iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089915

Ensembl Protein ID

ENSOARP00000000254.1

UniProt Accession

W5NQ14; W5NQ14_SHEEP

Genbank Protein ID

ENSOARP00000000254

Protein Name

Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; eIF-3-beta; eIF3 p36

Genbank Nucleotide ID

AMGL01056737

Gene Name

EIF3I; EIF3S2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000000261.1	ENSOART00000000280.1	ENSOARP00000000254.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	4.30e-23	80.6	50	87
UBD/Beta-Prp	8.70e-45	153.3	6	250

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcl..afsd.tllvsGsdDgtikvWDlrtgvll 36
           gHt+ v+c+  ++ d +++++Gs D+++++WD  tg++l
   Q: 50   GHTGAVWCVdaDW-DtKHVLTGSADNSCRLWDCETGKQL 87
           8*******98679.55*******************9986 PP

UBD/Beta-Prp

   S: 48   lsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsgh 136
           l+ghe  +t++k++++g++l t+++D +++vw   +g+ + t+ gh+  v++++ + +++++++Gs+d+  r+wd etg+ l  +l+ +
   Q: 6    LQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLA-LLKTN 93
           69********************************************************************************8.66665 PP
   S: 137  dgvvncvvvhpdgnllvsGslDr.....tvrlWdlktgkllrtl......tgghtdsvyslsfdsngkelvsgsldgtvklwdlqtgec 214
           + +v++  ++  gn+++ +++ +     +v ++dl+  + ++           ++++++s  + + g+++++g + g ++ ++ ++ge+
   Q: 94   S-AVRTCGFDFGGNIIMFSTDKQmgyqcFVSFFDLRDPSQIDSNepymriP-CNDSKITSAVWGPLGECIIAGHEGGELNQYSAKSGEV 180
           5.5555556666677776654432222269999997777777776666644.4899********************************* PP
   S: 215  vrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhnssvisvavlsfgdnvlvlgsed 286
           ++ +++h+++++++++s++ + +v++s+D++ +++d+++ +  kt+  ++   + +a+ls+++ ++vlg++ 
   Q: 181  LVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTER--PVNSAALSPNYDHVVLGGGQ 250
           ***********************************************955..788888899*9999999875 PP

Organism

Ovis aries

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

QKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA 60
DWDTKHVLTG SADNSCRLWD CETGKQLALL KTNSAVRTCG FDFGGNIIMF STDKQMGYQC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAAGCCGA TCCTGCTGCA GGGCCATGAG CGGTCCATTA CTCAGATTAA GTACAACCGC 60
GAGGGAGACC TCCTTTTCAC GGTGGCGAAG GACCCTGTGA GCGTCGGCCG AAGGGCGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0070062--C:extracellular exosome
GO:0003743--F:translation initiation factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000115	Aegilops tauschii	57.52	3.00e-34	139.00
IUUC-Aml-001321	Ailuropoda melanoleuca	99.69	0.00e+00	684.00
IUUC-Atr-002468	Amborella trichopoda	50.52	3.00e-52	197.00
IUUC-Apl-003841	Anas platyrhynchos	93.23	0.00e+00	644.00
IUUC-Aca-005123	Anolis carolinensis	91.67	0.00e+00	632.00
IUUC-Aly-005473	Arabidopsis lyrata	44.51	4.00e-82	297.00
IUUC-Ath-007094	Arabidopsis thaliana	46.48	2.00e-84	305.00
IUUC-Ago-008000	Ashbya gossypii	44.88	8.00e-81	293.00
IUUC-Acl-008098	Aspergillus clavatus	52.87	2.00e-101	362.00
IUUC-Afl-008494	Aspergillus flavus	53.07	1.00e-100	359.00
IUUC-Afu-009080	Aspergillus fumigatus	52.87	2.00e-101	361.00
IUUC-Ani-009230	Aspergillus nidulans	53.82	2.00e-101	361.00
IUUC-Aor-010114	Aspergillus oryzae	53.07	1.00e-100	359.00
IUUC-Ate-010285	Aspergillus terreus	55.05	4.00e-104	370.00
IUUC-Ame-011534	Astyanax mexicanus	80.98	3.00e-167	580.00
IUUC-Bgr-012121	Blumeria graminis	49.09	3.00e-90	325.00
IUUC-Bta-013143	Bos taurus	100.00	0.00e+00	682.00
IUUC-Bci-013950	Botrytis cinerea	52.15	1.00e-98	352.00
IUUC-Bdi-015019	Brachypodium distachyon	46.77	9.00e-87	313.00
IUUC-Bol-015709	Brassica oleracea	45.90	6.00e-81	295.00
IUUC-Bra-017760	Brassica rapa	45.90	2.00e-81	296.00
IUUC-Cel-018226	Caenorhabditis elegans	42.77	1.00e-81	296.00
IUUC-Cja-019741	Callithrix jacchus	99.07	0.00e+00	678.00
IUUC-Cfa-021204	Canis familiaris	99.08	0.00e+00	681.00
IUUC-Cpo-021661	Cavia porcellus	99.08	0.00e+00	680.00
IUUC-Cre-022952	Chlamydomonas reinhardtii	43.79	2.00e-81	295.00
IUUC-Csa-024038	Chlorocebus sabaeus	99.07	0.00e+00	678.00
IUUC-Cin-025597	Ciona intestinalis	59.57	8.00e-117	412.00
IUUC-Cgl-026583	Colletotrichum gloeosporioides	51.38	2.00e-94	338.00
IUUC-Cne-026838	Cryptococcus neoformans	49.39	7.00e-93	333.00
IUUC-Cme-027304	Cyanidioschyzon merolae	45.00	3.00e-78	285.00
IUUC-Dre-028567	Danio rerio	83.64	3.00e-170	590.00
IUUC-Dno-029171	Dasypus novemcinctus	98.77	0.00e+00	675.00
IUUC-Dor-030257	Dipodomys ordii	85.14	9.00e-86	310.00
IUUC-Dse-031191	Dothistroma septosporum	49.85	8.00e-93	333.00
IUUC-Dme-031879	Drosophila melanogaster	60.92	1.00e-119	422.00
IUUC-Ete-032336	Echinops telfairi	97.20	2.00e-125	441.00
IUUC-Eca-033259	Equus caballus	99.38	0.00e+00	682.00
IUUC-Eeu-035153	Erinaceus europaeus	77.85	8.00e-61	227.00
IUUC-Fca-036489	Felis catus	99.38	0.00e+00	682.00
IUUC-Fal-037485	Ficedula albicollis	92.92	0.00e+00	642.00
IUUC-Fox-037860	Fusarium oxysporum	49.69	2.00e-93	335.00
IUUC-Fso-038188	Fusarium solani	50.31	2.00e-92	332.00
IUUC-Gmo-039311	Gadus morhua	83.95	2.00e-170	590.00
IUUC-Ggr-040045	Gaeumannomyces graminis	51.07	4.00e-96	344.00
IUUC-Gga-040645	Gallus gallus	90.96	0.00e+00	635.00
IUUC-Gac-042086	Gasterosteus aculeatus	83.64	5.00e-169	586.00
IUUC-Gma-043246	Glycine max	45.85	3.00e-85	308.00
IUUC-Ggo-045578	Gorilla gorilla	99.07	0.00e+00	678.00
IUUC-Hsa-046734	Homo sapiens	99.07	0.00e+00	678.00
IUUC-Hvu-047553	Hordeum vulgare	46.15	3.00e-86	311.00
IUUC-Itr-048467	Ictidomys tridecemlineatus	98.77	0.00e+00	679.00
IUUC-Kpa-049325	Komagataella pastoris	44.31	1.00e-82	300.00
IUUC-Lch-049620	Latimeria chalumnae	86.20	5.00e-159	553.00
IUUC-Lpe-051338	Leersia perrieri	45.81	6.00e-79	287.00
IUUC-Loc-052094	Lepisosteus oculatus	79.32	4.00e-157	546.00
IUUC-Lma-053047	Leptosphaeria maculans	49.39	7.00e-93	333.00
IUUC-Laf-053801	Loxodonta africana	99.37	0.00e+00	667.00
IUUC-Mcc-055498	Macaca mulatta	88.58	3.00e-165	574.00
IUUC-Meu-056729	Macropus eugenii	90.46	4.00e-175	606.00
IUUC-Mor-057025	Magnaporthe oryzae	51.23	8.00e-94	336.00
IUUC-Mpo-057511	Magnaporthe poae	51.84	3.00e-96	345.00
IUUC-Mtr-058051	Medicago truncatula	47.24	7.00e-86	310.00
IUUC-Mla-059061	Melampsora laricipopulina	48.44	3.00e-84	305.00
IUUC-Mga-059229	Meleagris gallopavo	92.35	0.00e+00	635.00
IUUC-Mvi-060399	Microbotryum violaceum	47.43	8.00e-83	300.00
IUUC-Mmr-060764	Microcebus murinus	99.38	0.00e+00	679.00
IUUC-Mdo-062088	Monodelphis domestica	97.55	0.00e+00	667.00
IUUC-Mmu-064304	Mus musculus	99.07	0.00e+00	679.00
IUUC-Mac-065520	Musa acuminata	48.14	2.00e-87	315.00
IUUC-Mpu-066340	Mustela putorius furo	99.38	0.00e+00	682.00
IUUC-Mlu-067111	Myotis lucifugus	99.08	0.00e+00	679.00
IUUC-Nfi-068478	Neosartorya fischeri	52.87	3.00e-101	361.00
IUUC-Ncr-068820	Neurospora crassa	51.68	1.00e-95	342.00
IUUC-Nle-069903	Nomascus leucogenys	98.77	0.00e+00	679.00
IUUC-Opr-070221	Ochotona princeps	96.60	0.00e+00	658.00
IUUC-Ont-071765	Oreochromis niloticus	84.57	1.00e-171	595.00
IUUC-Oan-073660	Ornithorhynchus anatinus	95.24	4.00e-170	590.00
IUUC-Ocu-074039	Oryctolagus cuniculus	99.08	0.00e+00	680.00
IUUC-Oba-075395	Oryza barthii	39.38	5.00e-68	250.00
IUUC-Obr-076334	Oryza brachyantha	43.08	2.00e-77	282.00
IUUC-Ogl-077060	Oryza glaberrima	46.18	4.00e-83	301.00
IUUC-Ogu-078207	Oryza glumaepatula	46.60	5.00e-86	310.00
IUUC-Oin-079878	Oryza indica	46.15	5.00e-85	307.00
IUUC-Olo-080677	Oryza longistaminata	39.05	2.00e-75	276.00
IUUC-Ome-081228	Oryza meridionalis	35.12	9.00e-35	140.00
IUUC-Oni-082411	Oryza nivara	39.82	6.00e-68	250.00
IUUC-Opu-083136	Oryza punctata	45.23	4.00e-84	304.00
IUUC-Oru-084916	Oryza rufipogon	44.91	3.00e-83	301.00
IUUC-Osa-085454	Oryza sativa	46.15	5.00e-85	307.00
IUUC-Ola-087053	Oryzias latipes	84.26	3.00e-170	590.00
IUUC-Olu-087602	Ostreococcus lucimarinus	48.29	1.00e-88	319.00
IUUC-Oga-088154	Otolemur garnettii	98.77	0.00e+00	677.00
IUUC-Ptr-091124	Pan troglodytes	79.38	8.00e-149	519.00
IUUC-Pan-092035	Papio anubis	99.07	0.00e+00	678.00
IUUC-Psi-094096	Pelodiscus sinensis	89.40	3.00e-118	417.00
IUUC-Pno-094988	Phaeosphaeria nodorum	46.32	1.00e-81	296.00
IUUC-Ppa-095536	Physcomitrella patens	49.07	7.00e-91	327.00
IUUC-Pfo-096101	Poecilia formosa	83.95	4.00e-170	590.00
IUUC-Pab-097726	Pongo abelii	99.07	0.00e+00	678.00
IUUC-Pop-099617	Populus trichocarpa	48.00	1.00e-87	316.00
IUUC-Pca-101014	Procavia capensis	99.38	0.00e+00	680.00
IUUC-Ppe-101320	Prunus persica	46.77	9.00e-84	303.00
IUUC-Pva-102789	Pteropus vampyrus	86.42	2.00e-164	571.00
IUUC-Pgr-103479	Puccinia graminis	47.81	2.00e-83	302.00
IUUC-Ptt-103981	Puccinia triticina	48.12	3.00e-85	308.00
IUUC-Pte-104278	Pyrenophora teres	50.00	9.00e-92	330.00
IUUC-Pyt-104492	Pyrenophora triticirepentis	50.00	9.00e-92	330.00
IUUC-Rno-105867	Rattus norvegicus	75.15	7.00e-140	489.00
IUUC-Sce-106251	Saccharomyces cerevisiae	44.88	2.00e-82	298.00
IUUC-Sha-107039	Sarcophilus harrisii	97.24	0.00e+00	667.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	52.31	6.00e-95	340.00
IUUC-Spo-108314	Schizosaccharomyces pombe	48.92	6.00e-91	327.00
IUUC-Ssl-108478	Sclerotinia sclerotiorum	51.53	8.00e-98	350.00
IUUC-Smo-108728	Selaginella moellendorffii	48.15	1.00e-85	309.00
IUUC-Sit-110801	Setaria italica	45.54	8.00e-85	306.00
IUUC-Sly-111326	Solanum lycopersicum	46.93	3.00e-85	308.00
IUUC-Stu-112458	Solanum tuberosum	47.24	4.00e-85	307.00
IUUC-Sbi-114063	Sorghum bicolor	45.23	6.00e-84	303.00
IUUC-Sre-115096	Sporisorium reilianum	47.88	4.00e-83	301.00
IUUC-Ssc-116080	Sus scrofa	99.69	0.00e+00	681.00
IUUC-Tgu-116988	Taeniopygia guttata	92.59	0.00e+00	638.00
IUUC-Tru-118766	Takifugu rubripes	84.57	3.00e-171	593.00
IUUC-Tni-120197	Tetraodon nigroviridis	83.95	1.00e-170	592.00
IUUC-Tca-121316	Theobroma cacao	46.46	6.00e-85	307.00
IUUC-Tre-122097	Trichoderma reesei	50.76	1.00e-94	339.00
IUUC-Tvi-122442	Trichoderma virens	50.76	6.00e-95	340.00
IUUC-Tae-125800	Triticum aestivum	46.15	4.00e-86	311.00
IUUC-Tur-126334	Triticum urartu	40.00	5.00e-68	251.00
IUUC-Tme-127038	Tuber melanosporum	53.50	1.00e-101	362.00
IUUC-Ttr-128659	Tursiops truncatus	92.90	5.00e-172	596.00
IUUC-Uma-129464	Ustilago maydis	48.18	7.00e-83	300.00
IUUC-Vda-129841	Verticillium dahliae	52.76	2.00e-96	345.00
IUUC-Vvi-131076	Vitis vinifera	47.55	6.00e-86	310.00
IUUC-Xtr-132395	Xenopus tropicalis	89.81	0.00e+00	628.00
IUUC-Xma-133383	Xiphophorus maculatus	83.64	2.00e-169	587.00
IUUC-Yli-134586	Yarrowia lipolytica	49.24	3.00e-81	294.00
IUUC-Zma-135904	Zea mays	45.54	1.00e-84	305.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence