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Tag Content
iUUCD ID IUUC-Ame-011521
Ensembl Protein ID ENSAMXP00000010405.1
UniProt Accession W5KS43; W5KS43_ASTMX
Genbank Protein ID ENSAMXP00000010405
Protein Name E3 ubiquitin-protein ligase RNF168; RING finger protein 168; RING-type E3 ubiquitin transferase RNF168
Genbank Nucleotide ID APWO01033771
Gene Name rnf168; RNF168
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSAMXG00000010126.1 ENSAMXT00000010405.1 ENSAMXP00000010405.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 8.10e-07 29.7 28 67
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C+iCle f + p++lpC H+f++ C+ + +       + +  CPlCr
   Q: 28   CPICLEIFLE-PVTLPCEHTFCKPCFlETV------DKANMCCPLCR 67
           ********99.9*************97777......999*******8 PP
   
Organism Astyanax mexicanus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
 E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).
Protein Sequence
(Fasta)
MPPVSEVEPK PKLVQGGSGQ LTRADCLCPI CLEIFLEPVT LPCEHTFCKP CFLETVDKAN 60
MCCPLCRKRV STWARLNTRK KTLVNVELWK RIQKAFPVQC QRRLNGVEEE QEEVLIPKPK 120
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Protein Fasta Sequence


>IUUC-Ame-011521|E3,RING|Astyanax mexicanus
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Nucleotide Sequence
(Fasta)
ATGCCACCAG TGTCAGAGGT GGAGCCGAAG CCCAAGCTGG TGCAGGGGGG CTCTGGACAG 60
CTCACTCGGG CAGACTGCTT ATGCCCCATC TGTCTGGAGA TCTTCCTGGA GCCTGTCACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Ame-011521|E3,RING|Astyanax mexicanus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR034725--RNF168
IPR018957--Znf_C3HC4_RING-type
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF00097--zf-C3HC4
SMART

SM00184--RING
Gene Ontology

GO:0008270--F:zinc ion binding
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000755 Aegilops tauschii 39.47 7.00e-11 62.00
IUUC-Aml-001573 Ailuropoda melanoleuca 53.04 5.00e-35 142.00
IUUC-Apl-003963 Anas platyrhynchos 57.60 1.00e-42 167.00
IUUC-Aca-004420 Anolis carolinensis 58.26 1.00e-39 157.00
IUUC-Bta-013002 Bos taurus 53.85 3.00e-35 142.00
IUUC-Cja-019945 Callithrix jacchus 54.24 3.00e-35 143.00
IUUC-Cfa-020533 Canis familiaris 51.33 1.00e-33 137.00
IUUC-Cpo-021643 Cavia porcellus 55.17 1.00e-37 150.00
IUUC-Csa-023638 Chlorocebus sabaeus 53.11 2.00e-37 150.00
IUUC-Cho-024319 Choloepus hoffmanni 54.70 5.00e-36 145.00
IUUC-Cin-025679 Ciona intestinalis 36.41 6.00e-26 111.00
IUUC-Csv-026052 Ciona savignyi 39.84 8.00e-23 100.00
IUUC-Dre-028519 Danio rerio 54.28 6.00e-100 357.00
IUUC-Dno-029294 Dasypus novemcinctus 53.91 2.00e-35 144.00
IUUC-Ete-032714 Echinops telfairi 54.29 4.00e-32 132.00
IUUC-Eca-033343 Equus caballus 53.45 2.00e-38 154.00
IUUC-Fca-036251 Felis catus 52.54 6.00e-36 145.00
IUUC-Fal-037048 Ficedula albicollis 60.32 9.00e-45 174.00
IUUC-Gmo-039400 Gadus morhua 65.00 2.00e-48 184.00
IUUC-Gga-040444 Gallus gallus 51.37 2.00e-45 177.00
IUUC-Gac-041735 Gasterosteus aculeatus 55.88 6.00e-55 207.00
IUUC-Gma-044332 Glycine max 44.74 9.00e-13 67.80
IUUC-Hsa-046424 Homo sapiens 56.03 1.00e-36 147.00
IUUC-Itr-048965 Ictidomys tridecemlineatus 59.04 2.00e-31 130.00
IUUC-Lch-050649 Latimeria chalumnae 51.00 3.00e-41 162.00
IUUC-Loc-051847 Lepisosteus oculatus 55.82 2.00e-51 196.00
IUUC-Laf-053938 Loxodonta africana 54.29 1.00e-35 144.00
IUUC-Mcc-055360 Macaca mulatta 53.04 1.00e-35 144.00
IUUC-Meu-056684 Macropus eugenii 51.83 3.00e-37 149.00
IUUC-Mga-059699 Meleagris gallopavo 54.70 4.00e-45 176.00
IUUC-Mmr-060779 Microcebus murinus 55.93 2.00e-37 150.00
IUUC-Mdo-062225 Monodelphis domestica 51.28 1.00e-36 147.00
IUUC-Mmu-064239 Mus musculus 55.43 1.00e-30 127.00
IUUC-Mpu-066141 Mustela putorius furo 48.66 8.00e-40 158.00
IUUC-Mlu-067945 Myotis lucifugus 54.65 3.00e-36 146.00
IUUC-Nle-069769 Nomascus leucogenys 53.10 1.00e-33 137.00
IUUC-Opr-070905 Ochotona princeps 62.65 2.00e-32 134.00
IUUC-Ont-071477 Oreochromis niloticus 61.88 6.00e-48 184.00
IUUC-Oan-073587 Ornithorhynchus anatinus 56.30 1.00e-36 144.00
IUUC-Ocu-073832 Oryctolagus cuniculus 51.65 5.00e-36 145.00
IUUC-Ola-086478 Oryzias latipes 65.38 2.00e-47 181.00
IUUC-Oga-088318 Otolemur garnettii 55.14 6.00e-33 135.00
IUUC-Oar-089647 Ovis aries 54.70 1.00e-35 144.00
IUUC-Ptr-090516 Pan troglodytes 56.90 2.00e-37 150.00
IUUC-Pan-092302 Papio anubis 54.31 7.00e-37 148.00
IUUC-Psi-093604 Pelodiscus sinensis 57.94 1.00e-41 164.00
IUUC-Pfo-096441 Poecilia formosa 64.86 2.00e-53 202.00
IUUC-Pab-097729 Pongo abelii 55.75 1.00e-35 144.00
IUUC-Pop-099737 Populus trichocarpa 38.46 9.00e-11 62.80
IUUC-Pca-100552 Procavia capensis 56.82 1.00e-30 128.00
IUUC-Pva-102780 Pteropus vampyrus 53.45 1.00e-34 141.00
IUUC-Rno-105461 Rattus norvegicus 52.85 1.00e-36 147.00
IUUC-Sha-106809 Sarcophilus harrisii 52.99 4.00e-36 146.00
IUUC-Sly-110934 Solanum lycopersicum 44.58 3.00e-13 69.30
IUUC-Stu-112446 Solanum tuberosum 46.05 5.00e-13 68.60
IUUC-Sar-113579 Sorex araneus 51.72 2.00e-34 140.00
IUUC-Sbi-113834 Sorghum bicolor 42.11 1.00e-11 64.30
IUUC-Tgu-117187 Taeniopygia guttata 55.22 2.00e-43 168.00
IUUC-Tru-118182 Takifugu rubripes 42.15 4.00e-53 202.00
IUUC-Tni-120205 Tetraodon nigroviridis 41.64 1.00e-51 196.00
IUUC-Tca-121416 Theobroma cacao 40.20 5.00e-13 68.60
IUUC-Tre-121992 Trichoderma reesei 36.26 1.00e-09 57.40
IUUC-Tvi-122557 Trichoderma virens 38.37 3.00e-08 53.10
IUUC-Tae-123092 Triticum aestivum 39.47 7.00e-11 62.00
IUUC-Tur-126688 Triticum urartu 38.16 6.00e-11 61.60
IUUC-Tbe-127622 Tupaia belangeri 54.03 2.00e-38 153.00
IUUC-Ttr-128988 Tursiops truncatus 54.70 3.00e-35 143.00
IUUC-Vda-129783 Verticillium dahliae 32.97 6.00e-09 55.50
IUUC-Vpa-130302 Vicugna pacos 53.85 7.00e-35 142.00
IUUC-Vvi-131424 Vitis vinifera 44.74 4.00e-11 62.00
IUUC-Xtr-132196 Xenopus tropicalis 56.28 1.00e-42 167.00
Created Date 25-Jun-2017

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