iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120069

UUCD1 version

UUC-TeN-00747

Ensembl Protein ID

ENSTNIP00000021008.1

UniProt Accession

H3DKG2; H3DKG2_TETNG

Protein Name

Uncharacterized protein

Gene Name

HECW2 (1 of many)

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000017849.1	ENSTNIT00000021241.1	ENSTNIP00000021008.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.10e-118	395.2	1241	1573

Active Site

Position(s)	Description	Evidence
1541	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+f gE+gld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al+++ lld
   Q: 1241 DLQRSKLYVSFMGEDGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALVHQYLLD 1326
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   die++ ldltf+v+ee++g+++e+eLkpgG++ipV ++Nk+eY+++
   Q: 1327 AFFTRPFYKGLLRIPCDLSDLEFLDEEFHQSLQWMKDN---DIEDM-LDLTFTVNEEVFGQITERELKPGGARIPVSEKNKKEYIER 1409
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+++q+e++ +Gf+ev++ +l+s+F+++elel++ G+++id+ d++++t+y g y++++ +i+wFw ++e+f++e+r +
   Q: 1410 MVKWRIERGVAQQTESLVRGFYEVVDVRLVSVFDARELELVMAGTRSIDLADWRNNTEYGGCYHDNHIVIRWFWAAVERFNNEQRLR 1496
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ ++lP+++TCfn+L+LP+Y+s + l+ekL +A+eet+ F+l+
   Q: 1497 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITSLPRAHTCFNRLDLPPYPSFSMLYEKLVTAVEETSTFGLE 1573
           **************************************************************************985 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

MRPSLATAVL PPRTRSHNAP NLSVGTREHL SAPRRRSPNL RHTLSPENLR TLTERGGAAA 60
VDTVSVVSSP IGLTRANSDT DLVTSESRSS LTASTLEYTL NRGQNLVISW DIKEEVDATD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGTTGTGCCT GAACGTGCGC TCACGAGCAA ACTTTGTGCC TCTTTCAATC AAGTTGGTGA 60
ACAAGTTCAC AAGTTCCAGT TGCATCTTCT AATGATTAAT CAGCAGTTTT TCACACCTGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	64.05	0.00e+00	1872.00
IUUC-Dno-029963	Dasypus novemcinctus	64.11	0.00e+00	1795.00
IUUC-Fca-036157	Felis catus	63.70	0.00e+00	1845.00
IUUC-Gmo-039291	Gadus morhua	72.95	0.00e+00	1187.00
IUUC-Gac-042456	Gasterosteus aculeatus	89.99	0.00e+00	1491.00
IUUC-Ggo-044862	Gorilla gorilla	65.08	0.00e+00	1791.00
IUUC-Hsa-046219	Homo sapiens	64.48	0.00e+00	1884.00
IUUC-Mmu-064165	Mus musculus	63.14	0.00e+00	1866.00
IUUC-Nle-069308	Nomascus leucogenys	64.54	0.00e+00	1861.00
IUUC-Ont-071918	Oreochromis niloticus	77.09	0.00e+00	2308.00
IUUC-Ola-087225	Oryzias latipes	89.00	0.00e+00	1431.00
IUUC-Ptr-090806	Pan troglodytes	64.54	0.00e+00	1867.00
IUUC-Pan-091838	Papio anubis	64.73	0.00e+00	1777.00
IUUC-Pab-098405	Pongo abelii	64.54	0.00e+00	1861.00
IUUC-Rno-105943	Rattus norvegicus	64.59	0.00e+00	1885.00
IUUC-Tru-118706	Takifugu rubripes	81.07	0.00e+00	1550.00
IUUC-Vpa-130498	Vicugna pacos	60.07	0.00e+00	974.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence