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Tag Content
UUCD2 ID IUUC-Mcc-055294
UUCD1 version UUC-MaM-00418
Ensembl Protein ID ENSMMUP00000018645.2
UniProt Accession H9FUJ1; F7AKS9; H9FUJ1_MACMU
Genbank Protein ID AFE78300.1; AFH32437.1
Protein Name E3 ubiquitin-protein ligase Mdm2 isoform MDM2
Genbank Nucleotide ID JSUE03007143; JU475633
Gene Name MDM2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMMUG00000014193.3 ENSMMUT00000019919.2 ENSMMUP00000018645.2
ENSMMUG00000014193.3 ENSMMUT00000019916.3 ENSMMUP00000018642.2
ENSMMUG00000014193.3 ENSMMUT00000019920.3 ENSMMUP00000018646.3
ENSMMUG00000014193.3 ENSMMUT00000019926.3 ENSMMUP00000018652.3
ENSMMUG00000014193.3 ENSMMUT00000019927.3 ENSMMUP00000018653.3
ENSMMUG00000014193.3 ENSMMUT00000019925.3 ENSMMUP00000018651.3
ENSMMUG00000014193.3 ENSMMUT00000019923.2 ENSMMUP00000018649.2
ENSMMUG00000014193.3 ENSMMUT00000019917.2 ENSMMUP00000018643.1
ENSMMUG00000014193.3 ENSMMUT00000019918.2 ENSMMUP00000018644.1
ENSMMUG00000014193.3 ENSMMUT00000019922.2 ENSMMUP00000018648.1
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 99.40 0.00e+00 872.00 IUUC-Hsa-046376
E3 activity/RING/RING 80.44 0.00e+00 662.00 IUUC-Mmu-063207
E3 activity/RING/RING 83.27 0.00e+00 689.00 IUUC-Rno-105641
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Macaca mulatta
Protein Sequence
(Fasta)
MVRSRQMCNT NMSVPTDGAV TTSQIPASEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVL 60
FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY RNLVVVNQQE 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mcc-055294|E3,RING|Macaca mulatta
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGGGCGCGCA CCGCGGCACC GCGGCTAGCT TGGCTGCTCG TGGGGCCTCT CCGGCCCTGT 60
GTATCGGGAA GATGGAGCAA GAAGCCGAGC CCGAGGGGCG GCCCCGACCC CTCTGACCGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mcc-055294|E3,RING|Macaca mulatta
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
Interpro

IPR028340--Mdm2
IPR015459--MDM2_E3_ligase
IPR016495--p53_neg-reg_MDM_2/4
IPR003121--SWIB_MDM2_domain
IPR001876--Znf_RanBP2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2
PS50089--ZF_RING_2
Pfam

PF02201--SWIB
PF00641--zf-RanBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0016604--C:nuclear body
GO:0005730--C:nucleolus
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0003283--P:atrial septum development
GO:0003181--P:atrioventricular valve morphogenesis
GO:0001568--P:blood vessel development
GO:0001974--P:blood vessel remodeling
GO:0060411--P:cardiac septum morphogenesis
GO:0071456--P:cellular response to hypoxia
GO:0006977--P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0003203--P:endocardial cushion morphogenesis
GO:0045184--P:establishment of protein localization
GO:0043066--P:negative regulation of apoptotic process
GO:0071157--P:negative regulation of cell cycle arrest
GO:0043518--P:negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0018205--P:peptidyl-lysine modification
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006461--P:protein complex assembly
GO:0031648--P:protein destabilization
GO:0034504--P:protein localization to nucleus
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0002027--P:regulation of heart rate
GO:0046677--P:response to antibiotic
GO:0007089--P:traversing start control point of mitotic cell cycle
GO:0003281--P:ventricular septum development
KEGG mcc:718284
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002039 Ailuropoda melanoleuca 94.73 0.00e+00 826.00
IUUC-Apl-003193 Anas platyrhynchos 65.39 4.00e-158 551.00
IUUC-Aca-004305 Anolis carolinensis 59.13 1.00e-117 416.00
IUUC-Ame-010675 Astyanax mexicanus 45.14 4.00e-84 305.00
IUUC-Bta-013270 Bos taurus 93.70 0.00e+00 790.00
IUUC-Cja-019744 Callithrix jacchus 96.15 0.00e+00 820.00
IUUC-Cfa-020807 Canis familiaris 92.44 0.00e+00 756.00
IUUC-Cpo-022182 Cavia porcellus 89.84 0.00e+00 751.00
IUUC-Csa-023541 Chlorocebus sabaeus 99.80 0.00e+00 862.00
IUUC-Cho-024831 Choloepus hoffmanni 74.29 1.00e-89 322.00
IUUC-Cin-025448 Ciona intestinalis 28.77 4.00e-21 94.70
IUUC-Csv-026151 Ciona savignyi 31.17 4.00e-11 61.60
IUUC-Dre-028419 Danio rerio 43.54 1.00e-50 193.00
IUUC-Dno-028950 Dasypus novemcinctus 93.09 0.00e+00 818.00
IUUC-Dor-031048 Dipodomys ordii 72.18 2.00e-172 598.00
IUUC-Ete-032264 Echinops telfairi 68.97 1.00e-172 598.00
IUUC-Eca-033301 Equus caballus 83.57 0.00e+00 729.00
IUUC-Eeu-035005 Erinaceus europaeus 81.06 0.00e+00 645.00
IUUC-Fca-035454 Felis catus 94.50 0.00e+00 813.00
IUUC-Fal-036720 Ficedula albicollis 61.46 1.00e-73 270.00
IUUC-Gmo-039296 Gadus morhua 41.42 6.00e-45 174.00
IUUC-Gga-040251 Gallus gallus 66.53 2.00e-152 532.00
IUUC-Ggo-044948 Gorilla gorilla 90.22 0.00e+00 770.00
IUUC-Hsa-046376 Homo sapiens 99.40 0.00e+00 872.00
IUUC-Itr-048328 Ictidomys tridecemlineatus 92.71 0.00e+00 766.00
IUUC-Lch-050037 Latimeria chalumnae 57.64 6.00e-116 410.00
IUUC-Loc-051837 Lepisosteus oculatus 50.91 2.00e-112 399.00
IUUC-Laf-053483 Loxodonta africana 85.77 0.00e+00 738.00
IUUC-Mga-060007 Meleagris gallopavo 65.34 3.00e-144 504.00
IUUC-Mmr-060673 Microcebus murinus 94.70 0.00e+00 824.00
IUUC-Mdo-063057 Monodelphis domestica 74.19 0.00e+00 661.00
IUUC-Mmu-063207 Mus musculus 80.44 0.00e+00 641.00
IUUC-Mpu-065836 Mustela putorius furo 93.08 0.00e+00 818.00
IUUC-Mlu-068193 Myotis lucifugus 88.89 0.00e+00 781.00
IUUC-Nle-069927 Nomascus leucogenys 99.40 0.00e+00 872.00
IUUC-Opr-070590 Ochotona princeps 85.66 0.00e+00 710.00
IUUC-Ont-071984 Oreochromis niloticus 40.16 6.00e-73 268.00
IUUC-Oan-072744 Ornithorhynchus anatinus 72.62 5.00e-162 563.00
IUUC-Ocu-074071 Oryctolagus cuniculus 93.54 0.00e+00 790.00
IUUC-Ola-087329 Oryzias latipes 41.70 6.00e-72 265.00
IUUC-Oga-088135 Otolemur garnettii 85.05 0.00e+00 743.00
IUUC-Oar-090078 Ovis aries 93.28 0.00e+00 823.00
IUUC-Ptr-091399 Pan troglodytes 99.40 0.00e+00 873.00
IUUC-Pan-092720 Papio anubis 100.00 0.00e+00 877.00
IUUC-Psi-093591 Pelodiscus sinensis 66.74 3.00e-131 461.00
IUUC-Pma-094500 Petromyzon marinus 62.50 8.00e-19 86.70
IUUC-Pfo-096316 Poecilia formosa 41.41 4.00e-72 265.00
IUUC-Pab-097696 Pongo abelii 98.99 0.00e+00 862.00
IUUC-Pca-100974 Procavia capensis 83.53 0.00e+00 768.00
IUUC-Pva-102488 Pteropus vampyrus 87.32 0.00e+00 721.00
IUUC-Rno-105641 Rattus norvegicus 83.27 0.00e+00 671.00
IUUC-Sha-107314 Sarcophilus harrisii 73.74 0.00e+00 682.00
IUUC-Sar-112938 Sorex araneus 86.12 0.00e+00 749.00
IUUC-Ssc-115495 Sus scrofa 93.28 0.00e+00 778.00
IUUC-Tgu-116623 Taeniopygia guttata 64.67 2.00e-150 525.00
IUUC-Tru-117820 Takifugu rubripes 40.23 7.00e-72 264.00
IUUC-Tsy-119162 Tarsius syrichta 64.95 2.00e-90 325.00
IUUC-Tbe-127816 Tupaia belangeri 91.63 2.00e-118 419.00
IUUC-Ttr-129194 Tursiops truncatus 83.19 0.00e+00 672.00
IUUC-Vpa-130326 Vicugna pacos 87.70 0.00e+00 732.00
IUUC-Xtr-132216 Xenopus tropicalis 56.44 2.00e-119 422.00
Created Date 25-Jun-2017

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