iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ggo-045444

Ensembl Protein ID

ENSGGOP00000023833.1

UniProt Accession

G3S6X6; G3S6X6_GORGO

Protein Name

E3 ubiquitin-protein ligase

Gene Name

SIAH1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000000938.2	ENSGGOT00000000945.2	ENSGGOP00000023833.1

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	81.96	2.00e-125	446.00	IUUC-Dme-031700
E3 activity/RING/RING	100.00	0.00e+00	655.00	IUUC-Hsa-046357
E3 activity/RING/RING	99.65	8.00e-169	590.00	IUUC-Mmu-064129

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Gorilla gorilla

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MTGKATPPSL YSWRGVLFTC LPAARTRKRK EMSRQTATAL PTGTSKCPPS QRVPALTGTT 60
ASNNDLASLF ECPVCFDYVL PPILQCQSGH LVCSNCRPKL TCCPTCRGPL GSIRNLAMEK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGCTCAG GGAGCGCACT TCCTTCTCAG CCAGCGCGTC GCCCCCTGCA TCCGTGGCCT 60
CCACCGGAGC TGGGCAGGAG CCTACCCAGT GAATCTGGAG AAAACAAACT TGGGAGACAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR018121--7-in-absentia-prot_TRAF-dom
IPR004162--SINA-like
IPR008974--TRAF-like
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR013010--Znf_SIAH

PROSITE

PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF03145--Sina

Gene Ontology

GO:0030877--C:beta-catenin destruction complex
GO:0005634--C:nucleus
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007275--P:multicellular organism development
GO:2001244--P:positive regulation of intrinsic apoptotic signaling pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ggo:101149013

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000061	Aegilops tauschii	37.09	2.00e-44	172.00
IUUC-Aml-001186	Ailuropoda melanoleuca	97.76	0.00e+00	638.00
IUUC-Atr-002857	Amborella trichopoda	36.19	2.00e-44	172.00
IUUC-Apl-003813	Anas platyrhynchos	99.65	6.00e-170	589.00
IUUC-Aca-005014	Anolis carolinensis	99.65	1.00e-170	591.00
IUUC-Aly-006207	Arabidopsis lyrata	33.94	1.00e-41	163.00
IUUC-Ath-007049	Arabidopsis thaliana	32.87	4.00e-42	164.00
IUUC-Ame-011196	Astyanax mexicanus	88.34	5.00e-171	593.00
IUUC-Bta-012887	Bos taurus	97.44	0.00e+00	637.00
IUUC-Bdi-014200	Brachypodium distachyon	37.73	4.00e-45	174.00
IUUC-Bol-016263	Brassica oleracea	33.57	2.00e-42	166.00
IUUC-Bra-016910	Brassica rapa	36.82	3.00e-41	162.00
IUUC-Cel-018320	Caenorhabditis elegans	61.98	2.00e-114	405.00
IUUC-Cja-019796	Callithrix jacchus	99.04	0.00e+00	649.00
IUUC-Cfa-020642	Canis familiaris	96.30	4.00e-172	596.00
IUUC-Cpo-022348	Cavia porcellus	100.00	1.00e-170	591.00
IUUC-Csa-023974	Chlorocebus sabaeus	100.00	0.00e+00	655.00
IUUC-Cin-025674	Ciona intestinalis	78.01	9.00e-135	472.00
IUUC-Csv-026233	Ciona savignyi	84.25	4.00e-132	463.00
IUUC-Dre-028041	Danio rerio	88.34	1.00e-171	595.00
IUUC-Dno-029764	Dasypus novemcinctus	99.65	2.00e-170	591.00
IUUC-Dme-031700	Drosophila melanogaster	83.87	7.00e-120	423.00
IUUC-Ete-032423	Echinops telfairi	99.25	1.00e-159	555.00
IUUC-Eca-033536	Equus caballus	99.65	6.00e-170	589.00
IUUC-Eeu-035314	Erinaceus europaeus	95.70	6.00e-160	556.00
IUUC-Fca-035362	Felis catus	97.76	0.00e+00	641.00
IUUC-Fal-037487	Ficedula albicollis	94.89	2.00e-179	620.00
IUUC-Gga-040269	Gallus gallus	99.65	6.00e-170	589.00
IUUC-Gac-042282	Gasterosteus aculeatus	97.52	1.00e-167	582.00
IUUC-Gma-042926	Glycine max	34.44	1.00e-40	159.00
IUUC-Hsa-046357	Homo sapiens	100.00	0.00e+00	655.00
IUUC-Hvu-047574	Hordeum vulgare	36.73	2.00e-44	172.00
IUUC-Itr-048046	Ictidomys tridecemlineatus	100.00	1.00e-170	591.00
IUUC-Lch-049504	Latimeria chalumnae	98.94	5.00e-169	586.00
IUUC-Lpe-050879	Leersia perrieri	40.25	1.00e-42	166.00
IUUC-Loc-052191	Lepisosteus oculatus	98.94	7.00e-170	589.00
IUUC-Laf-053668	Loxodonta africana	99.65	6.00e-170	589.00
IUUC-Mcc-054640	Macaca mulatta	100.00	0.00e+00	655.00
IUUC-Mtr-058747	Medicago truncatula	34.81	4.00e-42	165.00
IUUC-Mga-059503	Meleagris gallopavo	95.62	1.00e-170	591.00
IUUC-Mmr-060794	Microcebus murinus	100.00	1.00e-170	591.00
IUUC-Mmu-064129	Mus musculus	99.65	4.00e-170	590.00
IUUC-Mac-065670	Musa acuminata	35.44	2.00e-42	166.00
IUUC-Mpu-066488	Mustela putorius furo	97.76	0.00e+00	638.00
IUUC-Mlu-067207	Myotis lucifugus	99.65	6.00e-171	592.00
IUUC-Nle-069706	Nomascus leucogenys	99.36	0.00e+00	653.00
IUUC-Ont-071849	Oreochromis niloticus	97.53	2.00e-168	584.00
IUUC-Ocu-074876	Oryctolagus cuniculus	98.08	0.00e+00	642.00
IUUC-Oba-075454	Oryza barthii	40.66	1.00e-42	166.00
IUUC-Obr-076037	Oryza brachyantha	35.43	2.00e-40	159.00
IUUC-Ogl-077712	Oryza glaberrima	40.66	1.00e-42	166.00
IUUC-Ogu-078910	Oryza glumaepatula	40.66	1.00e-42	167.00
IUUC-Oin-079749	Oryza indica	40.66	1.00e-42	166.00
IUUC-Olo-080244	Oryza longistaminata	35.43	3.00e-40	159.00
IUUC-Ome-081318	Oryza meridionalis	40.66	1.00e-42	166.00
IUUC-Oni-083109	Oryza nivara	40.66	1.00e-42	166.00
IUUC-Opu-084065	Oryza punctata	41.08	6.00e-43	167.00
IUUC-Oru-084785	Oryza rufipogon	40.66	1.00e-42	166.00
IUUC-Osa-085610	Oryza sativa	40.66	1.00e-42	166.00
IUUC-Ola-086814	Oryzias latipes	97.52	1.00e-167	582.00
IUUC-Oga-088399	Otolemur garnettii	100.00	1.00e-170	591.00
IUUC-Oar-089323	Ovis aries	96.81	0.00e+00	632.00
IUUC-Ptr-090692	Pan troglodytes	100.00	3.00e-171	593.00
IUUC-Pan-092012	Papio anubis	100.00	0.00e+00	655.00
IUUC-Psi-093687	Pelodiscus sinensis	95.24	2.00e-180	624.00
IUUC-Pma-094387	Petromyzon marinus	93.66	2.00e-160	557.00
IUUC-Ppa-095212	Physcomitrella patens	36.19	6.00e-41	160.00
IUUC-Pfo-097134	Poecilia formosa	97.52	1.00e-167	582.00
IUUC-Pab-097555	Pongo abelii	100.00	0.00e+00	655.00
IUUC-Pop-099970	Populus trichocarpa	34.90	3.00e-44	171.00
IUUC-Ppe-101760	Prunus persica	36.10	7.00e-44	170.00
IUUC-Rno-104866	Rattus norvegicus	99.65	4.00e-170	590.00
IUUC-Sha-106547	Sarcophilus harrisii	97.12	0.00e+00	634.00
IUUC-Smo-109412	Selaginella moellendorffii	33.91	5.00e-40	157.00
IUUC-Sit-110595	Setaria italica	37.45	1.00e-41	163.00
IUUC-Sly-111259	Solanum lycopersicum	38.04	3.00e-41	162.00
IUUC-Stu-112571	Solanum tuberosum	38.04	3.00e-41	162.00
IUUC-Sbi-114090	Sorghum bicolor	37.11	3.00e-42	165.00
IUUC-Tgu-116579	Taeniopygia guttata	99.65	6.00e-170	589.00
IUUC-Tru-118250	Takifugu rubripes	92.91	2.00e-158	551.00
IUUC-Tni-120488	Tetraodon nigroviridis	97.16	3.00e-164	570.00
IUUC-Tca-121228	Theobroma cacao	35.50	3.00e-41	161.00
IUUC-Tae-123647	Triticum aestivum	37.09	2.00e-44	172.00
IUUC-Tur-126259	Triticum urartu	34.88	7.00e-39	154.00
IUUC-Ttr-129166	Tursiops truncatus	99.17	4.00e-143	500.00
IUUC-Vvi-131233	Vitis vinifera	34.60	1.00e-42	166.00
IUUC-Xtr-132553	Xenopus tropicalis	99.29	3.00e-170	590.00
IUUC-Xma-133670	Xiphophorus maculatus	97.52	1.00e-167	582.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence