iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Rno-105867

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Eukaryotic translation initiation factor 3 subunit I; Eukaryotic translation initiation factor 3 subunit 2; eIF-3-beta; eIF3 p36

Genbank Nucleotide ID

AABR07049993

Gene Name

Eif3i; EIF3I; EIF3S2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSRNOG00000047185.2	ENSRNOT00000071922.2	ENSRNOP00000067288.2

Annotation

Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	8.10e-22	76.8	62	97

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtcl..afsd.tllvsGsdDgtikvWDlrtgv 34
           gHt+ v+c+  ++ d +++++Gs D+++++WD  tg+
   Q: 62   GHTGAVWCVdaDW-DtKHVLTGSADNSCRLWDCETGK 97
           8*******98679.55****************99987 PP

Organism

Rattus norvegicus

Functional Description
(View)

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.

Protein Sequence
(Fasta)

YSHCLSPRVT ARMKPILLQG HERSITQIKY NREGDLLFTV AKDPIVNVWY SVNGERLGTY 60
MGHTGAVWCV DADWDTKHVL TGSADNSCRL WDCETGKRLV AVLRRASRAQ STGTTLASSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TACTCACATT GCCTCTCTCC TCGCGTCACC GCCAGGATGG TGAGTTCCAG GCACGCTGTG 60
CTGCTGTCGG GGGTCCTCAG TAGACTTGGG ACAGGGTTTC AGGCACTGAC ACTCCGGTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0396--Initiation factor
KW-0597--Phosphoprotein
KW-0648--Protein biosynthesis
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR027525--eIF3i
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00400--WD40

SMART

SM00320--WD40

Gene Ontology

GO:0016282--C:eukaryotic 43S preinitiation complex
GO:0033290--C:eukaryotic 48S preinitiation complex
GO:0071541--C:eukaryotic translation initiation factor 3 complex, eIF3m
GO:0070062--C:extracellular exosome
GO:0003743--F:translation initiation factor activity
GO:0001731--P:formation of translation preinitiation complex
GO:0006446--P:regulation of translational initiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000115	Aegilops tauschii	56.64	4.00e-34	138.00
IUUC-Aml-001321	Ailuropoda melanoleuca	76.05	1.00e-143	501.00
IUUC-Atr-002468	Amborella trichopoda	59.12	6.00e-45	173.00
IUUC-Apl-003841	Anas platyrhynchos	72.92	1.00e-135	476.00
IUUC-Aca-005123	Anolis carolinensis	71.04	9.00e-136	476.00
IUUC-Aly-005473	Arabidopsis lyrata	42.25	4.00e-69	254.00
IUUC-Ath-007094	Arabidopsis thaliana	42.73	1.00e-70	260.00
IUUC-Ago-008000	Ashbya gossypii	40.64	8.00e-70	257.00
IUUC-Acl-008098	Aspergillus clavatus	47.75	4.00e-82	297.00
IUUC-Afl-008494	Aspergillus flavus	47.32	3.00e-81	295.00
IUUC-Afu-009080	Aspergillus fumigatus	48.06	2.00e-82	299.00
IUUC-Ani-009230	Aspergillus nidulans	48.04	3.00e-82	298.00
IUUC-Aor-010114	Aspergillus oryzae	47.32	3.00e-81	295.00
IUUC-Ate-010285	Aspergillus terreus	48.50	4.00e-81	294.00
IUUC-Ame-011534	Astyanax mexicanus	65.76	9.00e-125	439.00
IUUC-Bgr-012121	Blumeria graminis	44.08	1.00e-72	266.00
IUUC-Bta-013143	Bos taurus	76.12	6.00e-144	503.00
IUUC-Bci-013950	Botrytis cinerea	46.88	7.00e-81	293.00
IUUC-Bdi-015019	Brachypodium distachyon	43.94	1.00e-74	273.00
IUUC-Bol-015709	Brassica oleracea	42.17	2.00e-67	250.00
IUUC-Bra-017760	Brassica rapa	42.17	1.00e-67	251.00
IUUC-Cel-018226	Caenorhabditis elegans	40.06	4.00e-69	254.00
IUUC-Cja-019741	Callithrix jacchus	77.30	9.00e-144	502.00
IUUC-Cfa-021204	Canis familiaris	75.75	4.00e-143	500.00
IUUC-Cpo-021661	Cavia porcellus	77.54	3.00e-143	501.00
IUUC-Cre-022952	Chlamydomonas reinhardtii	43.41	2.00e-72	266.00
IUUC-Csa-024038	Chlorocebus sabaeus	77.30	9.00e-144	502.00
IUUC-Cin-025597	Ciona intestinalis	53.78	8.00e-101	360.00
IUUC-Cgl-026583	Colletotrichum gloeosporioides	45.70	2.00e-77	282.00
IUUC-Cne-026838	Cryptococcus neoformans	45.83	1.00e-77	283.00
IUUC-Cme-027304	Cyanidioschyzon merolae	41.98	7.00e-67	247.00
IUUC-Dre-028567	Danio rerio	66.97	4.00e-126	444.00
IUUC-Dno-029171	Dasypus novemcinctus	76.62	1.00e-141	496.00
IUUC-Dor-030257	Dipodomys ordii	56.59	4.00e-35	141.00
IUUC-Dse-031191	Dothistroma septosporum	45.51	1.00e-78	286.00
IUUC-Dme-031879	Drosophila melanogaster	52.29	2.00e-96	345.00
IUUC-Ete-032336	Echinops telfairi	63.55	1.00e-70	258.00
IUUC-Eca-033259	Equus caballus	76.05	1.00e-143	501.00
IUUC-Eeu-035153	Erinaceus europaeus	77.18	6.00e-61	227.00
IUUC-Fca-036489	Felis catus	76.05	1.00e-143	501.00
IUUC-Fal-037485	Ficedula albicollis	73.23	6.00e-136	476.00
IUUC-Fox-037860	Fusarium oxysporum	45.02	1.00e-77	283.00
IUUC-Fso-038188	Fusarium solani	45.32	6.00e-76	277.00
IUUC-Gmo-039311	Gadus morhua	66.26	2.00e-124	438.00
IUUC-Ggr-040045	Gaeumannomyces graminis	45.92	3.00e-78	285.00
IUUC-Gga-040645	Gallus gallus	71.26	2.00e-134	471.00
IUUC-Gac-042086	Gasterosteus aculeatus	66.97	5.00e-124	437.00
IUUC-Gma-043246	Glycine max	42.06	1.00e-72	266.00
IUUC-Ggo-045578	Gorilla gorilla	77.30	9.00e-144	502.00
IUUC-Hsa-046734	Homo sapiens	77.30	9.00e-144	502.00
IUUC-Hvu-047553	Hordeum vulgare	43.33	3.00e-74	271.00
IUUC-Itr-048467	Ictidomys tridecemlineatus	76.92	1.00e-142	499.00
IUUC-Kpa-049325	Komagataella pastoris	39.88	3.00e-71	262.00
IUUC-Lch-049620	Latimeria chalumnae	68.23	2.00e-113	402.00
IUUC-Lpe-051338	Leersia perrieri	41.14	6.00e-66	244.00
IUUC-Loc-052094	Lepisosteus oculatus	62.80	6.00e-112	397.00
IUUC-Lma-053047	Leptosphaeria maculans	45.40	2.00e-77	282.00
IUUC-Laf-053801	Loxodonta africana	76.80	3.00e-139	488.00
IUUC-Mcc-055498	Macaca mulatta	67.18	7.00e-112	396.00
IUUC-Meu-056729	Macropus eugenii	69.11	1.00e-122	432.00
IUUC-Mor-057025	Magnaporthe oryzae	45.65	2.00e-76	279.00
IUUC-Mpo-057511	Magnaporthe poae	45.92	4.00e-78	285.00
IUUC-Mtr-058051	Medicago truncatula	42.48	4.00e-73	268.00
IUUC-Mla-059061	Melampsora laricipopulina	45.26	2.00e-71	262.00
IUUC-Mga-059229	Meleagris gallopavo	72.17	2.00e-133	468.00
IUUC-Mvi-060399	Microbotryum violaceum	41.18	8.00e-69	253.00
IUUC-Mmr-060764	Microcebus murinus	77.30	1.00e-143	502.00
IUUC-Mdo-062088	Monodelphis domestica	76.07	2.00e-140	491.00
IUUC-Mmu-064304	Mus musculus	77.30	1.00e-143	502.00
IUUC-Mac-065520	Musa acuminata	43.25	1.00e-71	263.00
IUUC-Mpu-066340	Mustela putorius furo	76.05	1.00e-143	501.00
IUUC-Mlu-067111	Myotis lucifugus	76.92	3.00e-142	497.00
IUUC-Nfi-068478	Neosartorya fischeri	48.20	2.00e-82	298.00
IUUC-Ncr-068820	Neurospora crassa	46.39	9.00e-78	283.00
IUUC-Nle-069903	Nomascus leucogenys	76.92	1.00e-142	498.00
IUUC-Opr-070221	Ochotona princeps	74.85	1.00e-137	482.00
IUUC-Ont-071765	Oreochromis niloticus	67.58	2.00e-126	445.00
IUUC-Oan-073660	Ornithorhynchus anatinus	72.20	2.00e-118	417.00
IUUC-Ocu-074039	Oryctolagus cuniculus	77.23	5.00e-143	500.00
IUUC-Oba-075395	Oryza barthii	35.65	6.00e-56	210.00
IUUC-Obr-076334	Oryza brachyantha	39.27	1.00e-64	239.00
IUUC-Ogl-077060	Oryza glaberrima	42.30	2.00e-72	266.00
IUUC-Ogu-078207	Oryza glumaepatula	42.73	4.00e-73	268.00
IUUC-Oin-079878	Oryza indica	42.30	4.00e-72	265.00
IUUC-Olo-080677	Oryza longistaminata	35.84	1.00e-63	237.00
IUUC-Ome-081228	Oryza meridionalis	57.14	4.00e-27	114.00
IUUC-Oni-082411	Oryza nivara	36.72	6.00e-56	210.00
IUUC-Opu-083136	Oryza punctata	41.69	3.00e-72	265.00
IUUC-Oru-085072	Oryza rufipogon	33.84	1.00e-49	189.00
IUUC-Osa-085776	Oryza sativa	41.69	2.00e-72	265.00
IUUC-Ola-087053	Oryzias latipes	67.46	6.00e-126	443.00
IUUC-Olu-087602	Ostreococcus lucimarinus	47.83	3.00e-77	281.00
IUUC-Oga-088154	Otolemur garnettii	76.92	5.00e-142	496.00
IUUC-Oar-089915	Ovis aries	76.05	2.00e-143	501.00
IUUC-Ptr-091124	Pan troglodytes	61.85	4.00e-105	374.00
IUUC-Pan-092035	Papio anubis	77.30	9.00e-144	502.00
IUUC-Psi-094096	Pelodiscus sinensis	66.37	2.00e-80	291.00
IUUC-Pno-094988	Phaeosphaeria nodorum	40.91	2.00e-63	236.00
IUUC-Ppa-095536	Physcomitrella patens	46.22	6.00e-77	280.00
IUUC-Pfo-096101	Poecilia formosa	68.10	5.00e-126	443.00
IUUC-Pab-097726	Pongo abelii	77.30	9.00e-144	502.00
IUUC-Pop-099665	Populus trichocarpa	44.82	5.00e-72	264.00
IUUC-Pca-101014	Procavia capensis	77.30	9.00e-144	502.00
IUUC-Ppe-101320	Prunus persica	45.43	3.00e-71	261.00
IUUC-Pva-102789	Pteropus vampyrus	74.54	6.00e-139	486.00
IUUC-Pgr-103479	Puccinia graminis	45.81	4.00e-73	268.00
IUUC-Ptt-103981	Puccinia triticina	44.91	4.00e-72	264.00
IUUC-Pte-104278	Pyrenophora teres	45.10	1.00e-74	272.00
IUUC-Pyt-104492	Pyrenophora triticirepentis	45.10	1.00e-74	272.00
IUUC-Sce-106251	Saccharomyces cerevisiae	40.46	6.00e-71	261.00
IUUC-Sha-107039	Sarcophilus harrisii	75.77	3.00e-140	491.00
IUUC-Sja-107758	Schizosaccharomyces japonicus	46.13	2.00e-78	285.00
IUUC-Spo-108314	Schizosaccharomyces pombe	44.01	2.00e-76	278.00
IUUC-Ssl-108478	Sclerotinia sclerotiorum	46.59	4.00e-80	291.00
IUUC-Smo-108728	Selaginella moellendorffii	46.22	3.00e-76	278.00
IUUC-Sit-110801	Setaria italica	41.52	1.00e-71	263.00
IUUC-Sly-111326	Solanum lycopersicum	42.30	1.00e-70	259.00
IUUC-Stu-112458	Solanum tuberosum	41.47	5.00e-70	257.00
IUUC-Sbi-114063	Sorghum bicolor	41.52	2.00e-71	262.00
IUUC-Sre-115096	Sporisorium reilianum	43.81	2.00e-71	262.00
IUUC-Ssc-116080	Sus scrofa	76.12	4.00e-144	504.00
IUUC-Tgu-116988	Taeniopygia guttata	72.92	2.00e-135	475.00
IUUC-Tru-118766	Takifugu rubripes	67.88	3.00e-126	444.00
IUUC-Tni-120197	Tetraodon nigroviridis	67.58	2.00e-126	444.00
IUUC-Tca-121316	Theobroma cacao	42.35	9.00e-72	263.00
IUUC-Tre-122097	Trichoderma reesei	45.56	1.00e-76	279.00
IUUC-Tvi-122442	Trichoderma virens	45.86	4.00e-77	281.00
IUUC-Tae-125800	Triticum aestivum	43.11	4.00e-75	275.00
IUUC-Tur-126334	Triticum urartu	36.67	7.00e-55	207.00
IUUC-Tme-127038	Tuber melanosporum	47.21	1.00e-83	303.00
IUUC-Ttr-128659	Tursiops truncatus	69.85	3.00e-118	417.00
IUUC-Uma-129464	Ustilago maydis	44.11	4.00e-71	261.00
IUUC-Vda-129841	Verticillium dahliae	46.92	1.00e-79	289.00
IUUC-Vvi-131076	Vitis vinifera	42.18	2.00e-71	262.00
IUUC-Xtr-132395	Xenopus tropicalis	70.86	8.00e-134	469.00
IUUC-Xma-133383	Xiphophorus maculatus	67.79	2.00e-125	441.00
IUUC-Yli-134586	Yarrowia lipolytica	44.67	2.00e-67	249.00
IUUC-Zma-135904	Zea mays	41.52	5.00e-72	264.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence