iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074652

Ensembl Protein ID

ENSOCUP00000021438.2

UniProt Accession

G1TWJ2; G1TWJ2_RABIT

Genbank Protein ID

ENSOCUP00000021438

Protein Name

Presenilin

Genbank Nucleotide ID

AAGW02026632

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000021898.2	ENSOCUT00000025548.2	ENSOCUP00000021438.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	4.40e-08	33.0	358	396

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeantgsleaavnnLL 40
           +eta+e++++iFP+l+ys+ +v+ + +++ +++++++L 
   Q: 358  VETAQERNEPIFPALIYSSAMVWTVGMAKLDPSSQGALQ 396
           89********************************99985 PP

Organism

Oryctolagus cuniculus

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MQKVLAQWGR PGARSRARTA QAPPRQRLRA APAVEGRRRQ PRGGAGPRRG GACEGAGSVS 60
GNCATGLRLV AEAGAARGRV MLTFMASDSE EEVCDERTSL MSAESPTPHS CQEGRRGPED 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTTTTTTAT TTTTAAGTAA AGCTACTCAG ACAACGCCCA ATTATTGACA CTCTCAACGC 60
ATCTCCCCCT GACCCCCGCA AGGGTCCTCC AATCCCGAAA TCGCAGTCCC CAAGGTCAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN
PR01074--PRESENILIN2

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0005637--C:nuclear inner membrane
GO:0004190--F:aspartic-type endopeptidase activity
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	86.59	2.00e-176	612.00
IUUC-Apl-003959	Anas platyrhynchos	76.06	7.00e-162	563.00
IUUC-Aca-005160	Anolis carolinensis	75.22	3.00e-160	558.00
IUUC-Ame-010686	Astyanax mexicanus	79.69	2.00e-147	514.00
IUUC-Bta-013097	Bos taurus	93.99	0.00e+00	702.00
IUUC-Cja-018824	Callithrix jacchus	92.75	0.00e+00	720.00
IUUC-Cfa-020253	Canis familiaris	93.75	0.00e+00	720.00
IUUC-Cpo-021401	Cavia porcellus	94.24	0.00e+00	728.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	32.92	6.00e-30	125.00
IUUC-Csa-023369	Chlorocebus sabaeus	95.09	0.00e+00	734.00
IUUC-Dre-028526	Danio rerio	69.60	1.00e-144	506.00
IUUC-Dor-031127	Dipodomys ordii	90.62	0.00e+00	676.00
IUUC-Ete-033081	Echinops telfairi	82.98	5.00e-91	328.00
IUUC-Eca-034387	Equus caballus	93.85	0.00e+00	692.00
IUUC-Eeu-034846	Erinaceus europaeus	77.97	2.00e-145	508.00
IUUC-Fca-035396	Felis catus	93.16	0.00e+00	741.00
IUUC-Fal-037457	Ficedula albicollis	75.97	2.00e-159	555.00
IUUC-Gga-040706	Gallus gallus	75.70	4.00e-157	547.00
IUUC-Gac-042511	Gasterosteus aculeatus	66.74	2.00e-130	459.00
IUUC-Ggo-045338	Gorilla gorilla	94.73	0.00e+00	745.00
IUUC-Hsa-046455	Homo sapiens	94.73	0.00e+00	746.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	95.31	0.00e+00	736.00
IUUC-Lch-049638	Latimeria chalumnae	68.75	4.00e-145	507.00
IUUC-Loc-052427	Lepisosteus oculatus	73.74	1.00e-157	548.00
IUUC-Laf-053758	Loxodonta africana	89.36	0.00e+00	714.00
IUUC-Mcc-054755	Macaca mulatta	93.87	0.00e+00	739.00
IUUC-Mmr-060890	Microcebus murinus	93.75	0.00e+00	719.00
IUUC-Mdo-062197	Monodelphis domestica	80.22	7.00e-174	603.00
IUUC-Mmu-063823	Mus musculus	94.20	0.00e+00	731.00
IUUC-Mac-064858	Musa acuminata	43.27	6.00e-23	101.00
IUUC-Mpu-066181	Mustela putorius furo	93.97	0.00e+00	720.00
IUUC-Nle-069596	Nomascus leucogenys	94.43	0.00e+00	684.00
IUUC-Opr-070344	Ochotona princeps	94.93	0.00e+00	764.00
IUUC-Ont-071867	Oreochromis niloticus	71.17	2.00e-132	465.00
IUUC-Oan-073378	Ornithorhynchus anatinus	75.54	2.00e-155	541.00
IUUC-Ola-086707	Oryzias latipes	69.65	4.00e-106	377.00
IUUC-Oga-088560	Otolemur garnettii	93.79	0.00e+00	691.00
IUUC-Oar-089200	Ovis aries	92.65	0.00e+00	685.00
IUUC-Ptr-090569	Pan troglodytes	94.87	0.00e+00	732.00
IUUC-Pan-091742	Papio anubis	95.09	0.00e+00	734.00
IUUC-Psi-093297	Pelodiscus sinensis	76.32	5.00e-131	460.00
IUUC-Pma-094612	Petromyzon marinus	77.04	1.00e-126	446.00
IUUC-Ppa-095431	Physcomitrella patens	31.47	6.00e-27	115.00
IUUC-Pab-098531	Pongo abelii	95.09	0.00e+00	734.00
IUUC-Pca-101120	Procavia capensis	91.85	0.00e+00	712.00
IUUC-Pva-102934	Pteropus vampyrus	84.93	0.00e+00	688.00
IUUC-Rno-106052	Rattus norvegicus	92.63	0.00e+00	738.00
IUUC-Sha-106876	Sarcophilus harrisii	79.65	3.00e-172	597.00
IUUC-Sly-110865	Solanum lycopersicum	58.18	3.00e-08	50.10
IUUC-Ssc-115380	Sus scrofa	95.76	0.00e+00	759.00
IUUC-Tgu-117280	Taeniopygia guttata	76.46	1.00e-159	555.00
IUUC-Tbe-127632	Tupaia belangeri	93.93	1.00e-179	622.00
IUUC-Ttr-129008	Tursiops truncatus	94.01	0.00e+00	721.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence