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Basic Information Integrated Annotations

Tag Content
iUUCD ID IUUC-Hsa-046908
UUCD1 version UUC-HoS-00301
Ensembl Protein ID ENSP00000290663.6
UniProt Accession Q96G25; A9IZ91; A9IZ92; Q5JUY8; Q96FQ4; MED8_HUMAN
Genbank Protein ID AAM76709.1; CAI23382.1; CAP58853.1; CAP58854.1; AAH10019.3; AAH10543.2; ENSP00000290663
Protein Name Mediator of RNA polymerase II transcription subunit 8; Activator-recruited cofactor 32 kDa component; Mediator complex subunit 8
Genbank Nucleotide ID AF521562; AL139289; AL139289; AL139289; BC010019; BC010543; BG722466
Gene Name MED8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000159479.16 ENST00000290663.10 ENSP00000290663.6
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsiteCircNetmiRTarBase
microRNATRANSFACTargetScanRepTar
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
UniProtPHOSIDABioGRID
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box SOCS 12149480
Organism Homo sapiens
Functional Description
(View)

Functional Description



     Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. May be part of a multisubunit E3 ubiquitin-protein ligase complex with the elongin BC complex (ELOB and ELOC), CUL2 and RBX1.
Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. May be part of a multisubunit E3 ubiquitin-protein ligase complex with the elongin BC complex (ELOB and ELOC), CUL2 and RBX1.
Protein Sequence
(Fasta)
MQREEKQLEA SLDALLSQVA DLKNSLGSFI CKLENEYGRL TWPSVLDSFA LLSGQLNTLN 60
KVLKHEKTPL FRNQVIIPLV LSPDRDEDLM RQTEGRVPVF SHEVVPDHLR TKPDPEVEEQ 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Hsa-046908|E3,SOCS|Homo sapiens
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Nucleotide Sequence
(Fasta)
GGAAAACCGG AAGTGAAATC GTGGCAGCCG CCTCGGCCGC CGCAATGCAG GTGAGAGTTG 60
CGTTGGGCGT ACTAGCGGCT GGCAAGCTTC GGGTACAGGG ACCGAGAGTG GGCTGGCTAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Hsa-046908|E3,SOCS|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway

Interpro

IPR019364--Mediatior_Med8_fun/met

Pfam

PF10232--Med8

Gene Ontology

GO:0016592--C:mediator complex
GO:0005654--C:nucleoplasm
GO:0001104--F:RNA polymerase II transcription cofactor activity
GO:0016567--P:protein ubiquitination
GO:0006367--P:transcription initiation from RNA polymerase II promoter

KEGG hsa:112950
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001562 Ailuropoda melanoleuca 96.27 9.00e-130 456.00
IUUC-Apl-004218 Anas platyrhynchos 88.72 7.00e-112 396.00
IUUC-Aca-005363 Anolis carolinensis 86.94 5.00e-123 434.00
IUUC-Ame-011384 Astyanax mexicanus 68.27 5.00e-102 363.00
IUUC-Bta-012751 Bos taurus 96.28 8.00e-129 452.00
IUUC-Cel-018292 Caenorhabditis elegans 26.73 6.00e-19 87.80
IUUC-Cja-019318 Callithrix jacchus 93.69 2.00e-141 495.00
IUUC-Cfa-020106 Canis familiaris 97.30 9.00e-60 223.00
IUUC-Cpo-022416 Cavia porcellus 97.01 1.00e-120 425.00
IUUC-Csa-023695 Chlorocebus sabaeus 99.25 1.00e-133 469.00
IUUC-Cin-025570 Ciona intestinalis 45.31 1.00e-42 166.00
IUUC-Csv-025808 Ciona savignyi 42.86 6.00e-43 167.00
IUUC-Dre-027606 Danio rerio 72.73 1.00e-68 251.00
IUUC-Dno-029924 Dasypus novemcinctus 97.01 2.00e-119 421.00
IUUC-Dor-030115 Dipodomys ordii 93.73 5.00e-131 460.00
IUUC-Dme-031887 Drosophila melanogaster 42.49 3.00e-51 194.00
IUUC-Eca-034101 Equus caballus 97.76 1.00e-131 462.00
IUUC-Eeu-034655 Erinaceus europaeus 88.85 2.00e-122 431.00
IUUC-Fca-036172 Felis catus 96.32 1.00e-130 459.00
IUUC-Fal-036877 Ficedula albicollis 88.01 2.00e-113 402.00
IUUC-Gmo-039244 Gadus morhua 64.21 1.00e-88 319.00
IUUC-Gga-040751 Gallus gallus 88.81 6.00e-113 400.00
IUUC-Gac-041885 Gasterosteus aculeatus 67.90 1.00e-94 339.00
IUUC-Ggo-045201 Gorilla gorilla 100.00 4.00e-154 537.00
IUUC-Itr-048814 Ictidomys tridecemlineatus 97.76 8.00e-132 462.00
IUUC-Lch-049994 Latimeria chalumnae 73.45 5.00e-66 243.00
IUUC-Loc-051765 Lepisosteus oculatus 71.38 8.00e-103 366.00
IUUC-Laf-053336 Loxodonta africana 95.15 9.00e-129 452.00
IUUC-Mcc-055259 Macaca mulatta 98.01 1.00e-151 528.00
IUUC-Meu-056166 Macropus eugenii 88.35 2.00e-108 384.00
IUUC-Mga-059317 Meleagris gallopavo 87.97 3.00e-111 394.00
IUUC-Mmr-061501 Microcebus murinus 91.36 5.00e-136 476.00
IUUC-Mdo-062026 Monodelphis domestica 91.08 1.00e-119 422.00
IUUC-Mmu-063469 Mus musculus 96.64 4.00e-129 453.00
IUUC-Mpu-065945 Mustela putorius furo 97.01 3.00e-130 457.00
IUUC-Mlu-067414 Myotis lucifugus 95.15 1.00e-126 445.00
IUUC-Nle-069411 Nomascus leucogenys 98.01 1.00e-150 525.00
IUUC-Opr-070733 Ochotona princeps 92.45 2.00e-126 444.00
IUUC-Ont-071344 Oreochromis niloticus 67.90 8.00e-96 343.00
IUUC-Oan-073366 Ornithorhynchus anatinus 83.76 5.00e-102 363.00
IUUC-Ocu-074762 Oryctolagus cuniculus 96.68 2.00e-124 438.00
IUUC-Ola-086874 Oryzias latipes 66.42 1.00e-90 326.00
IUUC-Oga-088187 Otolemur garnettii 96.63 8.00e-129 452.00
IUUC-Oar-089832 Ovis aries 96.27 6.00e-129 453.00
IUUC-Ptr-091178 Pan troglodytes 99.00 4.00e-152 530.00
IUUC-Pan-092520 Papio anubis 99.63 9.00e-135 472.00
IUUC-Psi-093517 Pelodiscus sinensis 86.84 2.00e-116 412.00
IUUC-Pma-094752 Petromyzon marinus 58.61 3.00e-78 285.00
IUUC-Pfo-096659 Poecilia formosa 68.27 2.00e-90 325.00
IUUC-Pca-101064 Procavia capensis 85.38 3.00e-120 424.00
IUUC-Pva-102173 Pteropus vampyrus 91.03 1.00e-134 472.00
IUUC-Spo-108036 Schizosaccharomyces pombe 28.81 9.00e-04 37.00
IUUC-Sar-113363 Sorex araneus 94.76 2.00e-126 444.00
IUUC-Ssc-115563 Sus scrofa 95.00 5.00e-145 506.00
IUUC-Tgu-116686 Taeniopygia guttata 87.97 2.00e-113 401.00
IUUC-Tru-118003 Takifugu rubripes 66.79 3.00e-89 321.00
IUUC-Tsy-118875 Tarsius syrichta 82.72 3.00e-121 427.00
IUUC-Tni-120624 Tetraodon nigroviridis 62.13 4.00e-82 297.00
IUUC-Tca-121018 Theobroma cacao 23.81 2.00e-03 34.30
IUUC-Tbe-127611 Tupaia belangeri 85.37 2.00e-104 371.00
IUUC-Ttr-129198 Tursiops truncatus 96.04 2.00e-146 511.00
IUUC-Vpa-130245 Vicugna pacos 96.15 3.00e-49 188.00
IUUC-Xtr-132397 Xenopus tropicalis 77.99 1.00e-114 405.00
IUUC-Xma-134285 Xiphophorus maculatus 68.27 4.00e-93 334.00
Created Date 25-Jun-2017

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