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Tag Content
iUUCD ID IUUC-Xtr-132346
Ensembl Protein ID ENSXETP00000009249.3
UniProt Accession Q05B17; WDR48_XENTR
Genbank Protein ID AAI23018.1
Protein Name WD repeat-containing protein 48; USP1-associated factor 1
Genbank Nucleotide ID BC123017
Gene Name wdr48; uaf1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSXETG00000004247.3 ENSXETT00000009249.3 ENSXETP00000009249.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 2.90e-33 112.6 208 245
UBD/Beta-Prp 3.80e-48 164.4 30 294
ULD/UBL/SUMO 2.00e-59 198.5 560 667
ULD/UDP/UFD/RAWUL 1.70e-23 83.1 569 674
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf.sd.tllvsGsdDgtikvWDlrtgvll 36
    gHtd v +l + d t +sGs Dgti++W+l +++++
   Q: 208 GHTDNVKALLLnRDgTQCLSGSSDGTIRLWSLGQQRCI 245
    8********88*888*****************999997 PP
   


   UBD/Beta-Prp

   S: 10   ksvitcvkfspdksllatgsrdgtikvwdvttgkl...lrslsgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghed 95
    + +++++ p + l+t++rd+ i++w+v + k ++s++ h++ v+++ + +gk+l+++s+D t+kvw+ +g c++tl+ h+d
   Q: 30 RNGVNALQLDPALNRLFTAGRDSIIRIWNVNQHKQdpyIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKD 118
    556677888899999*****************999999*************************************************** PP
   S: 96 svlslsfspsgdklvsGshdrtirvwdletgqclee........tlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtlt 176
    +v +l++ ++++ ++s++ dr i +wd++t + l + lsg+++++ ++++++ g ++vsGs+ +++r+Wd +t + l +l+
   Q: 119 YVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTAsnntvttsSLSGNKDSIYSLAMNQMGTVIVSGSTEKVLRVWDPRTCQKLMKLK 207
    **********************************99****************************************************9 PP
   S: 177 gghtdsvyslsfdsngkelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn 264
    g htd v+ l ++++g++++sgs dgt++lw+l +++c+ t++ h++ v+ +++ + ++++sg+ D+ i++ dlr+ d+ + ++
   Q: 208 G-HTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNEGFTHVYSGGRDRKIYCTDLRNPDIRLLICEEK 294
    9.**************************************************************************999887776666 PP
   


   ULD/UBL/SUMO

   S: 1    eskffkapvslkvagqdGsevlfklklsa....qlkklmeavYvkrinldensvrfv.fngqkireqetpeelevededkiellcq... 81
    ++kf+k+p++l++++++G+++l+k++lsa q++k+me+vY+k+in+d +s++++ +n++k++eqe++e+++v++e+kiellcq
   Q: 560 MPKFNKIPFYLQPHSSSGAKTLKKDRLSAsdmlQVRKVMEHVYEKIINVDTESQTTSsSNNEKPGEQEKEEDIAVLAEEKIELLCQdqi 648
    8********************************************************9****************************777 PP
   S: 82 ...............ksGG 85
    ksGG
   Q: 649 ldpnmdlrtvkhfiwKSGG 667
    7777777777777777776 PP
   


   ULD/UDP/UFD/RAWUL

   S: 4    sLeplesnkakddsklkkkylrcsarltVkhlkkflaeklkl........sssy.....................evdllcedevLedn 63
    L+p++s++ak+ lkk++l++s++l+V++++++++ek+++ s +++llc+d++L++n
   Q: 569 YLQPHSSSGAKT---LKKDRLSASDMLQVRKVMEHVYEKIINvdtesqttS--SsnnekpgeqekeediavlaeeKIELLCQDQILDPN 652
    69**********...***************************998766663..0447999999999*********************** PP
   S: 64 etLeeikyifiwkkegpLvLqYr 86
    ++L+++ ++fiwk++g+L+L+Yr
   Q: 653 MDLRTV-KHFIWKSGGDLTLHYR 674
    ******.***************9 PP
   

Organism Xenopus tropicalis
Functional Description
(View)

Functional Description



     Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. May play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes.
Protein Sequence
(Fasta)
MAAHHRQNTA GRRKVQVSYV IRDEVEKYNR NGVNALQLDP ALNRLFTAGR DSIIRIWNVN 60
QHKQDPYIAS MEHHTDWVND IVLCCNGKTL ISASSDTTVK VWNAHKGFCM STLRTHKDYV 120
It may take some time, please wait.

Protein Fasta Sequence



>IUUC-Xtr-132346|E3,WD_repeat;UBD,Beta-Prp;ULD,SUMO;ULD,RAWUL|Xenopus tropicalis
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAAGATGGC GGCGCATCAC AGGCAGAACA CGGCTGGGCG GAGGAAAGTT CAGGTAGGAG 60
CGGTGCTTGG GATCGCACAC GGCCGGTGCC CGCCCTCACA CTGTTGGCTG CCGGTGTTCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence



>IUUC-Xtr-132346|E3,WD_repeat;UBD,Beta-Prp;ULD,SUMO;ULD,RAWUL|Xenopus tropicalis
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0967--Endosome
KW-0458--Lysosome
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR021772--DUF3337
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF11816--DUF3337
PF00400--WD40

PRINTS

PR00320--GPROTEINBRPT

SMART

SM00320--WD40

Gene Ontology

GO:0005770--C:late endosome
GO:0005764--C:lysosome
GO:0005634--C:nucleus
GO:0016579--P:protein deubiquitination

KEGG xtr:780319
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-001160 Aegilops tauschii 40.24 3.00e-98 352.00
IUUC-Aml-001533 Ailuropoda melanoleuca 94.84 0.00e+00 1227.00
IUUC-Atr-003009 Amborella trichopoda 34.20 8.00e-113 400.00
IUUC-Apl-003709 Anas platyrhynchos 95.34 0.00e+00 644.00
IUUC-Aca-004875 Anolis carolinensis 96.02 0.00e+00 1259.00
IUUC-Aly-005464 Arabidopsis lyrata 39.49 1.00e-94 341.00
IUUC-Ath-006969 Arabidopsis thaliana 39.06 3.00e-90 326.00
IUUC-Acl-008203 Aspergillus clavatus 29.76 1.00e-57 218.00
IUUC-Afl-008571 Aspergillus flavus 35.63 5.00e-47 182.00
IUUC-Afu-009072 Aspergillus fumigatus 35.03 2.00e-45 177.00
IUUC-Ani-009413 Aspergillus nidulans 36.12 3.00e-47 183.00
IUUC-Ang-009571 Aspergillus niger 29.12 2.00e-56 214.00
IUUC-Aor-010064 Aspergillus oryzae 35.63 3.00e-47 183.00
IUUC-Ate-010463 Aspergillus terreus 35.03 1.00e-46 181.00
IUUC-Ame-010875 Astyanax mexicanus 92.93 0.00e+00 1073.00
IUUC-Bgr-012288 Blumeria graminis 33.14 4.00e-41 162.00
IUUC-Bta-013379 Bos taurus 94.84 0.00e+00 1229.00
IUUC-Bci-013859 Botrytis cinerea 28.81 2.00e-54 207.00
IUUC-Bdi-014645 Brachypodium distachyon 34.59 2.00e-111 396.00
IUUC-Bol-016450 Brassica oleracea 35.15 2.00e-99 357.00
IUUC-Bra-017237 Brassica rapa 33.65 6.00e-102 365.00
IUUC-Cel-018656 Caenorhabditis elegans 44.26 5.00e-155 541.00
IUUC-Cja-018804 Callithrix jacchus 94.84 0.00e+00 1226.00
IUUC-Cfa-020076 Canis familiaris 94.99 0.00e+00 1231.00
IUUC-Cpo-021721 Cavia porcellus 93.97 0.00e+00 1182.00
IUUC-Cre-022779 Chlamydomonas reinhardtii 31.01 2.00e-41 164.00
IUUC-Csa-023188 Chlorocebus sabaeus 94.99 0.00e+00 1231.00
IUUC-Cho-024932 Choloepus hoffmanni 93.81 0.00e+00 1231.00
IUUC-Cin-025591 Ciona intestinalis 56.86 0.00e+00 723.00
IUUC-Cgl-026540 Colletotrichum gloeosporioides 27.02 9.00e-20 92.40
IUUC-Cne-026819 Cryptococcus neoformans 35.53 1.00e-34 142.00
IUUC-Cme-027188 Cyanidioschyzon merolae 31.42 3.00e-71 263.00
IUUC-Dre-027926 Danio rerio 91.89 0.00e+00 1243.00
IUUC-Dno-029960 Dasypus novemcinctus 94.84 0.00e+00 1224.00
IUUC-Dor-030933 Dipodomys ordii 90.27 0.00e+00 667.00
IUUC-Dse-031532 Dothistroma septosporum 34.78 5.00e-46 179.00
IUUC-Dme-032168 Drosophila melanogaster 56.34 0.00e+00 681.00
IUUC-Ete-033107 Echinops telfairi 91.30 0.00e+00 1163.00
IUUC-Eca-034028 Equus caballus 95.13 0.00e+00 1233.00
IUUC-Eeu-034894 Erinaceus europaeus 91.65 0.00e+00 812.00
IUUC-Fca-035619 Felis catus 94.70 0.00e+00 903.00
IUUC-Fal-036869 Ficedula albicollis 95.93 0.00e+00 1225.00
IUUC-Fox-037907 Fusarium oxysporum 33.05 2.00e-41 164.00
IUUC-Fso-038101 Fusarium solani 32.77 1.00e-40 161.00
IUUC-Gmo-038627 Gadus morhua 93.66 0.00e+00 1257.00
IUUC-Ggr-039995 Gaeumannomyces graminis 31.37 1.00e-42 168.00
IUUC-Gga-040555 Gallus gallus 95.87 0.00e+00 1263.00
IUUC-Gac-042497 Gasterosteus aculeatus 93.36 0.00e+00 1230.00
IUUC-Gma-043089 Glycine max 34.46 1.00e-112 400.00
IUUC-Ggo-045561 Gorilla gorilla 94.99 0.00e+00 1231.00
IUUC-Hsa-045710 Homo sapiens 94.99 0.00e+00 1231.00
IUUC-Hvu-047730 Hordeum vulgare 35.39 2.00e-83 302.00
IUUC-Itr-049030 Ictidomys tridecemlineatus 93.68 0.00e+00 860.00
IUUC-Kpa-049237 Komagataella pastoris 30.46 2.00e-29 124.00
IUUC-Lch-049507 Latimeria chalumnae 95.58 0.00e+00 1232.00
IUUC-Lpe-051608 Leersia perrieri 34.78 6.00e-108 384.00
IUUC-Loc-052373 Lepisosteus oculatus 92.06 0.00e+00 1214.00
IUUC-Lma-053025 Leptosphaeria maculans 31.24 5.00e-59 223.00
IUUC-Laf-053706 Loxodonta africana 94.42 0.00e+00 1192.00
IUUC-Mcc-055046 Macaca mulatta 94.99 0.00e+00 1231.00
IUUC-Meu-056840 Macropus eugenii 76.28 3.00e-138 485.00
IUUC-Mor-057284 Magnaporthe oryzae 32.54 2.00e-43 171.00
IUUC-Mpo-057418 Magnaporthe poae 31.09 3.00e-41 163.00
IUUC-Mtr-058571 Medicago truncatula 35.29 4.00e-110 392.00
IUUC-Mla-059101 Melampsora laricipopulina 44.61 3.00e-45 177.00
IUUC-Mga-059297 Meleagris gallopavo 95.87 0.00e+00 1263.00
IUUC-Mvi-060419 Microbotryum violaceum 40.64 1.00e-37 152.00
IUUC-Mmr-061196 Microcebus murinus 88.19 0.00e+00 1102.00
IUUC-Mdo-062762 Monodelphis domestica 91.62 0.00e+00 1239.00
IUUC-Mmu-063915 Mus musculus 94.10 0.00e+00 1238.00
IUUC-Mac-065434 Musa acuminata 34.54 2.00e-105 376.00
IUUC-Mpu-065999 Mustela putorius furo 94.63 0.00e+00 813.00
IUUC-Mlu-068226 Myotis lucifugus 94.53 0.00e+00 1222.00
IUUC-Nfi-068416 Neosartorya fischeri 35.33 3.00e-46 180.00
IUUC-Ncr-068825 Neurospora crassa 30.77 4.00e-39 156.00
IUUC-Nle-069416 Nomascus leucogenys 94.99 0.00e+00 1231.00
IUUC-Opr-070515 Ochotona princeps 90.71 0.00e+00 1156.00
IUUC-Ont-072052 Oreochromis niloticus 91.04 0.00e+00 1183.00
IUUC-Oan-073636 Ornithorhynchus anatinus 93.06 0.00e+00 1216.00
IUUC-Ocu-074799 Oryctolagus cuniculus 94.84 0.00e+00 1228.00
IUUC-Oba-075146 Oryza barthii 35.17 3.00e-109 389.00
IUUC-Obr-076699 Oryza brachyantha 35.07 5.00e-110 391.00
IUUC-Ogl-077883 Oryza glaberrima 33.86 9.00e-66 244.00
IUUC-Ogu-078114 Oryza glumaepatula 34.72 6.00e-108 384.00
IUUC-Oin-079575 Oryza indica 35.51 1.00e-112 400.00
IUUC-Olo-080531 Oryza longistaminata 33.08 7.00e-99 354.00
IUUC-Ome-081368 Oryza meridionalis 41.27 7.00e-99 354.00
IUUC-Oni-082457 Oryza nivara 35.17 2.00e-109 389.00
IUUC-Opu-084050 Oryza punctata 35.04 2.00e-108 386.00
IUUC-Oru-084330 Oryza rufipogon 35.17 3.00e-109 389.00
IUUC-Osa-085408 Oryza sativa 35.51 1.00e-112 400.00
IUUC-Ola-087546 Oryzias latipes 93.13 0.00e+00 1235.00
IUUC-Olu-087710 Ostreococcus lucimarinus 32.29 3.00e-83 302.00
IUUC-Oga-087998 Otolemur garnettii 93.77 0.00e+00 1204.00
IUUC-Oar-090303 Ovis aries 94.84 0.00e+00 1229.00
IUUC-Ptr-090588 Pan troglodytes 94.99 0.00e+00 1231.00
IUUC-Pan-092722 Papio anubis 94.99 0.00e+00 1231.00
IUUC-Psi-093911 Pelodiscus sinensis 95.31 0.00e+00 1257.00
IUUC-Pma-094580 Petromyzon marinus 86.85 0.00e+00 1168.00
IUUC-Pno-095085 Phaeosphaeria nodorum 28.68 1.00e-53 205.00
IUUC-Ppa-095594 Physcomitrella patens 35.94 1.00e-113 403.00
IUUC-Pfo-096994 Poecilia formosa 93.11 0.00e+00 1233.00
IUUC-Pab-097586 Pongo abelii 94.99 0.00e+00 1230.00
IUUC-Pop-099740 Populus trichocarpa 34.11 1.00e-102 367.00
IUUC-Pca-100458 Procavia capensis 97.12 1.00e-105 377.00
IUUC-Ppe-102060 Prunus persica 33.89 3.00e-109 389.00
IUUC-Pva-102698 Pteropus vampyrus 90.86 0.00e+00 1217.00
IUUC-Pgr-103649 Puccinia graminis 39.08 8.00e-48 186.00
IUUC-Ptt-103910 Puccinia triticina 43.50 4.00e-53 203.00
IUUC-Pte-104181 Pyrenophora teres 35.84 2.00e-48 187.00
IUUC-Pyt-104439 Pyrenophora triticirepentis 35.54 6.00e-48 186.00
IUUC-Rno-104978 Rattus norvegicus 94.11 0.00e+00 1206.00
IUUC-Sha-107079 Sarcophilus harrisii 93.61 0.00e+00 1157.00
IUUC-Sja-107716 Schizosaccharomyces japonicus 33.84 2.00e-46 181.00
IUUC-Spo-108325 Schizosaccharomyces pombe 30.06 1.00e-52 201.00
IUUC-Ssl-108542 Sclerotinia sclerotiorum 28.86 9.00e-52 198.00
IUUC-Smo-109427 Selaginella moellendorffii 34.72 2.00e-110 393.00
IUUC-Sit-110755 Setaria italica 36.09 1.00e-113 404.00
IUUC-Sly-111099 Solanum lycopersicum 39.96 3.00e-93 336.00
IUUC-Sar-113408 Sorex araneus 94.12 0.00e+00 736.00
IUUC-Sbi-113789 Sorghum bicolor 35.03 2.00e-110 393.00
IUUC-Sre-114998 Sporisorium reilianum 40.59 2.00e-52 201.00
IUUC-Ssc-115434 Sus scrofa 94.99 0.00e+00 1231.00
IUUC-Tgu-116517 Taeniopygia guttata 96.17 0.00e+00 1260.00
IUUC-Tru-118174 Takifugu rubripes 93.53 0.00e+00 1236.00
IUUC-Tsy-118935 Tarsius syrichta 94.99 0.00e+00 1248.00
IUUC-Tni-119744 Tetraodon nigroviridis 93.66 0.00e+00 1212.00
IUUC-Tca-121360 Theobroma cacao 34.71 6.00e-113 401.00
IUUC-Tre-122198 Trichoderma reesei 28.57 3.00e-53 203.00
IUUC-Tvi-122389 Trichoderma virens 28.83 5.00e-53 202.00
IUUC-Tae-125576 Triticum aestivum 35.12 2.00e-112 399.00
IUUC-Tur-126699 Triticum urartu 34.89 1.00e-109 390.00
IUUC-Tme-126932 Tuber melanosporum 30.68 8.00e-55 209.00
IUUC-Tbe-127267 Tupaia belangeri 79.30 0.00e+00 696.00
IUUC-Ttr-129153 Tursiops truncatus 94.84 0.00e+00 1253.00
IUUC-Uma-129604 Ustilago maydis 37.89 9.00e-51 196.00
IUUC-Vda-129925 Verticillium dahliae 28.70 9.00e-54 205.00
IUUC-Vpa-130553 Vicugna pacos 93.55 0.00e+00 936.00
IUUC-Vvi-130995 Vitis vinifera 34.27 9.00e-109 387.00
IUUC-Xma-134266 Xiphophorus maculatus 90.58 0.00e+00 651.00
IUUC-Yli-134451 Yarrowia lipolytica 27.39 2.00e-38 154.00
IUUC-Zma-135647 Zea mays 35.13 5.00e-112 398.00
Created Date 25-Jun-2017

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