iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052414

Ensembl Protein ID

ENSLOCP00000020102.1

UniProt Accession

W5NHJ3; W5NHJ3_LEPOC

Genbank Protein ID

ENSLOCP00000020102

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Genbank Nucleotide ID

AHAT01015749

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000016285.1	ENSLOCT00000020132.1	ENSLOCP00000020099.1
ENSLOCG00000016285.1	ENSLOCT00000020135.1	ENSLOCP00000020102.1
ENSLOCG00000016285.1	ENSLOCT00000020137.1	ENSLOCP00000020104.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	59.21	1.00e-179	627.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Lepisosteus oculatus

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MARPPYTKPP GLVLLHKIET RELEAFSSSP VKLAPERALG EMYLEDNRNS TAVNYLDGTY 60
EFTTAPAATP IYNPTTVSYH SAPVDTHGSA SDANLHSLGS VPTSPLVFVP SNPRLSPFVH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGGACTG AATTCCCTCC CTCTCTGAGG CCTAGGTCAA TGTCAGATGT CAGGGCCTGA 60
GACAGGTACC TTGTCTTCCT GTGGGGGCTG GTTGGTTCTG GATGGCTGTT TGGTCCTTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005634--C:nucleus
GO:0030284--F:estrogen receptor activity
GO:0043565--F:sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	67.39	5.00e-146	510.00
IUUC-Apl-003688	Anas platyrhynchos	59.45	3.00e-169	588.00
IUUC-Aca-005222	Anolis carolinensis	58.27	6.00e-174	603.00
IUUC-Ame-010731	Astyanax mexicanus	62.55	2.00e-163	568.00
IUUC-Bta-013112	Bos taurus	57.14	9.00e-160	556.00
IUUC-Cja-019408	Callithrix jacchus	57.61	2.00e-161	562.00
IUUC-Cfa-020694	Canis familiaris	59.07	3.00e-159	555.00
IUUC-Cpo-021426	Cavia porcellus	55.78	1.00e-157	550.00
IUUC-Csa-023736	Chlorocebus sabaeus	64.10	1.00e-156	546.00
IUUC-Dre-027698	Danio rerio	58.91	4.00e-165	574.00
IUUC-Dno-029477	Dasypus novemcinctus	66.82	5.00e-151	528.00
IUUC-Dor-030572	Dipodomys ordii	67.80	7.00e-143	500.00
IUUC-Ete-032849	Echinops telfairi	53.62	8.00e-110	390.00
IUUC-Eca-033605	Equus caballus	57.25	1.00e-156	546.00
IUUC-Eeu-034683	Erinaceus europaeus	64.32	7.00e-65	241.00
IUUC-Fca-035928	Felis catus	68.30	4.00e-145	507.00
IUUC-Fal-036754	Ficedula albicollis	61.31	0.00e+00	636.00
IUUC-Gmo-038872	Gadus morhua	60.62	2.00e-136	479.00
IUUC-Gga-040988	Gallus gallus	58.67	0.00e+00	626.00
IUUC-Gac-042015	Gasterosteus aculeatus	61.82	1.00e-153	536.00
IUUC-Ggo-044749	Gorilla gorilla	57.96	1.00e-161	562.00
IUUC-Hsa-046944	Homo sapiens	57.61	3.00e-160	558.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	59.40	8.00e-164	570.00
IUUC-Mcc-054781	Macaca mulatta	57.96	2.00e-161	562.00
IUUC-Meu-056232	Macropus eugenii	58.55	1.00e-166	580.00
IUUC-Mga-059319	Meleagris gallopavo	58.50	3.00e-180	624.00
IUUC-Mmr-061636	Microcebus murinus	51.90	2.00e-79	289.00
IUUC-Mdo-062661	Monodelphis domestica	58.75	1.00e-171	596.00
IUUC-Mmu-063330	Mus musculus	56.94	7.00e-164	570.00
IUUC-Mpu-065757	Mustela putorius furo	58.23	6.00e-165	573.00
IUUC-Mlu-067712	Myotis lucifugus	64.24	6.00e-155	540.00
IUUC-Nle-069283	Nomascus leucogenys	56.33	2.00e-160	559.00
IUUC-Opr-070391	Ochotona princeps	55.04	1.00e-163	569.00
IUUC-Ont-071369	Oreochromis niloticus	58.75	3.00e-148	518.00
IUUC-Oan-073734	Ornithorhynchus anatinus	47.42	5.00e-71	261.00
IUUC-Ocu-074292	Oryctolagus cuniculus	56.92	4.00e-161	561.00
IUUC-Ola-087052	Oryzias latipes	61.41	9.00e-162	563.00
IUUC-Oga-088586	Otolemur garnettii	56.54	3.00e-159	555.00
IUUC-Oar-090156	Ovis aries	67.32	2.00e-148	518.00
IUUC-Ptr-091321	Pan troglodytes	57.96	2.00e-161	562.00
IUUC-Pan-092851	Papio anubis	57.79	8.00e-161	560.00
IUUC-Psi-093434	Pelodiscus sinensis	58.66	2.00e-179	622.00
IUUC-Pfo-097379	Poecilia formosa	65.39	2.00e-164	572.00
IUUC-Pab-097735	Pongo abelii	57.96	1.00e-161	562.00
IUUC-Pva-102125	Pteropus vampyrus	57.91	3.00e-161	561.00
IUUC-Rno-106121	Rattus norvegicus	58.36	5.00e-163	567.00
IUUC-Sha-107547	Sarcophilus harrisii	59.17	7.00e-171	593.00
IUUC-Sar-113650	Sorex araneus	50.84	1.00e-100	360.00
IUUC-Tgu-117175	Taeniopygia guttata	59.86	0.00e+00	639.00
IUUC-Tru-117545	Takifugu rubripes	62.52	2.00e-166	579.00
IUUC-Tsy-119586	Tarsius syrichta	50.62	6.00e-136	477.00
IUUC-Tni-120121	Tetraodon nigroviridis	59.11	4.00e-166	578.00
IUUC-Tbe-127548	Tupaia belangeri	59.35	1.00e-114	407.00
IUUC-Ttr-128374	Tursiops truncatus	52.75	1.00e-145	509.00
IUUC-Vpa-130464	Vicugna pacos	55.88	4.00e-94	338.00
IUUC-Xtr-132171	Xenopus tropicalis	60.71	3.00e-171	595.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence