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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063127
UUCD1 version UUC-MuM-01182
Ensembl Protein ID ENSMUSP00000023457.5
UniProt Accession Q6NXL6; Q3ZTK4; Q8BXW0; SENP5_MOUSE
Genbank Protein ID AAT01901.1; BAC31483.1; AAH67014.1; AAH80830.1
Protein Name Sentrin-specific protease 5; SUMO/Smt3-specific isopeptidase 3; Sentrin/SUMO-specific protease SENP5
Genbank Nucleotide ID AY522918; AK043171; BC067014; BC080830
Gene Name Senp5; Smt3ip3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000022772.11 ENSMUST00000023457.11 ENSMUSP00000023457.5
ENSMUSG00000022772.11 ENSMUST00000155515.7 ENSMUSP00000117481.1
ENSMUSG00000022772.11 ENSMUST00000129900.1 ENSMUSP00000115257.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/ULP 2.60e-51 175.4 562 717
Active Site
Position(s) Description Evidence
640 N/A {ECO:0000250}
657 {ECO:0000250}
707 {ECO:0000250}
Domain Profile

   DUB/ULP
   S: 2    svtnedlkcLeegeflnDviidfylkylvleklkkekverihifssffykklkqkerrrvktwtrkvdlfekdlifvpineaaHWslav 90
           +++++dl +L+ +++lnD++i++y + l+++ +     +++h+f+sff+++l +k+++ vk+wt+kvdlf+k+l+++pi+ ++HWsl+ 
   Q: 562  MLDMDDLATLDGQNWLNDQVINMYGE-LIMDAVP----DKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLIT 645
           6789**********************.******7....9************************************************** PP
   S: 91   vcfkkksilllDSlrgasksnvvkklreylevevkkkskrefskeklkgsnpk.vpqQkNssDCGvyvlqyves 163
           v+++++ i ++DS+ g + + +v+++r+yl +e+++k++ ef +  ++++++k +pqQkN+sDCGv+vlqy+++
   Q: 646  VTLSSRIISFYDSQ-GIHFKFCVENIRKYLLTEAREKNRPEFLQ-GWQTAVTKcIPQQKNDSDCGVFVLQYCKC 717
           **************.****************************9.999999999******************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division (By similarity).
 Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division (By similarity).
Protein Sequence
(Fasta)
MKKQKKILWK KGIHLAFSEK WNAGFGSFKK FYFPQNLCFL KAKLGRPVAW HRQVKHFQCN 60
KGLHIQKTWI QDVPFCSKTK SGLATQNVST LYPKVKRKDS KHFISSSRSL LKLQADKLLS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063127|DUB,ULP|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGGGACAGCA GTGCACCCAG CGCCTCGAGG TTAACGCCCT AGTCACGCTC TTCGCACAAG 60
GCGTGGGCGG AGCTTCTGGC GGAAGGGCAA GGAAGGAGGT GACGCGAAAA GCAGGCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063127|DUB,ULP|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
Interpro

IPR003653--Peptidase_C48_C
IPR033465--SENP5
PROSITE

PS50600--ULP_PROTEASE
Pfam

PF02902--Peptidase_C48
Gene Ontology

GO:0005730--C:nucleolus
GO:0005634--C:nucleus
GO:0004175--F:endopeptidase activity
GO:0070139--F:SUMO-specific endopeptidase activity
GO:0016929--F:SUMO-specific protease activity
GO:0007049--P:cell cycle
GO:0051301--P:cell division
GO:0016926--P:protein desumoylation
KEGG mmu:320213
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002198 Ailuropoda melanoleuca 81.74 0.00e+00 1237.00
IUUC-Apl-003396 Anas platyrhynchos 58.60 4.00e-174 604.00
IUUC-Aca-004954 Anolis carolinensis 52.32 2.00e-164 572.00
IUUC-Ame-011963 Astyanax mexicanus 57.05 4.00e-98 352.00
IUUC-Bta-013424 Bos taurus 80.13 0.00e+00 1204.00
IUUC-Cja-019271 Callithrix jacchus 80.54 0.00e+00 1222.00
IUUC-Cfa-020809 Canis familiaris 81.61 0.00e+00 1231.00
IUUC-Cpo-021633 Cavia porcellus 73.49 0.00e+00 1093.00
IUUC-Csa-023353 Chlorocebus sabaeus 78.76 0.00e+00 1188.00
IUUC-Cho-024452 Choloepus hoffmanni 80.40 2.00e-117 416.00
IUUC-Dre-027542 Danio rerio 54.55 3.00e-91 329.00
IUUC-Dno-029354 Dasypus novemcinctus 78.39 0.00e+00 1195.00
IUUC-Dor-030333 Dipodomys ordii 68.78 0.00e+00 962.00
IUUC-Ete-033044 Echinops telfairi 73.79 0.00e+00 1103.00
IUUC-Eca-033652 Equus caballus 80.54 0.00e+00 1214.00
IUUC-Eeu-035194 Erinaceus europaeus 66.85 0.00e+00 979.00
IUUC-Fca-035818 Felis catus 81.16 0.00e+00 1224.00
IUUC-Fal-036870 Ficedula albicollis 58.32 4.00e-170 591.00
IUUC-Gmo-039618 Gadus morhua 51.05 3.00e-91 328.00
IUUC-Gga-040485 Gallus gallus 59.96 2.00e-175 609.00
IUUC-Gac-041779 Gasterosteus aculeatus 55.19 6.00e-91 327.00
IUUC-Ggo-044587 Gorilla gorilla 81.48 0.00e+00 1227.00
IUUC-Hsa-045747 Homo sapiens 81.88 0.00e+00 1235.00
IUUC-Itr-048302 Ictidomys tridecemlineatus 81.34 0.00e+00 1232.00
IUUC-Lch-049644 Latimeria chalumnae 55.22 4.00e-123 435.00
IUUC-Loc-052661 Lepisosteus oculatus 62.09 2.00e-107 381.00
IUUC-Laf-054540 Loxodonta africana 77.08 0.00e+00 1134.00
IUUC-Mcc-054914 Macaca mulatta 78.49 0.00e+00 1185.00
IUUC-Meu-056903 Macropus eugenii 59.60 3.00e-166 578.00
IUUC-Mga-059450 Meleagris gallopavo 49.61 5.00e-178 618.00
IUUC-Mmr-061697 Microcebus murinus 80.24 0.00e+00 1212.00
IUUC-Mdo-062859 Monodelphis domestica 52.65 0.00e+00 637.00
IUUC-Mpu-066657 Mustela putorius furo 81.48 0.00e+00 1225.00
IUUC-Mlu-067515 Myotis lucifugus 78.39 0.00e+00 1173.00
IUUC-Nle-070025 Nomascus leucogenys 80.13 0.00e+00 1183.00
IUUC-Ont-071806 Oreochromis niloticus 60.77 3.00e-93 334.00
IUUC-Oan-073271 Ornithorhynchus anatinus 54.45 0.00e+00 687.00
IUUC-Ocu-074334 Oryctolagus cuniculus 80.27 0.00e+00 1185.00
IUUC-Ola-086926 Oryzias latipes 54.58 9.00e-82 296.00
IUUC-Oga-088748 Otolemur garnettii 79.14 0.00e+00 1193.00
IUUC-Oar-089661 Ovis aries 80.40 0.00e+00 1205.00
IUUC-Ptr-090815 Pan troglodytes 81.48 0.00e+00 1231.00
IUUC-Pan-091869 Papio anubis 78.76 0.00e+00 1188.00
IUUC-Psi-093629 Pelodiscus sinensis 50.32 0.00e+00 633.00
IUUC-Pfo-096553 Poecilia formosa 58.50 5.00e-85 306.00
IUUC-Pab-098245 Pongo abelii 81.45 0.00e+00 1237.00
IUUC-Pca-101132 Procavia capensis 66.71 0.00e+00 974.00
IUUC-Pva-102530 Pteropus vampyrus 80.54 0.00e+00 1207.00
IUUC-Rno-105307 Rattus norvegicus 92.15 0.00e+00 1426.00
IUUC-Sha-107362 Sarcophilus harrisii 84.21 2.00e-147 514.00
IUUC-Ssc-115758 Sus scrofa 78.39 0.00e+00 1164.00
IUUC-Tgu-116496 Taeniopygia guttata 56.55 1.00e-173 603.00
IUUC-Tsy-119395 Tarsius syrichta 73.96 0.00e+00 1104.00
IUUC-Tni-120025 Tetraodon nigroviridis 62.60 2.00e-92 332.00
IUUC-Tbe-127305 Tupaia belangeri 71.99 2.00e-123 436.00
IUUC-Ttr-129053 Tursiops truncatus 76.64 0.00e+00 1132.00
IUUC-Vpa-130688 Vicugna pacos 79.70 0.00e+00 1191.00
IUUC-Xtr-132040 Xenopus tropicalis 63.04 3.00e-146 512.00
Created Date 25-Jun-2017

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