iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028181

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Cylindromatosis (turban tumor syndrome), b

Genbank Nucleotide ID

CR548630

Gene Name

cyldb

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000089724.2	ENSDART00000126211.2	ENSDARP00000107136.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.00e-09	38.0	345	688

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           G++ + N+CY++++L +L+  +   + +++   ++      +++kg      ++++++l  ++++ v  ++++k  +++  +   +e++
   Q: 345  GIQGHFNSCYLDATLFSLFTSSVAFDRIFN---RSA-----DSKKGISHILRRDIVNCL--RRSGFVPAENVMKFREQLGCKSFASEEK 423
           9999***************99988888888...222.....223344444446777777..7778888888899888988887789*** PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlk.sqik...clecdnvs.sreepfldlsl 174
           D +Ef++ ll+++         k +++ e  ++  ++++  ek++      +++l+++++  s++k    ++c  v+  r+ + +++  
   Q: 424  DPEEFITLLLQHVLHIE--PLLKIRSQGEFPQEAYTHQIIVEKNQVAAVPSVQQLLEMSFVtSNLKfeeIPSCLIVQmPRFGKKFKMFP 510
           **********9987766..44555555555555678888899999999999*******98745666555799*9999999999999999 PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenk.yycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdls 262
           ++  ++e    +++d+L+   +e+ l+g+ + y+c +c  +++    l+          ++k ++ +++++++++ +++ ++p++L+l 
   Q: 511  KIIPSTEL---DITDVLHCSPRECFLCGHLAkYECVQCLMDRK----LQPG--------KIKQYCSTCNTQVHNHPTRQEHTPQKLTLP 584
           99888888...*****************9755******86663....3333........36667777788888899999999******9 PP
   S: 263  pfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.................................ekgkWllfdDskVtevk 318
              +++   q  ++  +L+av++        HYv++vk                                  e g++l  + +++++ +
   Q: 585  DCPAEDAPVQ--RHPMQLFAVLCINT----SHYVSFVKYgpdprswiffdsmadrcgddnkgysipvirscpEVGDFLSQSEEEISSAD 667
           7777755444..9**********988....9********76444444444444444444444444444444333334444445555555 PP
   S: 319  eeevleetg...staYvlfYk 336
            ++  e  +    + Y+++Y+
   Q: 668  LSQCSEAVRrlmVDSYMCLYQ 688
           555554333566666666665 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MELNEQRYFI VLRRNKKGLS RGTIGRAEGE TAEEELIGMV CEGGGSIRSS RTVKKHDTYP 60
LSRHQAGLLM LVCPASRRLE LLGNLQLFSA ICELARDDLV MVKHKKIFQP CLVKNLVQIG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGATCTCCC GGCCGCTCTG TGTTCATCAA ACACTCTCCA TTCAACATGG AGCTCAACGA 60
GCAGCGGTAC TTCATCGTCC TGAGGAGAAA CAAGAAAGGC CTGTCCCGCG GGACTATCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000938--CAP-Gly_domain
IPR001394--Peptidase_C19_UCH
IPR028889--USP_dom

PROSITE

PS50245--CAP_GLY_2
PS50235--USP_3

Pfam

PF01302--CAP_GLY
PF00443--UCH

SMART

SM01052--CAP_GLY

Gene Ontology

GO:0005829--C:cytosol
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0070266--P:necroptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:2001238--P:positive regulation of extrinsic apoptotic signaling pathway
GO:2001242--P:regulation of intrinsic apoptotic signaling pathway
GO:0007346--P:regulation of mitotic cell cycle

KEGG

dre:564158

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Gmo-039117	Gadus morhua	60.84	2.00e-161	561.00
IUUC-Ola-087256	Oryzias latipes	64.17	5.00e-157	547.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence