iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090156

Ensembl Protein ID

ENSOARP00000003565.1

UniProt Accession

W5NZG7; W5NZG7_SHEEP

Genbank Protein ID

ENSOARP00000003565

Protein Name

Estrogen receptor

Genbank Nucleotide ID

AMGL01108383

Gene Name

ESR1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000003344.1	ENSOART00000003629.1	ENSOARP00000003565.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/UMI	91.05	0.00e+00	814.00	IUUC-Hsa-046944

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Ovis aries

Protein Sequence
(Fasta)

MVKERLETAG NTGSGVFLVH KADASPFLAL LSTGQIGKLG DQLSWFPARP NSDNRRQGGR 60
ERLASTSDKG SMAMESAKET RYCAVCNDYA SGYHYGVWSC EGCKAFFKRS IQGHNDYMCP 120

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Nucleotide Sequence
(Fasta)

ATGGTTAAGG AGAGGCTAGA AACTGCAGGA AACACAGGCA GTGGAGTGTT CCTGGTGCAC 60
AAAGCTGATG CTTCCCCTTT TCTTGCTTTG CTGTCAACAG GTCAGATTGG CAAGTTGGGT 120

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Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0675--Receptor
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000536--Nucl_hrmn_rcpt_lig-bd
IPR001723--Nuclear_hrmn_rcpt
IPR024178--Oest_rcpt/oest-rel_rcp
IPR001292--Oestr_rcpt
IPR024736--Oestrogen-typ_rcpt_final_C_dom
IPR001628--Znf_hrmn_rcpt
IPR013088--Znf_NHR/GATA

PROSITE

PS00031--NUCLEAR_REC_DBD_1
PS51030--NUCLEAR_REC_DBD_2

Pfam

PF12743--ESR1_C
PF00104--Hormone_recep
PF02159--Oest_recep
PF00105--zf-C4

PRINTS

PR00398--STRDHORMONER
PR00047--STROIDFINGER

SMART

SM00430--HOLI
SM00399--ZnF_C4

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000790--C:nuclear chromatin
GO:0005886--C:plasma membrane
GO:0035327--C:transcriptionally active chromatin
GO:0003682--F:chromatin binding
GO:0001046--F:core promoter sequence-specific DNA binding
GO:0034056--F:estrogen response element binding
GO:0000978--F:RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0038052--F:RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
GO:0005496--F:steroid binding
GO:0001077--F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0008270--F:zinc ion binding
GO:0008209--P:androgen metabolic process
GO:0001547--P:antral ovarian follicle growth
GO:0071392--P:cellular response to estradiol stimulus
GO:0071391--P:cellular response to estrogen stimulus
GO:0002064--P:epithelial cell development
GO:0060750--P:epithelial cell proliferation involved in mammary gland duct elongation
GO:0008584--P:male gonad development
GO:0060749--P:mammary gland alveolus development
GO:0060745--P:mammary gland branching involved in pregnancy
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:1903799--P:negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048146--P:positive regulation of fibroblast proliferation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060527--P:prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060523--P:prostate epithelial cord elongation
GO:0071168--P:protein localization to chromatin
GO:0042981--P:regulation of apoptotic process
GO:0060687--P:regulation of branching involved in prostate gland morphogenesis
GO:0050727--P:regulation of inflammatory response
GO:0034121--P:regulation of toll-like receptor signaling pathway
GO:0060065--P:uterus development
GO:0060068--P:vagina development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001925	Ailuropoda melanoleuca	93.08	0.00e+00	805.00
IUUC-Apl-003688	Anas platyrhynchos	80.52	0.00e+00	633.00
IUUC-Aca-005222	Anolis carolinensis	82.54	0.00e+00	689.00
IUUC-Ame-010731	Astyanax mexicanus	58.70	5.00e-128	451.00
IUUC-Bta-013112	Bos taurus	98.21	0.00e+00	845.00
IUUC-Cja-019408	Callithrix jacchus	91.95	0.00e+00	791.00
IUUC-Cfa-020694	Canis familiaris	91.72	0.00e+00	789.00
IUUC-Cpo-021426	Cavia porcellus	85.01	0.00e+00	736.00
IUUC-Csa-023736	Chlorocebus sabaeus	91.95	0.00e+00	788.00
IUUC-Dre-027698	Danio rerio	60.93	9.00e-127	447.00
IUUC-Dno-029477	Dasypus novemcinctus	88.36	0.00e+00	725.00
IUUC-Dor-030572	Dipodomys ordii	88.34	0.00e+00	738.00
IUUC-Ete-032849	Echinops telfairi	82.08	7.00e-169	587.00
IUUC-Eca-033605	Equus caballus	91.26	0.00e+00	787.00
IUUC-Eeu-034683	Erinaceus europaeus	90.65	2.00e-109	389.00
IUUC-Fca-035928	Felis catus	91.29	0.00e+00	783.00
IUUC-Fal-036754	Ficedula albicollis	78.22	0.00e+00	709.00
IUUC-Gmo-038872	Gadus morhua	55.77	2.00e-110	392.00
IUUC-Gga-040988	Gallus gallus	78.26	0.00e+00	694.00
IUUC-Gac-042015	Gasterosteus aculeatus	62.27	1.00e-125	443.00
IUUC-Ggo-044749	Gorilla gorilla	91.72	0.00e+00	788.00
IUUC-Hsa-046944	Homo sapiens	91.05	0.00e+00	780.00
IUUC-Itr-048863	Ictidomys tridecemlineatus	91.28	0.00e+00	786.00
IUUC-Loc-052414	Lepisosteus oculatus	67.91	1.00e-158	553.00
IUUC-Mcc-054781	Macaca mulatta	91.72	0.00e+00	787.00
IUUC-Meu-056232	Macropus eugenii	89.01	0.00e+00	749.00
IUUC-Mga-059319	Meleagris gallopavo	78.67	0.00e+00	698.00
IUUC-Mmr-061636	Microcebus murinus	93.58	3.00e-114	404.00
IUUC-Mdo-062661	Monodelphis domestica	89.71	0.00e+00	766.00
IUUC-Mmu-063330	Mus musculus	89.49	0.00e+00	734.00
IUUC-Mpu-065757	Mustela putorius furo	91.98	0.00e+00	788.00
IUUC-Mlu-067712	Myotis lucifugus	90.60	0.00e+00	773.00
IUUC-Nle-069283	Nomascus leucogenys	91.95	0.00e+00	788.00
IUUC-Opr-070391	Ochotona princeps	88.59	0.00e+00	803.00
IUUC-Ont-071369	Oreochromis niloticus	54.75	3.00e-114	405.00
IUUC-Oan-073734	Ornithorhynchus anatinus	71.30	5.00e-129	453.00
IUUC-Ocu-074292	Oryctolagus cuniculus	91.50	0.00e+00	786.00
IUUC-Oba-075103	Oryza barthii	28.21	6.00e-03	35.40
IUUC-Ogu-079042	Oryza glumaepatula	28.21	2.00e-03	37.70
IUUC-Olo-080944	Oryza longistaminata	25.00	2.00e-03	35.40
IUUC-Oni-082560	Oryza nivara	28.21	5.00e-03	35.80
IUUC-Ola-087052	Oryzias latipes	52.18	1.00e-120	427.00
IUUC-Oga-088586	Otolemur garnettii	90.62	0.00e+00	783.00
IUUC-Ptr-091321	Pan troglodytes	91.95	0.00e+00	789.00
IUUC-Pan-092851	Papio anubis	91.72	0.00e+00	787.00
IUUC-Psi-093434	Pelodiscus sinensis	79.33	0.00e+00	753.00
IUUC-Pfo-097379	Poecilia formosa	57.02	8.00e-127	447.00
IUUC-Pab-097735	Pongo abelii	91.95	0.00e+00	789.00
IUUC-Pva-102125	Pteropus vampyrus	88.37	0.00e+00	753.00
IUUC-Rno-106121	Rattus norvegicus	89.71	0.00e+00	735.00
IUUC-Sha-107547	Sarcophilus harrisii	89.04	0.00e+00	756.00
IUUC-Spo-108346	Schizosaccharomyces pombe	41.18	2.10e+00	25.80
IUUC-Sar-113650	Sorex araneus	86.21	6.00e-125	440.00
IUUC-Tgu-117175	Taeniopygia guttata	78.63	0.00e+00	711.00
IUUC-Tru-117545	Takifugu rubripes	61.70	4.00e-129	455.00
IUUC-Tsy-119586	Tarsius syrichta	95.42	2.00e-168	585.00
IUUC-Tni-120121	Tetraodon nigroviridis	59.09	2.00e-129	456.00
IUUC-Tbe-127548	Tupaia belangeri	80.94	0.00e+00	630.00
IUUC-Ttr-128374	Tursiops truncatus	88.37	0.00e+00	744.00
IUUC-Vpa-130464	Vicugna pacos	82.61	9.00e-157	546.00
IUUC-Xtr-132171	Xenopus tropicalis	75.39	6.00e-172	597.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence