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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Rno-105122
UUCD1 version UUC-RaN-00862
Ensembl Protein ID ENSRNOP00000027411.5
UniProt Accession Q5XFW6; WDR6_RAT
Genbank Protein ID EDL77156.1; AAH84708.1
Protein Name WD repeat-containing protein 6
Genbank Nucleotide ID CH473954; BC084708
Gene Name Wdr6
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000020185.7 ENSRNOT00000027411.7 ENSRNOP00000027411.5
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-21 76.4 207 240
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf..sdtllvsGsdDgtikvWDlrt 32
           gH + ++++++  s +ll+++s D ++++W + +
   Q: 207  GHVGVIFSMSYleSKGLLATASEDRSVRIWKVGD 240
           8*********99766***************9865 PP
   
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.
 Enhances the STK11/LKB1-induced cell growth suppression activity. Negative regulator of amino acid starvation-induced autophagy.
Protein Sequence
(Fasta)
MDAFGDYVWP RATSELILLP VTGLECVGDR LLAGEGPDLL VYNLDFGGHL RMVKRVQNLL 60
GHYLIHGFRV QPEPKGDLDS EAMIAVFGSK GLRVVKISWG QSHLRELWRS GLWNMSDWIW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Rno-105122|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACATGACAGT GCTGTTTTAT TTGAACAATG TCACCGGTGG GGGCGAGACT GTCTTCCCTG 60
TAGCAGACAA CAGGACCTAC GATGAAATGG TAAGGGCCAA TGGGCTACTC TATTACTCTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105122|E3,WD_repeat|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0131--Cell cycle
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0043560--F:insulin receptor substrate binding
GO:0007049--P:cell cycle
GO:0008286--P:insulin receptor signaling pathway
GO:0048009--P:insulin-like growth factor receptor signaling pathway
KEGG rno:301007
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000976 Aegilops tauschii 21.63 2.00e-21 98.20
IUUC-Aml-001786 Ailuropoda melanoleuca 88.89 0.00e+00 1983.00
IUUC-Atr-003053 Amborella trichopoda 22.35 6.00e-33 137.00
IUUC-Apl-003178 Anas platyrhynchos 47.97 1.00e-143 503.00
IUUC-Aca-004886 Anolis carolinensis 44.90 0.00e+00 862.00
IUUC-Aly-005509 Arabidopsis lyrata 24.31 1.00e-37 152.00
IUUC-Ath-007109 Arabidopsis thaliana 27.16 3.00e-28 121.00
IUUC-Ago-007817 Ashbya gossypii 22.29 1.00e-41 165.00
IUUC-Acl-008020 Aspergillus clavatus 22.76 3.00e-20 94.40
IUUC-Afl-008608 Aspergillus flavus 21.48 7.00e-16 79.30
IUUC-Afu-009035 Aspergillus fumigatus 22.77 5.00e-33 137.00
IUUC-Ani-009359 Aspergillus nidulans 22.60 2.00e-21 98.60
IUUC-Ang-009692 Aspergillus niger 21.49 5.00e-23 103.00
IUUC-Aor-010056 Aspergillus oryzae 21.77 5.00e-27 117.00
IUUC-Ate-010299 Aspergillus terreus 21.77 9.00e-26 112.00
IUUC-Ame-011051 Astyanax mexicanus 33.78 4.00e-153 536.00
IUUC-Bgr-012077 Blumeria graminis 19.96 2.00e-08 55.10
IUUC-Bta-012793 Bos taurus 86.47 0.00e+00 1904.00
IUUC-Bci-013679 Botrytis cinerea 21.02 2.00e-09 58.50
IUUC-Bdi-014401 Brachypodium distachyon 23.41 1.00e-34 142.00
IUUC-Bol-015628 Brassica oleracea 24.31 2.00e-29 124.00
IUUC-Bra-017446 Brassica rapa 23.80 1.00e-32 135.00
IUUC-Cja-018910 Callithrix jacchus 87.64 0.00e+00 1964.00
IUUC-Cfa-021260 Canis familiaris 88.89 0.00e+00 1991.00
IUUC-Cpo-022205 Cavia porcellus 85.16 0.00e+00 1942.00
IUUC-Csa-023510 Chlorocebus sabaeus 87.20 0.00e+00 1932.00
IUUC-Cgl-026380 Colletotrichum gloeosporioides 26.25 3.00e-08 53.90
IUUC-Dre-028004 Danio rerio 33.97 1.00e-157 550.00
IUUC-Dno-029804 Dasypus novemcinctus 82.61 0.00e+00 1827.00
IUUC-Dor-030512 Dipodomys ordii 82.85 0.00e+00 1457.00
IUUC-Dme-032047 Drosophila melanogaster 24.44 4.00e-27 117.00
IUUC-Ete-033076 Echinops telfairi 79.86 0.00e+00 672.00
IUUC-Eca-033727 Equus caballus 87.71 0.00e+00 1571.00
IUUC-Eeu-035210 Erinaceus europaeus 81.33 0.00e+00 1848.00
IUUC-Fca-035433 Felis catus 89.16 0.00e+00 1995.00
IUUC-Fal-036807 Ficedula albicollis 46.94 3.00e-166 578.00
IUUC-Fox-037749 Fusarium oxysporum 21.74 8.00e-19 89.70
IUUC-Fso-038164 Fusarium solani 22.51 3.00e-15 77.80
IUUC-Gmo-039180 Gadus morhua 35.08 7.00e-143 501.00
IUUC-Gga-040482 Gallus gallus 44.60 5.00e-180 625.00
IUUC-Gac-042066 Gasterosteus aculeatus 35.06 6.00e-149 521.00
IUUC-Gma-042704 Glycine max 26.49 3.00e-23 105.00
IUUC-Ggo-044942 Gorilla gorilla 88.53 0.00e+00 1954.00
IUUC-Hsa-046408 Homo sapiens 88.44 0.00e+00 1980.00
IUUC-Hvu-047448 Hordeum vulgare 21.73 1.00e-26 115.00
IUUC-Itr-048756 Ictidomys tridecemlineatus 89.16 0.00e+00 2046.00
IUUC-Kpa-049257 Komagataella pastoris 21.59 1.00e-37 152.00
IUUC-Lch-050170 Latimeria chalumnae 42.67 0.00e+00 877.00
IUUC-Lpe-051575 Leersia perrieri 21.40 6.00e-34 140.00
IUUC-Loc-052341 Lepisosteus oculatus 35.85 2.00e-138 486.00
IUUC-Lma-053318 Leptosphaeria maculans 24.71 5.00e-13 70.50
IUUC-Laf-054299 Loxodonta africana 84.53 0.00e+00 1879.00
IUUC-Mcc-055438 Macaca mulatta 87.56 0.00e+00 1944.00
IUUC-Meu-056206 Macropus eugenii 47.43 0.00e+00 645.00
IUUC-Mor-056928 Magnaporthe oryzae 22.88 9.00e-13 69.70
IUUC-Mtr-058455 Medicago truncatula 24.80 2.00e-30 128.00
IUUC-Mga-059962 Meleagris gallopavo 47.12 8.00e-155 540.00
IUUC-Mvi-060438 Microbotryum violaceum 26.10 7.00e-16 80.10
IUUC-Mmr-061353 Microcebus murinus 88.00 0.00e+00 1995.00
IUUC-Mdo-062061 Monodelphis domestica 50.16 0.00e+00 897.00
IUUC-Mmu-064386 Mus musculus 94.31 0.00e+00 2146.00
IUUC-Mac-065653 Musa acuminata 23.65 1.00e-44 176.00
IUUC-Mpu-066420 Mustela putorius furo 88.62 0.00e+00 2008.00
IUUC-Mlu-068104 Myotis lucifugus 84.80 0.00e+00 1905.00
IUUC-Nfi-068301 Neosartorya fischeri 22.27 1.00e-33 139.00
IUUC-Ncr-068718 Neurospora crassa 22.76 2.00e-13 72.00
IUUC-Nle-069836 Nomascus leucogenys 88.17 0.00e+00 1463.00
IUUC-Ont-071605 Oreochromis niloticus 35.28 5.00e-163 568.00
IUUC-Oan-073645 Ornithorhynchus anatinus 48.46 0.00e+00 994.00
IUUC-Ocu-074708 Oryctolagus cuniculus 85.60 0.00e+00 1876.00
IUUC-Oba-075290 Oryza barthii 26.83 7.00e-22 100.00
IUUC-Obr-076647 Oryza brachyantha 23.14 2.00e-32 135.00
IUUC-Ogl-077628 Oryza glaberrima 28.19 7.00e-28 120.00
IUUC-Ogu-078209 Oryza glumaepatula 26.22 5.00e-22 100.00
IUUC-Oin-079342 Oryza indica 27.73 7.00e-29 123.00
IUUC-Olo-080623 Oryza longistaminata 26.65 1.00e-25 110.00
IUUC-Ome-081776 Oryza meridionalis 25.24 4.00e-22 100.00
IUUC-Oni-082311 Oryza nivara 27.73 7.00e-29 123.00
IUUC-Opu-083195 Oryza punctata 26.98 2.00e-27 118.00
IUUC-Oru-085006 Oryza rufipogon 26.52 3.00e-21 98.20
IUUC-Osa-085317 Oryza sativa 27.89 3.00e-27 118.00
IUUC-Ola-087145 Oryzias latipes 35.89 1.00e-150 528.00
IUUC-Olu-087785 Ostreococcus lucimarinus 25.49 4.00e-11 63.90
IUUC-Oga-088206 Otolemur garnettii 88.00 0.00e+00 2020.00
IUUC-Oar-089802 Ovis aries 85.79 0.00e+00 1880.00
IUUC-Ptr-091528 Pan troglodytes 80.00 0.00e+00 1742.00
IUUC-Pan-092782 Papio anubis 87.73 0.00e+00 1950.00
IUUC-Psi-093102 Pelodiscus sinensis 48.00 9.00e-134 470.00
IUUC-Pno-095063 Phaeosphaeria nodorum 29.38 4.00e-07 50.80
IUUC-Ppa-095436 Physcomitrella patens 23.85 1.00e-35 145.00
IUUC-Pfo-097423 Poecilia formosa 33.33 2.00e-141 497.00
IUUC-Pab-097763 Pongo abelii 88.27 0.00e+00 1949.00
IUUC-Pop-099090 Populus trichocarpa 27.41 6.00e-26 113.00
IUUC-Pca-100173 Procavia capensis 83.20 0.00e+00 1851.00
IUUC-Ppe-101580 Prunus persica 27.57 8.00e-27 116.00
IUUC-Pva-102715 Pteropus vampyrus 87.82 0.00e+00 1930.00
IUUC-Pgr-103424 Puccinia graminis 24.41 9.00e-14 72.80
IUUC-Pte-104316 Pyrenophora teres 24.14 2.00e-12 68.20
IUUC-Pyt-104676 Pyrenophora triticirepentis 23.50 9.00e-12 66.20
IUUC-Sce-106465 Saccharomyces cerevisiae 21.50 5.00e-28 120.00
IUUC-Sha-107208 Sarcophilus harrisii 48.74 0.00e+00 1025.00
IUUC-Sja-107771 Schizosaccharomyces japonicus 22.62 5.00e-38 153.00
IUUC-Spo-108272 Schizosaccharomyces pombe 22.86 2.00e-21 97.80
IUUC-Ssl-108576 Sclerotinia sclerotiorum 21.70 2.00e-05 45.40
IUUC-Smo-108961 Selaginella moellendorffii 24.00 1.00e-44 176.00
IUUC-Sit-109932 Setaria italica 22.73 7.00e-35 143.00
IUUC-Sly-111685 Solanum lycopersicum 23.98 8.00e-34 139.00
IUUC-Sar-112998 Sorex araneus 84.37 0.00e+00 1926.00
IUUC-Sbi-114074 Sorghum bicolor 23.09 1.00e-37 152.00
IUUC-Ssc-115619 Sus scrofa 87.52 0.00e+00 949.00
IUUC-Tgu-117485 Taeniopygia guttata 46.85 4.00e-158 551.00
IUUC-Tru-118104 Takifugu rubripes 36.15 6.00e-165 575.00
IUUC-Tni-119995 Tetraodon nigroviridis 36.47 5.00e-159 555.00
IUUC-Tca-121790 Theobroma cacao 27.46 3.00e-25 111.00
IUUC-Tre-122080 Trichoderma reesei 21.00 4.00e-12 67.80
IUUC-Tvi-122306 Trichoderma virens 21.32 5.00e-13 70.50
IUUC-Tae-125371 Triticum aestivum 23.45 5.00e-37 150.00
IUUC-Tur-126787 Triticum urartu 23.25 6.00e-32 133.00
IUUC-Tme-126957 Tuber melanosporum 26.71 3.00e-08 54.30
IUUC-Tbe-128082 Tupaia belangeri 89.93 2.00e-153 536.00
IUUC-Ttr-128387 Tursiops truncatus 93.04 0.00e+00 985.00
IUUC-Vda-129804 Verticillium dahliae 21.04 7.00e-10 60.10
IUUC-Vpa-130257 Vicugna pacos 86.14 4.00e-158 551.00
IUUC-Vvi-131701 Vitis vinifera 29.18 5.00e-28 120.00
IUUC-Xtr-132622 Xenopus tropicalis 42.51 0.00e+00 870.00
IUUC-Xma-134014 Xiphophorus maculatus 34.23 8.00e-153 534.00
IUUC-Yli-134589 Yarrowia lipolytica 21.85 3.00e-25 110.00
IUUC-Zma-135732 Zea mays 21.88 4.00e-40 160.00
Created Date 25-Jun-2017

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