iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000002890.3	ENSMMUT00000004095.3	ENSMMUP00000003864.3
ENSMMUG00000002890.3	ENSMMUT00000004092.2	ENSMMUP00000003861.1
ENSMMUG00000002890.3	ENSMMUT00000004093.3	ENSMMUP00000003862.3
ENSMMUG00000002890.3	ENSMMUT00000057044.1	ENSMMUP00000045302.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.20e-06	29.2	16	61

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw.pglknssskefrCPlCr 46
           C +C  +++d  ++ pCgH+f++ Cl  + +   +ss k  +CPlC+
   Q: 16   CTLCVGPLED-AVTAPCGHTFCRLCLPTLsQMGAQSSGKILLCPLCQ 61
           9*********.999***********95553224555666668****7 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MPSTPSLKVV HELPACTLCV GPLEDAVTAP CGHTFCRLCL PTLSQMGAQS SGKILLCPLC 60
QEEEQAETPM ATVPLGPLGE TYCEEHGEKI YFFCENDAEF LCVFCREGPT HQAHTVGFLD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCCCTCAA CCCCGTCCCT GAAGGTGGTC CACGAGCTGC CCGCCTGTAC CCTCTGTGTG 60
GGGCCGCTGG AGGATGCGGT GACCGCTCCC TGTGGACACA CCTTCTGCCG GCTCTGCCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR000315--Znf_B-box
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box
PF00097--zf-C3HC4

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005622--C:intracellular
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:1901253--P:negative regulation of intracellular transport of viral material
GO:1902187--P:negative regulation of viral release from host cell
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1900246--P:positive regulation of RIG-I signaling pathway
GO:0032481--P:positive regulation of type I interferon production

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012749	Bos taurus	88.06	5.00e-179	620.00
IUUC-Cja-019423	Callithrix jacchus	90.32	0.00e+00	817.00
IUUC-Csa-023062	Chlorocebus sabaeus	99.25	1.00e-135	475.00
IUUC-Dor-030723	Dipodomys ordii	72.04	0.00e+00	672.00
IUUC-Eca-033832	Equus caballus	80.95	1.00e-128	452.00
IUUC-Eeu-035346	Erinaceus europaeus	80.56	8.00e-130	456.00
IUUC-Ggo-044848	Gorilla gorilla	96.99	0.00e+00	850.00
IUUC-Hsa-046266	Homo sapiens	96.99	0.00e+00	837.00
IUUC-Itr-048326	Ictidomys tridecemlineatus	78.23	0.00e+00	705.00
IUUC-Mdo-062286	Monodelphis domestica	63.27	2.00e-167	582.00
IUUC-Mmu-063387	Mus musculus	73.99	4.00e-115	407.00
IUUC-Nle-069027	Nomascus leucogenys	96.34	0.00e+00	833.00
IUUC-Opr-070615	Ochotona princeps	76.99	0.00e+00	699.00
IUUC-Ocu-074940	Oryctolagus cuniculus	82.58	0.00e+00	712.00
IUUC-Ptr-091302	Pan troglodytes	96.99	0.00e+00	831.00
IUUC-Pan-091860	Papio anubis	95.91	0.00e+00	848.00
IUUC-Pab-097674	Pongo abelii	95.70	0.00e+00	828.00
IUUC-Pva-102190	Pteropus vampyrus	81.08	0.00e+00	776.00
IUUC-Sar-113135	Sorex araneus	72.13	3.00e-130	457.00
IUUC-Ssc-115476	Sus scrofa	82.80	0.00e+00	685.00
IUUC-Tbe-127674	Tupaia belangeri	74.92	7.00e-114	403.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence