iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059319

Ensembl Protein ID

ENSMGAP00000013378.1

UniProt Accession

G1NJ86; G1NJ86_MELGA

Protein Name

Estrogen receptor; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000012692.1	ENSMGAT00000014284.1	ENSMGAP00000013378.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	79.29	0.00e+00	875.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Meleagris gallopavo

Functional Description
(View)

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.

Protein Sequence
(Fasta)

MTMTLHTKAS GVTLLHQIQG TELETLSRPQ LKIPLERSLS DMYVESNKTG VFNYPEGATY 60
DFGTTAPVYG STTLSYAPTS ESFGSSSLAG FHSLNNVPPS PVVFLQTAPQ LSPFIHHHNQ 120

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Nucleotide Sequence
(Fasta)

TGTGCCTTTC CAGTGCTCAC CCTGCATTTA TTTGTATACT CCTCCTTGCT GAGATCATAG 60
GAATACCTGT GTAGTGCTGC TTTATTTATT ATGATTTCTG CTGAGTCTCA GACTAAGTTC 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0446--Lipid-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0754--Steroid-binding
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00543--OESTROGENR
PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0030284--F:estrogen receptor activity
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0008584--P:male gonad development
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0010628--P:positive regulation of gene expression
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	85.56	0.00e+00	734.00
IUUC-Apl-003688	Anas platyrhynchos	98.50	0.00e+00	1001.00
IUUC-Aca-005222	Anolis carolinensis	83.36	0.00e+00	960.00
IUUC-Ame-010731	Astyanax mexicanus	51.65	2.00e-139	488.00
IUUC-Bta-013112	Bos taurus	74.71	0.00e+00	838.00
IUUC-Cja-019408	Callithrix jacchus	80.20	0.00e+00	882.00
IUUC-Cfa-020694	Canis familiaris	78.29	0.00e+00	860.00
IUUC-Cpo-021426	Cavia porcellus	75.21	0.00e+00	823.00
IUUC-Csa-023736	Chlorocebus sabaeus	84.41	0.00e+00	789.00
IUUC-Dre-027698	Danio rerio	51.62	3.00e-139	488.00
IUUC-Dno-029477	Dasypus novemcinctus	80.89	0.00e+00	724.00
IUUC-Dor-030572	Dipodomys ordii	84.94	0.00e+00	703.00
IUUC-Ete-032849	Echinops telfairi	62.55	2.00e-170	591.00
IUUC-Eca-033605	Equus caballus	75.84	0.00e+00	839.00
IUUC-Eeu-034683	Erinaceus europaeus	84.11	1.00e-99	356.00
IUUC-Fca-035928	Felis catus	87.84	0.00e+00	731.00
IUUC-Fal-036754	Ficedula albicollis	96.77	0.00e+00	1120.00
IUUC-Gmo-038872	Gadus morhua	54.25	1.00e-113	402.00
IUUC-Gga-040988	Gallus gallus	99.32	0.00e+00	1125.00
IUUC-Gac-042015	Gasterosteus aculeatus	65.51	2.00e-129	455.00
IUUC-Ggo-044749	Gorilla gorilla	80.14	0.00e+00	877.00
IUUC-Hsa-046944	Homo sapiens	79.29	0.00e+00	865.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	79.03	0.00e+00	874.00
IUUC-Loc-052414	Lepisosteus oculatus	60.60	0.00e+00	687.00
IUUC-Mcc-054781	Macaca mulatta	80.31	0.00e+00	878.00
IUUC-Meu-056232	Macropus eugenii	82.54	0.00e+00	923.00
IUUC-Mmr-061636	Microcebus murinus	74.18	9.00e-143	499.00
IUUC-Mdo-062661	Monodelphis domestica	84.41	0.00e+00	946.00
IUUC-Mmu-063330	Mus musculus	77.13	0.00e+00	843.00
IUUC-Mpu-065757	Mustela putorius furo	77.09	0.00e+00	872.00
IUUC-Mlu-067712	Myotis lucifugus	79.49	0.00e+00	785.00
IUUC-Nle-069283	Nomascus leucogenys	79.29	0.00e+00	849.00
IUUC-Opr-070391	Ochotona princeps	77.95	0.00e+00	886.00
IUUC-Ont-071369	Oreochromis niloticus	51.37	3.00e-124	438.00
IUUC-Oan-073734	Ornithorhynchus anatinus	72.89	2.00e-130	457.00
IUUC-Ocu-074292	Oryctolagus cuniculus	79.76	0.00e+00	879.00
IUUC-Oba-075103	Oryza barthii	26.92	1.10e-02	34.30
IUUC-Ogu-079042	Oryza glumaepatula	26.92	3.00e-03	36.60
IUUC-Olo-080944	Oryza longistaminata	26.92	4.00e-03	34.30
IUUC-Oni-082560	Oryza nivara	26.92	8.00e-03	35.00
IUUC-Ola-087052	Oryzias latipes	53.31	5.00e-134	471.00
IUUC-Oga-088586	Otolemur garnettii	78.80	0.00e+00	854.00
IUUC-Oar-090156	Ovis aries	78.67	0.00e+00	749.00
IUUC-Ptr-091321	Pan troglodytes	80.14	0.00e+00	877.00
IUUC-Pan-092851	Papio anubis	80.14	0.00e+00	876.00
IUUC-Psi-093434	Pelodiscus sinensis	87.78	0.00e+00	1026.00
IUUC-Pfo-097379	Poecilia formosa	57.32	3.00e-139	488.00
IUUC-Pab-097735	Pongo abelii	79.97	0.00e+00	874.00
IUUC-Pva-102125	Pteropus vampyrus	78.15	0.00e+00	867.00
IUUC-Rno-106121	Rattus norvegicus	77.17	0.00e+00	844.00
IUUC-Sha-107547	Sarcophilus harrisii	84.58	0.00e+00	946.00
IUUC-Sar-113650	Sorex araneus	68.99	5.00e-160	556.00
IUUC-Tgu-117175	Taeniopygia guttata	96.94	0.00e+00	1122.00
IUUC-Tru-117545	Takifugu rubripes	53.04	1.00e-142	500.00
IUUC-Tsy-119586	Tarsius syrichta	69.83	0.00e+00	743.00
IUUC-Tni-120121	Tetraodon nigroviridis	51.89	2.00e-144	505.00
IUUC-Tbe-127548	Tupaia belangeri	74.10	6.00e-169	587.00
IUUC-Ttr-128374	Tursiops truncatus	71.64	0.00e+00	758.00
IUUC-Vpa-130464	Vicugna pacos	75.14	5.00e-141	493.00
IUUC-Xtr-132171	Xenopus tropicalis	76.44	0.00e+00	818.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence