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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045675
Ensembl Protein ID ENSP00000423067.2
UniProt Accession Q8NI36; A2RUS4; Q68E02; Q8N1Q2; WDR36_HUMAN
Genbank Protein ID AAM43838.1; AAI33026.1; AAI36518.1; BAC04527.1; CAH18068.1
Protein Name WD repeat-containing protein 36; T-cell activation WD repeat-containing protein
Genbank Nucleotide ID AF385437; BC133025; BC136517; AK095312; CR749211
Gene Name WDR36
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000134987.11 ENST00000506538.6 ENSP00000423067.2
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.20e-20 71.9 620 656
UBD/Beta-Prp 1.20e-48 167.5 491 660
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvl 35
           gH++ ++++af +d + l+s++ D++i+ WDl +g l
   Q: 620  GHQGQINDMAFsPDgRWLISAAMDCSIRTWDLPSGCL 656
           8***********99999***************99976 PP
   

   UBD/Beta-Prp
   S: 91   kghedsvlslsfspsgdklvsGshdrtirvwdletgqclee..tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgght 180
           k+ + +++++++   g++ v+G +  t+ v+++++g    +   ++ h+g+v++v+v++ ++l v+ +  + +++W+ k++ l++  +    
   Q: 491  KKDDITATAVDITSCGNFAVIGLSSGTVDVYNMQSGIHRGSfgKDQAHKGSVRGVAVDGLNQLTVTTGSEGLLKFWNFKNKILIHSVSL--S 580
           4444455667777788*******************998887889*******************************************75..6 PP
   S: 181  dsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktl 260
           +s + + +++++  l  + +d ++ + d++t ++vr++ gh+ ++++++fsp++ +l+s+++D sir Wdl sg l+ ++
   Q: 581  SSPNIMLLHRDSGILGLALDDFSISVLDIETRKIVREFSGHQGQINDMAFSPDGRWLISAAMDCSIRTWDLPSGCLIDCF 660
           6677777788889999999****************************************************999777666 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.
 Involved in the nucleolar processing of SSU 18S rRNA. Involved in T-cell activation and highly coregulated with IL2.
Protein Sequence
(Fasta)
MCCTEGSLRK RDSQRAPEAV LCLQLWQRTV PLDTLKGLGT CFPSGPELRG AGIAAAMERA 60
SERRTASALF AGFRALGLFS NDIPHVVRFS ALKRRFYVTT CVGKSFHTYD VQKLSLVAVS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045675|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCAAGGAATA CTGACTTAAT CCAGGAATCC CAATAACATT TAATATTTAT CTTCCTTTTC 60
TGGGAGGAAT CTACACTTAT CCAAGTTGCC CAAGTGAGCA GTTCCCTCCC CACAAGTAAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045675|E3,WD_repeat;UBD,Beta-Prp|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0225--Disease mutation
KW-0955--Glaucoma
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0690--Ribosome biogenesis
KW-0698--rRNA processing
KW-0716--Sensory transduction
KW-0844--Vision
KW-0853--WD repeat
Interpro

IPR024977--Apc4_WD40_dom
IPR007319--SSU_processome_Utp21
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12894--ANAPC4_WD40
PF04192--Utp21
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0034388--C:Pwp2p-containing subcomplex of 90S preribosome
GO:0032040--C:small-subunit processome
GO:0003723--F:RNA binding
GO:0030516--P:regulation of axon extension
GO:0050896--P:response to stimulus
GO:0001895--P:retina homeostasis
GO:0006364--P:rRNA processing
GO:0007601--P:visual perception
KEGG hsa:134430
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001096 Aegilops tauschii 35.57 9.00e-146 511.00
IUUC-Aml-002289 Ailuropoda melanoleuca 91.96 0.00e+00 1738.00
IUUC-Atr-002859 Amborella trichopoda 32.44 6.00e-123 435.00
IUUC-Apl-003505 Anas platyrhynchos 74.08 0.00e+00 1216.00
IUUC-Aca-004339 Anolis carolinensis 72.64 0.00e+00 1299.00
IUUC-Aly-005913 Arabidopsis lyrata 36.62 1.00e-156 547.00
IUUC-Ath-006767 Arabidopsis thaliana 36.66 7.00e-160 558.00
IUUC-Ago-007763 Ashbya gossypii 32.50 2.00e-120 427.00
IUUC-Acl-008275 Aspergillus clavatus 32.96 3.00e-90 326.00
IUUC-Afl-008457 Aspergillus flavus 32.54 7.00e-90 325.00
IUUC-Afu-008914 Aspergillus fumigatus 33.50 3.00e-104 373.00
IUUC-Ani-009225 Aspergillus nidulans 32.11 1.00e-102 367.00
IUUC-Aor-010046 Aspergillus oryzae 31.81 1.00e-114 408.00
IUUC-Ate-010337 Aspergillus terreus 32.57 4.00e-115 409.00
IUUC-Ame-010963 Astyanax mexicanus 67.49 0.00e+00 1214.00
IUUC-Bgr-011973 Blumeria graminis 30.17 3.00e-112 400.00
IUUC-Bta-012462 Bos taurus 88.76 0.00e+00 1659.00
IUUC-Bci-013940 Botrytis cinerea 31.23 2.00e-113 404.00
IUUC-Bdi-014725 Brachypodium distachyon 35.01 3.00e-148 519.00
IUUC-Bol-016534 Brassica oleracea 35.81 3.00e-152 532.00
IUUC-Bra-016781 Brassica rapa 35.56 2.00e-150 526.00
IUUC-Cel-018581 Caenorhabditis elegans 29.24 7.00e-96 345.00
IUUC-Cja-019675 Callithrix jacchus 97.32 0.00e+00 1750.00
IUUC-Cfa-020118 Canis familiaris 92.36 0.00e+00 1644.00
IUUC-Cpo-021798 Cavia porcellus 93.00 0.00e+00 1620.00
IUUC-Cre-022566 Chlamydomonas reinhardtii 30.51 1.00e-28 121.00
IUUC-Csa-023547 Chlorocebus sabaeus 98.81 0.00e+00 1796.00
IUUC-Cho-024518 Choloepus hoffmanni 78.00 0.00e+00 1329.00
IUUC-Cin-025339 Ciona intestinalis 46.24 0.00e+00 789.00
IUUC-Cgl-026476 Colletotrichum gloeosporioides 29.37 4.00e-112 399.00
IUUC-Cne-026859 Cryptococcus neoformans 35.08 3.00e-146 512.00
IUUC-Cme-027173 Cyanidioschyzon merolae 28.19 2.00e-86 313.00
IUUC-Dre-027733 Danio rerio 64.70 0.00e+00 1193.00
IUUC-Dno-029439 Dasypus novemcinctus 92.74 0.00e+00 1654.00
IUUC-Dor-030329 Dipodomys ordii 77.37 0.00e+00 1389.00
IUUC-Dse-031511 Dothistroma septosporum 29.23 1.00e-103 371.00
IUUC-Dme-031694 Drosophila melanogaster 39.65 0.00e+00 690.00
IUUC-Ete-032930 Echinops telfairi 81.67 0.00e+00 1374.00
IUUC-Eca-033302 Equus caballus 91.99 0.00e+00 1739.00
IUUC-Eeu-034516 Erinaceus europaeus 89.37 0.00e+00 1729.00
IUUC-Fca-036064 Felis catus 94.32 0.00e+00 1664.00
IUUC-Fal-037024 Ficedula albicollis 71.86 0.00e+00 1296.00
IUUC-Fox-037787 Fusarium oxysporum 29.01 3.00e-94 340.00
IUUC-Fso-038378 Fusarium solani 29.11 1.00e-96 348.00
IUUC-Gmo-039637 Gadus morhua 53.05 3.00e-155 541.00
IUUC-Ggr-040108 Gaeumannomyces graminis 29.37 3.00e-105 377.00
IUUC-Gga-040982 Gallus gallus 72.70 0.00e+00 1328.00
IUUC-Gac-041565 Gasterosteus aculeatus 56.71 0.00e+00 961.00
IUUC-Gma-043414 Glycine max 34.90 2.00e-153 536.00
IUUC-Ggo-045463 Gorilla gorilla 98.95 0.00e+00 1890.00
IUUC-Hvu-047352 Hordeum vulgare 34.97 2.00e-132 467.00
IUUC-Itr-048088 Ictidomys tridecemlineatus 93.31 0.00e+00 1708.00
IUUC-Kpa-049164 Komagataella pastoris 33.16 2.00e-113 403.00
IUUC-Lch-050476 Latimeria chalumnae 69.02 0.00e+00 1278.00
IUUC-Lpe-051556 Leersia perrieri 28.78 5.00e-96 345.00
IUUC-Loc-052820 Lepisosteus oculatus 68.83 0.00e+00 1240.00
IUUC-Lma-052961 Leptosphaeria maculans 32.30 4.00e-106 379.00
IUUC-Laf-054006 Loxodonta africana 90.91 0.00e+00 1622.00
IUUC-Mcc-055037 Macaca mulatta 97.69 0.00e+00 1860.00
IUUC-Mor-057280 Magnaporthe oryzae 29.81 5.00e-108 386.00
IUUC-Mpo-057408 Magnaporthe poae 29.13 5.00e-101 362.00
IUUC-Mtr-058473 Medicago truncatula 34.03 6.00e-151 528.00
IUUC-Mla-058892 Melampsora laricipopulina 33.64 1.00e-118 420.00
IUUC-Mga-059598 Meleagris gallopavo 61.42 0.00e+00 1025.00
IUUC-Mvi-060334 Microbotryum violaceum 34.92 7.00e-120 425.00
IUUC-Mmr-061239 Microcebus murinus 91.89 0.00e+00 1725.00
IUUC-Mdo-062471 Monodelphis domestica 81.08 0.00e+00 1430.00
IUUC-Mmu-063872 Mus musculus 88.75 0.00e+00 1649.00
IUUC-Mac-064631 Musa acuminata 34.82 2.00e-134 473.00
IUUC-Mpu-066039 Mustela putorius furo 94.41 0.00e+00 1716.00
IUUC-Mlu-067485 Myotis lucifugus 93.89 0.00e+00 1701.00
IUUC-Nfi-068319 Neosartorya fischeri 30.35 4.00e-102 366.00
IUUC-Ncr-068725 Neurospora crassa 29.34 6.00e-101 362.00
IUUC-Nle-069050 Nomascus leucogenys 98.63 0.00e+00 1891.00
IUUC-Opr-070437 Ochotona princeps 80.41 5.00e-140 491.00
IUUC-Ont-071574 Oreochromis niloticus 58.67 0.00e+00 1039.00
IUUC-Oan-072826 Ornithorhynchus anatinus 75.03 0.00e+00 1350.00
IUUC-Ocu-073995 Oryctolagus cuniculus 94.08 0.00e+00 1634.00
IUUC-Oba-075407 Oryza barthii 32.27 1.00e-120 427.00
IUUC-Obr-076451 Oryza brachyantha 35.60 1.00e-155 544.00
IUUC-Ogl-077535 Oryza glaberrima 35.15 7.00e-149 521.00
IUUC-Ogu-077995 Oryza glumaepatula 31.83 2.00e-119 423.00
IUUC-Oin-079431 Oryza indica 35.46 4.00e-151 528.00
IUUC-Olo-080495 Oryza longistaminata 31.82 5.00e-117 416.00
IUUC-Oni-082336 Oryza nivara 34.28 5.00e-139 488.00
IUUC-Opu-084028 Oryza punctata 33.22 3.00e-125 442.00
IUUC-Oru-084500 Oryza rufipogon 31.89 3.00e-118 419.00
IUUC-Osa-086242 Oryza sativa 35.35 4.00e-151 528.00
IUUC-Ola-086612 Oryzias latipes 55.76 0.00e+00 813.00
IUUC-Olu-087703 Ostreococcus lucimarinus 30.83 1.00e-109 391.00
IUUC-Oga-088572 Otolemur garnettii 92.33 0.00e+00 1661.00
IUUC-Oar-090363 Ovis aries 91.84 0.00e+00 1681.00
IUUC-Ptr-090477 Pan troglodytes 99.47 0.00e+00 1874.00
IUUC-Pan-092914 Papio anubis 98.88 0.00e+00 1774.00
IUUC-Psi-093019 Pelodiscus sinensis 73.49 0.00e+00 1323.00
IUUC-Pma-094303 Petromyzon marinus 50.64 0.00e+00 795.00
IUUC-Pno-094938 Phaeosphaeria nodorum 31.95 3.00e-99 356.00
IUUC-Ppa-095720 Physcomitrella patens 34.88 2.00e-150 526.00
IUUC-Pfo-097034 Poecilia formosa 57.06 0.00e+00 986.00
IUUC-Pab-097669 Pongo abelii 98.88 0.00e+00 1771.00
IUUC-Pop-098835 Populus trichocarpa 34.68 3.00e-149 522.00
IUUC-Pca-101097 Procavia capensis 80.24 0.00e+00 638.00
IUUC-Ppe-101430 Prunus persica 34.39 2.00e-153 536.00
IUUC-Pva-103152 Pteropus vampyrus 90.40 0.00e+00 1744.00
IUUC-Pgr-103517 Puccinia graminis 31.36 2.00e-124 440.00
IUUC-Ptt-103697 Puccinia triticina 32.46 2.00e-99 357.00
IUUC-Pte-104121 Pyrenophora teres 30.55 1.00e-106 381.00
IUUC-Pyt-104672 Pyrenophora triticirepentis 30.95 1.00e-108 387.00
IUUC-Rno-105435 Rattus norvegicus 89.07 0.00e+00 1619.00
IUUC-Sce-106202 Saccharomyces cerevisiae 31.88 2.00e-111 397.00
IUUC-Sha-107272 Sarcophilus harrisii 81.19 0.00e+00 1377.00
IUUC-Sja-107744 Schizosaccharomyces japonicus 36.13 4.00e-152 532.00
IUUC-Spo-108256 Schizosaccharomyces pombe 35.90 2.00e-151 530.00
IUUC-Ssl-108618 Sclerotinia sclerotiorum 31.07 1.00e-112 400.00
IUUC-Smo-108762 Selaginella moellendorffii 35.95 2.00e-156 546.00
IUUC-Sit-110051 Setaria italica 35.20 2.00e-149 523.00
IUUC-Sly-111181 Solanum lycopersicum 34.71 2.00e-153 536.00
IUUC-Stu-112018 Solanum tuberosum 34.27 1.00e-152 533.00
IUUC-Sar-113348 Sorex araneus 88.94 0.00e+00 1162.00
IUUC-Sbi-114282 Sorghum bicolor 35.38 1.00e-149 524.00
IUUC-Sre-114946 Sporisorium reilianum 32.27 3.00e-94 340.00
IUUC-Ssc-115287 Sus scrofa 90.21 0.00e+00 1721.00
IUUC-Tgu-117138 Taeniopygia guttata 68.50 0.00e+00 1090.00
IUUC-Tru-118232 Takifugu rubripes 58.36 0.00e+00 1011.00
IUUC-Tsy-119502 Tarsius syrichta 77.60 0.00e+00 1407.00
IUUC-Tni-120378 Tetraodon nigroviridis 57.29 0.00e+00 988.00
IUUC-Tca-121506 Theobroma cacao 35.04 6.00e-145 508.00
IUUC-Tre-122166 Trichoderma reesei 29.15 4.00e-105 376.00
IUUC-Tvi-122385 Trichoderma virens 29.34 1.00e-105 378.00
IUUC-Tae-122836 Triticum aestivum 34.85 3.00e-151 529.00
IUUC-Tur-126490 Triticum urartu 32.02 2.00e-112 400.00
IUUC-Tme-127157 Tuber melanosporum 33.52 4.00e-113 402.00
IUUC-Tbe-127981 Tupaia belangeri 85.80 0.00e+00 1441.00
IUUC-Ttr-128886 Tursiops truncatus 89.99 0.00e+00 1701.00
IUUC-Uma-129439 Ustilago maydis 31.87 3.00e-101 363.00
IUUC-Vda-129760 Verticillium dahliae 29.11 7.00e-103 369.00
IUUC-Vpa-130456 Vicugna pacos 91.25 0.00e+00 1735.00
IUUC-Vvi-131086 Vitis vinifera 34.10 3.00e-147 516.00
IUUC-Xtr-131829 Xenopus tropicalis 68.35 0.00e+00 1241.00
IUUC-Xma-133588 Xiphophorus maculatus 57.06 0.00e+00 970.00
IUUC-Yli-134328 Yarrowia lipolytica 31.24 1.00e-111 397.00
IUUC-Zma-135808 Zea mays 34.89 1.00e-148 520.00
Created Date 25-Jun-2017

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