iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tni-120804

UUCD1 version

UUC-TeN-01174

Ensembl Protein ID

ENSTNIP00000001136.1

UniProt Accession

H3BYS0; H3BYS0_TETNG

Protein Name

Ubiquitinyl hydrolase 1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTNIG00000015543.1	ENSTNIT00000003165.1	ENSTNIP00000001136.1
ENSTNIG00000015543.1	ENSTNIT00000018842.1	ENSTNIP00000018615.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.60e-55	187.7	332	872
UBD/Alpha-Helix/UBA	5.50e-17	61.5	729	767

Active Site

Position(s)	Description	Evidence
341	Nucleophile	{ECO:0000256\|PIRSR:PIRSR016308-1}
835	Proton acceptor	{ECO:0000256\|PIRSR:PIRSR016308-1}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeel......................wkskkka 67
           tG+kNlgNtCY+  v+Q+L++ip++++++   + +++ + +p +p+++++++++kl + l                       k+++k 
   Q: 332  TGIKNLGNTCYLSTVMQVLFSIPDFQRMYVG-NLQRIFDYSPLDPSQDFATQMAKLGHGLlsgqyskppmkselieqvmneeHKHQQKG 419
           7******************************.7777778889******************9999999999999988876654499999* PP
   S: 68   vsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikc 156
           vspr+l++ +++ ++efs+++qqDa+Efl +l++ +e++                               +++  sd+F++ ++++i+c
   Q: 420  VSPRMLKALVSRGHPEFSSNRQQDAHEFLLHLINLVERNS-----------------------------AGSENPSDVFRFLVEERIQC 479
           *************************************999.............................6788999************* PP
   S: 157  lecdnvssreepfldlslpvpgkeetkke...........................slqdcLesftkeeelegenkyycekckkkqeae 218
            + ++v  ++   + ++lp p++   + e                            ++ cL++ft++e++ +   ++++  ++k+  +
   Q: 480  CQSRRVRYSQRVDYCIQLPAPMEAAINREellayetkrkeaeeniqplpepvrariPFTACLQAFTEPENVPD---FWSSALQAKSAGV 565
           777777766666677777777666555558999**************************************97...************* PP
   S: 219  kklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts........................................ 267
           k+ ++ ++Pe+Lil++k+f+f  + ++++k++  +++p+ Ldls   t                                         
   Q: 566  KTSRFASFPEYLILQIKKFTFGVD-WVPKKLDLAIDVPDFLDLSLRATGlqageeelpdlmppivlpedtrddpvyeqlkdpeapeide 653
           *********************776.*******************777776777777777777777777777777777777777777777 PP
   S: 268  ........................................................................................p 268
                                                                                                   p
   Q: 654  aavmqlaemgfpleacrkavyytgnmgpemafnwiiahmeepdfaepltlpsmmdsgpstsdsvmgatpldpnsppeesiailtsmgfP 742
           76666666666666666666666666666666666666666666666666666666666666666666655555555555555555550 PP
   S: 269  eekqke.......................................................................kkkYeLiavvvH 286
                +                                                                       + +YeL+a ++H
   Q: 743  -----RphsisalkatnnnleraldwifthpepeesealsdmadtepndngfsnanshsdatlspdrdttgprikdgPGRYELFAFISH 826
           .....055555555555555566666666666666666777777777777788888888889999999999999999************ PP
   S: 287  sG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           +G s+ sGHYv+++k+ +g+W+ ++D+kV  +  e+  +   + +Y++fY+r
   Q: 827  MGeSTMSGHYVCHIKK-EGRWVIYNDHKVCLS--ERPPK---DLGYIYFYHR 872
           ****************.9***********988..78888...89******97 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraannnleaAveyLldg 41
            e+ ++ l++MGF+r + + aL a+nnnle+A+++++++
   Q: 729  PEESIAILTSMGFPRPHSISALKATNNNLERALDWIFTH 767
           5899*********************************98 PP

Organism

Tetraodon nigroviridis

Protein Sequence
(Fasta)

ARRYSAACSR NAKMATDLGE LLVPYMPTIR VPRTGDRVFK SECAFSFDSP ESEGGLYVCM 60
NTFLGFGREH VERHYRKTGQ SVYMHLKRHV KEKATGAAGG AIPRRRNGKV FLDLELNRDF 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTCGGCGCT ACTCTGCCGC CTGCAGCAGG AATGCGAAGA TGGCCACGGA CCTCGGAGAG 60
CTGCTGGTCC CCTACATGCC CACCATCAGG GTTCCCAGGA CCGGGGACCG GGTCTTCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR015940--UBA
IPR009060--UBA-like
IPR016652--Ubiquitinyl_hydrolase
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS50030--UBA
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00627--UBA
PF00443--UCH
PF02148--zf-UBP

SMART

SM00165--UBA
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001356	Ailuropoda melanoleuca	73.70	0.00e+00	1254.00
IUUC-Apl-003712	Anas platyrhynchos	72.95	0.00e+00	1230.00
IUUC-Aca-004634	Anolis carolinensis	74.51	0.00e+00	1268.00
IUUC-Ame-011470	Astyanax mexicanus	82.64	0.00e+00	1461.00
IUUC-Bta-013349	Bos taurus	73.88	0.00e+00	1262.00
IUUC-Cja-019021	Callithrix jacchus	73.55	0.00e+00	1244.00
IUUC-Cfa-020614	Canis familiaris	73.95	0.00e+00	1252.00
IUUC-Cpo-022484	Cavia porcellus	72.87	0.00e+00	1185.00
IUUC-Csa-024078	Chlorocebus sabaeus	73.90	0.00e+00	1253.00
IUUC-Cho-024522	Choloepus hoffmanni	60.73	0.00e+00	924.00
IUUC-Cme-027335	Cyanidioschyzon merolae	25.73	3.00e-54	207.00
IUUC-Dre-027651	Danio rerio	84.86	0.00e+00	1524.00
IUUC-Dno-028975	Dasypus novemcinctus	73.61	0.00e+00	1247.00
IUUC-Dor-030130	Dipodomys ordii	54.25	0.00e+00	802.00
IUUC-Ete-032251	Echinops telfairi	61.99	0.00e+00	977.00
IUUC-Eca-033568	Equus caballus	73.58	0.00e+00	1187.00
IUUC-Fca-036280	Felis catus	73.75	0.00e+00	1188.00
IUUC-Fal-036610	Ficedula albicollis	73.59	0.00e+00	1211.00
IUUC-Gmo-038906	Gadus morhua	82.53	0.00e+00	1465.00
IUUC-Gga-041215	Gallus gallus	73.13	0.00e+00	1283.00
IUUC-Gac-042441	Gasterosteus aculeatus	88.41	0.00e+00	1584.00
IUUC-Ggo-044446	Gorilla gorilla	73.78	0.00e+00	1253.00
IUUC-Hsa-046546	Homo sapiens	73.55	0.00e+00	1248.00
IUUC-Hvu-047563	Hordeum vulgare	44.25	8.00e-158	550.00
IUUC-Itr-048147	Ictidomys tridecemlineatus	67.40	0.00e+00	1133.00
IUUC-Kpa-049156	Komagataella pastoris	29.16	1.00e-95	343.00
IUUC-Lch-050425	Latimeria chalumnae	74.09	0.00e+00	1320.00
IUUC-Loc-052072	Lepisosteus oculatus	77.41	0.00e+00	1353.00
IUUC-Laf-053909	Loxodonta africana	72.34	0.00e+00	1233.00
IUUC-Mcc-054686	Macaca mulatta	73.78	0.00e+00	1253.00
IUUC-Meu-056361	Macropus eugenii	74.84	0.00e+00	969.00
IUUC-Mga-059972	Meleagris gallopavo	71.04	0.00e+00	1176.00
IUUC-Mmr-060916	Microcebus murinus	72.84	0.00e+00	1250.00
IUUC-Mdo-062302	Monodelphis domestica	75.29	0.00e+00	1336.00
IUUC-Mmu-063639	Mus musculus	73.40	0.00e+00	1251.00
IUUC-Mac-065634	Musa acuminata	38.24	2.00e-165	575.00
IUUC-Mpu-066533	Mustela putorius furo	73.59	0.00e+00	1252.00
IUUC-Mlu-067786	Myotis lucifugus	69.70	0.00e+00	1177.00
IUUC-Nle-069997	Nomascus leucogenys	72.95	0.00e+00	1170.00
IUUC-Ont-071859	Oreochromis niloticus	89.55	0.00e+00	1606.00
IUUC-Oan-072959	Ornithorhynchus anatinus	75.93	4.00e-111	393.00
IUUC-Ocu-074265	Oryctolagus cuniculus	72.31	0.00e+00	1243.00
IUUC-Ola-087344	Oryzias latipes	87.39	0.00e+00	1587.00
IUUC-Oga-088734	Otolemur garnettii	73.56	0.00e+00	1233.00
IUUC-Oar-089636	Ovis aries	73.94	0.00e+00	1227.00
IUUC-Ptr-090982	Pan troglodytes	73.67	0.00e+00	1251.00
IUUC-Pan-091991	Papio anubis	73.90	0.00e+00	1254.00
IUUC-Psi-093509	Pelodiscus sinensis	74.60	0.00e+00	1308.00
IUUC-Pfo-096029	Poecilia formosa	91.46	0.00e+00	1659.00
IUUC-Pab-098672	Pongo abelii	70.19	0.00e+00	1159.00
IUUC-Pva-102545	Pteropus vampyrus	72.96	0.00e+00	1052.00
IUUC-Rno-105210	Rattus norvegicus	73.05	0.00e+00	1236.00
IUUC-Sar-113733	Sorex araneus	75.80	0.00e+00	629.00
IUUC-Tgu-116591	Taeniopygia guttata	73.73	0.00e+00	1292.00
IUUC-Tru-118627	Takifugu rubripes	93.63	0.00e+00	1707.00
IUUC-Tsy-119278	Tarsius syrichta	66.18	0.00e+00	1059.00
IUUC-Tbe-127699	Tupaia belangeri	60.75	0.00e+00	675.00
IUUC-Ttr-128295	Tursiops truncatus	66.78	0.00e+00	1132.00
IUUC-Vpa-130170	Vicugna pacos	65.33	0.00e+00	1011.00
IUUC-Xtr-132809	Xenopus tropicalis	69.24	0.00e+00	1224.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence