iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-134265

Ensembl Protein ID

ENSXMAP00000002092.1

UniProt Accession

M3ZIQ0; M3ZIQ0_XIPMA

Genbank Protein ID

ENSXMAP00000002092

Protein Name

Histone deacetylase

Genbank Nucleotide ID

AGAJ01010978

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000002072.1	ENSXMAT00000002097.1	ENSXMAP00000002092.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	67.94	0.00e+00	1207.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
768	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Xiphophorus maculatus

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

LVDVSTAALP SQVPSAASAI LPMDLRIVDH SHHHHQQPPC RQDQHLQQEL VALKHKQELQ 60
RQLLIAEFHR QHEQLSRQHE VQLQEHIKHQ QDLLALKHQQ ELLEHHRKME QQHHEQQLEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTAGTGGATG TGAGCACAGC GGCGCTCCCC TCGCAGGTTC CCTCCGCCGC CTCTGCCATC 60
CTTCCCATGG ACCTCCGCAT TGTGGACCAC TCTCACCACC ACCACCAGCA GCCTCCCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk
IPR015943--WD40/YVTN_repeat-like_dom

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

PRINTS

PR01270--HDASUPER

Gene Ontology

GO:0000118--C:histone deacetylase complex
GO:0046872--F:metal ion binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0048701--P:embryonic cranial skeleton morphogenesis
GO:0001755--P:neural crest cell migration
GO:0090299--P:regulation of neural crest formation
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	72.33	0.00e+00	1246.00
IUUC-Apl-003250	Anas platyrhynchos	68.36	0.00e+00	1201.00
IUUC-Aca-004668	Anolis carolinensis	66.12	0.00e+00	1210.00
IUUC-Bta-013215	Bos taurus	72.25	0.00e+00	1239.00
IUUC-Cja-019816	Callithrix jacchus	69.48	0.00e+00	1243.00
IUUC-Cfa-020861	Canis familiaris	72.03	0.00e+00	1231.00
IUUC-Cpo-021562	Cavia porcellus	69.32	0.00e+00	1242.00
IUUC-Csa-023612	Chlorocebus sabaeus	68.68	0.00e+00	1217.00
IUUC-Csv-026359	Ciona savignyi	53.04	5.00e-91	327.00
IUUC-Dre-028284	Danio rerio	75.55	0.00e+00	1315.00
IUUC-Dno-029951	Dasypus novemcinctus	67.77	0.00e+00	1152.00
IUUC-Dor-030362	Dipodomys ordii	60.47	0.00e+00	996.00
IUUC-Dme-031766	Drosophila melanogaster	58.55	3.00e-157	550.00
IUUC-Fca-036187	Felis catus	72.42	0.00e+00	1275.00
IUUC-Gmo-038473	Gadus morhua	74.42	0.00e+00	1276.00
IUUC-Gga-040501	Gallus gallus	70.90	0.00e+00	1229.00
IUUC-Gac-042335	Gasterosteus aculeatus	82.97	0.00e+00	1492.00
IUUC-Ggo-045380	Gorilla gorilla	69.10	0.00e+00	1213.00
IUUC-Hsa-046925	Homo sapiens	69.48	0.00e+00	1236.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	69.10	0.00e+00	1215.00
IUUC-Lch-050325	Latimeria chalumnae	70.62	0.00e+00	1189.00
IUUC-Loc-052231	Lepisosteus oculatus	73.22	0.00e+00	1322.00
IUUC-Laf-054490	Loxodonta africana	67.46	0.00e+00	1199.00
IUUC-Mcc-055265	Macaca mulatta	68.54	0.00e+00	1222.00
IUUC-Meu-056676	Macropus eugenii	75.83	1.00e-179	624.00
IUUC-Mmr-061633	Microcebus murinus	64.52	0.00e+00	1089.00
IUUC-Mmu-063089	Mus musculus	71.41	0.00e+00	1220.00
IUUC-Mpu-065887	Mustela putorius furo	72.93	0.00e+00	1256.00
IUUC-Mlu-067470	Myotis lucifugus	69.57	0.00e+00	1258.00
IUUC-Nle-069099	Nomascus leucogenys	61.40	0.00e+00	688.00
IUUC-Ont-071613	Oreochromis niloticus	83.36	0.00e+00	1523.00
IUUC-Oan-073275	Ornithorhynchus anatinus	70.76	0.00e+00	1253.00
IUUC-Ola-087031	Oryzias latipes	81.72	0.00e+00	1477.00
IUUC-Oga-088201	Otolemur garnettii	66.01	0.00e+00	1108.00
IUUC-Oar-089997	Ovis aries	66.92	0.00e+00	1062.00
IUUC-Ptr-091116	Pan troglodytes	69.48	0.00e+00	1249.00
IUUC-Pan-092132	Papio anubis	70.23	0.00e+00	870.00
IUUC-Psi-093734	Pelodiscus sinensis	80.89	0.00e+00	816.00
IUUC-Pma-094347	Petromyzon marinus	68.62	0.00e+00	685.00
IUUC-Pfo-096293	Poecilia formosa	93.70	0.00e+00	1709.00
IUUC-Pab-098491	Pongo abelii	65.97	0.00e+00	1145.00
IUUC-Pca-101004	Procavia capensis	60.61	1.00e-172	600.00
IUUC-Pva-102961	Pteropus vampyrus	51.90	1.00e-171	597.00
IUUC-Rno-105005	Rattus norvegicus	71.27	0.00e+00	1210.00
IUUC-Sha-107646	Sarcophilus harrisii	71.97	1.00e-164	573.00
IUUC-Ssc-115428	Sus scrofa	70.51	0.00e+00	1221.00
IUUC-Tgu-116776	Taeniopygia guttata	70.47	0.00e+00	1224.00
IUUC-Tru-118180	Takifugu rubripes	82.13	0.00e+00	1471.00
IUUC-Tsy-119468	Tarsius syrichta	60.00	1.00e-147	517.00
IUUC-Tni-120196	Tetraodon nigroviridis	81.26	0.00e+00	1442.00
IUUC-Ttr-128360	Tursiops truncatus	66.04	0.00e+00	765.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence