iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000013638.1	ENSORLT00000017115.1	ENSORLP00000017114.1
ENSORLG00000013638.1	ENSORLT00000017121.1	ENSORLP00000017120.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-99	333.6	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           d kk l+v fvgE+++d+gGv +ef+ l++kel +p++g+f+y+e+++  ++ n++      e ++lF+++G ++g+a+++  +++l
   Q: 726  DYKKPLKVIFVGEDAVDAGGVRKEFFLLIMKELLDPKYGMFRYHEDSRLIWFSNKTF-----EDIDLFNLIGLICGLAIYNLTIVEL 807
           78999***********************************************99977.....69*********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll+kk +l+dl+e++p++ +sl++++++ e+d+ee+ ++l+f+++ee++g t+++eL+p+Ge+ +V++ N++++v+++
   Q: 808  HFPLALYKKLLKKKPTLDDLKELMPDVGRSLQQLLDYTEDDVEET-FCLNFTITEENYGATEVHELVPNGEELSVNKGNRQDFVNAY 893
           *************************************99888887.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y +++++++ +e f++Gf++v+  ++l+lF+++el+ ++ G++++d+ +l+k t+ykg+y +++p+i+ Fwev++e+  e++k+f
   Q: 894  VDYVFNSSVASLFECFYSGFHKVCGGKVLELFQPSELQAMVIGNTNYDWTELEKSTEYKGEYWAEHPTIKLFWEVFHELPLEKKKQF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+++lk    vi+   + ++ lP ++TCfn+L+LP+Y+s e l+ekLl Ai++++gF+l
   Q: 981  LLFLTGSDRIPILGMKSLK---LVIQPtGGGEQFLPVAHTCFNLLDLPKYTSPEALREKLLQAIDHNRGFNL 1049
           *******************...6666658899**************************************87 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MLCWGNASYG QLGLGGIDEE IVVEPRKCEF FHGKRVRDVG CGRRHTAFLL EDGTVYTCGC 60
NDLGQLGHEK SRKKPEQVVA LDAQIIVALS CGESHTLALN DKGQVFSWGL GSDGQLGLNN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCTCTGCT GGGGAAACGC CTCCTACGGT CAGCTCGGCT TGGGAGGGAT TGACGAAGAG 60
ATTGTGGTGG AGCCGCGAAA ATGTGAATTC TTCCACGGGA AGCGGGTGCG GGACGTGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001666	Ailuropoda melanoleuca	74.24	0.00e+00	1519.00
IUUC-Apl-003295	Anas platyrhynchos	72.78	0.00e+00	1522.00
IUUC-Aca-004336	Anolis carolinensis	73.55	0.00e+00	1535.00
IUUC-Ame-010768	Astyanax mexicanus	76.85	0.00e+00	1624.00
IUUC-Bta-013279	Bos taurus	73.67	0.00e+00	1510.00
IUUC-Cja-019023	Callithrix jacchus	73.96	0.00e+00	1515.00
IUUC-Cfa-021074	Canis familiaris	74.15	0.00e+00	1517.00
IUUC-Cpo-021461	Cavia porcellus	72.12	0.00e+00	1471.00
IUUC-Csa-024261	Chlorocebus sabaeus	73.96	0.00e+00	1513.00
IUUC-Cin-025232	Ciona intestinalis	43.54	0.00e+00	801.00
IUUC-Dre-028829	Danio rerio	78.79	0.00e+00	1635.00
IUUC-Dno-029445	Dasypus novemcinctus	70.77	0.00e+00	1195.00
IUUC-Dor-030158	Dipodomys ordii	79.30	0.00e+00	728.00
IUUC-Dme-032103	Drosophila melanogaster	44.34	0.00e+00	859.00
IUUC-Ete-033072	Echinops telfairi	66.70	0.00e+00	1315.00
IUUC-Eca-033317	Equus caballus	73.67	0.00e+00	1509.00
IUUC-Fca-035682	Felis catus	74.41	0.00e+00	1518.00
IUUC-Fal-036969	Ficedula albicollis	72.52	0.00e+00	1515.00
IUUC-Gmo-038671	Gadus morhua	79.85	0.00e+00	1682.00
IUUC-Gga-041174	Gallus gallus	72.56	0.00e+00	1523.00
IUUC-Gac-042600	Gasterosteus aculeatus	85.17	0.00e+00	1744.00
IUUC-Gma-043616	Glycine max	38.02	1.00e-53	203.00
IUUC-Ggo-044589	Gorilla gorilla	74.15	0.00e+00	1538.00
IUUC-Hsa-046772	Homo sapiens	74.24	0.00e+00	1536.00
IUUC-Lch-050147	Latimeria chalumnae	71.05	0.00e+00	1238.00
IUUC-Loc-052684	Lepisosteus oculatus	76.99	0.00e+00	1599.00
IUUC-Laf-053844	Loxodonta africana	73.48	0.00e+00	1504.00
IUUC-Mcc-055531	Macaca mulatta	72.22	0.00e+00	1497.00
IUUC-Mtr-058277	Medicago truncatula	36.25	2.00e-52	199.00
IUUC-Mga-060151	Meleagris gallopavo	70.29	0.00e+00	1220.00
IUUC-Mmr-060954	Microcebus murinus	74.15	0.00e+00	1518.00
IUUC-Mdo-062246	Monodelphis domestica	72.55	0.00e+00	1381.00
IUUC-Mmu-063369	Mus musculus	74.14	0.00e+00	1528.00
IUUC-Mpu-065936	Mustela putorius furo	73.19	0.00e+00	1377.00
IUUC-Mlu-067326	Myotis lucifugus	73.67	0.00e+00	1482.00
IUUC-Nle-069453	Nomascus leucogenys	74.60	0.00e+00	1519.00
IUUC-Ont-071720	Oreochromis niloticus	86.67	0.00e+00	1801.00
IUUC-Oan-073464	Ornithorhynchus anatinus	72.78	0.00e+00	1379.00
IUUC-Ocu-074207	Oryctolagus cuniculus	71.02	0.00e+00	1360.00
IUUC-Oga-088435	Otolemur garnettii	74.62	0.00e+00	1524.00
IUUC-Oar-089233	Ovis aries	73.77	0.00e+00	1512.00
IUUC-Ptr-091368	Pan troglodytes	74.34	0.00e+00	1539.00
IUUC-Pan-092300	Papio anubis	73.96	0.00e+00	1513.00
IUUC-Psi-093406	Pelodiscus sinensis	73.89	0.00e+00	1540.00
IUUC-Pma-094113	Petromyzon marinus	67.11	0.00e+00	1044.00
IUUC-Ppa-095354	Physcomitrella patens	33.49	3.00e-148	519.00
IUUC-Pfo-097021	Poecilia formosa	85.14	0.00e+00	1818.00
IUUC-Pab-098327	Pongo abelii	74.24	0.00e+00	1536.00
IUUC-Pva-102909	Pteropus vampyrus	65.91	0.00e+00	1262.00
IUUC-Rno-105457	Rattus norvegicus	74.34	0.00e+00	1533.00
IUUC-Sha-106632	Sarcophilus harrisii	72.99	0.00e+00	1521.00
IUUC-Sar-113679	Sorex araneus	62.61	0.00e+00	792.00
IUUC-Tgu-116849	Taeniopygia guttata	69.03	0.00e+00	1415.00
IUUC-Tru-118206	Takifugu rubripes	81.26	0.00e+00	1640.00
IUUC-Tsy-119521	Tarsius syrichta	61.89	0.00e+00	1200.00
IUUC-Tni-120233	Tetraodon nigroviridis	81.65	0.00e+00	1639.00
IUUC-Vpa-130448	Vicugna pacos	73.77	0.00e+00	1514.00
IUUC-Xtr-132719	Xenopus tropicalis	65.27	0.00e+00	1265.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence