iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000031634.13	ENSMUST00000034051.6	ENSMUSP00000034051.6
ENSMUSG00000031634.13	ENSMUST00000210081.1	ENSMUSP00000147651.1
ENSMUSG00000031634.13	ENSMUST00000123307.7	ENSMUSP00000147971.1
ENSMUSG00000031634.13	ENSMUST00000209443.1	ENSMUSP00000147993.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Protein-protein Interaction
IID	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
DUB/ULP	84.45	0.00e+00	808.00	IUUC-Hsa-046929

Active Site

Position(s)	Description	Evidence
294	N/A	{ECO:0000269\|PubMed:21228277}
418		{ECO:0000269\|PubMed:21228277}
420		{ECO:0000269\|PubMed:21228277}

Organism

Mus musculus

Functional Description
(View)

Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:17182609, PubMed:21228277). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity).

Protein Sequence
(Fasta)

MDILFRIRGG FDLAFQLAPP KEMFIKNALR QVLSDLTTKL SSDALVLRVC NSSVYLWPNS 60
DANTGELTDS SACKNVVRFI QFDQEEDTKR KFIKKKDKKL TDTQQIVNID LMLEISTPLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTCCGGGA CGACCCTTGC TTGCACGAAG TAGGTGTTCT TGCCATCGCC AGTGGTGCTT 60
GGTAAGTGAT TCTGGTTGTC AGTGACCTCC CCGTATTTAC CCCTAGGACT TCGTCAACCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR012462--Peptidase_C78_UfSP1/2

Pfam

PF07910--Peptidase_C78

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005783--C:endoplasmic reticulum
GO:0005634--C:nucleus
GO:0016790--F:thiolester hydrolase activity
GO:0071567--F:UFM1 hydrolase activity
GO:0006508--P:proteolysis
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway

KEGG

mmu:192169

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000578	Aegilops tauschii	40.00	4.00e-70	258.00
IUUC-Aml-001757	Ailuropoda melanoleuca	84.38	0.00e+00	808.00
IUUC-Atr-002641	Amborella trichopoda	44.31	2.00e-71	263.00
IUUC-Apl-003911	Anas platyrhynchos	68.60	0.00e+00	640.00
IUUC-Aca-005294	Anolis carolinensis	72.35	0.00e+00	702.00
IUUC-Aly-006185	Arabidopsis lyrata	44.30	4.00e-70	259.00
IUUC-Ath-006919	Arabidopsis thaliana	41.06	2.00e-69	257.00
IUUC-Ame-011931	Astyanax mexicanus	55.10	9.00e-149	520.00
IUUC-Bta-012389	Bos taurus	85.31	0.00e+00	820.00
IUUC-Bdi-014306	Brachypodium distachyon	42.57	1.00e-67	251.00
IUUC-Bol-016591	Brassica oleracea	42.33	9.00e-72	264.00
IUUC-Bra-017122	Brassica rapa	39.95	8.00e-63	234.00
IUUC-Cel-018132	Caenorhabditis elegans	52.06	2.00e-81	296.00
IUUC-Cja-019735	Callithrix jacchus	82.19	0.00e+00	801.00
IUUC-Cfa-020814	Canis familiaris	82.86	0.00e+00	797.00
IUUC-Cpo-021576	Cavia porcellus	83.15	0.00e+00	795.00
IUUC-Cre-022668	Chlamydomonas reinhardtii	58.08	2.00e-66	244.00
IUUC-Csa-023368	Chlorocebus sabaeus	84.23	0.00e+00	816.00
IUUC-Cho-024731	Choloepus hoffmanni	77.45	0.00e+00	697.00
IUUC-Cin-025359	Ciona intestinalis	50.28	6.00e-107	381.00
IUUC-Csv-025886	Ciona savignyi	68.29	1.00e-87	315.00
IUUC-Dre-027673	Danio rerio	56.49	3.00e-161	561.00
IUUC-Dno-030101	Dasypus novemcinctus	82.00	0.00e+00	781.00
IUUC-Dor-030612	Dipodomys ordii	80.95	0.00e+00	754.00
IUUC-Dme-032198	Drosophila melanogaster	47.02	1.00e-79	290.00
IUUC-Ete-032738	Echinops telfairi	71.92	0.00e+00	650.00
IUUC-Eca-034093	Equus caballus	84.23	0.00e+00	809.00
IUUC-Eeu-034624	Erinaceus europaeus	80.95	0.00e+00	786.00
IUUC-Fca-035542	Felis catus	82.07	0.00e+00	789.00
IUUC-Fal-036770	Ficedula albicollis	74.03	0.00e+00	704.00
IUUC-Gmo-039601	Gadus morhua	54.55	1.00e-149	523.00
IUUC-Gga-040670	Gallus gallus	72.73	0.00e+00	691.00
IUUC-Gac-042013	Gasterosteus aculeatus	54.57	8.00e-155	540.00
IUUC-Gma-043320	Glycine max	44.20	4.00e-77	282.00
IUUC-Ggo-045051	Gorilla gorilla	84.45	0.00e+00	815.00
IUUC-Hsa-046929	Homo sapiens	84.45	0.00e+00	815.00
IUUC-Itr-047967	Ictidomys tridecemlineatus	83.80	0.00e+00	802.00
IUUC-Lch-049884	Latimeria chalumnae	62.26	2.00e-180	625.00
IUUC-Lpe-051425	Leersia perrieri	54.46	2.00e-71	263.00
IUUC-Loc-052568	Lepisosteus oculatus	59.44	1.00e-158	553.00
IUUC-Laf-053435	Loxodonta africana	81.43	0.00e+00	786.00
IUUC-Mcc-055106	Macaca mulatta	84.23	0.00e+00	818.00
IUUC-Mtr-057740	Medicago truncatula	44.38	3.00e-78	286.00
IUUC-Mga-060094	Meleagris gallopavo	73.16	0.00e+00	681.00
IUUC-Mmr-061634	Microcebus murinus	81.43	0.00e+00	770.00
IUUC-Mdo-062862	Monodelphis domestica	74.95	0.00e+00	728.00
IUUC-Mac-065086	Musa acuminata	44.55	2.00e-72	267.00
IUUC-Mpu-066461	Mustela putorius furo	83.73	0.00e+00	806.00
IUUC-Mlu-067443	Myotis lucifugus	81.29	0.00e+00	783.00
IUUC-Nle-069354	Nomascus leucogenys	84.45	0.00e+00	815.00
IUUC-Opr-070818	Ochotona princeps	89.63	2.00e-134	472.00
IUUC-Ont-072430	Oreochromis niloticus	56.30	1.00e-159	556.00
IUUC-Oan-072972	Ornithorhynchus anatinus	79.49	2.00e-95	341.00
IUUC-Ocu-074052	Oryctolagus cuniculus	83.37	0.00e+00	805.00
IUUC-Oba-075331	Oryza barthii	58.73	2.00e-67	250.00
IUUC-Obr-076810	Oryza brachyantha	53.52	6.00e-71	261.00
IUUC-Ogl-077185	Oryza glaberrima	58.73	2.00e-67	250.00
IUUC-Ogu-078014	Oryza glumaepatula	58.73	2.00e-67	250.00
IUUC-Oin-080170	Oryza indica	58.73	2.00e-67	250.00
IUUC-Olo-080561	Oryza longistaminata	58.73	2.00e-67	250.00
IUUC-Ome-081878	Oryza meridionalis	58.73	1.00e-67	250.00
IUUC-Oni-083106	Oryza nivara	58.73	2.00e-67	249.00
IUUC-Opu-083384	Oryza punctata	52.04	2.00e-70	260.00
IUUC-Oru-085240	Oryza rufipogon	58.73	2.00e-67	250.00
IUUC-Osa-086230	Oryza sativa	58.73	1.00e-67	251.00
IUUC-Ola-087525	Oryzias latipes	61.58	4.00e-135	474.00
IUUC-Oga-088657	Otolemur garnettii	83.37	0.00e+00	806.00
IUUC-Oar-089494	Ovis aries	85.31	0.00e+00	828.00
IUUC-Ptr-091189	Pan troglodytes	84.45	0.00e+00	815.00
IUUC-Pan-092071	Papio anubis	84.67	0.00e+00	820.00
IUUC-Psi-092991	Pelodiscus sinensis	73.00	0.00e+00	721.00
IUUC-Pma-094182	Petromyzon marinus	71.43	1.00e-61	228.00
IUUC-Ppa-095743	Physcomitrella patens	54.98	7.00e-71	261.00
IUUC-Pfo-096271	Poecilia formosa	57.08	8.00e-157	546.00
IUUC-Pab-097928	Pongo abelii	81.51	0.00e+00	775.00
IUUC-Pop-098826	Populus trichocarpa	42.39	2.00e-74	273.00
IUUC-Pca-100279	Procavia capensis	76.67	0.00e+00	752.00
IUUC-Ppe-101401	Prunus persica	45.64	3.00e-69	256.00
IUUC-Pva-102713	Pteropus vampyrus	82.07	0.00e+00	786.00
IUUC-Rno-105697	Rattus norvegicus	94.58	0.00e+00	898.00
IUUC-Sha-106956	Sarcophilus harrisii	75.16	0.00e+00	734.00
IUUC-Smo-109070	Selaginella moellendorffii	43.24	1.00e-80	294.00
IUUC-Sit-109821	Setaria italica	44.35	1.00e-73	270.00
IUUC-Sly-110903	Solanum lycopersicum	44.51	5.00e-73	268.00
IUUC-Stu-111930	Solanum tuberosum	44.38	3.00e-72	266.00
IUUC-Sar-113264	Sorex araneus	83.08	0.00e+00	802.00
IUUC-Sbi-114732	Sorghum bicolor	36.36	5.00e-53	202.00
IUUC-Ssc-115435	Sus scrofa	79.53	0.00e+00	759.00
IUUC-Tgu-116761	Taeniopygia guttata	81.33	9.00e-125	439.00
IUUC-Tru-118435	Takifugu rubripes	53.48	2.00e-146	512.00
IUUC-Tsy-119445	Tarsius syrichta	77.97	0.00e+00	728.00
IUUC-Tni-119948	Tetraodon nigroviridis	70.22	2.00e-98	351.00
IUUC-Tca-121332	Theobroma cacao	44.83	5.00e-73	269.00
IUUC-Tae-123925	Triticum aestivum	42.27	2.00e-71	263.00
IUUC-Tur-126833	Triticum urartu	51.83	6.00e-68	252.00
IUUC-Tbe-127826	Tupaia belangeri	77.32	0.00e+00	715.00
IUUC-Ttr-129116	Tursiops truncatus	90.62	2.00e-145	508.00
IUUC-Vpa-130588	Vicugna pacos	82.94	0.00e+00	776.00
IUUC-Vvi-130898	Vitis vinifera	45.31	1.00e-74	273.00
IUUC-Xtr-132571	Xenopus tropicalis	62.47	5.00e-177	613.00
IUUC-Xma-133755	Xiphophorus maculatus	55.34	1.00e-154	539.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence