAAACACTGC TTGCTGTGTT TTGATGTTGG TGGCTAAGCT 60
TATCCAGTGT ATTGTGTTTG GCCCTCTGCG AGTGAGTGAG AGACAGGTAA GTCCTCATAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0036513--C:Derlin-1 retrotranslocation complex
GO:0005794--C:Golgi apparatus
GO:0030176--C:integral component of endoplasmic reticulum membrane
GO:0048471--C:perinuclear region of cytoplasm
GO:0004872--F:receptor activity
GO:0034450--F:ubiquitin-ubiquitin ligase activity
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0032092--P:positive regulation of protein binding
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0051259--P:protein oligomerization
GO:0030433--P:ubiquitin-dependent ERAD pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	93.54	0.00e+00	1025.00
IUUC-Apl-003404	Anas platyrhynchos	88.08	0.00e+00	940.00
IUUC-Aca-004559	Anolis carolinensis	85.47	0.00e+00	879.00
IUUC-Ame-011640	Astyanax mexicanus	73.92	0.00e+00	773.00
IUUC-Bta-012980	Bos taurus	95.02	0.00e+00	1057.00
IUUC-Cel-018598	Caenorhabditis elegans	24.29	5.00e-30	125.00
IUUC-Cja-019577	Callithrix jacchus	95.37	0.00e+00	1060.00
IUUC-Cfa-020793	Canis familiaris	95.54	0.00e+00	1036.00
IUUC-Cpo-022387	Cavia porcellus	96.26	0.00e+00	1034.00
IUUC-Csa-023168	Chlorocebus sabaeus	96.26	0.00e+00	1073.00
IUUC-Cho-024433	Choloepus hoffmanni	95.74	0.00e+00	855.00
IUUC-Cin-025215	Ciona intestinalis	48.33	2.00e-144	505.00
IUUC-Csv-026133	Ciona savignyi	49.15	1.00e-131	462.00
IUUC-Dre-027594	Danio rerio	72.05	0.00e+00	726.00
IUUC-Dno-029407	Dasypus novemcinctus	96.60	0.00e+00	1039.00
IUUC-Dor-030961	Dipodomys ordii	96.95	0.00e+00	1061.00
IUUC-Ete-032962	Echinops telfairi	88.53	0.00e+00	887.00
IUUC-Eca-033683	Equus caballus	94.10	0.00e+00	1011.00
IUUC-Eeu-034515	Erinaceus europaeus	98.52	2.00e-79	289.00
IUUC-Fca-035398	Felis catus	96.29	0.00e+00	999.00
IUUC-Fal-036758	Ficedula albicollis	81.18	0.00e+00	880.00
IUUC-Gmo-039014	Gadus morhua	73.95	0.00e+00	712.00
IUUC-Gga-040575	Gallus gallus	88.61	0.00e+00	978.00
IUUC-Gac-041414	Gasterosteus aculeatus	73.09	0.00e+00	696.00
IUUC-Hsa-046272	Homo sapiens	95.73	0.00e+00	1068.00
IUUC-Lch-050491	Latimeria chalumnae	80.53	0.00e+00	827.00
IUUC-Loc-052758	Lepisosteus oculatus	78.15	0.00e+00	780.00
IUUC-Laf-053452	Loxodonta africana	97.32	0.00e+00	1036.00
IUUC-Mcc-055820	Macaca mulatta	96.17	0.00e+00	1045.00
IUUC-Meu-056726	Macropus eugenii	87.17	0.00e+00	764.00
IUUC-Mga-059937	Meleagris gallopavo	88.93	0.00e+00	953.00
IUUC-Mmr-060730	Microcebus murinus	95.55	0.00e+00	1030.00
IUUC-Mdo-062771	Monodelphis domestica	92.44	0.00e+00	999.00
IUUC-Mmu-064219	Mus musculus	95.57	0.00e+00	1054.00
IUUC-Mpu-066796	Mustela putorius furo	95.99	0.00e+00	1036.00
IUUC-Mlu-068189	Myotis lucifugus	93.24	0.00e+00	996.00
IUUC-Nle-069239	Nomascus leucogenys	95.91	0.00e+00	1069.00
IUUC-Opr-070702	Ochotona princeps	88.04	9.00e-143	499.00
IUUC-Ont-072033	Oreochromis niloticus	75.05	0.00e+00	762.00
IUUC-Oan-073717	Ornithorhynchus anatinus	85.52	0.00e+00	875.00
IUUC-Ocu-074145	Oryctolagus cuniculus	93.42	0.00e+00	1043.00
IUUC-Ogl-077929	Oryza glaberrima	53.49	7.00e-12	63.20
IUUC-Ola-087152	Oryzias latipes	72.05	0.00e+00	729.00
IUUC-Oga-088486	Otolemur garnettii	97.15	0.00e+00	1046.00
IUUC-Oar-089310	Ovis aries	95.54	0.00e+00	1057.00
IUUC-Ptr-090649	Pan troglodytes	96.06	0.00e+00	1066.00
IUUC-Pan-091692	Papio anubis	91.28	0.00e+00	1005.00
IUUC-Psi-093064	Pelodiscus sinensis	94.97	0.00e+00	777.00
IUUC-Pma-094763	Petromyzon marinus	77.87	3.00e-97	347.00
IUUC-Ppa-095969	Physcomitrella patens	29.38	3.00e-36	146.00
IUUC-Pfo-096810	Poecilia formosa	73.90	0.00e+00	738.00
IUUC-Pab-097859	Pongo abelii	95.99	0.00e+00	1048.00
IUUC-Pop-099576	Populus trichocarpa	27.35	5.00e-29	122.00
IUUC-Pca-100344	Procavia capensis	94.15	0.00e+00	986.00
IUUC-Pva-103114	Pteropus vampyrus	66.90	0.00e+00	645.00
IUUC-Rno-105880	Rattus norvegicus	93.72	0.00e+00	1028.00
IUUC-Sha-107015	Sarcophilus harrisii	93.39	0.00e+00	975.00
IUUC-Smo-109664	Selaginella moellendorffii	31.35	4.00e-33	135.00
IUUC-Sar-113397	Sorex araneus	98.11	0.00e+00	766.00
IUUC-Ssc-115988	Sus scrofa	91.32	1.00e-145	508.00
IUUC-Tgu-116717	Taeniopygia guttata	89.10	0.00e+00	920.00
IUUC-Tru-117805	Takifugu rubripes	72.36	0.00e+00	759.00
IUUC-Tsy-119442	Tarsius syrichta	90.14	0.00e+00	960.00
IUUC-Tni-119777	Tetraodon nigroviridis	72.45	7.00e-173	599.00
IUUC-Tbe-127322	Tupaia belangeri	68.67	1.00e-115	409.00
IUUC-Ttr-128181	Tursiops truncatus	95.16	0.00e+00	1052.00
IUUC-Vpa-130483	Vicugna pacos	85.95	0.00e+00	666.00
IUUC-Xtr-132614	Xenopus tropicalis	80.88	0.00e+00	775.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence