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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063875
Ensembl Protein ID ENSMUSP00000118491.1
UniProt Accession Q8CBW3; Q3U8V0; Q60747; Q91ZM5; Q923I9; Q99KH4; ABI1_MOUSE
Genbank Protein ID AAL16036.1; AAK59381.1; BAC28722.1; BAE30917.1; BAE31015.1; BAE30044.1; AAH04657.1; AAB00373.1
Protein Name Abl interactor 1; Abelson interactor 1; Ablphilin-1; Eps8 SH3 domain-binding protein; Spectrin SH3 domain-binding protein 1; e3B1
Genbank Nucleotide ID AF420251; AY033645; AK034476; AK152061; AK152184; AK151026; BC004657; U17698
Gene Name Abi1; Ssh3bp1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000058835.14 ENSMUST00000123948.7 ENSMUSP00000118491.1
ENSMUSG00000058835.14 ENSMUST00000091394.12 ENSMUSP00000088957.6
ENSMUSG00000058835.14 ENSMUST00000114544.9 ENSMUSP00000110191.3
ENSMUSG00000058835.14 ENSMUST00000153931.7 ENSMUSP00000120769.1
ENSMUSG00000058835.14 ENSMUST00000078977.13 ENSMUSP00000077997.7
ENSMUSG00000058835.14 ENSMUST00000093171.12 ENSMUSP00000090860.6
ENSMUSG00000058835.14 ENSMUST00000139038.7 ENSMUSP00000116093.1
ENSMUSG00000058835.14 ENSMUST00000140164.7 ENSMUSP00000120462.1
ENSMUSG00000058835.14 ENSMUST00000149719.7 ENSMUSP00000120621.1
ENSMUSG00000058835.14 ENSMUST00000126112.7 ENSMUSP00000117335.1
ENSMUSG00000058835.14 ENSMUST00000178908.1 ENSMUSP00000136846.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.10e-14 55.2 422 476
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           ekv ++ydy+  +ddeL++k+G +++vi  +++d gW +g    +   GlfP n+ve +
   Q: 422  EKVVAIYDYTKDKDDELSFKEGAIIYVI--KKNDDGWFEG--VCNRVTGLFPGNYVESI 476
           789*************************..99********..79************987 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
 May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons.
Protein Sequence
(Fasta)
MAELQMLLEE EIPSGKRALI ESYQNLTRVA DYCENNYIQA TDKRKALEET KAYTTQSLAS 60
VAYQINALAN NVLQLLDIQA SQLRRMESSI NHISQTVDIH KEKVARREIG ILTTNKNTSR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063875|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGTGGGGGGG AGGAGGCGGG GAGAGTAAGG AGGAAGAGGA GGAGGTGCAG TCCCACAATA 60
CCCGGCGGAG GGAGGGTGGG TGGTTGGCGT CTGGTCTGTG CGGAGCTCGG GTCCCCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063875|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0472--Membrane
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0628--Postsynaptic cell membrane
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
Interpro

IPR028457--ABI
IPR028456--ABI1/ABI2
IPR012849--Abl-interactor_HHR_dom
IPR001452--SH3_domain
IPR000727--T_SNARE_dom
PROSITE

PS50002--SH3
PS50192--T_SNARE
Pfam

PF07815--Abi_HHR
PF00018--SH3_1
PRINTS

PR00452--SH3DOMAIN
SMART

SM00326--SH3
Gene Ontology

GO:0031252--C:cell leading edge
GO:0005913--C:cell-cell adherens junction
GO:0005856--C:cytoskeleton
GO:0070062--C:extracellular exosome
GO:0030175--C:filopodium
GO:0030426--C:growth cone
GO:0005622--C:intracellular
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:0014069--C:postsynaptic density
GO:0045211--C:postsynaptic membrane
GO:0031209--C:SCAR complex
GO:0098641--F:cadherin binding involved in cell-cell adhesion
GO:0032403--F:protein complex binding
GO:0030296--F:protein tyrosine kinase activator activity
GO:0017124--F:SH3 domain binding
GO:0008154--P:actin polymerization or depolymerization
GO:0048813--P:dendrite morphogenesis
GO:0072673--P:lamellipodium morphogenesis
GO:0035855--P:megakaryocyte development
GO:0018108--P:peptidyl-tyrosine phosphorylation
GO:0001756--P:somitogenesis
KEGG mmu:11308
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001375 Ailuropoda melanoleuca 90.96 0.00e+00 716.00
IUUC-Apl-003291 Anas platyrhynchos 89.59 0.00e+00 704.00
IUUC-Aca-004955 Anolis carolinensis 94.18 0.00e+00 643.00
IUUC-Cja-019099 Callithrix jacchus 92.32 0.00e+00 735.00
IUUC-Cfa-020201 Canis familiaris 92.13 0.00e+00 734.00
IUUC-Cpo-021955 Cavia porcellus 96.88 0.00e+00 721.00
IUUC-Csa-024155 Chlorocebus sabaeus 92.32 0.00e+00 735.00
IUUC-Cho-024588 Choloepus hoffmanni 96.67 8.00e-127 447.00
IUUC-Cin-025769 Ciona intestinalis 55.88 2.00e-66 246.00
IUUC-Csv-026114 Ciona savignyi 61.29 1.00e-66 247.00
IUUC-Dre-027960 Danio rerio 78.79 2.00e-175 608.00
IUUC-Dno-029586 Dasypus novemcinctus 98.34 0.00e+00 749.00
IUUC-Ete-032286 Echinops telfairi 91.32 0.00e+00 733.00
IUUC-Eca-033716 Equus caballus 91.49 0.00e+00 655.00
IUUC-Eeu-034628 Erinaceus europaeus 74.15 2.00e-104 372.00
IUUC-Fca-036186 Felis catus 91.14 0.00e+00 720.00
IUUC-Fal-037526 Ficedula albicollis 91.30 0.00e+00 725.00
IUUC-Gmo-039109 Gadus morhua 75.36 6.00e-174 603.00
IUUC-Gga-040990 Gallus gallus 90.94 0.00e+00 726.00
IUUC-Gac-042525 Gasterosteus aculeatus 81.56 0.00e+00 673.00
IUUC-Ggo-044789 Gorilla gorilla 91.55 0.00e+00 722.00
IUUC-Hsa-045845 Homo sapiens 92.32 0.00e+00 735.00
IUUC-Itr-048893 Ictidomys tridecemlineatus 99.13 2.00e-111 395.00
IUUC-Lch-050579 Latimeria chalumnae 84.51 5.00e-146 510.00
IUUC-Loc-052683 Lepisosteus oculatus 97.75 4.00e-133 468.00
IUUC-Laf-054032 Loxodonta africana 97.51 0.00e+00 743.00
IUUC-Mcc-055180 Macaca mulatta 92.32 0.00e+00 735.00
IUUC-Mga-059287 Meleagris gallopavo 83.23 0.00e+00 629.00
IUUC-Mmr-061282 Microcebus murinus 92.32 0.00e+00 735.00
IUUC-Mdo-062996 Monodelphis domestica 97.09 0.00e+00 736.00
IUUC-Mpu-065785 Mustela putorius furo 91.91 0.00e+00 737.00
IUUC-Mlu-068146 Myotis lucifugus 95.03 0.00e+00 677.00
IUUC-Nle-070077 Nomascus leucogenys 97.09 0.00e+00 729.00
IUUC-Opr-070618 Ochotona princeps 77.61 2.00e-97 349.00
IUUC-Ont-072203 Oreochromis niloticus 80.56 0.00e+00 628.00
IUUC-Oan-073650 Ornithorhynchus anatinus 95.84 0.00e+00 732.00
IUUC-Ocu-074682 Oryctolagus cuniculus 98.13 0.00e+00 748.00
IUUC-Ola-086642 Oryzias latipes 90.38 1.00e-118 420.00
IUUC-Oga-088619 Otolemur garnettii 84.16 3.00e-152 531.00
IUUC-Oar-089983 Ovis aries 98.34 0.00e+00 749.00
IUUC-Ptr-091652 Pan troglodytes 92.13 0.00e+00 734.00
IUUC-Pan-091799 Papio anubis 98.34 0.00e+00 749.00
IUUC-Psi-093802 Pelodiscus sinensis 95.63 0.00e+00 721.00
IUUC-Pma-094746 Petromyzon marinus 64.49 1.00e-118 419.00
IUUC-Pfo-097441 Poecilia formosa 82.83 0.00e+00 640.00
IUUC-Pab-098208 Pongo abelii 98.34 0.00e+00 749.00
IUUC-Pca-100439 Procavia capensis 59.58 3.00e-70 259.00
IUUC-Pva-102520 Pteropus vampyrus 91.34 0.00e+00 720.00
IUUC-Rno-106012 Rattus norvegicus 99.58 0.00e+00 747.00
IUUC-Sha-106615 Sarcophilus harrisii 94.30 0.00e+00 638.00
IUUC-Sar-113140 Sorex araneus 84.25 0.00e+00 652.00
IUUC-Ssc-115676 Sus scrofa 97.44 1.00e-74 271.00
IUUC-Tgu-117093 Taeniopygia guttata 90.62 0.00e+00 649.00
IUUC-Tru-117869 Takifugu rubripes 81.37 0.00e+00 639.00
IUUC-Tsy-119104 Tarsius syrichta 84.86 1.00e-166 578.00
IUUC-Tni-120003 Tetraodon nigroviridis 80.28 0.00e+00 628.00
IUUC-Tbe-127508 Tupaia belangeri 87.97 0.00e+00 665.00
IUUC-Ttr-129105 Tursiops truncatus 91.06 0.00e+00 683.00
IUUC-Vda-129903 Verticillium dahliae 40.35 9.00e-07 50.10
IUUC-Vpa-130514 Vicugna pacos 91.06 0.00e+00 637.00
IUUC-Xtr-131805 Xenopus tropicalis 82.28 0.00e+00 688.00
Created Date 25-Jun-2017

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