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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045992
Ensembl Protein ID ENSP00000399970.2
UniProt Accession Q66LE6; A8KAK0; Q5SQJ2; Q9P1Y7; 2ABD_HUMAN
Genbank Protein ID BAF85754.1; CAI16703.1; AAH47379.1; BAA96065.1
Protein Name Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; PP2A subunit B isoform B55-delta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform delta
Genbank Nucleotide ID AK293065; AL732395; BC047379; AB040974
Gene Name PPP2R2D; KIAA1541
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000175470.18 ENST00000455566.5 ENSP00000399970.2
ENSG00000175470.18 ENST00000616467.4 ENSP00000481133.2
ENSG00000175470.18 ENST00000482010.6 ENSP00000428418.2
ENSG00000175470.18 ENST00000470416.5 ENSP00000485636.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
miRWalkRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.80e-10 42.3 292 319
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 4    dsvtclaf..sdtllvsGsdDgt.ikvWDl 30
           +s+++++f  s++++ +  +D   +kvWDl
   Q: 292  SSISDVKFshSGRYMMT--RDYLsVKVWDL 319
           57888888855588888..99555*****7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
 B regulatory subunit of protein phosphatase 2A (PP2A) that plays a key role in cell cycle by controlling mitosis entry and exit. The activity of PP2A complexes containing PPP2R2D (PR55-delta) fluctuate during the cell cycle: the activity is high in interphase and low in mitosis. During mitosis, activity of PP2A is inhibited via interaction with phosphorylated ENSA and ARPP19 inhibitors. Within the PP2A complexes, the B regulatory subunits modulate substrate selectivity and catalytic activity, and also may direct the localization of the catalytic enzyme to a particular subcellular compartment (By similarity).
Protein Sequence
(Fasta)
MAGAGGGGCP AGGNDFQWCF SQVKGAIDED VAEADIISTV EFNYSGDLLA TGDKGGRVVI 60
FQREQENKSR PHSRGEYNVY STFQSHEPEF DYLKSLEIEE KINKIRWLPQ QNAAHFLLST 120
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Protein Fasta Sequence


>IUUC-Hsa-045992|E3,WD_repeat|Homo sapiens
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Nucleotide Sequence
(Fasta)
GTGTCCGGCC AAGCGGCGCC CTGAAGGCGT GTCCGGCCGC AGCTTAGGCT CTCCGGGAGT 60
CCCCGGAGAG TAGGGGCGGC CGGCGGCGCT AGTCTTCTGG GGAGCGCCGG GTGCACACCG 120
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Nucleotide Fasta Sequence


>IUUC-Hsa-045992|E3,WD_repeat|Homo sapiens
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Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR000009--PP2A_PR55
IPR018067--PP2A_PR55_CS
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS01024--PR55_1
PS01025--PR55_2
PRINTS

PR00600--PP2APR55
SMART

SM00320--WD40
Gene Ontology

GO:0005829--C:cytosol
GO:0000159--C:protein phosphatase type 2A complex
GO:0019888--F:protein phosphatase regulator activity
GO:0051301--P:cell division
GO:0032502--P:developmental process
GO:0010458--P:exit from mitosis
GO:0000278--P:mitotic cell cycle
GO:0007067--P:mitotic nuclear division
GO:0070262--P:peptidyl-serine dephosphorylation
KEGG hsa:55844
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001982 Ailuropoda melanoleuca 97.39 0.00e+00 826.00
IUUC-Apl-003842 Anas platyrhynchos 96.00 0.00e+00 813.00
IUUC-Aca-004276 Anolis carolinensis 97.27 0.00e+00 870.00
IUUC-Aly-006304 Arabidopsis lyrata 50.93 1.00e-135 476.00
IUUC-Ath-007621 Arabidopsis thaliana 51.45 1.00e-134 473.00
IUUC-Acl-008202 Aspergillus clavatus 56.16 4.00e-133 468.00
IUUC-Afl-008646 Aspergillus flavus 55.60 3.00e-134 472.00
IUUC-Afu-009027 Aspergillus fumigatus 56.16 3.00e-134 472.00
IUUC-Ani-009191 Aspergillus nidulans 56.25 1.00e-135 476.00
IUUC-Ang-009769 Aspergillus niger 55.89 2.00e-136 479.00
IUUC-Aor-010030 Aspergillus oryzae 55.39 1.00e-132 466.00
IUUC-Ate-010549 Aspergillus terreus 55.97 4.00e-133 468.00
IUUC-Bci-013801 Botrytis cinerea 54.95 1.00e-138 486.00
IUUC-Bdi-014176 Brachypodium distachyon 51.61 1.00e-135 476.00
IUUC-Bol-015921 Brassica oleracea 51.65 1.00e-135 476.00
IUUC-Bra-018100 Brassica rapa 51.65 1.00e-135 476.00
IUUC-Cel-018618 Caenorhabditis elegans 66.07 4.00e-173 601.00
IUUC-Cja-019573 Callithrix jacchus 98.57 0.00e+00 805.00
IUUC-Cfa-021111 Canis familiaris 97.15 0.00e+00 827.00
IUUC-Cpo-022206 Cavia porcellus 98.18 0.00e+00 879.00
IUUC-Cre-022876 Chlamydomonas reinhardtii 54.09 6.00e-135 474.00
IUUC-Csv-026097 Ciona savignyi 78.16 0.00e+00 700.00
IUUC-Cgl-026750 Colletotrichum gloeosporioides 54.83 1.00e-134 473.00
IUUC-Dno-028876 Dasypus novemcinctus 95.68 0.00e+00 859.00
IUUC-Dor-030390 Dipodomys ordii 92.86 0.00e+00 779.00
IUUC-Dse-031305 Dothistroma septosporum 55.93 8.00e-136 477.00
IUUC-Dme-032131 Drosophila melanogaster 79.72 0.00e+00 724.00
IUUC-Fal-037650 Ficedula albicollis 91.36 0.00e+00 826.00
IUUC-Fox-037988 Fusarium oxysporum 55.89 4.00e-134 471.00
IUUC-Fso-038460 Fusarium solani 54.85 6.00e-135 474.00
IUUC-Gmo-039380 Gadus morhua 94.55 0.00e+00 847.00
IUUC-Ggr-039883 Gaeumannomyces graminis 55.30 3.00e-136 478.00
IUUC-Gga-040518 Gallus gallus 96.82 0.00e+00 867.00
IUUC-Gac-042418 Gasterosteus aculeatus 94.77 0.00e+00 846.00
IUUC-Gma-044088 Glycine max 52.31 3.00e-129 455.00
IUUC-Ggo-044426 Gorilla gorilla 100.00 0.00e+00 815.00
IUUC-Itr-048097 Ictidomys tridecemlineatus 98.10 0.00e+00 830.00
IUUC-Lch-050206 Latimeria chalumnae 95.23 0.00e+00 860.00
IUUC-Loc-052535 Lepisosteus oculatus 95.68 0.00e+00 860.00
IUUC-Lma-053162 Leptosphaeria maculans 55.37 5.00e-134 471.00
IUUC-Laf-054373 Loxodonta africana 97.38 0.00e+00 826.00
IUUC-Mcc-054713 Macaca mulatta 99.55 0.00e+00 856.00
IUUC-Meu-056756 Macropus eugenii 90.24 0.00e+00 751.00
IUUC-Mor-057270 Magnaporthe oryzae 54.97 8.00e-136 477.00
IUUC-Mpo-057327 Magnaporthe poae 55.14 2.00e-136 479.00
IUUC-Mla-059127 Melampsora laricipopulina 56.12 2.00e-148 519.00
IUUC-Mga-059678 Meleagris gallopavo 96.67 0.00e+00 823.00
IUUC-Mmr-061468 Microcebus murinus 97.73 0.00e+00 877.00
IUUC-Mmu-063311 Mus musculus 97.27 0.00e+00 871.00
IUUC-Mac-065244 Musa acuminata 51.33 3.00e-129 455.00
IUUC-Mpu-066766 Mustela putorius furo 96.90 0.00e+00 824.00
IUUC-Mlu-066933 Myotis lucifugus 97.50 0.00e+00 869.00
IUUC-Nfi-068532 Neosartorya fischeri 56.16 2.00e-134 472.00
IUUC-Ncr-068905 Neurospora crassa 55.86 2.00e-137 482.00
IUUC-Nle-069157 Nomascus leucogenys 99.52 0.00e+00 810.00
IUUC-Ont-072224 Oreochromis niloticus 95.68 0.00e+00 855.00
IUUC-Oba-075715 Oryza barthii 51.63 6.00e-135 474.00
IUUC-Ogl-077077 Oryza glaberrima 52.03 8.00e-132 463.00
IUUC-Ogu-078251 Oryza glumaepatula 51.63 8.00e-135 474.00
IUUC-Oin-079114 Oryza indica 52.14 5.00e-133 468.00
IUUC-Ome-081711 Oryza meridionalis 51.52 1.00e-133 469.00
IUUC-Oni-082387 Oryza nivara 51.32 2.00e-132 466.00
IUUC-Opu-083739 Oryza punctata 52.02 4.00e-136 478.00
IUUC-Oru-084892 Oryza rufipogon 51.63 4.00e-135 474.00
IUUC-Osa-085869 Oryza sativa 51.52 9.00e-134 470.00
IUUC-Olu-087882 Ostreococcus lucimarinus 50.72 1.00e-128 453.00
IUUC-Oga-088573 Otolemur garnettii 96.67 0.00e+00 824.00
IUUC-Ptr-090847 Pan troglodytes 100.00 0.00e+00 815.00
IUUC-Pan-092846 Papio anubis 99.55 0.00e+00 856.00
IUUC-Psi-093292 Pelodiscus sinensis 97.72 0.00e+00 870.00
IUUC-Pma-094603 Petromyzon marinus 89.18 7.00e-101 359.00
IUUC-Pno-094992 Phaeosphaeria nodorum 56.21 2.00e-136 479.00
IUUC-Ppa-095378 Physcomitrella patens 50.50 1.00e-132 466.00
IUUC-Pfo-097231 Poecilia formosa 95.68 0.00e+00 855.00
IUUC-Pab-098445 Pongo abelii 99.52 0.00e+00 811.00
IUUC-Pop-099639 Populus trichocarpa 50.30 3.00e-128 452.00
IUUC-Ppe-102006 Prunus persica 50.40 2.00e-126 446.00
IUUC-Pte-104403 Pyrenophora teres 55.72 2.00e-135 476.00
IUUC-Pyt-104776 Pyrenophora triticirepentis 55.58 1.00e-134 473.00
IUUC-Rno-105189 Rattus norvegicus 97.05 0.00e+00 871.00
IUUC-Sce-106284 Saccharomyces cerevisiae 56.46 2.00e-119 422.00
IUUC-Sha-107195 Sarcophilus harrisii 95.77 0.00e+00 794.00
IUUC-Spo-108186 Schizosaccharomyces pombe 56.52 2.00e-135 475.00
IUUC-Smo-109077 Selaginella moellendorffii 53.14 3.00e-135 475.00
IUUC-Sit-110289 Setaria italica 52.14 2.00e-132 466.00
IUUC-Sly-111422 Solanum lycopersicum 51.31 4.00e-130 458.00
IUUC-Stu-111999 Solanum tuberosum 49.43 2.00e-125 442.00
IUUC-Sbi-114402 Sorghum bicolor 51.81 2.00e-133 469.00
IUUC-Tru-118028 Takifugu rubripes 95.45 0.00e+00 853.00
IUUC-Tni-119681 Tetraodon nigroviridis 95.45 0.00e+00 853.00
IUUC-Tca-121708 Theobroma cacao 51.51 8.00e-130 457.00
IUUC-Tre-122188 Trichoderma reesei 56.05 1.00e-133 470.00
IUUC-Tvi-122271 Trichoderma virens 55.79 3.00e-135 475.00
IUUC-Tae-124558 Triticum aestivum 51.62 8.00e-133 467.00
IUUC-Tbe-127340 Tupaia belangeri 93.10 0.00e+00 780.00
IUUC-Ttr-129227 Tursiops truncatus 95.24 0.00e+00 812.00
IUUC-Vda-130007 Verticillium dahliae 54.97 6.00e-135 474.00
IUUC-Xma-133068 Xiphophorus maculatus 95.91 0.00e+00 857.00
IUUC-Zma-135945 Zea mays 51.69 4.00e-133 468.00
Created Date 25-Jun-2017

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