iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033461

UUCD1 version

UUC-EqC-01066

Ensembl Protein ID

ENSECAP00000020680.1

UniProt Accession

F6V278; F6V278_HORSE

Protein Name

Uncharacterized protein

Gene Name

USP14

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000022985.1	ENSECAT00000024870.1	ENSECAP00000020680.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.50e-65	220.2	105	480
ULD/UDP/UBQ/UBQ_Other	1.10e-09	38.2	5	74

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs.... 85
           +Gl+NlgNtCYmN+++Qc+ ++pel+++l++ +  +l+++ +  + + ++ +l++lf ++ +++++++ p  ll+ l+++ ++f     
   Q: 105  CGLTNLGNTCYMNATVQCIRSVPELKDALKR-YAGALRASGEMASAQYITAALRDLFDSM-DKTSSSIPPIILLQFLHMAFPQFAekge 191
           7******************************.****************************.99999******************999*9 PP
   S: 86   ..gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldl 172
             +y qqDa+E++ +++  l+++l+  ++ +++e+ +       ++a+  +++k+ksli++ F++++++++kc e +++ +++   ++l
   Q: 192  qgQYLQQDANECWIHMMRVLQQKLEAIEDDSVKETDS-------SSASAVTPSKKKSLIDQFFGVEFETTMKCTESEEEEVTKGRENQL 273
           999*********************6644444444433.......347788999**********************99999888888888 PP
   S: 173  slpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdl 261
           +l+   ++e   + l   L+   +ee  +     ++++ +++    k+ k+++lP +L++++ Rf ++e+++++ k+ k v+fpl+Ld+
   Q: 274  QLSCFINQEV--KYLFTGLKLRLQEEITK-----QSPTLQRNALYIKSSKISRLPAYLTIQMVRFFYKEKESVNAKVLKDVKFPLMLDV 355
           8877777743..58999999999999998.....58899999999******************************************** PP
   S: 262  spfcts..........................peekqke.........................kkkYeLiavvvHsG.slssGHYvay 298
            + ct                           +     +                         +  Y+L av+ H+G s+ssGHYv++
   Q: 356  YELCTPelqekmisfrskfkdledkkvnqqtqT-----SdkksspqkevkyepfsfaddigsnnCGYYDLQAVLTHQGrSSSSGHYVSW 439
           *****9777777777777777766666555540.....05555666667777777777777777************************* PP
   S: 299  vknekgkWllfdDskVtevkeeevleetg....staYvlfY 335
           vk ++++W++fdD+kV+ v+ e++l+ +g    + aYvl+Y
   Q: 440  VKRKQDEWIKFDDDKVSIVTPEDILRLSGggdwHIAYVLLY 480
           **************************988************ PP

ULD/UDP/UBQ/UBQ_Other

   S: 2    qvtvksldgseltlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihllek 72
           +vtvk+ + +  ++++n +++  ++K +++ ++g++p++q+ ++kG  L+dd ++++ ++k+g+t++++ +
   Q: 5    TVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDD-DWGNIKIKNGMTLLMMGS 74
           79********99*************************************999.9**************965 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

MVLLTVTVKW GKEKFEGVEL NTDEPPMVFK AQLFALTGVQ PARQKVMVKG GTLKDDDWGN 60
IKIKNGMTLL MMGSADALPE EPSAKTVFVE DMTEEQLASA MELPCGLTNL GNTCYMNATV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGTTTTAT TAACAGTTAC TGTGAAATGG GGAAAGGAGA AATTTGAAGG TGTGGAATTG 60
AATACTGATG AACCTCCAAT GGTGTTCAAG GCTCAGCTTT TTGCACTGAC TGGAGTCCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR029071--Ubiquitin-rel_dom
IPR019954--Ubiquitin_CS
IPR000626--Ubiquitin_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00299--UBIQUITIN_1
PS50053--UBIQUITIN_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00213--UBQ

Gene Ontology

GO:0009986--C:cell surface
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045202--C:synapse
GO:0004866--F:endopeptidase inhibitor activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007268--P:chemical synaptic transmission
GO:1903070--P:negative regulation of ER-associated ubiquitin-dependent protein catabolic process
GO:0016579--P:protein deubiquitination
GO:0050920--P:regulation of chemotaxis
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ecb:100060643

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000893	Aegilops tauschii	30.83	1.00e-66	247.00
IUUC-Aml-002053	Ailuropoda melanoleuca	97.77	0.00e+00	934.00
IUUC-Atr-002725	Amborella trichopoda	41.97	8.00e-103	367.00
IUUC-Apl-004031	Anas platyrhynchos	90.08	0.00e+00	896.00
IUUC-Aca-004361	Anolis carolinensis	89.29	0.00e+00	917.00
IUUC-Aly-006176	Arabidopsis lyrata	42.89	2.00e-112	399.00
IUUC-Ath-007623	Arabidopsis thaliana	42.71	3.00e-113	401.00
IUUC-Ago-007796	Ashbya gossypii	32.22	5.00e-58	218.00
IUUC-Acl-008258	Aspergillus clavatus	36.70	6.00e-67	248.00
IUUC-Afl-008732	Aspergillus flavus	35.88	8.00e-69	254.00
IUUC-Afu-008755	Aspergillus fumigatus	37.50	8.00e-69	254.00
IUUC-Ani-009148	Aspergillus nidulans	38.88	1.00e-72	267.00
IUUC-Ang-009878	Aspergillus niger	37.99	2.00e-67	249.00
IUUC-Aor-010239	Aspergillus oryzae	35.88	4.00e-69	255.00
IUUC-Ate-010243	Aspergillus terreus	34.62	1.00e-76	280.00
IUUC-Ame-011327	Astyanax mexicanus	50.20	2.00e-127	449.00
IUUC-Bgr-012231	Blumeria graminis	34.72	5.00e-80	291.00
IUUC-Bta-012553	Bos taurus	96.56	0.00e+00	953.00
IUUC-Bci-013606	Botrytis cinerea	39.95	1.00e-70	260.00
IUUC-Bdi-014567	Brachypodium distachyon	43.67	3.00e-114	405.00
IUUC-Bol-015565	Brassica oleracea	42.80	3.00e-116	412.00
IUUC-Bra-017297	Brassica rapa	42.43	4.00e-115	407.00
IUUC-Cel-018140	Caenorhabditis elegans	41.40	8.00e-101	360.00
IUUC-Cja-019516	Callithrix jacchus	96.98	0.00e+00	950.00
IUUC-Cfa-020808	Canis familiaris	98.18	0.00e+00	966.00
IUUC-Cpo-021688	Cavia porcellus	96.37	0.00e+00	947.00
IUUC-Cre-022663	Chlamydomonas reinhardtii	38.08	4.00e-84	305.00
IUUC-Csa-023429	Chlorocebus sabaeus	97.97	0.00e+00	932.00
IUUC-Cho-024347	Choloepus hoffmanni	96.75	0.00e+00	954.00
IUUC-Cin-025198	Ciona intestinalis	54.38	7.00e-153	533.00
IUUC-Csv-026007	Ciona savignyi	53.01	2.00e-153	535.00
IUUC-Cgl-026757	Colletotrichum gloeosporioides	38.70	4.00e-64	238.00
IUUC-Cne-026963	Cryptococcus neoformans	34.47	1.00e-75	277.00
IUUC-Cme-027240	Cyanidioschyzon merolae	30.83	4.00e-60	225.00
IUUC-Dre-027647	Danio rerio	82.04	0.00e+00	833.00
IUUC-Dno-029967	Dasypus novemcinctus	97.17	0.00e+00	931.00
IUUC-Dor-030886	Dipodomys ordii	92.05	0.00e+00	763.00
IUUC-Dse-031466	Dothistroma septosporum	36.10	2.00e-57	217.00
IUUC-Dme-032079	Drosophila melanogaster	55.14	5.00e-159	553.00
IUUC-Ete-032351	Echinops telfairi	85.22	0.00e+00	852.00
IUUC-Eeu-035220	Erinaceus europaeus	74.18	0.00e+00	699.00
IUUC-Fca-036210	Felis catus	98.38	0.00e+00	967.00
IUUC-Fal-037528	Ficedula albicollis	90.20	0.00e+00	875.00
IUUC-Fox-037805	Fusarium oxysporum	39.38	2.00e-70	260.00
IUUC-Fso-038177	Fusarium solani	37.56	6.00e-68	251.00
IUUC-Gmo-038953	Gadus morhua	76.99	0.00e+00	765.00
IUUC-Ggr-039972	Gaeumannomyces graminis	34.30	5.00e-74	271.00
IUUC-Gga-040462	Gallus gallus	89.07	0.00e+00	883.00
IUUC-Gac-041312	Gasterosteus aculeatus	81.52	0.00e+00	803.00
IUUC-Gma-043255	Glycine max	43.23	3.00e-110	392.00
IUUC-Ggo-045458	Gorilla gorilla	81.69	0.00e+00	797.00
IUUC-Hsa-045706	Homo sapiens	97.98	0.00e+00	935.00
IUUC-Hvu-047821	Hordeum vulgare	47.22	3.00e-58	218.00
IUUC-Itr-048654	Ictidomys tridecemlineatus	97.17	0.00e+00	950.00
IUUC-Lch-050464	Latimeria chalumnae	81.91	0.00e+00	829.00
IUUC-Lpe-051419	Leersia perrieri	43.48	2.00e-110	392.00
IUUC-Loc-052732	Lepisosteus oculatus	81.47	0.00e+00	846.00
IUUC-Lma-053177	Leptosphaeria maculans	41.03	2.00e-71	263.00
IUUC-Laf-053822	Loxodonta africana	97.77	0.00e+00	963.00
IUUC-Mcc-055893	Macaca mulatta	97.97	0.00e+00	933.00
IUUC-Meu-056307	Macropus eugenii	81.84	0.00e+00	795.00
IUUC-Mor-057171	Magnaporthe oryzae	38.37	2.00e-68	253.00
IUUC-Mpo-057415	Magnaporthe poae	39.34	2.00e-70	259.00
IUUC-Mtr-057901	Medicago truncatula	43.20	3.00e-113	402.00
IUUC-Mla-058897	Melampsora laricipopulina	38.83	3.00e-74	272.00
IUUC-Mga-060016	Meleagris gallopavo	89.68	0.00e+00	893.00
IUUC-Mvi-060562	Microbotryum violaceum	39.63	4.00e-68	252.00
IUUC-Mmr-060624	Microcebus murinus	97.17	0.00e+00	1001.00
IUUC-Mdo-061809	Monodelphis domestica	91.94	0.00e+00	895.00
IUUC-Mmu-063869	Mus musculus	95.55	0.00e+00	940.00
IUUC-Mac-064876	Musa acuminata	40.00	1.00e-96	347.00
IUUC-Mpu-066480	Mustela putorius furo	97.77	0.00e+00	962.00
IUUC-Mlu-067866	Myotis lucifugus	97.77	0.00e+00	975.00
IUUC-Nfi-068393	Neosartorya fischeri	36.79	2.00e-66	246.00
IUUC-Ncr-068815	Neurospora crassa	38.27	3.00e-70	259.00
IUUC-Nle-070121	Nomascus leucogenys	98.02	6.00e-139	486.00
IUUC-Opr-070712	Ochotona princeps	76.92	5.00e-175	607.00
IUUC-Ont-071544	Oreochromis niloticus	81.87	0.00e+00	771.00
IUUC-Oan-073635	Ornithorhynchus anatinus	91.36	0.00e+00	755.00
IUUC-Ocu-074926	Oryctolagus cuniculus	95.55	0.00e+00	920.00
IUUC-Oba-075633	Oryza barthii	42.32	5.00e-110	390.00
IUUC-Obr-076423	Oryza brachyantha	42.97	2.00e-113	402.00
IUUC-Ogl-077913	Oryza glaberrima	42.57	9.00e-113	400.00
IUUC-Ogu-078435	Oryza glumaepatula	42.32	5.00e-110	390.00
IUUC-Oin-080072	Oryza indica	42.36	4.00e-110	391.00
IUUC-Olo-080535	Oryza longistaminata	39.31	9.00e-94	337.00
IUUC-Ome-081309	Oryza meridionalis	42.32	5.00e-110	390.00
IUUC-Oni-083113	Oryza nivara	42.32	5.00e-110	390.00
IUUC-Opu-083168	Oryza punctata	41.37	3.00e-104	372.00
IUUC-Oru-084253	Oryza rufipogon	42.32	5.00e-110	390.00
IUUC-Osa-085554	Oryza sativa	42.57	9.00e-113	400.00
IUUC-Ola-086998	Oryzias latipes	80.93	0.00e+00	795.00
IUUC-Olu-087818	Ostreococcus lucimarinus	35.63	4.00e-72	265.00
IUUC-Oga-088571	Otolemur garnettii	96.96	0.00e+00	951.00
IUUC-Oar-089526	Ovis aries	96.95	0.00e+00	953.00
IUUC-Ptr-091433	Pan troglodytes	97.97	0.00e+00	933.00
IUUC-Pan-091966	Papio anubis	97.97	0.00e+00	932.00
IUUC-Psi-093458	Pelodiscus sinensis	88.36	0.00e+00	850.00
IUUC-Pma-094343	Petromyzon marinus	69.34	1.00e-121	428.00
IUUC-Pno-095109	Phaeosphaeria nodorum	39.65	1.00e-66	247.00
IUUC-Ppa-095756	Physcomitrella patens	43.65	9.00e-113	400.00
IUUC-Pfo-096514	Poecilia formosa	82.28	0.00e+00	786.00
IUUC-Pab-098477	Pongo abelii	85.96	0.00e+00	741.00
IUUC-Pop-099221	Populus trichocarpa	41.77	5.00e-105	374.00
IUUC-Pca-100791	Procavia capensis	80.65	0.00e+00	631.00
IUUC-Ppe-101812	Prunus persica	41.60	4.00e-108	384.00
IUUC-Pva-102462	Pteropus vampyrus	93.24	0.00e+00	785.00
IUUC-Pgr-103623	Puccinia graminis	40.35	3.00e-74	272.00
IUUC-Ptt-103767	Puccinia triticina	39.10	2.00e-67	249.00
IUUC-Pte-104109	Pyrenophora teres	39.20	8.00e-71	261.00
IUUC-Pyt-104766	Pyrenophora triticirepentis	39.80	3.00e-71	262.00
IUUC-Rno-105351	Rattus norvegicus	95.75	0.00e+00	895.00
IUUC-Sce-106168	Saccharomyces cerevisiae	32.41	1.00e-62	233.00
IUUC-Sha-107491	Sarcophilus harrisii	91.92	0.00e+00	914.00
IUUC-Sja-107769	Schizosaccharomyces japonicus	33.33	8.00e-79	287.00
IUUC-Spo-108174	Schizosaccharomyces pombe	37.72	4.00e-81	295.00
IUUC-Ssl-108659	Sclerotinia sclerotiorum	35.27	3.00e-84	305.00
IUUC-Smo-108805	Selaginella moellendorffii	43.62	1.00e-109	389.00
IUUC-Sit-110361	Setaria italica	43.29	4.00e-116	411.00
IUUC-Sly-110965	Solanum lycopersicum	41.63	4.00e-109	388.00
IUUC-Sar-113355	Sorex araneus	83.68	0.00e+00	662.00
IUUC-Sbi-114778	Sorghum bicolor	44.20	3.00e-115	408.00
IUUC-Sre-115011	Sporisorium reilianum	36.34	2.00e-62	233.00
IUUC-Ssc-116273	Sus scrofa	97.35	0.00e+00	945.00
IUUC-Tgu-117063	Taeniopygia guttata	89.43	0.00e+00	874.00
IUUC-Tru-118381	Takifugu rubripes	79.27	0.00e+00	796.00
IUUC-Tsy-119076	Tarsius syrichta	82.16	4.00e-118	417.00
IUUC-Tni-119941	Tetraodon nigroviridis	81.10	0.00e+00	787.00
IUUC-Tca-121246	Theobroma cacao	41.88	5.00e-110	390.00
IUUC-Tre-121969	Trichoderma reesei	37.95	4.00e-68	252.00
IUUC-Tvi-122543	Trichoderma virens	34.87	3.00e-78	285.00
IUUC-Tae-125484	Triticum aestivum	42.60	1.00e-110	393.00
IUUC-Tur-126128	Triticum urartu	41.87	1.00e-39	157.00
IUUC-Tbe-128030	Tupaia belangeri	90.57	0.00e+00	862.00
IUUC-Ttr-128701	Tursiops truncatus	96.70	0.00e+00	781.00
IUUC-Uma-129657	Ustilago maydis	36.80	5.00e-65	241.00
IUUC-Vda-129723	Verticillium dahliae	32.65	2.00e-71	263.00
IUUC-Vpa-130284	Vicugna pacos	70.70	0.00e+00	645.00
IUUC-Vvi-131037	Vitis vinifera	42.77	4.00e-109	388.00
IUUC-Xtr-132235	Xenopus tropicalis	84.68	0.00e+00	876.00
IUUC-Xma-133840	Xiphophorus maculatus	82.28	0.00e+00	812.00
IUUC-Yli-134453	Yarrowia lipolytica	37.18	2.00e-83	303.00
IUUC-Zma-135669	Zea mays	36.92	2.00e-96	346.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence