iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Csa-023546

Ensembl Protein ID

ENSCSAP00000001173.1

UniProt Accession

A0A0D9QXT4; A0A0D9QXT4_CHLSB

Genbank Protein ID

ENSCSAP00000001173

Protein Name

Katanin p80 WD40 repeat-containing subunit B1; p80 katanin

Genbank Nucleotide ID

AQIB01137325

Gene Name

KATNB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCSAG00000004849.1	ENSCSAT00000002883.1	ENSCSAP00000001173.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.90e-45	150.8	145	180
UBD/Beta-Prp	3.40e-60	203.7	15	258

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgv 34
           gH+  v+cl+f +d + l+s++dD+t+k+WDl+ g+
   Q: 145  GHSQAVRCLRFsPDgKWLASAADDHTVKLWDLTAGK 180
           8***********999*****************9997 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkg 92
           ++ +h ++v + v  + +++llatg++d ++ +w++ +++++ sl gh+++v +v+++  ++++v gs+ + i+vwdl++ k+++tl g
   Q: 15   EIVAHASNVSSLVLGKGSGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMG 103
           6778888999989999************************************************************************* PP
   S: 93   hedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtd 181
           h+++++sl+f+p+g++++sGs+d  i++wd++ + c+    +gh+++v+c++++pdg+ l+s+++D tv+lWdl  gk++ ++ g ht+
   Q: 104  HKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF-RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG-HTG 190
           *************************************9.9********************************************9.*** PP
   S: 182  svyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWd 250
           +v+ ++f++n   l+sgs d+t+++wdl++ ++v   +g   +v+sv f p++  l+sg +D s+r++ 
   Q: 191  PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYG 258
           ***********************************************************766.556544 PP

Organism

Chlorocebus sabaeus

Functional Description
(View)

Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.

Protein Sequence
(Fasta)

MATPVVTKTA WKLQEIVAHA SNVSSLVLGK GSGRLLATGG DDCRVNLWSI NKPNCIMSLT 60
GHTSPVESVR LNTPEELIVA GSQSGSIRVW DLEAAKILRT LMGHKANICS LDFHPYGEFV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGCAA GTGGGGGTCG CGCCTGGAGC AGAGCCTCGG CCTCCGGAGC CGCAGCTGCA 60
GGTGGAGTGG GCAACGGGAC GAGGTGGCGA GGGGACGGTG GGCCCTGGGC TGGGCCGAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR003143--Cyt_cd1_C
IPR020472--G-protein_beta_WD-40_rep
IPR026962--Katanin_bsu1
IPR028021--Katanin_C-terminal
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF13925--Katanin_con80
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0030424--C:axon
GO:0005813--C:centrosome
GO:0005829--C:cytosol
GO:0008352--C:katanin complex
GO:0005874--C:microtubule
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0000922--C:spindle pole
GO:0008568--F:microtubule-severing ATPase activity
GO:0051301--P:cell division
GO:0051013--P:microtubule severing
GO:0007079--P:mitotic chromosome movement towards spindle pole
GO:0007026--P:negative regulation of microtubule depolymerization
GO:0031117--P:positive regulation of microtubule depolymerization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000954	Aegilops tauschii	48.10	1.00e-84	308.00
IUUC-Aml-002187	Ailuropoda melanoleuca	89.22	0.00e+00	1085.00
IUUC-Atr-002899	Amborella trichopoda	54.33	3.00e-101	363.00
IUUC-Apl-003305	Anas platyrhynchos	77.84	0.00e+00	1010.00
IUUC-Aca-004635	Anolis carolinensis	80.34	0.00e+00	956.00
IUUC-Aly-005711	Arabidopsis lyrata	51.68	1.00e-100	360.00
IUUC-Ath-007606	Arabidopsis thaliana	51.68	1.00e-100	360.00
IUUC-Ame-010870	Astyanax mexicanus	56.66	2.00e-97	348.00
IUUC-Bta-012527	Bos taurus	95.48	0.00e+00	1174.00
IUUC-Bdi-014652	Brachypodium distachyon	53.38	2.00e-102	367.00
IUUC-Bol-015242	Brassica oleracea	50.67	7.00e-99	355.00
IUUC-Bra-017390	Brassica rapa	51.01	2.00e-99	356.00
IUUC-Cja-019706	Callithrix jacchus	97.26	0.00e+00	1100.00
IUUC-Cfa-020139	Canis familiaris	80.76	0.00e+00	752.00
IUUC-Cpo-021710	Cavia porcellus	95.11	0.00e+00	1155.00
IUUC-Cre-022746	Chlamydomonas reinhardtii	41.55	1.00e-68	254.00
IUUC-Cin-025156	Ciona intestinalis	42.26	8.00e-158	550.00
IUUC-Csv-025962	Ciona savignyi	49.66	1.00e-89	322.00
IUUC-Dre-028215	Danio rerio	62.21	0.00e+00	843.00
IUUC-Dno-029314	Dasypus novemcinctus	94.66	0.00e+00	1111.00
IUUC-Dor-030482	Dipodomys ordii	95.57	0.00e+00	1196.00
IUUC-Dme-032188	Drosophila melanogaster	40.69	5.00e-59	222.00
IUUC-Eca-034143	Equus caballus	95.42	0.00e+00	1177.00
IUUC-Fca-035924	Felis catus	96.49	0.00e+00	1149.00
IUUC-Fal-037387	Ficedula albicollis	79.51	0.00e+00	998.00
IUUC-Gmo-038692	Gadus morhua	58.93	0.00e+00	738.00
IUUC-Gga-040597	Gallus gallus	79.33	0.00e+00	1039.00
IUUC-Gac-042004	Gasterosteus aculeatus	61.99	0.00e+00	820.00
IUUC-Gma-044134	Glycine max	31.76	2.00e-103	370.00
IUUC-Ggo-044761	Gorilla gorilla	99.54	0.00e+00	1109.00
IUUC-Hsa-045698	Homo sapiens	99.24	0.00e+00	1141.00
IUUC-Hvu-047649	Hordeum vulgare	53.38	1.00e-102	367.00
IUUC-Itr-048697	Ictidomys tridecemlineatus	94.96	0.00e+00	1136.00
IUUC-Lch-049674	Latimeria chalumnae	67.99	0.00e+00	919.00
IUUC-Lpe-051554	Leersia perrieri	54.39	7.00e-105	375.00
IUUC-Loc-052623	Lepisosteus oculatus	66.96	0.00e+00	894.00
IUUC-Laf-054587	Loxodonta africana	96.66	0.00e+00	1169.00
IUUC-Mcc-055851	Macaca mulatta	99.69	0.00e+00	1109.00
IUUC-Meu-056704	Macropus eugenii	90.58	0.00e+00	1177.00
IUUC-Mtr-058053	Medicago truncatula	52.68	2.00e-103	369.00
IUUC-Mga-059608	Meleagris gallopavo	78.81	0.00e+00	1025.00
IUUC-Mmr-061154	Microcebus murinus	94.51	0.00e+00	1110.00
IUUC-Mdo-062365	Monodelphis domestica	86.82	0.00e+00	1106.00
IUUC-Mmu-063754	Mus musculus	95.14	0.00e+00	1135.00
IUUC-Mac-064439	Musa acuminata	51.16	4.00e-99	356.00
IUUC-Mpu-066245	Mustela putorius furo	96.03	0.00e+00	1105.00
IUUC-Mlu-067692	Myotis lucifugus	96.45	0.00e+00	1135.00
IUUC-Nle-070051	Nomascus leucogenys	96.19	0.00e+00	1088.00
IUUC-Opr-070855	Ochotona princeps	95.57	0.00e+00	1156.00
IUUC-Ont-071883	Oreochromis niloticus	59.12	0.00e+00	819.00
IUUC-Oan-073293	Ornithorhynchus anatinus	90.08	0.00e+00	1026.00
IUUC-Ocu-074644	Oryctolagus cuniculus	96.49	0.00e+00	1171.00
IUUC-Oba-075448	Oryza barthii	54.73	3.00e-105	376.00
IUUC-Obr-076385	Oryza brachyantha	53.72	3.00e-104	373.00
IUUC-Ogl-077427	Oryza glaberrima	54.73	1.00e-105	377.00
IUUC-Ogu-079022	Oryza glumaepatula	49.35	2.00e-97	350.00
IUUC-Oin-079811	Oryza indica	52.27	2.00e-102	367.00
IUUC-Olo-080245	Oryza longistaminata	52.27	2.00e-102	367.00
IUUC-Ome-081239	Oryza meridionalis	54.14	7.00e-102	365.00
IUUC-Oni-082640	Oryza nivara	54.73	3.00e-105	376.00
IUUC-Opu-083748	Oryza punctata	51.83	2.00e-105	377.00
IUUC-Oru-084609	Oryza rufipogon	54.73	3.00e-105	376.00
IUUC-Osa-086267	Oryza sativa	49.35	2.00e-97	350.00
IUUC-Ola-087483	Oryzias latipes	56.15	0.00e+00	628.00
IUUC-Oga-087964	Otolemur garnettii	95.73	0.00e+00	1177.00
IUUC-Oar-089483	Ovis aries	93.97	0.00e+00	1133.00
IUUC-Ptr-091387	Pan troglodytes	99.39	0.00e+00	1143.00
IUUC-Pan-092623	Papio anubis	99.69	0.00e+00	1109.00
IUUC-Psi-093830	Pelodiscus sinensis	81.85	0.00e+00	1050.00
IUUC-Pma-094135	Petromyzon marinus	46.00	4.00e-41	160.00
IUUC-Ppa-095379	Physcomitrella patens	54.67	1.00e-96	347.00
IUUC-Pfo-096755	Poecilia formosa	57.99	0.00e+00	794.00
IUUC-Pab-097564	Pongo abelii	98.11	0.00e+00	975.00
IUUC-Pop-099149	Populus trichocarpa	52.68	6.00e-103	368.00
IUUC-Pca-100357	Procavia capensis	100.00	9.00e-127	447.00
IUUC-Ppe-101237	Prunus persica	52.68	1.00e-102	367.00
IUUC-Pva-102397	Pteropus vampyrus	92.21	0.00e+00	1070.00
IUUC-Rno-105349	Rattus norvegicus	95.11	0.00e+00	1179.00
IUUC-Smo-109409	Selaginella moellendorffii	53.98	9.00e-100	357.00
IUUC-Sit-110360	Setaria italica	54.73	4.00e-105	375.00
IUUC-Sly-111307	Solanum lycopersicum	53.02	1.00e-98	354.00
IUUC-Stu-112053	Solanum tuberosum	51.34	8.00e-99	355.00
IUUC-Sar-112953	Sorex araneus	82.02	6.00e-109	387.00
IUUC-Sbi-114389	Sorghum bicolor	47.46	4.00e-94	339.00
IUUC-Ssc-115949	Sus scrofa	93.86	0.00e+00	865.00
IUUC-Tgu-117461	Taeniopygia guttata	78.68	0.00e+00	1028.00
IUUC-Tru-117865	Takifugu rubripes	58.37	0.00e+00	784.00
IUUC-Tsy-119036	Tarsius syrichta	84.49	2.00e-82	299.00
IUUC-Tni-120903	Tetraodon nigroviridis	60.79	0.00e+00	771.00
IUUC-Tca-121185	Theobroma cacao	51.68	4.00e-100	359.00
IUUC-Tae-125263	Triticum aestivum	53.72	7.00e-103	368.00
IUUC-Tur-126181	Triticum urartu	48.45	3.00e-94	339.00
IUUC-Tbe-127518	Tupaia belangeri	81.88	0.00e+00	628.00
IUUC-Ttr-128172	Tursiops truncatus	96.18	0.00e+00	1134.00
IUUC-Vvi-131489	Vitis vinifera	53.36	2.00e-103	370.00
IUUC-Xtr-132915	Xenopus tropicalis	73.03	0.00e+00	955.00
IUUC-Xma-134133	Xiphophorus maculatus	57.70	0.00e+00	786.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence