iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tur-126189

Ensembl Protein ID

TRIUR3_10883-P1

UniProt Accession

M8B3J8; M8B3J8_TRIUA

Genbank Protein ID

EMS68144.1

Protein Name

Ubiquitin-activating enzyme E1 2

Genbank Nucleotide ID

KD010878

Gene Name

TRIUR3_10883

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TRIUR3_10883	TRIUR3_10883-T1	TRIUR3_10883-P1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E1	1.20e-172	575.5	409	897

Active Site

Position(s)	Description	Evidence
590	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU10132}

Domain Profile

   S: 1    YDRQirlwGeeaqeklksakvllvGagglGcEllKnLvlaGv.....gsitvvDmdtvevsnlnrqFLfraedvgksKAevaaealkelnpdvn 89
           YD Qi ++G++ q+kl++ak+++vG g+lGcE+lKnL+l+G+     g++tv+D+d +e+snl+rqFLfr++++g++K+ vaa a+  +np+ +
   Q: 409  YDAQISVFGSKLQNKLEQAKIFMVGSGALGCEFLKNLALMGIscsqnGKLTVTDDDVIEKSNLSRQFLFRDWNIGQPKSTVAATAAMAINPKLH 502
           ********************************************************************************************** PP
   S: 90   veaheesiteleeeiv...FfkkfdvVvlaldnrearrkvnrlclnarvpliesgtlGllGqvrviikgltecyscsddppqktiPfctlketp 180
           vea +++ ++++e+++   F +++d Vv+aldn+ ar++++++c++ ++pl+esgtlG + +++ +i++lte y +s+dpp+k++P+ct+ ++p
   Q: 503  VEALQNRASPETENVFndaFWENLDAVVNALDNVTARMYIDSRCVYFQKPLLESGTLGAKCNTQMVIPHLTENYGASRDPPEKQAPMCTVHSFP 596
           **************99****************************************************************************** PP
   S: 181  naaehtiewa............vlfnklleeeageeevlekldseekeegkdkvkselksedeenfeeaieiavkafakttinsikqllksfec 262
            +++h+++wa              +n +l++ ++ +  +     ++ ++ +++v + l + + e+f+++i++a+ +f+ +++n +kql+  f+ 
   Q: 597  HNIDHCLTWArsefegllektpTEVNGFLSNPSAYVAAARTAGDAQARDQLERVIECLHGDKCETFQDCITWARLKFEDYFSNRVKQLTYTFPE 690
           ***************999999988888888888888888888899999999999999999********************************** PP
   S: 263  divtkskspfwv...........................................................sfcsnaealqvpekvekdeevvk 297
           d +t+s++pfw+                                                             +++  ++ ++ek+++   ++ 
   Q: 691  DSMTSSGAPFWSapkrfprplefsstdpsqlnfilaasilraetfgipipdwaktpnkvaaeavdkvivpeFQPKQGVKIVTDEKATSISSASV 784
           ****************************************************988888888888776666222333344444555555544443 PP
   S: 298  asap..lylllralerfekk..kgrkpgelsfekddds..avdlvtaaanlraeslgiepkldddlikeiagniipaiattnavvgGlaaqEvi 385
           ++ +  ++ l+++le+ +k+  +g  ++ ++fekddd   ++d+++ +an+ra +++i++ +d+ + k iag+iipaiat +a+  Gl+++E++
   Q: 785  DD-AgvIEELITKLEQISKTlpPGFHMNPIQFEKDDDTnfHMDVIAGFANMRARNYSIPE-VDKLKAKFIAGRIIPAIATATAMATGLVCLELY 876
           33.369************976689************************************.********************************* PP
   S: 386  Kvvsg..kfeplknfflfdae 404
           Kv+ g  k e ++n+f ++a+
   Q: 877  KVLAGrhKVEDYRNTFANLAI 897
           *****9999*******99876 PP

Organism

Triticum urartu

Protein Sequence
(Fasta)

MARPTEIDED LHSRQLAVYG RETMKRLFAS NVLVSGLQGL GAEIAKNLVL AGVKSVTLHD 60
DGNVELWDLS SNFFLSEKDV GQNRAQACVL KLQDLNNAVV ISTLTGDLTK EHLSKFQAVV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCAGGC CCACGGAGAT CGACGAGGAC CTCCACAGCC GCCAGCTCGC CGTGTACGGC 60
CGCGAGACCA TGAAGCGTCT CTTCGCCTCC AACGTCCTCG TCTCCGGGCT CCAGGGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0436--Ligase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR032420--E1_4HB
IPR032418--E1_FCCH
IPR016040--NAD(P)-bd_dom
IPR000594--ThiF_NAD_FAD-bd
IPR018965--Ub-activating_enz_E1_C
IPR019572--UBA_E1_Cys
IPR018075--UBQ-activ_enz_E1
IPR018074--UBQ-activ_enz_E1_CS
IPR033127--UBQ-activ_enz_E1_Cys_AS
IPR000011--UBQ/SUMO-activ_enz_E1-like

PROSITE

PS00536--UBIQUITIN_ACTIVAT_1
PS00865--UBIQUITIN_ACTIVAT_2

Pfam

PF16191--E1_4HB
PF16190--E1_FCCH
PF09358--E1_UFD
PF00899--ThiF
PF10585--UBA_e1_thiolCys

PRINTS

PR01849--UBIQUITINACT

SMART

SM00985--UBA_e1_C

Gene Ontology

GO:0005524--F:ATP binding
GO:0008641--F:small protein activating enzyme activity
GO:0006464--P:cellular protein modification process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000367	Aegilops tauschii	99.11	0.00e+00	1943.00
IUUC-Aml-001311	Ailuropoda melanoleuca	45.84	0.00e+00	888.00
IUUC-Ago-007873	Ashbya gossypii	45.53	0.00e+00	813.00
IUUC-Acl-008181	Aspergillus clavatus	45.30	0.00e+00	810.00
IUUC-Afl-008455	Aspergillus flavus	46.21	0.00e+00	804.00
IUUC-Afu-009065	Aspergillus fumigatus	45.97	0.00e+00	845.00
IUUC-Ani-009371	Aspergillus nidulans	46.20	0.00e+00	810.00
IUUC-Ang-009737	Aspergillus niger	46.60	0.00e+00	821.00
IUUC-Aor-010007	Aspergillus oryzae	46.21	0.00e+00	805.00
IUUC-Ate-010466	Aspergillus terreus	46.67	0.00e+00	858.00
IUUC-Bta-012767	Bos taurus	46.15	0.00e+00	897.00
IUUC-Bci-013721	Botrytis cinerea	45.82	0.00e+00	799.00
IUUC-Bdi-014843	Brachypodium distachyon	95.37	0.00e+00	1871.00
IUUC-Cel-018260	Caenorhabditis elegans	39.16	0.00e+00	651.00
IUUC-Cja-019152	Callithrix jacchus	45.96	0.00e+00	890.00
IUUC-Cpo-022526	Cavia porcellus	46.40	0.00e+00	885.00
IUUC-Csa-023780	Chlorocebus sabaeus	46.15	0.00e+00	895.00
IUUC-Cne-026960	Cryptococcus neoformans	44.75	0.00e+00	842.00
IUUC-Dre-028149	Danio rerio	47.20	0.00e+00	875.00
IUUC-Dno-028884	Dasypus novemcinctus	46.01	0.00e+00	887.00
IUUC-Dor-030229	Dipodomys ordii	44.13	0.00e+00	840.00
IUUC-Fox-038007	Fusarium oxysporum	47.34	6.00e-137	479.00
IUUC-Fso-038339	Fusarium solani	47.06	0.00e+00	838.00
IUUC-Ggr-039823	Gaeumannomyces graminis	45.11	0.00e+00	852.00
IUUC-Ggo-045336	Gorilla gorilla	46.06	0.00e+00	876.00
IUUC-Hsa-045982	Homo sapiens	45.96	0.00e+00	873.00
IUUC-Hvu-047418	Hordeum vulgare	98.13	0.00e+00	1954.00
IUUC-Itr-048460	Ictidomys tridecemlineatus	46.06	0.00e+00	892.00
IUUC-Kpa-049112	Komagataella pastoris	46.35	0.00e+00	831.00
IUUC-Loc-052936	Lepisosteus oculatus	47.06	0.00e+00	883.00
IUUC-Laf-053948	Loxodonta africana	46.69	0.00e+00	871.00
IUUC-Mcc-055843	Macaca mulatta	46.06	0.00e+00	892.00
IUUC-Meu-056258	Macropus eugenii	46.11	0.00e+00	880.00
IUUC-Mor-057269	Magnaporthe oryzae	44.90	0.00e+00	840.00
IUUC-Mpo-057435	Magnaporthe poae	45.41	0.00e+00	841.00
IUUC-Mla-059176	Melampsora laricipopulina	46.50	0.00e+00	866.00
IUUC-Mdo-062032	Monodelphis domestica	44.74	0.00e+00	857.00
IUUC-Mmu-063721	Mus musculus	45.57	0.00e+00	883.00
IUUC-Mac-065505	Musa acuminata	81.87	0.00e+00	1701.00
IUUC-Mpu-066409	Mustela putorius furo	45.96	0.00e+00	893.00
IUUC-Mlu-067217	Myotis lucifugus	45.96	0.00e+00	881.00
IUUC-Nfi-068407	Neosartorya fischeri	46.20	0.00e+00	825.00
IUUC-Nle-070072	Nomascus leucogenys	43.25	0.00e+00	797.00
IUUC-Opr-070715	Ochotona princeps	35.65	8.00e-155	540.00
IUUC-Ocu-074544	Oryctolagus cuniculus	46.21	0.00e+00	897.00
IUUC-Ogl-077887	Oryza glaberrima	92.11	0.00e+00	1820.00
IUUC-Oin-079370	Oryza indica	89.52	0.00e+00	1806.00
IUUC-Ome-081942	Oryza meridionalis	92.50	0.00e+00	1827.00
IUUC-Oni-082365	Oryza nivara	92.50	0.00e+00	1827.00
IUUC-Opu-083977	Oryza punctata	92.21	0.00e+00	1823.00
IUUC-Osa-085949	Oryza sativa	92.11	0.00e+00	1853.00
IUUC-Oga-088594	Otolemur garnettii	46.48	0.00e+00	880.00
IUUC-Oar-090068	Ovis aries	46.01	0.00e+00	889.00
IUUC-Pan-092114	Papio anubis	46.15	0.00e+00	893.00
IUUC-Pab-097861	Pongo abelii	46.06	0.00e+00	863.00
IUUC-Pca-100347	Procavia capensis	43.18	0.00e+00	707.00
IUUC-Pgr-103336	Puccinia graminis	45.77	0.00e+00	833.00
IUUC-Ptt-103939	Puccinia triticina	46.41	0.00e+00	833.00
IUUC-Rno-105462	Rattus norvegicus	45.37	0.00e+00	868.00
IUUC-Sha-107142	Sarcophilus harrisii	46.09	0.00e+00	880.00
IUUC-Ssl-108497	Sclerotinia sclerotiorum	45.00	0.00e+00	805.00
IUUC-Smo-108912	Selaginella moellendorffii	72.70	0.00e+00	1529.00
IUUC-Sly-111237	Solanum lycopersicum	80.20	0.00e+00	1630.00
IUUC-Stu-112001	Solanum tuberosum	80.30	0.00e+00	1634.00
IUUC-Sre-115148	Sporisorium reilianum	45.57	0.00e+00	813.00
IUUC-Tre-122009	Trichoderma reesei	46.83	0.00e+00	820.00
IUUC-Tvi-122259	Trichoderma virens	47.11	0.00e+00	832.00
IUUC-Tae-125113	Triticum aestivum	99.11	0.00e+00	1937.00
IUUC-Tme-127055	Tuber melanosporum	44.55	0.00e+00	795.00
IUUC-Ttr-128331	Tursiops truncatus	45.72	0.00e+00	873.00
IUUC-Uma-129387	Ustilago maydis	45.22	0.00e+00	816.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence