iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-070065

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01101839

Gene Name

CBLC

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000001721.2	ENSNLET00000002166.1	ENSNLEP00000002053.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	3.40e-06	27.5	305	344

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C iC e+ kd +++ pCgH+ +  Cl +w     + s +++CP Cr
   Q: 305  CKICAESNKD-VKIEPCGHLLCSRCLAAW-----QHSDSQTCPFCR 344
           99********.******************.....6889999****8 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MALAVAPWGR QWEEARALGR AVRMLQRLEE QCGDPRLSVS PPSLRDLLPR TAQLLREVAH 60
SRRAAGGGGP GGPGGPGDFL LIYLANLEAK SRQVAALLPP RGQRSANDEL FRAGSRLRRQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCTCTGG CGGTGGCCCC GTGGGGGCGA CAGTGGGAAG AGGCCCGCGC CCTGGGCCGG 60
GCAGTCAGGA TGCTGCAGCG CCTAGAAGAG CAATGCGGCG ACCCCCGGCT GTCCGTGAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR024162--Adaptor_Cbl
IPR014741--Adaptor_Cbl_EF_hand-like
IPR003153--Adaptor_Cbl_N_hlx
IPR014742--Adaptor_Cbl_SH2-like
IPR024159--Cbl_PTB
IPR011992--EF-hand-dom_pair
IPR000980--SH2
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS51506--CBL_PTB
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF02262--Cbl_N
PF02761--Cbl_N2
PF02762--Cbl_N3

SMART

SM00184--RING

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0005509--F:calcium ion binding
GO:0004871--F:signal transducer activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007166--P:cell surface receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0043407--P:negative regulation of MAP kinase activity
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002286	Ailuropoda melanoleuca	71.17	1.00e-143	502.00
IUUC-Bta-012705	Bos taurus	70.19	2.00e-149	521.00
IUUC-Cja-019179	Callithrix jacchus	75.95	0.00e+00	650.00
IUUC-Cfa-020593	Canis familiaris	65.84	9.00e-139	486.00
IUUC-Cpo-021289	Cavia porcellus	63.83	1.00e-134	472.00
IUUC-Csa-023966	Chlorocebus sabaeus	78.37	1.00e-173	602.00
IUUC-Dor-030246	Dipodomys ordii	75.38	2.00e-103	369.00
IUUC-Eca-033921	Equus caballus	59.68	3.00e-108	385.00
IUUC-Fca-035747	Felis catus	55.23	3.00e-115	408.00
IUUC-Ggo-044622	Gorilla gorilla	77.87	1.00e-144	506.00
IUUC-Hsa-045735	Homo sapiens	82.70	0.00e+00	690.00
IUUC-Itr-049001	Ictidomys tridecemlineatus	66.57	3.00e-125	441.00
IUUC-Laf-053983	Loxodonta africana	69.70	3.00e-154	538.00
IUUC-Meu-056304	Macropus eugenii	70.30	7.00e-39	154.00
IUUC-Mmr-061310	Microcebus murinus	68.28	2.00e-147	515.00
IUUC-Mmu-064155	Mus musculus	61.64	4.00e-142	498.00
IUUC-Mpu-066655	Mustela putorius furo	70.19	2.00e-149	521.00
IUUC-Mlu-067929	Myotis lucifugus	65.23	2.00e-108	385.00
IUUC-Ocu-074049	Oryctolagus cuniculus	65.54	3.00e-106	378.00
IUUC-Oga-087952	Otolemur garnettii	70.13	2.00e-168	584.00
IUUC-Oar-089382	Ovis aries	67.87	3.00e-142	498.00
IUUC-Ptr-090579	Pan troglodytes	54.64	9.00e-106	376.00
IUUC-Pan-092075	Papio anubis	79.11	0.00e+00	641.00
IUUC-Pab-098100	Pongo abelii	81.42	3.00e-177	614.00
IUUC-Pca-100830	Procavia capensis	79.05	4.00e-110	391.00
IUUC-Pva-102714	Pteropus vampyrus	82.38	2.00e-119	422.00
IUUC-Rno-105348	Rattus norvegicus	64.38	5.00e-146	510.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence