iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045110

UUCD1 version

UUC-GoG-00022

Ensembl Protein ID

ENSGGOP00000000409.2

UniProt Accession

G3QDT2; G3QDT2_GORGO

Protein Name

Uncharacterized protein

Gene Name

CUL4A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000415.2	ENSGGOT00000000418.2	ENSGGOP00000000409.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/Cullin	5.20e-177	590.7	65	444

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/Cullin

   S: 1    klreavkkilrqesvkkeyeelytavynlclskvgaklYkklkevleefi.kqvkkkveesedeq.lLktynreWekfreqlkvlrkif 87
           kl+eav+++++++s+++++eely+av+nlc++kv+ +lYk+l++++e+++ +q+   +e+s d+  +Lk++n++W+++++q+ ++r+if
   Q: 65   KLHEAVRAVQSSTSIRYNLEELYQAVENLCSHKVSPMLYKQLRQACEDHVqAQILPFREDSLDSVlFLKKINTCWQDHCRQMIMIRSIF 153
           5899**********************************************99************************************* PP
   S: 88   ayldrtyvkkskkvsevrkLaldlwrkeived..ikkrllelllklieaeRkgeavdrrllsgvveslveLslnklaiykesFEakfle 174
           ++ldrtyv +++++ ++++++l+l+r++i++d  +++++++ +l lie+eR+geavdr+ll+++  +l++L     ++yk+sFE kfle
   Q: 154  LFLDRTYVLQNSTLPSIWDMGLELFRTHIISDkmVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDL-----QVYKDSFELKFLE 237
           *******************************************************************9998.....9************ PP
   S: 175  atqefykaesaeflqenevdeYlkkvearlneeeeraaryleestetkLlevvekeliakhlesll.aelvallrdkktedlsrmykLl 262
           +t+ +y+ae ++++qe+ev eYl++v +rl+ee +r+ +yl++st+++L+++vek+l+ +hl+++l ++l++ll++++  dl++my+L+
   Q: 238  ETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILqKGLDHLLDENRVPDLAQMYQLF 326
           ****************************************************************9989********************* PP
   S: 263  srvlngleellkeleshikeqgkaaltaeekekdpkkyVerllelknklqklvseaFnndakFlkaldkafetfvnknsvlkaaksp.E 350
           srv+ g + ll++++++ik+ g+a+++++ek+kd   +V++ll++k+k++++++ +F+++++F++ ++++fetf+nk+     +++p E
   Q: 327  SRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKR-----PNKPaE 407
           **********************************...*****************************************.....66666* PP
   S: 351  llAryiDqlLrksskglteeeleaqldkvllvfkyis 387
           l+A+++D++Lr+++k++t+eele++ldk++++f++i+
   Q: 408  LIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIH 444
           ***********************************98 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ 60
DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCGGACG AGGCCCCGCG GAAGGGCAGC TTCTCGGCGC TCGTGGGCCG CACCAACGGC 60
CTCACCAAGC CCGCGGCCCT GGCAGCCGCG CCCGCCAAGC CGGGGGGCGC GGGCGGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR016157--Cullin_CS
IPR016158--Cullin_homology
IPR001373--Cullin_N
IPR019559--Cullin_neddylation_domain
IPR016159--Cullin_repeat-like_dom
IPR011991--WHTH_DNA-bd_dom

PROSITE

PS01256--CULLIN_1
PS50069--CULLIN_2

Pfam

PF00888--Cullin
PF10557--Cullin_Nedd8

SMART

SM00182--CULLIN
SM00884--Cullin_Nedd8

Gene Ontology

GO:0031464--C:Cul4A-RING E3 ubiquitin ligase complex
GO:0030097--P:hemopoiesis
GO:0001701--P:in utero embryonic development
GO:0030853--P:negative regulation of granulocyte differentiation
GO:0008284--P:positive regulation of cell proliferation
GO:1900087--P:positive regulation of G1/S transition of mitotic cell cycle
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:2000001--P:regulation of DNA damage checkpoint
GO:2000819--P:regulation of nucleotide-excision repair
GO:0051246--P:regulation of protein metabolic process
GO:0035019--P:somatic stem cell population maintenance

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Csa-024139	Chlorocebus sabaeus	85.90	0.00e+00	1202.00
IUUC-Meu-056492	Macropus eugenii	73.71	3.00e-171	595.00
IUUC-Opr-070671	Ochotona princeps	85.21	7.00e-118	417.00
IUUC-Pan-092191	Papio anubis	85.30	0.00e+00	1191.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence