iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oga-089072

Ensembl Protein ID

ENSOGAP00000002635.2

UniProt Accession

H0WLS7; H0WLS7_OTOGA

Genbank Protein ID

ENSOGAP00000002635

Protein Name

Coronin

Genbank Nucleotide ID

AAQR03123115

Gene Name

CORO1A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOGAG00000002942.2	ENSOGAT00000002946.2	ENSOGAP00000002635.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.10e-17	63.4	79	116

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 1    gHtdsvtclaf...sdtllvsGsdDgtikvWDlrtgvl 35
           gHt++v ++a+   +d+ ++sGs D+t++vW++ +g l
   Q: 79   GHTAPVLDIAWcphNDNVIASGSEDCTVMVWEIPDGGL 116
           8***********9877****************998875 PP

Organism

Otolemur garnettii

Protein Sequence
(Fasta)

MSRQVVRSSK FRHVFGQPAK ADQCYEDVRV SQTTWDSGFC AVNPKFVALI CEASGGGAFL 60
VLPLGKTGRV DKNVPTVCGH TAPVLDIAWC PHNDNVIASG SEDCTVMVWE IPDGGLTLPL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGATGAGC CGGCAGGTGG TCCGCTCTAG CAAGTTTCGC CACGTGTTTG GACAGCCAGC 60
CAAGGCCGAC CAGTGCTATG AGGACGTTCG TGTTTCACAG ACCACCTGGG ACAGTGGCTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR029508--CORO1A
IPR015505--Coronin
IPR015048--DUF1899
IPR015049--Trimer_CC
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF08953--DUF1899
PF08954--Trimer_CC
PF00400--WD40

SMART

SM01166--DUF1899
SM00320--WD40

Gene Ontology

GO:0005884--C:actin filament
GO:0030424--C:axon
GO:0005911--C:cell-cell junction
GO:0030864--C:cortical actin cytoskeleton
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0001772--C:immunological synapse
GO:0030027--C:lamellipodium
GO:0001891--C:phagocytic cup
GO:0045335--C:phagocytic vesicle
GO:0043234--C:protein complex
GO:0003723--F:RNA binding
GO:0007015--P:actin filament organization
GO:0006816--P:calcium ion transport
GO:0031589--P:cell-substrate adhesion
GO:0071353--P:cellular response to interleukin-4
GO:0061502--P:early endosome to recycling endosome transport
GO:0048873--P:homeostasis of number of cells within a tissue
GO:0030595--P:leukocyte chemotaxis
GO:0043320--P:natural killer cell degranulation
GO:0051126--P:negative regulation of actin nucleation
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0031339--P:negative regulation of vesicle fusion
GO:0038180--P:nerve growth factor signaling pathway
GO:0001845--P:phagolysosome assembly
GO:0050918--P:positive chemotaxis
GO:0030335--P:positive regulation of cell migration
GO:0042102--P:positive regulation of T cell proliferation
GO:0008360--P:regulation of cell shape
GO:0051279--P:regulation of release of sequestered calcium ion into cytosol
GO:0043029--P:T cell homeostasis
GO:0032796--P:uropod organization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002012	Ailuropoda melanoleuca	95.68	0.00e+00	913.00
IUUC-Ame-011101	Astyanax mexicanus	68.56	0.00e+00	677.00
IUUC-Bta-013168	Bos taurus	95.03	0.00e+00	909.00
IUUC-Cja-019660	Callithrix jacchus	95.03	0.00e+00	911.00
IUUC-Cfa-020938	Canis familiaris	95.46	0.00e+00	913.00
IUUC-Cpo-022056	Cavia porcellus	93.52	0.00e+00	897.00
IUUC-Csa-023193	Chlorocebus sabaeus	95.03	0.00e+00	908.00
IUUC-Dno-029363	Dasypus novemcinctus	95.25	0.00e+00	907.00
IUUC-Dor-030426	Dipodomys ordii	93.74	0.00e+00	896.00
IUUC-Eca-034229	Equus caballus	95.03	0.00e+00	909.00
IUUC-Eeu-034499	Erinaceus europaeus	92.87	0.00e+00	773.00
IUUC-Fca-036472	Felis catus	94.60	0.00e+00	903.00
IUUC-Gac-042545	Gasterosteus aculeatus	68.70	0.00e+00	677.00
IUUC-Ggo-045162	Gorilla gorilla	94.82	0.00e+00	908.00
IUUC-Hsa-046874	Homo sapiens	94.82	0.00e+00	908.00
IUUC-Itr-048911	Ictidomys tridecemlineatus	95.46	0.00e+00	914.00
IUUC-Laf-053427	Loxodonta africana	95.68	0.00e+00	904.00
IUUC-Mcc-055750	Macaca mulatta	95.10	0.00e+00	846.00
IUUC-Meu-056083	Macropus eugenii	87.90	0.00e+00	847.00
IUUC-Mmr-060858	Microcebus murinus	95.90	0.00e+00	915.00
IUUC-Mdo-062469	Monodelphis domestica	90.00	0.00e+00	855.00
IUUC-Mmu-063583	Mus musculus	93.09	0.00e+00	892.00
IUUC-Mpu-066451	Mustela putorius furo	96.16	0.00e+00	880.00
IUUC-Mlu-066978	Myotis lucifugus	94.60	0.00e+00	906.00
IUUC-Nle-069815	Nomascus leucogenys	95.03	0.00e+00	909.00
IUUC-Opr-070911	Ochotona princeps	92.22	0.00e+00	877.00
IUUC-Ont-072391	Oreochromis niloticus	68.75	0.00e+00	682.00
IUUC-Ocu-074429	Oryctolagus cuniculus	84.23	0.00e+00	775.00
IUUC-Oar-089676	Ovis aries	94.82	0.00e+00	907.00
IUUC-Ptr-091647	Pan troglodytes	94.82	0.00e+00	909.00
IUUC-Pan-092672	Papio anubis	95.03	0.00e+00	908.00
IUUC-Pab-098348	Pongo abelii	89.42	0.00e+00	839.00
IUUC-Pva-102668	Pteropus vampyrus	95.68	0.00e+00	914.00
IUUC-Rno-105604	Rattus norvegicus	92.01	0.00e+00	883.00
IUUC-Sha-107210	Sarcophilus harrisii	88.98	0.00e+00	871.00
IUUC-Sar-113292	Sorex araneus	94.62	0.00e+00	724.00
IUUC-Tbe-128025	Tupaia belangeri	94.10	1.00e-148	518.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence