iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045943

UUCD1 version

UUC-HoS-01061

Ensembl Protein ID

ENSP00000287156.4

UniProt Accession

O14933; A6NDM6; A8MY53; Q8N5D8; Q9UEZ0; UB2L6_HUMAN

Genbank Protein ID

CAB64566.1; CAB64566.1; CAB64566.1; CAB64566.1; AAD17525.1; BAG38109.1; CAG33407.1; EAW73757.1; EAW73759.1; AAH32491.1; AAB86433.1

Protein Name

Ubiquitin/ISG15-conjugating enzyme E2 L6; E2 ubiquitin-conjugating enzyme L6; Retinoic acid-induced gene B protein; UbcH8; Ubiquitin carrier protein L6; Ubiquitin-protein ligase L6

Genbank Nucleotide ID

AJ243268; AJ243269; AJ243270; AJ243271; AF061736; AK315755; CR457126; AK226165; CH471076; BC032491; AF031141

Gene Name

UBE2L6; UBCH8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000156587.15	ENST00000287156.8	ENSP00000287156.4
ENSG00000156587.15	ENST00000526659.1	ENSP00000434348.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20133869; 19258326; 19234166; 19073728; 17222803; 16709802

Classification

Family	E-value	Score	Start	End
E2/UBC	1.90e-41	142.7	6	141

Active Site

Position(s)	Description	Evidence
86	Glycyl thioester intermediate	{ECO:0000255\|PROSITE-ProRule:PRU00388, ECO:0000255\|PROSITE-ProRule:PRU10133}

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilkeeekW 92
           R+ kel++l+k+pp++++   +d++++  w++l+l p++ pY+ ++F+l+i+fp++YPfkPP +kf+tki+hPnv+enG++Cl i+ ++e+W
   Q: 6    RVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLL-PDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPII-SSENW 95
           899********************************.**************************************************.5**** PP
   S: 93   spalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvr 138
           +p+++  +vl +++ l+++pn+++pl+ + a+ll++n+e ++k+++
   Q: 96   KPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAE 141
           *******************************************986 PP

Organism

Homo sapiens

Functional Description
(View)

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.

Protein Sequence
(Fasta)

MMASMRVVKE LEDLQKKPPP YLRNLSSDDA NVLVWHALLL PDQPPYHLKA FNLRISFPPE 60
YPFKPPMIKF TTKIYHPNVD ENGQICLPII SSENWKPCTK TCQVLEALNV LVNRPNIREP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAAGGATC CCCGACTGCC GGGGAGCGGT GCTCGGAGGG CACAGGTCTA CGCCATCCCC 60
CACGCAGTTT CGGAGATGGA GCGCTGGGCC CATGGAGGGA AGGCGGCAGG CTCGGCGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0903--Direct protein sequencing
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0042296--F:ISG15 transferase activity
GO:0043130--F:ubiquitin binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0044267--P:cellular protein metabolic process
GO:0006464--P:cellular protein modification process
GO:0032020--P:ISG15-protein conjugation
GO:0019941--P:modification-dependent protein catabolic process
GO:0032480--P:negative regulation of type I interferon production
GO:0019985--P:translesion synthesis

KEGG

hsa:9246

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001818	Ailuropoda melanoleuca	71.24	2.00e-63	234.00
IUUC-Bta-012539	Bos taurus	69.93	5.00e-61	226.00
IUUC-Cja-019456	Callithrix jacchus	90.85	5.00e-80	289.00
IUUC-Cfa-021275	Canis familiaris	70.59	5.00e-63	233.00
IUUC-Cpo-022261	Cavia porcellus	66.01	1.00e-58	218.00
IUUC-Csa-023794	Chlorocebus sabaeus	90.79	5.00e-80	289.00
IUUC-Cho-024821	Choloepus hoffmanni	82.64	3.00e-68	249.00
IUUC-Dno-029632	Dasypus novemcinctus	80.39	3.00e-70	256.00
IUUC-Dor-030595	Dipodomys ordii	75.00	2.00e-48	184.00
IUUC-Eca-033746	Equus caballus	75.82	2.00e-66	244.00
IUUC-Fca-035417	Felis catus	71.90	2.00e-63	234.00
IUUC-Ggo-045537	Gorilla gorilla	98.69	2.00e-86	310.00
IUUC-Itr-048889	Ictidomys tridecemlineatus	69.93	1.00e-60	225.00
IUUC-Laf-053524	Loxodonta africana	74.51	8.00e-60	222.00
IUUC-Mcc-054818	Macaca mulatta	92.11	6.00e-81	292.00
IUUC-Meu-055936	Macropus eugenii	60.91	7.00e-35	138.00
IUUC-Mmr-060799	Microcebus murinus	87.58	2.00e-77	280.00
IUUC-Mmu-063359	Mus musculus	76.47	3.00e-66	243.00
IUUC-Mpu-066122	Mustela putorius furo	68.24	6.00e-59	219.00
IUUC-Mlu-067283	Myotis lucifugus	71.90	5.00e-60	223.00
IUUC-Nle-069829	Nomascus leucogenys	92.81	1.00e-81	295.00
IUUC-Opr-071062	Ochotona princeps	71.24	4.00e-62	229.00
IUUC-Oan-073297	Ornithorhynchus anatinus	70.37	9.00e-43	164.00
IUUC-Ocu-074709	Oryctolagus cuniculus	79.45	2.00e-65	241.00
IUUC-Oga-088256	Otolemur garnettii	84.97	6.00e-76	275.00
IUUC-Oar-089370	Ovis aries	69.18	1.00e-57	215.00
IUUC-Ptr-091324	Pan troglodytes	100.00	2.00e-87	313.00
IUUC-Pan-092601	Papio anubis	91.10	3.00e-76	276.00
IUUC-Pab-098184	Pongo abelii	97.39	4.00e-85	306.00
IUUC-Pca-101080	Procavia capensis	75.69	2.00e-61	227.00
IUUC-Rno-104863	Rattus norvegicus	73.86	1.00e-65	241.00
IUUC-Sha-107162	Sarcophilus harrisii	56.86	3.00e-46	177.00
IUUC-Ssc-115506	Sus scrofa	77.78	1.00e-67	248.00
IUUC-Tsy-118811	Tarsius syrichta	70.83	1.00e-56	211.00
IUUC-Ttr-129266	Tursiops truncatus	77.12	6.00e-68	249.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence