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Tag Content
UUCD2 ID IUUC-Ptr-091152
UUCD1 version UUC-PaT-00428
Ensembl Protein ID ENSPTRP00000021122.5
UniProt Accession H2QII6; RBP2_PANTR
Genbank Protein ID ENSPTRP00000021122
Protein Name E3 SUMO-protein ligase RanBP2; 358 kDa nucleoporin; Nuclear pore complex protein Nup358; Nucleoporin Nup358; Ran-binding protein 2
Genbank Nucleotide ID AACZ03015911
Gene Name RANBP2; NUP358
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSPTRG00000012332.5 ENSPTRT00000022893.5 ENSPTRP00000021122.5
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/ZnF/NZF 7.70e-50 166.0 1480 1507
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/NZF
   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           e+qW+CsaC  +Ne++++kC++C++pR+
   Q: 1480 EGQWDCSACLVQNEGSSTKCAACQNPRK 1507
           79*************************7 PP
   
Organism Pan troglodytes
Functional Description
(View)

Functional Description


     E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (By similarity). Binds single-stranded RNA (in vitro) (PubMed:22959972).
 E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I. Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates. Component of the nuclear export pathway. Specific docking site for the nuclear export factor exportin-1. Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB. Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (By similarity). Binds single-stranded RNA (in vitro) (PubMed:22959972).
Protein Sequence
(Fasta)
MRRSKADVER YIASVQGSTP SPRQKSIKGF YFAKLYYEAK EYDLAKKYIC TYINVQERDP 60
KAHRFLGLLY ELEENTDKAV ECYRRSVELN PTQKDLVLKI AELLCKNDVT DGRAKYWVER 120
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Protein Fasta Sequence


>IUUC-Ptr-091152|UBD,NZF|Pan troglodytes
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Nucleotide Sequence
(Fasta)
TTGTCCTCCG CCGGCTACGC AGCTGCGTCA CTGATTTGCA GTCGCTTTCC TCTTGGAAGT 60
GGCGACTGCT GCGGGGCTGA GCGCTGGTCT CACGCGCCTC CGGAGCCAGG TTGGCGGCGC 120
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Nucleotide Fasta Sequence


>IUUC-Ptr-091152|UBD,NZF|Pan troglodytes
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-1015--Disulfide bond
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0472--Membrane
KW-0479--Metal-binding
KW-0488--Methylation
KW-0509--mRNA transport
KW-0906--Nuclear pore complex
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0653--Protein transport
KW-1185--Reference proteome
KW-0677--Repeat
KW-0694--RNA-binding
KW-0802--TPR repeat
KW-0811--Translocation
KW-0813--Transport
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR029000--Cyclophilin-like_dom
IPR020892--Cyclophilin-type_PPIase_CS
IPR002130--Cyclophilin-type_PPIase_dom
IPR022011--IR1-M
IPR011993--PH_dom-like
IPR000156--Ran_bind_dom
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
IPR001876--Znf_RanBP2
PROSITE

PS00170--CSA_PPIASE_1
PS50072--CSA_PPIASE_2
PS50196--RANBD1
PS50005--TPR
PS50293--TPR_REGION
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
Pfam

PF12185--IR1-M
PF00160--Pro_isomerase
PF00638--Ran_BP1
PF00641--zf-RanBP
PRINTS

PR00153--CSAPPISMRASE
SMART

SM00160--RanBD
SM00028--TPR
SM00547--ZnF_RBZ
Gene Ontology

GO:0005642--C:annulate lamellae
GO:0005813--C:centrosome
GO:0005737--C:cytoplasm
GO:0005635--C:nuclear envelope
GO:0042405--C:nuclear inclusion body
GO:0031965--C:nuclear membrane
GO:0005643--C:nuclear pore
GO:0044614--C:nuclear pore cytoplasmic filaments
GO:0044615--C:nuclear pore nuclear basket
GO:0005634--C:nucleus
GO:0016874--F:ligase activity
GO:0003755--F:peptidyl-prolyl cis-trans isomerase activity
GO:0008536--F:Ran GTPase binding
GO:0003723--F:RNA binding
GO:0008270--F:zinc ion binding
GO:0051642--P:centrosome localization
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0051028--P:mRNA transport
GO:0006607--P:NLS-bearing protein import into nucleus
GO:0043547--P:positive regulation of GTPase activity
GO:0046604--P:positive regulation of mitotic centrosome separation
GO:0006457--P:protein folding
GO:0006606--P:protein import into nucleus
GO:0016925--P:protein sumoylation
GO:0006405--P:RNA export from nucleus
GO:0007051--P:spindle organization
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002141 Ailuropoda melanoleuca 87.21 0.00e+00 5333.00
IUUC-Apl-004213 Anas platyrhynchos 64.15 0.00e+00 1039.00
IUUC-Aca-005244 Anolis carolinensis 63.86 0.00e+00 2029.00
IUUC-Ame-011486 Astyanax mexicanus 54.32 0.00e+00 1307.00
IUUC-Bta-012952 Bos taurus 81.66 0.00e+00 2804.00
IUUC-Cja-019112 Callithrix jacchus 93.49 0.00e+00 5743.00
IUUC-Cfa-020158 Canis familiaris 83.01 0.00e+00 5046.00
IUUC-Cpo-022292 Cavia porcellus 79.67 0.00e+00 2572.00
IUUC-Csa-023696 Chlorocebus sabaeus 95.57 0.00e+00 5860.00
IUUC-Cho-024560 Choloepus hoffmanni 75.50 0.00e+00 981.00
IUUC-Dre-027540 Danio rerio 47.28 0.00e+00 1343.00
IUUC-Dno-029177 Dasypus novemcinctus 83.92 0.00e+00 2803.00
IUUC-Dor-030161 Dipodomys ordii 84.10 0.00e+00 1517.00
IUUC-Dme-032206 Drosophila melanogaster 34.29 8.00e-43 170.00
IUUC-Ete-032679 Echinops telfairi 80.19 0.00e+00 2115.00
IUUC-Eca-034415 Equus caballus 87.05 0.00e+00 5301.00
IUUC-Eeu-035195 Erinaceus europaeus 75.52 0.00e+00 2019.00
IUUC-Fca-036339 Felis catus 86.32 0.00e+00 2842.00
IUUC-Fal-036665 Ficedula albicollis 61.65 0.00e+00 1984.00
IUUC-Gmo-038469 Gadus morhua 45.64 0.00e+00 1256.00
IUUC-Gga-041154 Gallus gallus 62.44 0.00e+00 1796.00
IUUC-Gac-042057 Gasterosteus aculeatus 50.72 0.00e+00 1553.00
IUUC-Hsa-046168 Homo sapiens 98.88 0.00e+00 6109.00
IUUC-Itr-049075 Ictidomys tridecemlineatus 82.85 0.00e+00 2706.00
IUUC-Lch-050060 Latimeria chalumnae 58.04 0.00e+00 3431.00
IUUC-Loc-052650 Lepisosteus oculatus 55.27 0.00e+00 1665.00
IUUC-Laf-053667 Loxodonta africana 83.97 0.00e+00 2873.00
IUUC-Mcc-055115 Macaca mulatta 96.74 0.00e+00 5954.00
IUUC-Mga-059419 Meleagris gallopavo 60.62 0.00e+00 1944.00
IUUC-Mmr-061001 Microcebus murinus 89.25 0.00e+00 5615.00
IUUC-Mdo-061922 Monodelphis domestica 68.97 0.00e+00 2205.00
IUUC-Mmu-063291 Mus musculus 82.97 0.00e+00 2853.00
IUUC-Mpu-066011 Mustela putorius furo 87.61 0.00e+00 2651.00
IUUC-Mlu-067422 Myotis lucifugus 85.65 0.00e+00 5252.00
IUUC-Nle-069190 Nomascus leucogenys 95.25 0.00e+00 5709.00
IUUC-Opr-070420 Ochotona princeps 78.76 0.00e+00 2404.00
IUUC-Ont-071362 Oreochromis niloticus 52.70 0.00e+00 1618.00
IUUC-Oan-072832 Ornithorhynchus anatinus 69.78 0.00e+00 2233.00
IUUC-Ocu-073902 Oryctolagus cuniculus 83.18 0.00e+00 2900.00
IUUC-Ola-087304 Oryzias latipes 49.48 0.00e+00 2692.00
IUUC-Oga-088196 Otolemur garnettii 85.78 0.00e+00 3025.00
IUUC-Oar-089627 Ovis aries 81.39 0.00e+00 2764.00
IUUC-Pan-091914 Papio anubis 96.79 0.00e+00 5604.00
IUUC-Psi-093994 Pelodiscus sinensis 69.66 0.00e+00 2323.00
IUUC-Pma-094629 Petromyzon marinus 36.62 0.00e+00 943.00
IUUC-Pfo-096897 Poecilia formosa 53.01 0.00e+00 1296.00
IUUC-Pab-097566 Pongo abelii 98.05 0.00e+00 4367.00
IUUC-Pca-100141 Procavia capensis 79.69 0.00e+00 4717.00
IUUC-Pva-102323 Pteropus vampyrus 82.76 0.00e+00 1879.00
IUUC-Rno-105473 Rattus norvegicus 86.17 0.00e+00 2973.00
IUUC-Sha-106537 Sarcophilus harrisii 77.52 0.00e+00 2552.00
IUUC-Sar-113031 Sorex araneus 87.48 0.00e+00 1266.00
IUUC-Ssc-115622 Sus scrofa 81.69 0.00e+00 4426.00
IUUC-Tgu-116781 Taeniopygia guttata 60.57 0.00e+00 1918.00
IUUC-Tru-118684 Takifugu rubripes 54.60 0.00e+00 977.00
IUUC-Tsy-119490 Tarsius syrichta 85.78 0.00e+00 1480.00
IUUC-Tbe-127349 Tupaia belangeri 87.44 0.00e+00 1822.00
IUUC-Ttr-128883 Tursiops truncatus 84.47 0.00e+00 2386.00
IUUC-Vpa-130224 Vicugna pacos 80.65 0.00e+00 2600.00
IUUC-Xtr-132557 Xenopus tropicalis 54.37 0.00e+00 1737.00
Created Date 25-Jun-2017

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