iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cin-025269

UUCD1 version

UUC-CiI-00219

Ensembl Protein ID

ENSCINP00000012690.3

UniProt Accession

F6V304; F6V304_CIOIN

Protein Name

Defective in cullin neddylation protein

Gene Name

LOC100180811

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCING00000006132.3	ENSCINT00000012690.3	ENSCINP00000012690.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/DCUN1	7.10e-78	260.8	60	248

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/DCUN1

   S: 1    vskkkleelferYkdpqed.ligieglekfcedlgvdpediavLvlawkleaatlcefsreefldgltalgcdsieklqeklktlesel 88
           v+++kle+lf+  kdp +  ++g+eg++kfce+l+v+p++ +vL++awk++aat+cef+++ef++g+++lgcd ++kl+ kl+ l +e+
   Q: 60   VERRKLEALFNALKDPLDPdKVGVEGISKFCEELQVEPTSRIVLIIAWKFRAATQCEFTKKEFFEGMMELGCDDLSKLRIKLPVLANEI 148
           5789************8755********************************************************************* PP
   S: 89   kdeqkfkdiYrfafnfakdkgqksldldtaialwkLllaerefklldawlkfLeeekkksiskDtWnllLefskviakdlsnYdeegaW 177
            d++kf+d+Y+f+fnfak++gqk+l+l++aia+w++ll++r f +ld+w ++Le + k++i++DtWnllL+fs++i++d+snYdeegaW
   Q: 149  TDKNKFRDFYQFTFNFAKNPGQKGLELEMAIAYWNILLSDR-FTFLDLWAEYLETHYKRAIPRDTWNLLLDFSQMISSDMSNYDEEGAW 236
           **************************************999.*********************************************** PP
   S: 178  PvliDefveylk 189
           PvliD+fve++k
   Q: 237  PVLIDDFVEWAK 248
           **********85 PP

Organism

Ciona intestinalis

Functional Description
(View)

Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

Protein Sequence
(Fasta)

MHKLKSSQRE KVRQFISLTN LSEKSAISCL AKHDWRLDIA SDSFFSEPES YVVSDRRSHV 60
ERRKLEALFN ALKDPLDPDK VGVEGISKFC EELQVEPTSR IVLIIAWKFR AATQCEFTKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTTTCTCG GTGTTTAACC AAATTGAAAA CCAATAGTCT ATCAATTTGA TTTATTTGGT 60
TAAAATCTCC AGTTTTGTAA ATGTTGCCAA GACAATATTT CACTTTAGTA AACTGACTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR014764--DCN-prot
IPR005176--PONY_dom
IPR009060--UBA-like

PROSITE

PS51229--DCUN1

Pfam

PF03556--Cullin_binding

Gene Ontology

GO:0000151--C:ubiquitin ligase complex
GO:0097602--F:cullin family protein binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0032182--F:ubiquitin-like protein binding
GO:0051443--P:positive regulation of ubiquitin-protein transferase activity
GO:0045116--P:protein neddylation

KEGG

cin:100180811

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000561	Aegilops tauschii	44.94	2.00e-61	227.00
IUUC-Aml-001879	Ailuropoda melanoleuca	61.09	1.00e-99	354.00
IUUC-Atr-002697	Amborella trichopoda	40.91	7.00e-25	104.00
IUUC-Apl-003933	Anas platyrhynchos	61.60	4.00e-99	352.00
IUUC-Aca-005269	Anolis carolinensis	61.24	2.00e-99	353.00
IUUC-Aly-006285	Arabidopsis lyrata	37.25	6.00e-48	182.00
IUUC-Ath-007531	Arabidopsis thaliana	43.72	2.00e-61	226.00
IUUC-Ago-007806	Ashbya gossypii	26.64	5.00e-20	89.70
IUUC-Acl-008172	Aspergillus clavatus	25.36	2.00e-23	101.00
IUUC-Afl-008569	Aspergillus flavus	27.00	9.00e-28	115.00
IUUC-Ani-009241	Aspergillus nidulans	24.84	1.00e-23	102.00
IUUC-Ang-009664	Aspergillus niger	27.73	3.00e-22	97.10
IUUC-Aor-009902	Aspergillus oryzae	27.42	1.00e-10	57.00
IUUC-Ate-010414	Aspergillus terreus	27.76	1.00e-28	118.00
IUUC-Ame-011763	Astyanax mexicanus	59.77	4.00e-97	345.00
IUUC-Bgr-011991	Blumeria graminis	30.77	6.00e-25	106.00
IUUC-Bta-013561	Bos taurus	60.17	2.00e-92	330.00
IUUC-Bci-013824	Botrytis cinerea	30.86	6.00e-28	116.00
IUUC-Bdi-014138	Brachypodium distachyon	45.75	2.00e-62	230.00
IUUC-Bol-015564	Brassica oleracea	43.32	1.00e-60	224.00
IUUC-Bra-017111	Brassica rapa	42.51	3.00e-59	219.00
IUUC-Cel-018441	Caenorhabditis elegans	36.76	2.00e-49	187.00
IUUC-Cja-019502	Callithrix jacchus	61.09	3.00e-99	353.00
IUUC-Cfa-020523	Canis familiaris	60.58	5.00e-93	332.00
IUUC-Cpo-022196	Cavia porcellus	61.09	2.00e-99	353.00
IUUC-Cre-022620	Chlamydomonas reinhardtii	38.10	3.00e-48	184.00
IUUC-Csa-023551	Chlorocebus sabaeus	61.24	3.00e-100	356.00
IUUC-Cho-024373	Choloepus hoffmanni	60.70	3.00e-95	339.00
IUUC-Csv-026372	Ciona savignyi	56.39	3.00e-74	270.00
IUUC-Cgl-026386	Colletotrichum gloeosporioides	31.28	4.00e-23	99.40
IUUC-Cne-026950	Cryptococcus neoformans	29.81	2.00e-29	121.00
IUUC-Cme-027199	Cyanidioschyzon merolae	24.68	2.00e-08	52.00
IUUC-Dre-028247	Danio rerio	60.94	4.00e-99	352.00
IUUC-Dno-028974	Dasypus novemcinctus	61.24	3.00e-100	356.00
IUUC-Dor-030143	Dipodomys ordii	62.40	4.00e-98	348.00
IUUC-Dse-031365	Dothistroma septosporum	26.14	1.00e-24	105.00
IUUC-Dme-032197	Drosophila melanogaster	56.22	4.00e-84	303.00
IUUC-Ete-032371	Echinops telfairi	61.09	1.00e-99	354.00
IUUC-Eca-033242	Equus caballus	61.09	1.00e-99	353.00
IUUC-Eeu-035317	Erinaceus europaeus	61.48	7.00e-100	355.00
IUUC-Fca-036061	Felis catus	60.85	9.00e-100	354.00
IUUC-Fal-036715	Ficedula albicollis	61.20	1.00e-98	351.00
IUUC-Fox-037884	Fusarium oxysporum	35.45	1.00e-16	78.20
IUUC-Fso-038150	Fusarium solani	30.20	2.00e-20	91.30
IUUC-Gmo-038750	Gadus morhua	63.20	2.00e-100	356.00
IUUC-Ggr-039959	Gaeumannomyces graminis	25.47	1.00e-14	73.20
IUUC-Gga-040935	Gallus gallus	61.24	3.00e-100	355.00
IUUC-Gac-041478	Gasterosteus aculeatus	62.80	3.00e-100	356.00
IUUC-Gma-043545	Glycine max	42.51	4.00e-60	223.00
IUUC-Ggo-044972	Gorilla gorilla	62.15	3.00e-98	349.00
IUUC-Hsa-046089	Homo sapiens	61.24	3.00e-100	356.00
IUUC-Hvu-047636	Hordeum vulgare	40.16	4.00e-22	96.30
IUUC-Itr-047902	Ictidomys tridecemlineatus	61.60	9.00e-97	344.00
IUUC-Lch-050600	Latimeria chalumnae	63.35	2.00e-101	360.00
IUUC-Lpe-051540	Leersia perrieri	45.93	3.00e-63	233.00
IUUC-Loc-052509	Lepisosteus oculatus	62.55	4.00e-100	355.00
IUUC-Lma-053103	Leptosphaeria maculans	31.01	2.00e-32	131.00
IUUC-Laf-053972	Loxodonta africana	62.40	1.00e-99	354.00
IUUC-Mcc-054700	Macaca mulatta	62.15	1.00e-98	350.00
IUUC-Meu-056791	Macropus eugenii	52.40	1.00e-75	274.00
IUUC-Mor-056909	Magnaporthe oryzae	28.73	2.00e-26	111.00
IUUC-Mpo-057299	Magnaporthe poae	25.91	3.00e-20	90.50
IUUC-Mtr-057964	Medicago truncatula	42.11	3.00e-60	223.00
IUUC-Mla-058990	Melampsora laricipopulina	29.96	8.00e-22	96.30
IUUC-Mga-060072	Meleagris gallopavo	62.00	8.00e-100	354.00
IUUC-Mvi-060312	Microbotryum violaceum	33.46	4.00e-41	160.00
IUUC-Mmr-060851	Microcebus murinus	61.09	2.00e-99	353.00
IUUC-Mdo-063074	Monodelphis domestica	61.09	4.00e-100	357.00
IUUC-Mmu-063954	Mus musculus	60.85	1.00e-99	354.00
IUUC-Mac-065016	Musa acuminata	44.38	2.00e-44	170.00
IUUC-Mpu-066870	Mustela putorius furo	60.58	5.00e-93	332.00
IUUC-Mlu-067701	Myotis lucifugus	60.70	2.00e-98	350.00
IUUC-Ncr-068780	Neurospora crassa	24.00	1.00e-20	92.00
IUUC-Nle-069291	Nomascus leucogenys	61.24	3.00e-100	356.00
IUUC-Opr-070265	Ochotona princeps	45.91	9.00e-58	214.00
IUUC-Ont-071813	Oreochromis niloticus	64.00	2.00e-101	360.00
IUUC-Oan-073031	Ornithorhynchus anatinus	61.48	1.00e-99	354.00
IUUC-Ocu-074648	Oryctolagus cuniculus	61.09	1.00e-99	353.00
IUUC-Oba-074993	Oryza barthii	45.75	1.00e-63	234.00
IUUC-Obr-076341	Oryza brachyantha	45.75	2.00e-63	233.00
IUUC-Ogl-077099	Oryza glaberrima	45.75	1.00e-63	234.00
IUUC-Ogu-078285	Oryza glumaepatula	45.75	5.00e-63	232.00
IUUC-Oin-079441	Oryza indica	45.75	9.00e-64	234.00
IUUC-Olo-081037	Oryza longistaminata	45.75	9.00e-64	234.00
IUUC-Ome-081357	Oryza meridionalis	45.75	9.00e-64	234.00
IUUC-Oni-082632	Oryza nivara	45.75	8.00e-64	235.00
IUUC-Opu-083351	Oryza punctata	45.26	2.00e-58	217.00
IUUC-Oru-084306	Oryza rufipogon	45.75	9.00e-64	234.00
IUUC-Osa-085307	Oryza sativa	45.75	9.00e-64	234.00
IUUC-Ola-086371	Oryzias latipes	63.60	2.00e-101	360.00
IUUC-Olu-087646	Ostreococcus lucimarinus	36.84	5.00e-46	176.00
IUUC-Oga-089015	Otolemur garnettii	60.70	6.00e-99	352.00
IUUC-Oar-090405	Ovis aries	60.70	6.00e-99	352.00
IUUC-Ptr-090735	Pan troglodytes	61.09	1.00e-99	353.00
IUUC-Pan-092825	Papio anubis	62.15	1.00e-98	351.00
IUUC-Psi-093110	Pelodiscus sinensis	60.58	1.00e-92	330.00
IUUC-Pno-095145	Phaeosphaeria nodorum	30.20	4.00e-23	100.00
IUUC-Ppa-095321	Physcomitrella patens	40.96	2.00e-56	210.00
IUUC-Pfo-096813	Poecilia formosa	62.95	8.00e-99	352.00
IUUC-Pab-098197	Pongo abelii	60.59	2.00e-90	323.00
IUUC-Pop-098821	Populus trichocarpa	44.66	2.00e-25	106.00
IUUC-Pca-100218	Procavia capensis	60.31	6.00e-99	352.00
IUUC-Ppe-102032	Prunus persica	43.78	6.00e-63	232.00
IUUC-Pva-102691	Pteropus vampyrus	62.95	8.00e-101	358.00
IUUC-Pgr-103633	Puccinia graminis	28.17	1.00e-24	105.00
IUUC-Pyt-104428	Pyrenophora triticirepentis	33.01	2.00e-27	114.00
IUUC-Rno-105554	Rattus norvegicus	60.85	6.00e-100	355.00
IUUC-Sce-106358	Saccharomyces cerevisiae	24.90	6.00e-17	79.70
IUUC-Sha-106888	Sarcophilus harrisii	61.09	2.00e-99	353.00
IUUC-Spo-108207	Schizosaccharomyces pombe	30.37	8.00e-23	99.00
IUUC-Ssl-108410	Sclerotinia sclerotiorum	31.78	8.00e-30	122.00
IUUC-Smo-108750	Selaginella moellendorffii	39.92	5.00e-49	186.00
IUUC-Sit-110052	Setaria italica	45.38	1.00e-63	234.00
IUUC-Sly-111489	Solanum lycopersicum	42.28	2.00e-58	217.00
IUUC-Stu-112517	Solanum tuberosum	40.73	4.00e-58	216.00
IUUC-Sar-113509	Sorex araneus	44.36	2.00e-63	233.00
IUUC-Sbi-114113	Sorghum bicolor	44.98	4.00e-64	236.00
IUUC-Sre-115221	Sporisorium reilianum	28.52	2.00e-28	117.00
IUUC-Ssc-115547	Sus scrofa	61.24	3.00e-100	356.00
IUUC-Tgu-117147	Taeniopygia guttata	61.09	2.00e-99	353.00
IUUC-Tru-118316	Takifugu rubripes	62.06	4.00e-99	352.00
IUUC-Tsy-119599	Tarsius syrichta	61.09	1.00e-99	354.00
IUUC-Tni-120542	Tetraodon nigroviridis	62.35	4.00e-98	349.00
IUUC-Tca-121033	Theobroma cacao	41.70	9.00e-60	221.00
IUUC-Tre-121986	Trichoderma reesei	28.14	3.00e-20	90.90
IUUC-Tvi-122607	Trichoderma virens	28.96	2.00e-24	104.00
IUUC-Tae-125740	Triticum aestivum	38.54	2.00e-55	207.00
IUUC-Tur-126375	Triticum urartu	35.33	3.00e-52	197.00
IUUC-Tme-126878	Tuber melanosporum	39.27	5.00e-44	170.00
IUUC-Ttr-129086	Tursiops truncatus	54.09	1.00e-84	304.00
IUUC-Uma-129364	Ustilago maydis	30.39	1.00e-34	138.00
IUUC-Vda-129929	Verticillium dahliae	30.30	2.00e-20	92.00
IUUC-Vpa-130048	Vicugna pacos	51.36	1.00e-78	284.00
IUUC-Vvi-130834	Vitis vinifera	42.11	2.00e-59	221.00
IUUC-Xtr-131888	Xenopus tropicalis	62.26	4.00e-101	359.00
IUUC-Xma-133580	Xiphophorus maculatus	63.35	2.00e-101	360.00
IUUC-Yli-134595	Yarrowia lipolytica	30.17	1.00e-31	128.00
IUUC-Zma-135642	Zea mays	46.56	2.00e-64	237.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence