iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tca-121646

Ensembl Protein ID

EOY12001

UniProt Accession

A0A061F4P2; A0A061F4P2_THECC

Genbank Protein ID

EOY12001.1

Protein Name

E3 ubiquitin protein ligase upl2, putative isoform 1

Genbank Nucleotide ID

CM001885

Gene Name

TCM_030623

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
TCM_030623	EOY12003	EOY12003
TCM_030623	EOY12002	EOY12002
TCM_030623	EOY12001	EOY12001

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.20e-114	382.1	3434	3756
UBD/Alpha-Helix/UBM	7.70e-13	48.6	2708	2732
UBD/Alpha-Helix/UBA	2.10e-08	35.0	1294	1333

Active Site

Position(s)	Description	Evidence
3739	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           dlk rl+v+f+gEeg+d+gG+tre+++lls+ ++++ + lf ++ ++++t+qpn++s ++ +ehl++F+f+Gr+++kal+dg+lld+ +++sfyk++lg
   Q: 3434 DLKGRLNVQFQGEEGIDAGGLTREWYQLLSRVIFDKGALLF-TTVGNNATFQPNSNSVYQ-TEHLSYFKFVGRVVAKALFDGQLLDVYFTRSFYKHILG 3530
           899**********************************9999.566688999******986.5************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfn 198
           +k++++d+e+vdp++yk+lk+++en+ sdi +l++ +  +++++i     e++++eLkpgG+ni+Vt+e k+eYv+lv++++l++ i+ q+++f eGf+
   Q: 3531 VKVTYHDIEAVDPDYYKNLKWMLENDVSDIPDLTFSMDADEEKHIlyeKTEVTDYELKPGGRNIRVTEETKHEYVDLVADHILTNAIRPQINSFLEGFT 3629
           *************************7777777666666555555484444556778******************************************* PP
   S: 199  eviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirk.d 292
           e++p el+s+F+ +elelli+G +eid++dlk++t+y+g yt+ sp+iqwFwev+++f++e+ +++LqFvTg+s++Pl+Gf++l+    p++f+i+k +
   Q: 3630 ELVPRELISIFNDKELELLISGLPEIDLDDLKANTEYTG-YTAASPVIQWFWEVVKAFNKEDMARLLQFVTGTSKVPLEGFKALQgisgPQRFQIHKaY 3727
           *************************************66.*********************************************************99 PP
   S: 293  asddrlPssnTCfnyLkLPeYsskeilke 321
           ++++rlPs++TCfn+L+LPeY+ske+l+e
   Q: 3728 GAPERLPSAHTCFNQLDLPEYTSKEQLQE 3756
           999************************98 PP

UBD/Alpha-Helix/UBM

   S: 4    qvDpeVfsqLPeeiQeEvmaelrqq 28
           ++Dpe++++LP++iQ+Ev+a +r q
   Q: 2708 DIDPEFLAALPPDIQAEVLAQQRAQ 2732
           79******************99976 PP

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLldg 41
           de  ++ +veMGF+r +a +aLr+   n++e+A+e+L+++
   Q: 1294 DEGTIATIVEMGFSRARAEEALRRVeTNSVEMAMEWLISH 1333
           7889********************66***********987 PP

Organism

Theobroma cacao

Protein Sequence
(Fasta)

MKLKRRRYLE VPPKIRSFIN SVTSVPLENI EEPLKDFIWE FDKGDFHHWV ELFNHFDTFF 60
EKHIKSRKDL QVEDNFLGSD PPFPREAVLQ ILRVIRIVLE NCTNKHFYSS YEHLSSLLAS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTTCTCCA GTTATTACAA TTCTTCTCCA CTTCTCTCTC TTTTCTCTTC CTCTTCTTTT 60
TCTCTCTCTC TATCTCTCTT CCTTTCTTTC TTTGATCTCA TAAAAACCCT AATTTCCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR025527--DUF4414
IPR010309--E3_Ub_ligase_DUF908
IPR010314--E3_Ub_ligase_DUF913
IPR000569--HECT_dom
IPR015940--UBA
IPR009060--UBA-like
IPR003903--UIM_dom

PROSITE

PS50237--HECT
PS50030--UBA
PS50330--UIM

Pfam

PF14377--DUF4414
PF06012--DUF908
PF06025--DUF913
PF00632--HECT
PF00627--UBA

SMART

SM00119--HECTc
SM00165--UBA

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Atr-003044	Amborella trichopoda	63.01	0.00e+00	4029.00
IUUC-Aly-006083	Arabidopsis lyrata	66.35	0.00e+00	4389.00
IUUC-Ath-007472	Arabidopsis thaliana	66.97	0.00e+00	4533.00
IUUC-Bra-016637	Brassica rapa	62.60	0.00e+00	4127.00
IUUC-Cne-027095	Cryptococcus neoformans	38.59	5.00e-110	393.00
IUUC-Dre-028525	Danio rerio	50.48	3.00e-112	401.00
IUUC-Gma-044247	Glycine max	74.32	0.00e+00	4959.00
IUUC-Lpe-050915	Leersia perrieri	58.17	0.00e+00	3685.00
IUUC-Mtr-058088	Medicago truncatula	71.64	0.00e+00	2928.00
IUUC-Mvi-060320	Microbotryum violaceum	32.68	1.00e-125	445.00
IUUC-Mac-065557	Musa acuminata	56.35	0.00e+00	1687.00
IUUC-Oba-075252	Oryza barthii	58.76	0.00e+00	3702.00
IUUC-Obr-076762	Oryza brachyantha	58.22	0.00e+00	3695.00
IUUC-Ogl-077590	Oryza glaberrima	59.97	0.00e+00	1316.00
IUUC-Ogu-077981	Oryza glumaepatula	57.49	0.00e+00	2347.00
IUUC-Oin-079663	Oryza indica	57.32	0.00e+00	3443.00
IUUC-Olo-080326	Oryza longistaminata	58.80	0.00e+00	3689.00
IUUC-Oni-082342	Oryza nivara	58.76	0.00e+00	3736.00
IUUC-Opu-083428	Oryza punctata	58.81	0.00e+00	3672.00
IUUC-Oru-084559	Oryza rufipogon	58.82	0.00e+00	3700.00
IUUC-Osa-086200	Oryza sativa	60.92	0.00e+00	1366.00
IUUC-Pan-092368	Papio anubis	50.48	8.00e-113	403.00
IUUC-Ppa-095657	Physcomitrella patens	50.32	0.00e+00	1822.00
IUUC-Pop-099520	Populus trichocarpa	76.37	0.00e+00	5224.00
IUUC-Ppe-102109	Prunus persica	79.61	0.00e+00	5432.00
IUUC-Smo-109428	Selaginella moellendorffii	43.96	0.00e+00	1663.00
IUUC-Sit-110149	Setaria italica	57.52	0.00e+00	3519.00
IUUC-Sly-111285	Solanum lycopersicum	69.60	0.00e+00	4777.00
IUUC-Stu-112501	Solanum tuberosum	79.20	1.00e-159	555.00
IUUC-Sbi-113794	Sorghum bicolor	55.60	0.00e+00	2932.00
IUUC-Vvi-131559	Vitis vinifera	79.42	0.00e+00	2166.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence