iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-117621

Ensembl Protein ID

ENSTRUP00000015829.1

UniProt Accession

H2STU2; H2STU2_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

blk

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000006468.1	ENSTRUT00000015899.1	ENSTRUP00000015829.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.20e-13	52.0	27	84

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           ++++ +l+d++++n+ +L +k+Gd+++v+   + d+ W+++++  +g +G++P n+v+++e
   Q: 27   EHVFVALHDFKSTNSSDLPFKEGDKLKVL---QSDGQWWVAKSLESGLEGFIPCNYVARAE 84
           68899************************...99***********************9986 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCTCSGQNK VKDDKRRHKG QGNHTSEHVF VALHDFKSTN SSDLPFKEGD KLKVLQSDGQ 60
WWVAKSLESG LEGFIPCNYV ARAETMEMEK WFFNDMSRKE TERLLLAPGN QTGSFLVRES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGCA CCTGCAGTGG CCAGAACAAA GTCAAAGATG ACAAAAGGAG GCACAAGGGT 60
CAGGGCAACC ACACAGTGAG TGCATCACCT CCAGGATGAA GACAAGAGCC GTTTATAAAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002133	Ailuropoda melanoleuca	68.82	0.00e+00	653.00
IUUC-Apl-003307	Anas platyrhynchos	67.26	0.00e+00	662.00
IUUC-Aca-004357	Anolis carolinensis	66.74	0.00e+00	634.00
IUUC-Ame-010642	Astyanax mexicanus	75.61	0.00e+00	782.00
IUUC-Bta-012400	Bos taurus	68.30	0.00e+00	655.00
IUUC-Cfa-021056	Canis familiaris	68.82	0.00e+00	649.00
IUUC-Cpo-021779	Cavia porcellus	69.27	0.00e+00	667.00
IUUC-Csa-023557	Chlorocebus sabaeus	67.93	0.00e+00	653.00
IUUC-Dre-027517	Danio rerio	73.72	0.00e+00	769.00
IUUC-Eca-034218	Equus caballus	68.56	0.00e+00	653.00
IUUC-Fal-036946	Ficedula albicollis	66.44	0.00e+00	647.00
IUUC-Gmo-038861	Gadus morhua	75.34	0.00e+00	700.00
IUUC-Gga-040822	Gallus gallus	66.52	0.00e+00	669.00
IUUC-Gac-041860	Gasterosteus aculeatus	76.17	0.00e+00	776.00
IUUC-Gma-043628	Glycine max	29.06	2.00e-20	94.40
IUUC-Hsa-046719	Homo sapiens	67.48	0.00e+00	648.00
IUUC-Itr-048323	Ictidomys tridecemlineatus	68.99	0.00e+00	652.00
IUUC-Lch-050114	Latimeria chalumnae	69.13	0.00e+00	672.00
IUUC-Loc-052326	Lepisosteus oculatus	69.28	0.00e+00	724.00
IUUC-Laf-053387	Loxodonta africana	67.71	0.00e+00	646.00
IUUC-Mcc-055026	Macaca mulatta	67.93	0.00e+00	653.00
IUUC-Mga-059427	Meleagris gallopavo	67.79	0.00e+00	661.00
IUUC-Mmr-061660	Microcebus murinus	69.44	0.00e+00	659.00
IUUC-Mmu-063325	Mus musculus	67.47	0.00e+00	650.00
IUUC-Mpu-066582	Mustela putorius furo	69.04	0.00e+00	657.00
IUUC-Nle-069624	Nomascus leucogenys	67.41	0.00e+00	649.00
IUUC-Ont-072266	Oreochromis niloticus	79.02	0.00e+00	820.00
IUUC-Ocu-073907	Oryctolagus cuniculus	70.09	0.00e+00	665.00
IUUC-Ola-086668	Oryzias latipes	82.10	0.00e+00	778.00
IUUC-Oga-088057	Otolemur garnettii	69.20	0.00e+00	658.00
IUUC-Psi-093895	Pelodiscus sinensis	67.86	0.00e+00	665.00
IUUC-Pfo-096608	Poecilia formosa	78.41	0.00e+00	804.00
IUUC-Pab-097598	Pongo abelii	67.87	0.00e+00	648.00
IUUC-Pva-102135	Pteropus vampyrus	68.60	0.00e+00	654.00
IUUC-Rno-104891	Rattus norvegicus	68.37	0.00e+00	655.00
IUUC-Ssc-115696	Sus scrofa	69.04	0.00e+00	659.00
IUUC-Tgu-117056	Taeniopygia guttata	66.89	0.00e+00	652.00
IUUC-Ttr-128457	Tursiops truncatus	68.19	0.00e+00	657.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence