iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Laf-054005

UUCD1 version

UUC-LoA-00408

Ensembl Protein ID

ENSLAFP00000010016.3

UniProt Accession

G3T8J4; G3T8J4_LOXAF

Protein Name

Uncharacterized protein

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000011976.3	ENSLAFT00000011986.3	ENSLAFP00000010016.3
ENSLAFG00000011976.3	ENSLAFT00000036108.1	ENSLAFP00000023011.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-121	406.6	1236	1568

Active Site

Position(s)	Description	Evidence
1536	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1236 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1321
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1322 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1404
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1405 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1491
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1492 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1568
           **************************************************************************985 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MASSAREHLL FVRRRNPQMR YTLSPENLQS LAAQSSMPEN MTLQRANSDT DLVTSESRSS 60
LTASMYEYTL GQAQNLIIFW DIKEEVDPSD WIGLYHIDEN SPANFWDSKN RGVTGTQKGQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTAGCT CAGCCCGGGA ACATCTGCTT TTTGTGCGGC GTCGAAATCC CCAGATGCGC 60
TACACACTGA GCCCTGAGAA CCTCCAGAGC CTTGCTGCCC AGAGCTCCAT GCCGGAGAAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	95.61	0.00e+00	2962.00
IUUC-Apl-003935	Anas platyrhynchos	85.98	0.00e+00	2719.00
IUUC-Aca-004558	Anolis carolinensis	83.51	0.00e+00	2640.00
IUUC-Ame-010893	Astyanax mexicanus	88.33	0.00e+00	1307.00
IUUC-Bta-013093	Bos taurus	96.34	0.00e+00	1581.00
IUUC-Cja-019651	Callithrix jacchus	94.90	0.00e+00	2835.00
IUUC-Cfa-021232	Canis familiaris	99.37	0.00e+00	1632.00
IUUC-Cpo-021770	Cavia porcellus	89.38	0.00e+00	2798.00
IUUC-Csa-023970	Chlorocebus sabaeus	95.30	0.00e+00	2925.00
IUUC-Cho-024512	Choloepus hoffmanni	88.05	0.00e+00	2625.00
IUUC-Csv-026127	Ciona savignyi	72.27	3.00e-155	541.00
IUUC-Dre-028275	Danio rerio	85.34	0.00e+00	1486.00
IUUC-Dno-029963	Dasypus novemcinctus	95.10	0.00e+00	2800.00
IUUC-Dor-030282	Dipodomys ordii	88.78	0.00e+00	1972.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	660.00
IUUC-Ete-033132	Echinops telfairi	83.71	0.00e+00	1269.00
IUUC-Eca-033978	Equus caballus	94.47	0.00e+00	2924.00
IUUC-Eeu-035278	Erinaceus europaeus	63.60	0.00e+00	1188.00
IUUC-Fca-036157	Felis catus	95.55	0.00e+00	2930.00
IUUC-Fal-037110	Ficedula albicollis	83.98	0.00e+00	2386.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1017.00
IUUC-Gga-040821	Gallus gallus	86.08	0.00e+00	2712.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.54	0.00e+00	1893.00
IUUC-Ggo-044862	Gorilla gorilla	95.63	0.00e+00	2836.00
IUUC-Hsa-046219	Homo sapiens	95.80	0.00e+00	2992.00
IUUC-Lch-050526	Latimeria chalumnae	77.80	0.00e+00	2434.00
IUUC-Loc-052648	Lepisosteus oculatus	86.71	0.00e+00	1533.00
IUUC-Mcc-055314	Macaca mulatta	95.36	0.00e+00	2917.00
IUUC-Meu-056356	Macropus eugenii	70.32	0.00e+00	1138.00
IUUC-Mga-060074	Meleagris gallopavo	85.92	0.00e+00	2612.00
IUUC-Mmr-061526	Microcebus murinus	95.23	0.00e+00	2901.00
IUUC-Mdo-063017	Monodelphis domestica	91.67	0.00e+00	2820.00
IUUC-Mmu-064165	Mus musculus	93.79	0.00e+00	2894.00
IUUC-Mpu-065835	Mustela putorius furo	82.85	0.00e+00	1576.00
IUUC-Mlu-067709	Myotis lucifugus	89.77	0.00e+00	2752.00
IUUC-Nle-069308	Nomascus leucogenys	95.61	0.00e+00	2955.00
IUUC-Opr-070330	Ochotona princeps	81.56	0.00e+00	2378.00
IUUC-Ont-071345	Oreochromis niloticus	78.07	0.00e+00	1459.00
IUUC-Ocu-074775	Oryctolagus cuniculus	94.38	0.00e+00	2627.00
IUUC-Ola-087225	Oryzias latipes	64.14	0.00e+00	1847.00
IUUC-Oga-088177	Otolemur garnettii	93.34	0.00e+00	2801.00
IUUC-Oar-089452	Ovis aries	95.36	0.00e+00	2935.00
IUUC-Ptr-090806	Pan troglodytes	96.25	0.00e+00	2984.00
IUUC-Pan-091838	Papio anubis	95.17	0.00e+00	2800.00
IUUC-Psi-094090	Pelodiscus sinensis	85.82	0.00e+00	2705.00
IUUC-Pfo-096520	Poecilia formosa	68.37	0.00e+00	1531.00
IUUC-Pab-098405	Pongo abelii	95.74	0.00e+00	2961.00
IUUC-Pca-100441	Procavia capensis	91.85	0.00e+00	2333.00
IUUC-Pva-102324	Pteropus vampyrus	98.99	0.00e+00	1628.00
IUUC-Rno-105943	Rattus norvegicus	93.48	0.00e+00	2970.00
IUUC-Sha-106985	Sarcophilus harrisii	88.56	0.00e+00	2346.00
IUUC-Sar-113505	Sorex araneus	95.45	0.00e+00	1541.00
IUUC-Ssc-115439	Sus scrofa	94.44	0.00e+00	1947.00
IUUC-Tgu-117078	Taeniopygia guttata	91.60	0.00e+00	1773.00
IUUC-Tru-118671	Takifugu rubripes	83.16	0.00e+00	1450.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.69	0.00e+00	1430.00
IUUC-Tbe-127975	Tupaia belangeri	92.77	0.00e+00	2434.00
IUUC-Ttr-128469	Tursiops truncatus	90.15	0.00e+00	2654.00
IUUC-Vpa-130498	Vicugna pacos	85.78	0.00e+00	2455.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence